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FES (FES proto-oncogene, tyrosine kinase)

Identity

Other namesFPS
HGNC (Hugo) FES
LocusID (NCBI) 2242
Atlas_Id 40546
Location 15q26.1  [Link to chromosome band 15q26]
Location_base_pair Starts at 91428276 and ends at 91439006 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  Primary cutaneous CD30+ anaplastic large cell lymphoma

External links

Nomenclature
HGNC (Hugo)FES   3657
Cards
Entrez_Gene (NCBI)FES  2242  FES proto-oncogene, tyrosine kinase
AliasesFPS
GeneCards (Weizmann)FES
Ensembl hg19 (Hinxton)ENSG00000182511 [Gene_View]  chr15:91428276-91439006 [Contig_View]  FES [Vega]
Ensembl hg38 (Hinxton)ENSG00000182511 [Gene_View]  chr15:91428276-91439006 [Contig_View]  FES [Vega]
ICGC DataPortalENSG00000182511
TCGA cBioPortalFES
AceView (NCBI)FES
Genatlas (Paris)FES
WikiGenes2242
SOURCE (Princeton)FES
Genomic and cartography
GoldenPath hg19 (UCSC)FES  -     chr15:91428276-91439006 +  15q26.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)FES  -     15q26.1   [Description]    (hg38-Dec_2013)
EnsemblFES - 15q26.1 [CytoView hg19]  FES - 15q26.1 [CytoView hg38]
Mapping of homologs : NCBIFES [Mapview hg19]  FES [Mapview hg38]
OMIM190030   
Gene and transcription
Genbank (Entrez)AK300595 AK300605 AK309530 AK312545 AY513654
RefSeq transcript (Entrez)NM_001143783 NM_001143784 NM_001143785 NM_002005
RefSeq genomic (Entrez)NC_000015 NC_018926 NG_029671 NT_010194 NW_004929399
Consensus coding sequences : CCDS (NCBI)FES
Cluster EST : UnigeneHs.7636 [ NCBI ]
CGAP (NCI)Hs.7636
Alternative Splicing GalleryENSG00000182511
Gene ExpressionFES [ NCBI-GEO ]   FES [ EBI - ARRAY_EXPRESS ]   FES [ SEEK ]   FES [ MEM ]
Gene Expression Viewer (FireBrowse)FES [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2242
GTEX Portal (Tissue expression)FES
Protein : pattern, domain, 3D structure
UniProt/SwissProtP07332 (Uniprot)
NextProtP07332  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP07332
Splice isoforms : SwissVarP07332 (Swissvar)
Catalytic activity : Enzyme2.7.10.2 [ Enzyme-Expasy ]   2.7.10.22.7.10.2 [ IntEnz-EBI ]   2.7.10.2 [ BRENDA ]   2.7.10.2 [ KEGG ]   
PhosPhoSitePlusP07332
Domaine pattern : Prosite (Expaxy)F_BAR (PS51741)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)    SH2 (PS50001)   
Domains : Interpro (EBI)F_BAR    FCH_dom    Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser-Thr/Tyr_kinase_cat_dom    SH2    Tyr-prot_kinase_Fes/Fps    Tyr_kinase_AS    Tyr_kinase_cat_dom   
Domain families : Pfam (Sanger)FCH (PF00611)    Pkinase_Tyr (PF07714)    SH2 (PF00017)   
Domain families : Pfam (NCBI)pfam00611    pfam07714    pfam00017   
Domain families : Smart (EMBL)FCH (SM00055)  SH2 (SM00252)  TyrKc (SM00219)  
DMDM Disease mutations2242
Blocks (Seattle)FES
PDB (SRS)1WQU    2DCR    3BKB    3CBL    3CD3    4DYL    4E93   
PDB (PDBSum)1WQU    2DCR    3BKB    3CBL    3CD3    4DYL    4E93   
PDB (IMB)1WQU    2DCR    3BKB    3CBL    3CD3    4DYL    4E93   
PDB (RSDB)1WQU    2DCR    3BKB    3CBL    3CD3    4DYL    4E93   
Structural Biology KnowledgeBase1WQU    2DCR    3BKB    3CBL    3CD3    4DYL    4E93   
SCOP (Structural Classification of Proteins)1WQU    2DCR    3BKB    3CBL    3CD3    4DYL    4E93   
CATH (Classification of proteins structures)1WQU    2DCR    3BKB    3CBL    3CD3    4DYL    4E93   
SuperfamilyP07332
Human Protein AtlasENSG00000182511
Peptide AtlasP07332
HPRD01814
IPIIPI00294344   IPI01015757   IPI00658077   IPI00658126   IPI00916511   IPI00853479   IPI00979640   IPI00853554   IPI01014038   
Protein Interaction databases
DIP (DOE-UCLA)P07332
IntAct (EBI)P07332
FunCoupENSG00000182511
BioGRIDFES
STRING (EMBL)FES
ZODIACFES
Ontologies - Pathways
QuickGOP07332
