FDX1 (ferredoxin 1)

2014-11-01 Affiliation

Identity

HGNC

FDX1

LOCATION

11q22.3

LOCUSID

2230

ALIAS

ADX,FDX,LOH11CR1D

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 2230
MIM: 103260
HGNC: 3638
Ensembl: ENSG00000137714

Variants:

dbSNP: 2230
ClinVar: 2230
TCGA: ENSG00000137714
COSMIC: FDX1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000137714	ENST00000260270	P10109

Expression (GTEx)

100

150

200

250

300

350

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Disease	REACTOME	R-HSA-1643685
Diseases of metabolism	REACTOME	R-HSA-5668914
Metabolic disorders of biological oxidation enzymes	REACTOME	R-HSA-5579029
Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)	REACTOME	R-HSA-5579026
Metabolism	REACTOME	R-HSA-1430728
Metabolism of lipids and lipoproteins	REACTOME	R-HSA-556833
Metabolism of steroid hormones	REACTOME	R-HSA-196071
Pregnenolone biosynthesis	REACTOME	R-HSA-196108
Biological oxidations	REACTOME	R-HSA-211859
Phase 1 - Functionalization of compounds	REACTOME	R-HSA-211945
Cytochrome P450 - arranged by substrate type	REACTOME	R-HSA-211897
Endogenous sterols	REACTOME	R-HSA-211976
Mitochondrial iron-sulfur cluster biogenesis	REACTOME	R-HSA-1362409
Electron transport from NADPH to Ferredoxin	REACTOME	R-HSA-2395516

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
18519826	2008	Molecular genetics of successful smoking cessation: convergent genome-wide association study results.	130
20547883	2010	Humans possess two mitochondrial ferredoxins, Fdx1 and Fdx2, with distinct roles in steroidogenesis, heme, and Fe/S cluster biosynthesis.	74
21636783	2011	Structural basis for pregnenolone biosynthesis by the mitochondrial monooxygenase system.	72
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	62
22101253	2012	Both human ferredoxins 1 and 2 and ferredoxin reductase are important for iron-sulfur cluster biogenesis.	45
20689807	2010	Genetic variation and antioxidant response gene expression in the bronchial airway epithelium of smokers at risk for lung cancer.	23
20877624	2010	Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.	17
28001042	2017	Human Mitochondrial Ferredoxin 1 (FDX1) and Ferredoxin 2 (FDX2) Both Bind Cysteine Desulfurase and Donate Electrons for Iron-Sulfur Cluster Biosynthesis.	15
17188650	2007	Adrenodoxin supports reactions catalyzed by microsomal steroidogenic cytochrome P450s.	9
15927889	2005	Adrenodoxin (Adx) and CYP11A1 (P450scc) induce apoptosis by the generation of reactive oxygen species in mitochondria.	6

Citation

Dessen P

FDX1 (ferredoxin 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/63352/fdx1