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FES (FES proto-oncogene, tyrosine kinase)

Identity

Other namesFPS
HGNC (Hugo) FES
LocusID (NCBI) 2242
Location 15q26.1
Location_base_pair Starts at 91428276 and ends at 91439006 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)FES   3657
Cards
Entrez_Gene (NCBI)FES  2242  FES proto-oncogene, tyrosine kinase
GeneCards (Weizmann)FES
Ensembl hg19 (Hinxton)ENSG00000182511 [Gene_View]  chr15:91428276-91439006 [Contig_View]  FES [Vega]
Ensembl hg38 (Hinxton)ENSG00000182511 [Gene_View]  chr15:91428276-91439006 [Contig_View]  FES [Vega]
ICGC DataPortalENSG00000182511
cBioPortalFES
AceView (NCBI)FES
Genatlas (Paris)FES
WikiGenes2242
SOURCE (Princeton)FES
Genomic and cartography
GoldenPath hg19 (UCSC)FES  -     chr15:91428276-91439006 +  15q26.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)FES  -     15q26.1   [Description]    (hg38-Dec_2013)
EnsemblFES - 15q26.1 [CytoView hg19]  FES - 15q26.1 [CytoView hg38]
Mapping of homologs : NCBIFES [Mapview hg19]  FES [Mapview hg38]
OMIM190030   
Gene and transcription
Genbank (Entrez)AK300595 AK300605 AK309530 AK312545 AY513654
RefSeq transcript (Entrez)NM_001143783 NM_001143784 NM_001143785 NM_002005
RefSeq genomic (Entrez)AC_000147 NC_000015 NC_018926 NG_029671 NT_010194 NW_001838222 NW_004929399
Consensus coding sequences : CCDS (NCBI)FES
Cluster EST : UnigeneHs.7636 [ NCBI ]
CGAP (NCI)Hs.7636
Alternative Splicing : Fast-db (Paris)GSHG0010157
Alternative Splicing GalleryENSG00000182511
Gene ExpressionFES [ NCBI-GEO ]     FES [ SEEK ]   FES [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP07332 (Uniprot)
NextProtP07332  [Medical]
With graphics : InterProP07332
Splice isoforms : SwissVarP07332 (Swissvar)
Catalytic activity : Enzyme2.7.10.2 [ Enzyme-Expasy ]   2.7.10.22.7.10.2 [ IntEnz-EBI ]   2.7.10.2 [ BRENDA ]   2.7.10.2 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)FCH (PS50133)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)    SH2 (PS50001)   
Domains : Interpro (EBI)FCH_dom    Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser-Thr/Tyr_kinase_cat_dom    SH2    Tyr-prot_kinase_Fes/Fps    Tyr_kinase_AS    Tyr_kinase_cat_dom   
Related proteins : CluSTrP07332
Domain families : Pfam (Sanger)FCH (PF00611)    Pkinase_Tyr (PF07714)    SH2 (PF00017)   
Domain families : Pfam (NCBI)pfam00611    pfam07714    pfam00017   
Domain families : Smart (EMBL)FCH (SM00055)  SH2 (SM00252)  TyrKc (SM00219)  
DMDM Disease mutations2242
Blocks (Seattle)P07332
PDB (SRS)1WQU    2DCR    3BKB    3CBL    3CD3    4DYL    4E93   
PDB (PDBSum)1WQU    2DCR    3BKB    3CBL    3CD3    4DYL    4E93   
PDB (IMB)1WQU    2DCR    3BKB    3CBL    3CD3    4DYL    4E93   
PDB (RSDB)1WQU    2DCR    3BKB    3CBL    3CD3    4DYL    4E93   
Human Protein AtlasENSG00000182511
Peptide AtlasP07332
HPRD01814
IPIIPI00294344   IPI01015757   IPI00658077   IPI00658126   IPI00916511   IPI00853479   IPI00979640   IPI00853554   IPI01014038   
Protein Interaction databases
DIP (DOE-UCLA)P07332
IntAct (EBI)P07332
FunCoupENSG00000182511
BioGRIDFES
IntegromeDBFES
STRING (EMBL)FES
Ontologies - Pathways
QuickGOP07332
Ontology : AmiGOprotein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  protein binding  ATP binding  cytoplasm  Golgi apparatus  cytosol  focal adhesion  protein phosphorylation  multicellular organismal development  axon guidance  cell proliferation  regulation of cell shape  positive regulation of neuron projection development  microtubule cytoskeleton  cytoplasmic membrane-bounded vesicle  peptidyl-tyrosine phosphorylation  regulation of cell adhesion  positive regulation of microtubule polymerization  extrinsic component of cytoplasmic side of plasma membrane  cytoplasmic vesicle  immunoglobulin receptor binding  phosphatidylinositol binding  regulation of cell proliferation  regulation of mast cell degranulation  regulation of cell differentiation  positive regulation of myeloid cell differentiation  protein autophosphorylation  regulation of vesicle-mediated transport  regulation of cell motility  positive regulation of actin cytoskeleton reorganization  
Ontology : EGO-EBIprotein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  protein binding  ATP binding  cytoplasm  Golgi apparatus  cytosol  focal adhesion  protein phosphorylation  multicellular organismal development  axon guidance  cell proliferation  regulation of cell shape  positive regulation of neuron projection development  microtubule cytoskeleton  cytoplasmic membrane-bounded vesicle  peptidyl-tyrosine phosphorylation  regulation of cell adhesion  positive regulation of microtubule polymerization  extrinsic component of cytoplasmic side of plasma membrane  cytoplasmic vesicle  immunoglobulin receptor binding  phosphatidylinositol binding  regulation of cell proliferation  regulation of mast cell degranulation  regulation of cell differentiation  positive regulation of myeloid cell differentiation  protein autophosphorylation  regulation of vesicle-mediated transport  regulation of cell motility  positive regulation of actin cytoskeleton reorganization  
Pathways : KEGGAxon guidance   
Protein Interaction DatabaseFES
DoCM (Curated mutations)FES
Wikipedia pathwaysFES
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerFES [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FES
dbVarFES
ClinVarFES
1000_GenomesFES 
Exome Variant ServerFES
SNP (GeneSNP Utah)FES
SNP : HGBaseFES
Genetic variants : HAPMAPFES
Genomic VariantsFES  FES [DGVbeta]
Mutations
ICGC Data PortalENSG00000182511 
Somatic Mutations in Cancer : COSMICFES 
CONAN: Copy Number AnalysisFES 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)15:91428276-91439006
Mutations and Diseases : HGMDFES
OMIM190030   
MedgenFES
NextProtP07332 [Medical]
GENETestsFES
Disease Genetic AssociationFES
Huge Navigator FES [HugePedia]  FES [HugeCancerGEM]
snp3D : Map Gene to Disease2242
DGIdb (Drug Gene Interaction db)FES
General knowledge
Homologs : HomoloGeneFES
Homology/Alignments : Family Browser (UCSC)FES
Phylogenetic Trees/Animal Genes : TreeFamFES
Chemical/Protein Interactions : CTD2242
Chemical/Pharm GKB GenePA28098
Clinical trialFES
Cancer Resource (Charite)ENSG00000182511
Other databases
Probes
Litterature
PubMed83 Pubmed reference(s) in Entrez
CoreMineFES
GoPubMedFES
iHOPFES
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2014Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Dec 20 21:34:18 CET 2014

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