FERMT1 (FERM domain containing kindlin 1)

2010-03-01  

Identity

HGNC
LOCATION
20p12.3
LOCUSID
ALIAS
C20orf42,DTGCU2,KIND1,UNC112A,URP1
FUSION GENES

Other Information

Locus ID:

NCBI: 55612
MIM: 607900
HGNC: 15889
Ensembl: ENSG00000101311

Variants:

dbSNP: 55612
ClinVar: 55612
TCGA: ENSG00000101311
COSMIC: FERMT1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101311ENST00000217289Q9BQL6
ENSG00000101311ENST00000378844Q5JWV4
ENSG00000101311ENST00000536936G3V1L6

Expression (GTEx)

0
5
10
15
20
25

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
192400212009Kindlin-1 and -2 directly bind the C-terminal region of beta integrin cytoplasmic tails and exert integrin-specific activation effects.110
146340212004The Kindler syndrome protein is regulated by transforming growth factor-beta and involved in integrin-mediated adhesion.52
198047832009The structure of the N-terminus of kindlin-1: a domain important for alphaiibbeta3 integrin activation.39
203062912010A three-stage genome-wide association study of general cognitive ability: hunting the small effects.36
170127462006Kindlin-1 is a phosphoprotein involved in regulation of polarity, proliferation, and motility of epidermal keratinocytes.35
198542922010The role of kindlins in cell biology and relevance to human disease.34
185284352008Colocalization of kindlin-1, kindlin-2, and migfilin at keratinocyte focal adhesion and relevance to the pathophysiology of Kindler syndrome.27
276413292017FERMT1 mediates epithelial-mesenchymal transition to promote colon cancer metastasis via modulation of β-catenin transcriptional activity.24
197627152009Kindlin-1 Is required for RhoGTPase-mediated lamellipodia formation in keratinocytes.23
218322342011Role of the focal adhesion protein kindlin-1 in breast cancer growth and lung metastasis.22

Citation

Dessen P

FERMT1 (FERM domain containing kindlin 1)

Atlas Genet Cytogenet Oncol Haematol. 2010-03-01

Online version: http://atlasgeneticsoncology.org/gene/52820/fermt1