FES (FES proto-oncogene, tyrosine kinase)

2003-02-01  

Identity

HGNC
LOCATION
15q26.1
LOCUSID
ALIAS
FPS

Other Information

Locus ID:

NCBI: 2242
MIM: 190030
HGNC: 3657
Ensembl: ENSG00000182511

Variants:

dbSNP: 2242
ClinVar: 2242
TCGA: ENSG00000182511
COSMIC: FES

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000182511ENST00000328850P07332
ENSG00000182511ENST00000328850A0A024RC92
ENSG00000182511ENST00000394300P07332
ENSG00000182511ENST00000394302E7ENM8
ENSG00000182511ENST00000414248P07332
ENSG00000182511ENST00000416779C9J3W6
ENSG00000182511ENST00000443697E9PGC7
ENSG00000182511ENST00000444422P07332
ENSG00000182511ENST00000452243E7EMJ7
ENSG00000182511ENST00000464684E9PIJ7
ENSG00000182511ENST00000470152H0YNT6
ENSG00000182511ENST00000559355H0YNN8

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Axon guidanceKEGGhsa04360
Signal TransductionREACTOMER-HSA-162582
Signaling by SCF-KITREACTOMER-HSA-1433557
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Semaphorin interactionsREACTOMER-HSA-373755
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesionREACTOMER-HSA-399955
Sema3A PAK dependent Axon repulsionREACTOMER-HSA-399954
CRMPs in Sema3A signalingREACTOMER-HSA-399956

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
187753122008Structural coupling of SH2-kinase domains links Fes and Abl substrate recognition and kinase activation.90
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
119947472002Closing in on the biological functions of Fps/Fes and Fer.72
198651122010Mutual exclusion of ASXL1 and NPM1 mutations in a series of acute myeloid leukemias.34
180464542008Spatial recruitment and activation of the Fes kinase by ezrin promotes HGF-induced cell scattering.26
154859042004The human c-Fes tyrosine kinase binds tubulin and microtubules through separate domains and promotes microtubule assembly.20
175953342007The tyrosine kinase FES is an essential effector of KITD816V proliferation signal.17
190010852009Contributions of F-BAR and SH2 domains of Fes protein tyrosine kinase for coupling to the FcepsilonRI pathway in mast cells.13
157137452005Pigment epithelium-derived factor inhibits fibroblast-growth-factor-2-induced capillary morphogenesis of endothelial cells through Fyn.11
164556512006A growth-suppressive function for the c-fes protein-tyrosine kinase in colorectal cancer.11

Citation

Dessen P

FES (FES proto-oncogene, tyrosine kinase)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40546/fes