FERMT2 (FERM domain containing kindlin 2)

2010-10-01 Affiliation

Identity

HGNC

FERMT2

LOCATION

14q22.1

LOCUSID

10979

ALIAS

KIND2,MIG2,PLEKHC1,UNC112,UNC112B,mig-2

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 10979
MIM: 607746
HGNC: 15767
Ensembl: ENSG00000073712

Variants:

dbSNP: 10979
ClinVar: 10979
TCGA: ENSG00000073712
COSMIC: FERMT2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000073712	ENST00000341590	Q96AC1
ENSG00000073712	ENST00000341590	A0A024R687
ENSG00000073712	ENST00000343279	Q96AC1
ENSG00000073712	ENST00000395631	Q96AC1
ENSG00000073712	ENST00000395631	A0A024R687
ENSG00000073712	ENST00000399304	Q96AC1
ENSG00000073712	ENST00000553373	Q96AC1
ENSG00000073712	ENST00000553663	H0YJB6
ENSG00000073712	ENST00000554152	H0YJ34
ENSG00000073712	ENST00000554288	G3V3J0
ENSG00000073712	ENST00000554712	G3V281
ENSG00000073712	ENST00000555692	G3V5R2
ENSG00000073712	ENST00000557562	G3V379
ENSG00000073712	ENST00000635305	A0A0U1RRM8

Expression (GTEx)

100

150

200

250

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Cell-Cell communication	REACTOME	R-HSA-1500931
Cell junction organization	REACTOME	R-HSA-446728
Cell-extracellular matrix interactions	REACTOME	R-HSA-446353

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
18458155	2008	Kindlin-2 (Mig-2): a co-activator of beta3 integrins.	147
21325030	2011	Kindlin-2 regulates podocyte adhesion and fibronectin matrix deposition through interactions with phosphoinositides and integrins.	41
22648415	2012	Spatial coordination of kindlin-2 with talin head domain in interaction with integrin β cytoplasmic tails.	37
22030399	2011	Structural basis of phosphoinositide binding to kindlin-2 protein pleckstrin homology domain in regulating integrin activation.	36
22699938	2012	Kindlin 2 forms a transcriptional complex with β-catenin and TCF4 to enhance Wnt signalling.	35
19854292	2010	The role of kindlins in cell biology and relevance to human disease.	34
20702409	2010	Tyrosine phosphorylation of integrin beta3 regulates kindlin-2 binding and integrin activation.	28
23483548	2013	Kindlin 2 promotes breast cancer invasion via epigenetic silencing of the microRNA200 gene family.	28
18528435	2008	Colocalization of kindlin-1, kindlin-2, and migfilin at keratinocyte focal adhesion and relevance to the pathophysiology of Kindler syndrome.	27
22078565	2011	Membrane binding of the N-terminal ubiquitin-like domain of kindlin-2 is crucial for its regulation of integrin activation.	27

Citation

Dessen P

FERMT2 (FERM domain containing kindlin 2)

Atlas Genet Cytogenet Oncol Haematol. 2010-10-01

Online version: http://atlasgeneticsoncology.org/gene/51688/fermt2