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FER (FER tyrosine kinase)

Identity

Alias (NCBI)PPP1R74
TYK3
p94-Fer
HGNC (Hugo) FER
HGNC Alias symbTYK3
PPP1R74
HGNC Alias namephosphoprotein NCP94
 protein phosphatase 1, regulatory subunit 74
HGNC Previous namefer (fps/fes related) tyrosine kinase
LocusID (NCBI) 2241
Atlas_Id 40544
Location 5q21.3  [Link to chromosome band 5q21]
Location_base_pair Starts at 108747897 and ends at 109196840 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PJA2 (5q21.3) / FER (5q21.3)SSBP2 (5q14.1) / FER (5q21.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(5;5)(q14;q21) SSBP2/FER


External links

 

Nomenclature
HGNC (Hugo)FER   3655
Cards
Entrez_Gene (NCBI)FER    FER tyrosine kinase
AliasesPPP1R74; TYK3; p94-Fer
GeneCards (Weizmann)FER
Ensembl hg19 (Hinxton)ENSG00000151422 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000151422 [Gene_View]  ENSG00000151422 [Sequence]  chr5:108747897-109196840 [Contig_View]  FER [Vega]
ICGC DataPortalENSG00000151422
TCGA cBioPortalFER
AceView (NCBI)FER
Genatlas (Paris)FER
SOURCE (Princeton)FER
Genetics Home Reference (NIH)FER
Genomic and cartography
GoldenPath hg38 (UCSC)FER  -     chr5:108747897-109196840 +  5q21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FER  -     5q21.3   [Description]    (hg19-Feb_2009)
GoldenPathFER - 5q21.3 [CytoView hg19]  FER - 5q21.3 [CytoView hg38]
ImmunoBaseENSG00000151422
Genome Data Viewer NCBIFER [Mapview hg19]  
OMIM176942   
Gene and transcription
Genbank (Entrez)AK021888 AK092320 AK123847 AK293376 AK296874
RefSeq transcript (Entrez)NM_001308028 NM_001308031 NM_001308038 NM_005246
Consensus coding sequences : CCDS (NCBI)FER
Gene ExpressionFER [ NCBI-GEO ]   FER [ EBI - ARRAY_EXPRESS ]   FER [ SEEK ]   FER [ MEM ]
Gene Expression Viewer (FireBrowse)FER [ Firebrowse - Broad ]
GenevisibleExpression of FER in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2241
GTEX Portal (Tissue expression)FER
Human Protein AtlasENSG00000151422-FER [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP16591   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP16591  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP16591
Catalytic activity : Enzyme2.7.10.2 [ Enzyme-Expasy ]   2.7.10.22.7.10.2 [ IntEnz-EBI ]   2.7.10.2 [ BRENDA ]   2.7.10.2 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusP16591
Domaine pattern : Prosite (Expaxy)F_BAR (PS51741)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)    SH2 (PS50001)   
Domains : Interpro (EBI)AH/BAR_dom_sf    F_BAR    FCH_dom    Fer    Fer_F-BAR    Fes/Fps/Fer_SH2    Kinase-like_dom_sf    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser-Thr/Tyr_kinase_cat_dom    SH2    SH2_dom_sf    Tyr-prot_kinase_Fes/Fps    Tyr_kinase_AS    Tyr_kinase_cat_dom   
Domain families : Pfam (Sanger)FCH (PF00611)    PK_Tyr_Ser-Thr (PF07714)    SH2 (PF00017)   
Domain families : Pfam (NCBI)pfam00611    pfam07714    pfam00017   
Domain families : Smart (EMBL)FCH (SM00055)  SH2 (SM00252)  TyrKc (SM00219)  
Conserved Domain (NCBI)FER
PDB (RSDB)2KK6    6KC4   
PDB Europe2KK6    6KC4   
PDB (PDBSum)2KK6    6KC4   
PDB (IMB)2KK6    6KC4   
Structural Biology KnowledgeBase2KK6    6KC4   
SCOP (Structural Classification of Proteins)2KK6    6KC4   
CATH (Classification of proteins structures)2KK6    6KC4   
SuperfamilyP16591
AlphaFold pdb e-kbP16591   
Human Protein Atlas [tissue]ENSG00000151422-FER [tissue]
HPRD01491
Protein Interaction databases
DIP (DOE-UCLA)P16591
IntAct (EBI)P16591
BioGRIDFER
STRING (EMBL)FER
ZODIACFER
Ontologies - Pathways
QuickGOP16591
Ontology : AmiGOmicrotubule cytoskeleton organization  chromatin  regulation of protein phosphorylation  protein tyrosine kinase activity  transmembrane receptor protein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  signaling receptor binding  epidermal growth factor receptor binding  protein binding  ATP binding  nucleus  cytoplasm  cytosol  cytosol  cell cortex  protein phosphorylation  chemotaxis  cell adhesion  transmembrane receptor protein tyrosine kinase signaling pathway  tyrosine phosphorylation of STAT protein  protein phosphatase 1 binding  cell population proliferation  positive regulation of cell population proliferation  positive regulation of cell population proliferation  lipid binding  regulation of lamellipodium assembly  regulation of fibroblast migration  actin cytoskeleton  microtubule cytoskeleton  peptidyl-tyrosine phosphorylation  cytokine-mediated signaling pathway  lamellipodium  cell junction  cell differentiation  positive regulation of cell migration  positive regulation of actin filament polymerization  extrinsic component of cytoplasmic side of plasma membrane  extrinsic component of cytoplasmic side of plasma membrane  actin cytoskeleton reorganization  response to lipopolysaccharide  cellular response to insulin stimulus  negative regulation of mast cell activation involved in immune response  substrate