Ontology : AmiGOmicrotubule bundle formation  protein tyrosine kinase activity  protein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  protein binding  ATP binding  cytoplasm  Golgi apparatus  cytosol  focal adhesion  protein phosphorylation  chemotaxis  epidermal growth factor receptor signaling pathway  multicellular organism development  microtubule binding  cell proliferation  regulation of cell shape  positive regulation of neuron projection development  microtubule cytoskeleton  cytoplasmic, membrane-bounded vesicle  peptidyl-tyrosine phosphorylation  regulation of cell adhesion  positive regulation of microtubule polymerization  extrinsic component of cytoplasmic side of plasma membrane  cytoplasmic vesicle  immunoglobulin receptor binding  phosphatidylinositol binding  peptidyl-tyrosine autophosphorylation  regulation of cell proliferation  regulation of mast cell degranulation  innate immune response  regulation of cell differentiation  positive regulation of myeloid cell differentiation  protein autophosphorylation  centrosome organization  regulation of vesicle-mediated transport  regulation of cell motility  positive regulation of actin cytoskeleton reorganization  
Ontology : EGO-EBImicrotubule bundle formation  protein tyrosine kinase activity  protein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  protein binding  ATP binding  cytoplasm  Golgi apparatus  cytosol  focal adhesion  protein phosphorylation  chemotaxis  epidermal growth factor receptor signaling pathway  multicellular organism development  microtubule binding  cell proliferation  regulation of cell shape  positive regulation of neuron projection development  microtubule cytoskeleton  cytoplasmic, membrane-bounded vesicle  peptidyl-tyrosine phosphorylation  regulation of cell adhesion  positive regulation of microtubule polymerization  extrinsic component of cytoplasmic side of plasma membrane  cytoplasmic vesicle  immunoglobulin receptor binding  phosphatidylinositol binding  peptidyl-tyrosine autophosphorylation  regulation of cell proliferation  regulation of mast cell degranulation  innate immune response  regulation of cell differentiation  positive regulation of myeloid cell differentiation  protein autophosphorylation  centrosome organization  regulation of vesicle-mediated transport  regulation of cell motility  positive regulation of actin cytoskeleton reorganization  
Pathways : KEGGAxon guidance   
NDEx Network
Atlas of Cancer Signalling NetworkFES
Wikipedia pathwaysFES
Orthology - Evolution
OrthoDB2242
GeneTree (enSembl)ENSG00000182511
Phylogenetic Trees/Animal Genes : TreeFamFES
Homologs : HomoloGeneFES
Homology/Alignments : Family Browser (UCSC)FES
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerFES [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FES
dbVarFES
ClinVarFES
1000_GenomesFES 
Exome Variant ServerFES
ExAC (Exome Aggregation Consortium)FES (select the gene name)
Genetic variants : HAPMAP2242
Genomic Variants (DGV)FES [DGVbeta]
Mutations
ICGC Data PortalFES 
TCGA Data PortalFES 
Broad Tumor PortalFES
OASIS PortalFES [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFES 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FES
DgiDB (Drug Gene Interaction Database)FES
DoCM (Curated mutations)FES (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FES (select a term)
intoGenFES
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)15:91428276-91439006  ENSG00000182511
CONAN: Copy Number AnalysisFES 
Mutations and Diseases : HGMDFES
OMIM190030   
MedgenFES
Genetic Testing Registry FES
NextProtP07332 [Medical]
TSGene2242
GENETestsFES
Huge Navigator FES [HugePedia]
snp3D : Map Gene to Disease2242
BioCentury BCIQFES
ClinGenFES
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2242
Chemical/Pharm GKB GenePA28098
Clinical trialFES
Miscellaneous
canSAR (ICR)FES (select the gene name)
Probes
Litterature
PubMed85 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFES
EVEXFES
GoPubMedFES
iHOPFES
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 9 19:02:32 CEST 2016

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