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FERMT2 (fermitin family member 2)

Identity

Alias_namesPLEKHC1
pleckstrin homology domain containing, family C (with FERM domain) member 1
fermitin family homolog 2 (Drosophila)
Alias_symbol (synonym)mig-2
KIND2
UNC112B
Other aliasMIG2
UNC112
HGNC (Hugo) FERMT2
LocusID (NCBI) 10979
Atlas_Id 51688
Location 14q22.1  [Link to chromosome band 14q22]
Location_base_pair Starts at 52857271 and ends at 52951097 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ERO1A (14q22.1) / FERMT2 (14q22.1)FERMT2 (14q22.1) / FERMT2 (14q22.1)FERMT2 (14q22.1) / NPM1 (5q35.1)
FERMT2 (14q22.1) / SLC1A2 (11p13)FERMT2 (14q22.1) / SMG8 (17q22)GPR137C (14q22.1) / FERMT2 (14q22.1)
ERO1L FERMT2 14q22.1GPR137C 14q22.1 / FERMT2 14q22.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)FERMT2   15767
Cards
Entrez_Gene (NCBI)FERMT2  10979  fermitin family member 2
AliasesKIND2; MIG2; PLEKHC1; UNC112; 
UNC112B; mig-2
GeneCards (Weizmann)FERMT2
Ensembl hg19 (Hinxton)ENSG00000073712 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000073712 [Gene_View]  chr14:52857271-52951097 [Contig_View]  FERMT2 [Vega]
ICGC DataPortalENSG00000073712
TCGA cBioPortalFERMT2
AceView (NCBI)FERMT2
Genatlas (Paris)FERMT2
WikiGenes10979
SOURCE (Princeton)FERMT2
Genetics Home Reference (NIH)FERMT2
Genomic and cartography
GoldenPath hg38 (UCSC)FERMT2  -     chr14:52857271-52951097 -  14q22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FERMT2  -     14q22.1   [Description]    (hg19-Feb_2009)
EnsemblFERMT2 - 14q22.1 [CytoView hg19]  FERMT2 - 14q22.1 [CytoView hg38]
Mapping of homologs : NCBIFERMT2 [Mapview hg19]  FERMT2 [Mapview hg38]
OMIM607746   
Gene and transcription
Genbank (Entrez)AF443279 AK126426 AK291738 BC011125 BC017327
RefSeq transcript (Entrez)NM_001134999 NM_001135000 NM_006832
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FERMT2
Cluster EST : UnigeneHs.509343 [ NCBI ]
CGAP (NCI)Hs.509343
Alternative Splicing GalleryENSG00000073712
Gene ExpressionFERMT2 [ NCBI-GEO ]   FERMT2 [ EBI - ARRAY_EXPRESS ]   FERMT2 [ SEEK ]   FERMT2 [ MEM ]
Gene Expression Viewer (FireBrowse)FERMT2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10979
GTEX Portal (Tissue expression)FERMT2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96AC1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96AC1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96AC1
Splice isoforms : SwissVarQ96AC1
PhosPhoSitePlusQ96AC1
Domaine pattern : Prosite (Expaxy)PH_DOMAIN (PS50003)   
Domains : Interpro (EBI)Band_41_domain    FERM/acyl-CoA-bd_prot_3-hlx    FERM_central    PH_dom-like    PH_domain   
Domain families : Pfam (Sanger)FERM_M (PF00373)    PH (PF00169)   
Domain families : Pfam (NCBI)pfam00373    pfam00169   
Domain families : Smart (EMBL)B41 (SM00295)  PH (SM00233)  
Conserved Domain (NCBI)FERMT2
DMDM Disease mutations10979
Blocks (Seattle)FERMT2
PDB (SRS)2LGX    2LKO    2MSU    4F7H   
PDB (PDBSum)2LGX    2LKO    2MSU    4F7H   
PDB (IMB)2LGX    2LKO    2MSU    4F7H   
PDB (RSDB)2LGX    2LKO    2MSU    4F7H   
Structural Biology KnowledgeBase2LGX    2LKO    2MSU    4F7H   
SCOP (Structural Classification of Proteins)2LGX    2LKO    2MSU    4F7H   
CATH (Classification of proteins structures)2LGX    2LKO    2MSU    4F7H   
SuperfamilyQ96AC1
Human Protein AtlasENSG00000073712
Peptide AtlasQ96AC1
HPRD06374
IPIIPI00000856   IPI00383500   IPI01025993   IPI01025386   IPI00913848   IPI01025304   IPI01025609   IPI01025497   IPI01024906   