adhesion-dependent cell spreading  cellular response to reactive oxygen species  extracellular matrix-cell signaling  intracellular signal transduction  cellular response to macrophage colony-stimulating factor stimulus  response to platelet-derived growth factor  insulin receptor signaling pathway via phosphatidylinositol 3-kinase  Fc-epsilon receptor signaling pathway  Fc-epsilon receptor signaling pathway  Kit signaling pathway  regulation of epidermal growth factor receptor signaling pathway  regulation of mast cell degranulation  cell-cell adhesion mediated by cadherin  innate immune response  protein autophosphorylation  platelet-derived growth factor receptor signaling pathway  platelet-derived growth factor receptor signaling pathway  diapedesis  positive regulation of NF-kappaB transcription factor activity  interleukin-6-mediated signaling pathway  
Ontology : EGO-EBImicrotubule cytoskeleton organization  chromatin  regulation of protein phosphorylation  protein tyrosine kinase activity  transmembrane receptor protein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  signaling receptor binding  epidermal growth factor receptor binding  protein binding  ATP binding  nucleus  cytoplasm  cytosol  cytosol  cell cortex  protein phosphorylation  chemotaxis  cell adhesion  transmembrane receptor protein tyrosine kinase signaling pathway  tyrosine phosphorylation of STAT protein  protein phosphatase 1 binding  cell population proliferation  positive regulation of cell population proliferation  positive regulation of cell population proliferation  lipid binding  regulation of lamellipodium assembly  regulation of fibroblast migration  actin cytoskeleton  microtubule cytoskeleton  peptidyl-tyrosine phosphorylation  cytokine-mediated signaling pathway  lamellipodium  cell junction  cell differentiation  positive regulation of cell migration  positive regulation of actin filament polymerization  extrinsic component of cytoplasmic side of plasma membrane  extrinsic component of cytoplasmic side of plasma membrane  actin cytoskeleton reorganization  response to lipopolysaccharide  cellular response to insulin stimulus  negative regulation of mast cell activation involved in immune response  substrate adhesion-dependent cell spreading  cellular response to reactive oxygen species  extracellular matrix-cell signaling  intracellular signal transduction  cellular response to macrophage colony-stimulating factor stimulus  response to platelet-derived growth factor  insulin receptor signaling pathway via phosphatidylinositol 3-kinase  Fc-epsilon receptor signaling pathway  Fc-epsilon receptor signaling pathway  Kit signaling pathway  regulation of epidermal growth factor receptor signaling pathway  regulation of mast cell degranulation  cell-cell adhesion mediated by cadherin  innate immune response  protein autophosphorylation  platelet-derived growth factor receptor signaling pathway  platelet-derived growth factor receptor signaling pathway  diapedesis  positive regulation of NF-kappaB transcription factor activity  interleukin-6-mediated signaling pathway  
Pathways : KEGGAdherens junction   
NDEx NetworkFER
Atlas of Cancer Signalling NetworkFER
Wikipedia pathwaysFER
Orthology - Evolution
OrthoDB2241
GeneTree (enSembl)ENSG00000151422
Phylogenetic Trees/Animal Genes : TreeFamFER
Homologs : HomoloGeneFER
Homology/Alignments : Family Browser (UCSC)FER
Gene fusions - Rearrangements
Fusion : MitelmanSSBP2/FER [5q14.1/5q21.3]  
Fusion : QuiverFER
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFER [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FER
dbVarFER
ClinVarFER
MonarchFER
1000_GenomesFER 
Exome Variant ServerFER
GNOMAD BrowserENSG00000151422
Varsome BrowserFER
ACMGFER variants
VarityP16591
Genomic Variants (DGV)FER [DGVbeta]
DECIPHERFER [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFER 
Mutations
ICGC Data PortalFER 
TCGA Data PortalFER 
Broad Tumor PortalFER
OASIS PortalFER [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFER  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DFER
Mutations and Diseases : HGMDFER
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaFER
DgiDB (Drug Gene Interaction Database)FER
DoCM (Curated mutations)FER
CIViC (Clinical Interpretations of Variants in Cancer)FER
Cancer3DFER
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM176942   
Orphanet
DisGeNETFER
MedgenFER
Genetic Testing Registry FER
NextProtP16591 [Medical]
GENETestsFER
Target ValidationFER
Huge Navigator FER [HugePedia]
ClinGenFER
Clinical trials, drugs, therapy
MyCancerGenomeFER
Protein Interactions : CTDFER
Pharm GKB GenePA28095
PharosP16591
Clinical trialFER
Miscellaneous
canSAR (ICR)FER
HarmonizomeFER
DataMed IndexFER
Probes
Litterature
PubMed88 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXFER
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:09:20 CEST 2021

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