Atlas of Genetics and Cytogenetics in Oncology and Haematology

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FECH (ferrochelatase)

Identity

Alias_namesferrochelatase (protoporphyria)
Other aliasEPP
EPP1
FCE
HGNC (Hugo) FECH
LocusID (NCBI) 2235
Atlas_Id 56011
Location 18q21.31  [Link to chromosome band 18q21]
Location_base_pair Starts at 57544841 and ends at 57586737 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ATP8A2 (13q12.13) / FECH (18q21.31)FECH (18q21.31) / C1orf185 (1p32.3)FECH (18q21.31) / FECH (18q21.31)
FECH (18q21.31) / NCMAP (1p36.11)HLA-B (6p21.33) / FECH (18q21.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(1;18)(p36;q21) FECH/NCMAP

External links

Nomenclature
HGNC (Hugo)FECH   3647
LRG (Locus Reference Genomic)LRG_1080
Cards
Entrez_Gene (NCBI)FECH  2235  ferrochelatase
AliasesEPP; EPP1; FCE
GeneCards (Weizmann)FECH
Ensembl hg19 (Hinxton)ENSG00000066926 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000066926 [Gene_View]  ENSG00000066926 [Sequence]  chr18:57544841-57586737 [Contig_View]  FECH [Vega]
ICGC DataPortalENSG00000066926
TCGA cBioPortalFECH
AceView (NCBI)FECH
Genatlas (Paris)FECH
WikiGenes2235
SOURCE (Princeton)FECH
Genetics Home Reference (NIH)FECH
Genomic and cartography
GoldenPath hg38 (UCSC)FECH  -     chr18:57544841-57586737 -  18q21.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FECH  -     18q21.31   [Description]    (hg19-Feb_2009)
EnsemblFECH - 18q21.31 [CytoView hg19]  FECH - 18q21.31 [CytoView hg38]
Mapping of homologs : NCBIFECH [Mapview hg19]  FECH [Mapview hg38]
OMIM177000   612386   
Gene and transcription
Genbank (Entrez)AI767430 AJ709747 AK092416 AK223190 AK292937
RefSeq transcript (Entrez)NM_000140 NM_001012515
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FECH
Cluster EST : UnigeneHs.365365 [ NCBI ]
CGAP (NCI)Hs.365365
Alternative Splicing GalleryENSG00000066926
Gene ExpressionFECH [ NCBI-GEO ]   FECH [ EBI - ARRAY_EXPRESS ]   FECH [ SEEK ]   FECH [ MEM ]
Gene Expression Viewer (FireBrowse)FECH [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2235
GTEX Portal (Tissue expression)FECH
Human Protein AtlasENSG00000066926-FECH [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP22830   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP22830  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP22830
Splice isoforms : SwissVarP22830
Catalytic activity : Enzyme4.99.1.1 [ Enzyme-Expasy ]   4.99.1.14.99.1.1 [ IntEnz-EBI ]   4.99.1.1 [ BRENDA ]   4.99.1.1 [ KEGG ]   
PhosPhoSitePlusP22830
Domaine pattern : Prosite (Expaxy)FERROCHELATASE (PS00534)   
Domains : Interpro (EBI)Ferrochelatase    Ferrochelatase_AS    Ferrochelatase_C    Ferrochelatase_N   
Domain families : Pfam (Sanger)Ferrochelatase (PF00762)   
Domain families : Pfam (NCBI)pfam00762   
Conserved Domain (NCBI)FECH
DMDM Disease mutations2235
Blocks (Seattle)FECH
PDB (SRS)1HRK    2HRC    2HRE    2PNJ    2PO5    2PO7    2QD1    2QD2    2QD3    2QD4    2QD5    3AQI    3HCN    3HCO    3HCP    3HCR    3W1W    4F4D    4KLA    4KLC    4KLR    4KMM    4MK4   
PDB (PDBSum)1HRK    2HRC    2HRE    2PNJ    2PO5    2PO7    2QD1    2QD2    2QD3    2QD4    2QD5    3AQI    3HCN    3HCO    3HCP    3HCR    3W1W    4F4D    4KLA    4KLC    4KLR    4KMM    4MK4   
PDB (IMB)1HRK    2HRC    2HRE    2PNJ    2PO5    2PO7    2QD1    2QD2    2QD3    2QD4    2QD5    3AQI    3HCN    3HCO    3HCP    3HCR    3W1W    4F4D    4KLA    4KLC    4KLR    4KMM    4MK4   
PDB (RSDB)1HRK    2HRC    2HRE    2PNJ    2PO5    2PO7    2QD1    2QD2    2QD3    2QD4    2QD5    3AQI    3HCN    3HCO    3HCP    3HCR    3W1W    4F4D    4KLA    4KLC    4KLR    4KMM    4MK4   
Structural Biology KnowledgeBase1HRK    2HRC    2HRE    2PNJ    2PO5    2PO7    2QD1    2QD2    2QD3    2QD4    2QD5    3AQI    3HCN    3HCO    3HCP    3HCR    3W1W    4F4D    4KLA    4KLC    4KLR    4KMM    4MK4   
