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FES (FES proto-oncogene, tyrosine kinase)

Identity

Alias (NCBI)FPS
HGNC (Hugo) FES
HGNC Alias symbFPS
HGNC Alias nameOncogene FES, feline sarcoma virus
 c-fes/fps protein
HGNC Previous namefeline sarcoma (Snyder-Theilen) viral (v-fes)/Fujinami avian sarcoma (PRCII) viral (v-fps) oncogene homolog
 feline sarcoma oncogene
LocusID (NCBI) 2242
Atlas_Id 40546
Location 15q26.1  [Link to chromosome band 15q26]
Location_base_pair Starts at 90884504 and ends at 90895776 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  Primary cutaneous CD30+ anaplastic large cell lymphoma


External links

 

Nomenclature
HGNC (Hugo)FES   3657
Cards
Entrez_Gene (NCBI)FES    FES proto-oncogene, tyrosine kinase
AliasesFPS
GeneCards (Weizmann)FES
Ensembl hg19 (Hinxton)ENSG00000182511 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000182511 [Gene_View]  ENSG00000182511 [Sequence]  chr15:90884504-90895776 [Contig_View]  FES [Vega]
ICGC DataPortalENSG00000182511
TCGA cBioPortalFES
AceView (NCBI)FES
Genatlas (Paris)FES
SOURCE (Princeton)FES
Genetics Home Reference (NIH)FES
Genomic and cartography
GoldenPath hg38 (UCSC)FES  -     chr15:90884504-90895776 +  15q26.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FES  -     15q26.1   [Description]    (hg19-Feb_2009)
GoldenPathFES - 15q26.1 [CytoView hg19]  FES - 15q26.1 [CytoView hg38]
ImmunoBaseENSG00000182511
Genome Data Viewer NCBIFES [Mapview hg19]  
OMIM190030   
Gene and transcription
Genbank (Entrez)AK300595 AK300605 AK309530 AK312545 AY513654
RefSeq transcript (Entrez)NM_001143783 NM_001143784 NM_001143785 NM_002005
Consensus coding sequences : CCDS (NCBI)FES
Gene ExpressionFES [ NCBI-GEO ]   FES [ EBI - ARRAY_EXPRESS ]   FES [ SEEK ]   FES [ MEM ]
Gene Expression Viewer (FireBrowse)FES [ Firebrowse - Broad ]
GenevisibleExpression of FES in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2242
GTEX Portal (Tissue expression)FES
Human Protein AtlasENSG00000182511-FES [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP07332   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP07332  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP07332
Catalytic activity : Enzyme2.7.10.2 [ Enzyme-Expasy ]   2.7.10.22.7.10.2 [ IntEnz-EBI ]   2.7.10.2 [ BRENDA ]   2.7.10.2 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusP07332
Domaine pattern : Prosite (Expaxy)F_BAR (PS51741)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)    SH2 (PS50001)   
Domains : Interpro (EBI)AH/BAR_dom_sf    F_BAR    FCH_dom    Fes/Fps/Fer_SH2    Kinase-like_dom_sf    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser-Thr/Tyr_kinase_cat_dom    SH2    SH2_dom_sf    Tyr-prot_kinase_Fes/Fps    Tyr_kinase_AS    Tyr_kinase_cat_dom   
Domain families : Pfam (Sanger)FCH (PF00611)    PK_Tyr_Ser-Thr (PF07714)    SH2 (PF00017)   
Domain families : Pfam (NCBI)pfam00611    pfam07714    pfam00017   
Domain families : Smart (EMBL)FCH (SM00055)  SH2 (SM00252)  TyrKc (SM00219)  
Conserved Domain (NCBI)FES
PDB (RSDB)1WQU    2DCR    3BKB    3CBL    3CD3    4DYL    4E93    6JMF   
PDB Europe1WQU    2DCR    3BKB    3CBL    3CD3    4DYL    4E93    6JMF   
PDB (PDBSum)1WQU    2DCR    3BKB    3CBL    3CD3    4DYL    4E93    6JMF   
PDB (IMB)1WQU    2DCR    3BKB    3CBL    3CD3    4DYL    4E93    6JMF   
Structural Biology KnowledgeBase1WQU    2DCR    3BKB    3CBL    3CD3    4DYL    4E93    6JMF   
SCOP (Structural Classification of Proteins)1WQU    2DCR    3BKB    3CBL    3CD3    4DYL    4E93    6JMF   
CATH (Classification of proteins structures)1WQU    2DCR    3BKB    3CBL    3CD3    4DYL    4E93    6JMF   
SuperfamilyP07332
AlphaFold pdb e-kbP07332   
Human Protein Atlas [tissue]ENSG00000182511-FES [tissue]
HPRD01814
Protein Interaction databases
DIP (DOE-UCLA)P07332
IntAct (EBI)P07332
BioGRIDFES
STRING (EMBL)FES
ZODIACFES
Ontologies - Pathways
QuickGOP07332