Protein Interaction databases
DIP (DOE-UCLA)Q96AC1
IntAct (EBI)Q96AC1
FunCoupENSG00000073712
BioGRIDFERMT2
STRING (EMBL)FERMT2
ZODIACFERMT2
Ontologies - Pathways
QuickGOQ96AC1
Ontology : AmiGOstress fiber  protein binding  phosphatidylinositol-3,4,5-trisphosphate binding  nucleus  nucleoplasm  cytoplasm  cytosol  focal adhesion  cell cortex  cell-matrix adhesion  cell-matrix adhesion  transforming growth factor beta receptor signaling pathway  integrin-mediated signaling pathway  regulation of cell shape  cell surface  Wnt signaling pathway  extrinsic component of cytoplasmic side of plasma membrane  lamellipodium membrane  I band  filamentous actin  integrin activation  cell junction assembly  substrate adhesion-dependent cell spreading  focal adhesion assembly  protein localization to membrane  
Ontology : EGO-EBIstress fiber  protein binding  phosphatidylinositol-3,4,5-trisphosphate binding  nucleus  nucleoplasm  cytoplasm  cytosol  focal adhesion  cell cortex  cell-matrix adhesion  cell-matrix adhesion  transforming growth factor beta receptor signaling pathway  integrin-mediated signaling pathway  regulation of cell shape  cell surface  Wnt signaling pathway  extrinsic component of cytoplasmic side of plasma membrane  lamellipodium membrane  I band  filamentous actin  integrin activation  cell junction assembly  substrate adhesion-dependent cell spreading  focal adhesion assembly  protein localization to membrane  
NDEx NetworkFERMT2
Atlas of Cancer Signalling NetworkFERMT2
Wikipedia pathwaysFERMT2
Orthology - Evolution
OrthoDB10979
GeneTree (enSembl)ENSG00000073712
Phylogenetic Trees/Animal Genes : TreeFamFERMT2
HOVERGENQ96AC1
HOGENOMQ96AC1
Homologs : HomoloGeneFERMT2
Homology/Alignments : Family Browser (UCSC)FERMT2
Gene fusions - Rearrangements
Fusion : MitelmanERO1L/14q22.1 [FERMT2/del(14)(q22q22)|t(14;14)(q22;q22)]  
Fusion : MitelmanGPR137C/FERMT2 [14q22.1/14q22.1]  [t(14;14)(q22;q22)]  
Fusion: TCGAGPR137C 14q22.1 FERMT2 14q22.1 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFERMT2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FERMT2
dbVarFERMT2
ClinVarFERMT2
1000_GenomesFERMT2 
Exome Variant ServerFERMT2
ExAC (Exome Aggregation Consortium)FERMT2 (select the gene name)
Genetic variants : HAPMAP10979
Genomic Variants (DGV)FERMT2 [DGVbeta]
DECIPHERFERMT2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFERMT2 
Mutations
ICGC Data PortalFERMT2 
TCGA Data PortalFERMT2 
Broad Tumor PortalFERMT2
OASIS PortalFERMT2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFERMT2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFERMT2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FERMT2
DgiDB (Drug Gene Interaction Database)FERMT2
DoCM (Curated mutations)FERMT2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FERMT2 (select a term)
intoGenFERMT2
Cancer3DFERMT2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607746   
Orphanet
MedgenFERMT2
Genetic Testing Registry FERMT2
NextProtQ96AC1 [Medical]
TSGene10979
GENETestsFERMT2
Huge Navigator FERMT2 [HugePedia]
snp3D : Map Gene to Disease10979
BioCentury BCIQFERMT2
ClinGenFERMT2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10979
Chemical/Pharm GKB GenePA162388349
Clinical trialFERMT2
Miscellaneous
canSAR (ICR)FERMT2 (select the gene name)
Probes
Litterature
PubMed59 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFERMT2
EVEXFERMT2
GoPubMedFERMT2
iHOPFERMT2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:15:53 CEST 2017

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