SCOP (Structural Classification of Proteins)1HRK    2HRC    2HRE    2PNJ    2PO5    2PO7    2QD1    2QD2    2QD3    2QD4    2QD5    3AQI    3HCN    3HCO    3HCP    3HCR    3W1W    4F4D    4KLA    4KLC    4KLR    4KMM    4MK4   
CATH (Classification of proteins structures)1HRK    2HRC    2HRE    2PNJ    2PO5    2PO7    2QD1    2QD2    2QD3    2QD4    2QD5    3AQI    3HCN    3HCO    3HCP    3HCR    3W1W    4F4D    4KLA    4KLC    4KLR    4KMM    4MK4   
SuperfamilyP22830
Human Protein Atlas [tissue]ENSG00000066926-FECH [tissue]
Peptide AtlasP22830
HPRD01509
IPIIPI00027776   IPI00554589   
Protein Interaction databases
DIP (DOE-UCLA)P22830
IntAct (EBI)P22830
FunCoupENSG00000066926
BioGRIDFECH
STRING (EMBL)FECH
ZODIACFECH
Ontologies - Pathways
QuickGOP22830
Ontology : AmiGOferrochelatase activity  ferrochelatase activity  ferrochelatase activity  protein binding  mitochondrion  mitochondrial inner membrane  mitochondrial matrix  generation of precursor metabolites and energy  heme biosynthetic process  heme biosynthetic process  ferrous iron binding  response to light stimulus  response to lead ion  response to insecticide  response to ethanol  protoporphyrinogen IX metabolic process  response to arsenic-containing substance  2 iron, 2 sulfur cluster binding  response to methylmercury  response to platinum ion  cellular response to dexamethasone stimulus  
Ontology : EGO-EBIferrochelatase activity  ferrochelatase activity  ferrochelatase activity  protein binding  mitochondrion  mitochondrial inner membrane  mitochondrial matrix  generation of precursor metabolites and energy  heme biosynthetic process  heme biosynthetic process  ferrous iron binding  response to light stimulus  response to lead ion  response to insecticide  response to ethanol  protoporphyrinogen IX metabolic process  response to arsenic-containing substance  2 iron, 2 sulfur cluster binding  response to methylmercury  response to platinum ion  cellular response to dexamethasone stimulus  
Pathways : KEGGPorphyrin and chlorophyll metabolism   
NDEx NetworkFECH
Atlas of Cancer Signalling NetworkFECH
Wikipedia pathwaysFECH
Orthology - Evolution
OrthoDB2235
GeneTree (enSembl)ENSG00000066926
Phylogenetic Trees/Animal Genes : TreeFamFECH
HOVERGENP22830
HOGENOMP22830
Homologs : HomoloGeneFECH
Homology/Alignments : Family Browser (UCSC)FECH
Gene fusions - Rearrangements
Fusion : QuiverFECH
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFECH [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FECH
dbVarFECH
ClinVarFECH
1000_GenomesFECH 
Exome Variant ServerFECH
ExAC (Exome Aggregation Consortium)ENSG00000066926
GNOMAD BrowserENSG00000066926
Varsome BrowserFECH
Genetic variants : HAPMAP2235
Genomic Variants (DGV)FECH [DGVbeta]
DECIPHERFECH [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFECH 
Mutations
ICGC Data PortalFECH 
TCGA Data PortalFECH 
Broad Tumor PortalFECH
OASIS PortalFECH [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFECH  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFECH
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch FECH
DgiDB (Drug Gene Interaction Database)FECH
DoCM (Curated mutations)FECH (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FECH (select a term)
intoGenFECH
Cancer3DFECH(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM177000    612386   
Orphanet11304   
DisGeNETFECH
MedgenFECH
Genetic Testing Registry FECH
NextProtP22830 [Medical]
TSGene2235
GENETestsFECH
Target ValidationFECH
Huge Navigator FECH [HugePedia]
snp3D : Map Gene to Disease2235
BioCentury BCIQFECH
ClinGenFECH
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2235
Chemical/Pharm GKB GenePA28087
Clinical trialFECH
Miscellaneous
canSAR (ICR)FECH (select the gene name)
Probes
Litterature
PubMed109 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFECH
EVEXFECH
GoPubMedFECH
iHOPFECH
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Aug 27 11:22:50 CEST 2018
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