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FES (FES proto-oncogene, tyrosine kinase)

Identity

Other namesFPS
HGNC (Hugo) FES
LocusID (NCBI) 2242
Location 15q26.1
Location_base_pair Starts at 91428276 and ends at 91439006 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)FES   3657
Cards
Entrez_Gene (NCBI)FES  2242  FES proto-oncogene, tyrosine kinase
GeneCards (Weizmann)FES
Ensembl (Hinxton)ENSG00000182511 [Gene_View]  chr15:91428276-91439006 [Contig_View]  FES [Vega]
ICGC DataPortalENSG00000182511
cBioPortalFES
AceView (NCBI)FES
Genatlas (Paris)FES
WikiGenes2242
SOURCE (Princeton)NM_001143783 NM_001143784 NM_001143785 NM_002005
Genomic and cartography
GoldenPath (UCSC)FES  -  15q26.1   chr15:91428276-91439006 +  15q26.1   [Description]    (hg19-Feb_2009)
EnsemblFES - 15q26.1 [CytoView]
Mapping of homologs : NCBIFES [Mapview]
OMIM190030   
Gene and transcription
Genbank (Entrez)AK300595 AK300605 AK309530 AK312545 AY513654
RefSeq transcript (Entrez)NM_001143783 NM_001143784 NM_001143785 NM_002005
RefSeq genomic (Entrez)AC_000147 NC_000015 NC_018926 NG_029671 NT_010194 NW_001838222 NW_004929399
Consensus coding sequences : CCDS (NCBI)FES
Cluster EST : UnigeneHs.7636 [ NCBI ]
CGAP (NCI)Hs.7636
Alternative Splicing : Fast-db (Paris)GSHG0010157
Alternative Splicing GalleryENSG00000182511
Gene ExpressionFES [ NCBI-GEO ]     FES [ SEEK ]   FES [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP07332 (Uniprot)
NextProtP07332  [Medical]
With graphics : InterProP07332
Splice isoforms : SwissVarP07332 (Swissvar)
Catalytic activity : Enzyme2.7.10.2 [ Enzyme-Expasy ]   2.7.10.22.7.10.2 [ IntEnz-EBI ]   2.7.10.2 [ BRENDA ]   2.7.10.2 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)FCH (PS50133)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)    SH2 (PS50001)   
Domains : Interpro (EBI)FCH_dom [organisation]   Kinase-like_dom [organisation]   Prot_kinase_dom [organisation]   Protein_kinase_ATP_BS [organisation]   Ser-Thr/Tyr_kinase_cat_dom [organisation]   SH2 [organisation]   Tyr-prot_kinase_Fes/Fps [organisation]   Tyr_kinase_AS [organisation]   Tyr_kinase_cat_dom [organisation]  
Related proteins : CluSTrP07332
Domain families : Pfam (Sanger)FCH (PF00611)    Pkinase_Tyr (PF07714)    SH2 (PF00017)   
Domain families : Pfam (NCBI)pfam00611    pfam07714    pfam00017   
Domain families : Smart (EMBL)FCH (SM00055)  SH2 (SM00252)  TyrKc (SM00219)  
DMDM Disease mutations2242
Blocks (Seattle)P07332
PDB (SRS)1WQU    2DCR    3BKB    3CBL    3CD3    4DYL    4E93   
PDB (PDBSum)1WQU    2DCR    3BKB    3CBL    3CD3    4DYL    4E93   
PDB (IMB)1WQU    2DCR    3BKB    3CBL    3CD3    4DYL    4E93   
PDB (RSDB)1WQU    2DCR    3BKB    3CBL    3CD3    4DYL    4E93   
Human Protein AtlasENSG00000182511 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasP07332
HPRD01814
IPIIPI00294344   IPI01015757   IPI00658077   IPI00658126   IPI00916511   IPI00853479   IPI00979640   IPI00853554   IPI01014038   
Protein Interaction databases
DIP (DOE-UCLA)P07332
IntAct (EBI)P07332
FunCoupENSG00000182511
BioGRIDFES
InParanoidP07332
Interologous Interaction database P07332
IntegromeDBFES
STRING (EMBL)FES
Ontologies - Pathways
Ontology : AmiGOprotein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  protein binding  ATP binding  cytoplasm  Golgi apparatus  cytosol  focal adhesion  protein phosphorylation  multicellular organismal development  axon guidance  cell proliferation  regulation of cell shape  positive regulation of neuron projection development  microtubule cytoskeleton  cytoplasmic membrane-bounded vesicle  peptidyl-tyrosine phosphorylation  regulation of cell adhesion  positive regulation of microtubule polymerization  extrinsic component of cytoplasmic side of plasma membrane  cytoplasmic vesicle  immunoglobulin receptor binding  phosphatidylinositol binding  regulation of cell proliferation  regulation of mast cell degranulation  regulation of cell differentiation  positive regulation of myeloid cell differentiation  protein autophosphorylation  regulation of vesicle-mediated transport  regulation of cell motility  positive regulation of actin cytoskeleton reorganization  
Ontology : EGO-EBIprotein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  protein binding  ATP binding  cytoplasm  Golgi apparatus  cytosol  focal adhesion  protein phosphorylation  multicellular organismal development  axon guidance  cell proliferation  regulation of cell shape  positive regulation of neuron projection development  microtubule cytoskeleton  cytoplasmic membrane-bounded vesicle  peptidyl-tyrosine phosphorylation  regulation of cell adhesion  positive regulation of microtubule polymerization  extrinsic component of cytoplasmic side of plasma membrane  cytoplasmic vesicle  immunoglobulin receptor binding  phosphatidylinositol binding  regulation of cell proliferation  regulation of mast cell degranulation  regulation of cell differentiation  positive regulation of myeloid cell differentiation  protein autophosphorylation  regulation of vesicle-mediated transport  regulation of cell motility  positive regulation of actin cytoskeleton reorganization  
Pathways : KEGGAxon guidance   
Protein Interaction DatabaseFES
Wikipedia pathwaysFES
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)FES
snp3D : Map Gene to Disease2242
SNP (GeneSNP Utah)FES
SNP : HGBaseFES
Genetic variants : HAPMAPFES
Exome VariantFES
1000_GenomesFES 
ICGC programENSG00000182511 
Somatic Mutations in Cancer : COSMICFES 
CONAN: Copy Number AnalysisFES 
Mutations and Diseases : HGMDFES
Genomic VariantsFES  FES [DGVbeta]
dbVarFES
ClinVarFES
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM190030   
MedgenFES
GENETestsFES
Disease Genetic AssociationFES
Huge Navigator FES [HugePedia]  FES [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneFES
Homology/Alignments : Family Browser (UCSC)FES
Phylogenetic Trees/Animal Genes : TreeFamFES
Chemical/Protein Interactions : CTD2242
Chemical/Pharm GKB GenePA28098
Clinical trialFES
Cancer Resource (Charite)ENSG00000182511
Other databases
Probes
Litterature
PubMed83 Pubmed reference(s) in Entrez
CoreMineFES
iHOPFES
OncoSearchFES
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jul 30 13:54:25 CEST 2014

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