Ontology : AmiGOmicrotubule bundle formation  protein serine/threonine/tyrosine kinase activity  protein tyrosine kinase activity  protein tyrosine kinase activity  protein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  signaling receptor binding  protein binding  ATP binding  cytoplasm  Golgi apparatus  cytosol  focal adhesion  chemotaxis  centrosome cycle  cell adhesion  transmembrane receptor protein tyrosine kinase signaling pathway  microtubule binding  regulation of cell shape  positive regulation of neuron projection development  microtubule cytoskeleton  peptidyl-tyrosine phosphorylation  cell differentiation  regulation of cell adhesion  positive regulation of microtubule polymerization  extrinsic component of cytoplasmic side of plasma membrane  extrinsic component of cytoplasmic side of plasma membrane  cytoplasmic vesicle  immunoglobulin receptor binding  phosphatidylinositol binding  regulation of cell population proliferation  regulation of mast cell degranulation  regulation of mast cell degranulation  innate immune response  regulation of cell differentiation  positive regulation of myeloid cell differentiation  positive regulation of monocyte differentiation  protein autophosphorylation  regulation of vesicle-mediated transport  cellular response to vitamin D  regulation of cell motility  positive regulation of actin cytoskeleton reorganization  
Ontology : EGO-EBImicrotubule bundle formation  protein serine/threonine/tyrosine kinase activity  protein tyrosine kinase activity  protein tyrosine kinase activity  protein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  signaling receptor binding  protein binding  ATP binding  cytoplasm  Golgi apparatus  cytosol  focal adhesion  chemotaxis  centrosome cycle  cell adhesion  transmembrane receptor protein tyrosine kinase signaling pathway  microtubule binding  regulation of cell shape  positive regulation of neuron projection development  microtubule cytoskeleton  peptidyl-tyrosine phosphorylation  cell differentiation  regulation of cell adhesion  positive regulation of microtubule polymerization  extrinsic component of cytoplasmic side of plasma membrane  extrinsic component of cytoplasmic side of plasma membrane  cytoplasmic vesicle  immunoglobulin receptor binding  phosphatidylinositol binding  regulation of cell population proliferation  regulation of mast cell degranulation  regulation of mast cell degranulation  innate immune response  regulation of cell differentiation  positive regulation of myeloid cell differentiation  positive regulation of monocyte differentiation  protein autophosphorylation  regulation of vesicle-mediated transport  cellular response to vitamin D  regulation of cell motility  positive regulation of actin cytoskeleton reorganization  
Pathways : KEGGKEGG_AXON_GUIDANCE   
NDEx NetworkFES
Atlas of Cancer Signalling NetworkFES
Wikipedia pathwaysFES
Orthology - Evolution
OrthoDB2242
GeneTree (enSembl)ENSG00000182511
Phylogenetic Trees/Animal Genes : TreeFamFES
Homologs : HomoloGeneFES
Homology/Alignments : Family Browser (UCSC)FES
Gene fusions - Rearrangements
Fusion : QuiverFES
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFES [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FES
dbVarFES
ClinVarFES
MonarchFES
1000_GenomesFES 
Exome Variant ServerFES
GNOMAD BrowserENSG00000182511
Varsome BrowserFES
ACMGFES variants
VarityP07332
Genomic Variants (DGV)FES [DGVbeta]
DECIPHERFES [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFES 
Mutations
ICGC Data PortalFES 
TCGA Data PortalFES 
Broad Tumor PortalFES
OASIS PortalFES [ Somatic mutations - Copy number]
Cancer Gene: CensusFES 
Somatic Mutations in Cancer : COSMICFES  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DFES
Mutations and Diseases : HGMDFES
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaFES
DgiDB (Drug Gene Interaction Database)FES
DoCM (Curated mutations)FES
CIViC (Clinical Interpretations of Variants in Cancer)FES
Cancer3DFES
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM190030   
Orphanet
DisGeNETFES
MedgenFES
Genetic Testing Registry FES
NextProtP07332 [Medical]
GENETestsFES
Target ValidationFES
Huge Navigator FES [HugePedia]
ClinGenFES
Clinical trials, drugs, therapy
MyCancerGenomeFES
Protein Interactions : CTDFES
Pharm GKB GenePA28098
PharosP07332
Clinical trialFES
Miscellaneous
canSAR (ICR)FES
HarmonizomeFES
ARCHS4FES
DataMed IndexFES
Probes
Litterature
PubMed92 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXFES
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Thu Jan 20 12:33:30 CET 2022

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