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FEV (FEV, ETS transcription factor)

Identity

Alias_namesFEV (fifth Ewing variant)
FEV (ETS oncogene family)
Alias_symbol (synonym)Pet-1
Other aliasHSRNAFEV
PET-1
HGNC (Hugo) FEV
LocusID (NCBI) 54738
Atlas_Id 434
Location 2q35  [Link to chromosome band 2q35]
Location_base_pair Starts at 218981087 and ends at 218985657 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
EWSR1 (22q12.2) / FEV (2q35)FEV (2q35) / EWSR1 (22q12.2)FEV (2q35) / FUS (16p11.2)
FUS (16p11.2) / FEV (2q35)EWSR1 22q12.2 / FEV 2q35FUS 16p11.2 / FEV 2q35

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(16;21)(p11;q22) FUS/ERG


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 4 ]
  Bone tumors: an overview
Soft Tissues: Ewing's tumors/Primitive neurectodermal tumors (PNET)
Soft tissue tumors: an overview
Soft Tissues: Ewing's tumors/Primitive neurectodermal tumor with t(16;21)(p11;q22) FUS/ERG


External links

Nomenclature
HGNC (Hugo)FEV   18562
Cards
Entrez_Gene (NCBI)FEV  54738  FEV, ETS transcription factor
AliasesHSRNAFEV; PET-1
GeneCards (Weizmann)FEV
Ensembl hg19 (Hinxton)ENSG00000163497 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000163497 [Gene_View]  chr2:218981087-218985657 [Contig_View]  FEV [Vega]
ICGC DataPortalENSG00000163497
TCGA cBioPortalFEV
AceView (NCBI)FEV
Genatlas (Paris)FEV
WikiGenes54738
SOURCE (Princeton)FEV
Genetics Home Reference (NIH)FEV
Genomic and cartography
GoldenPath hg38 (UCSC)FEV  -     chr2:218981087-218985657 -  2q35   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FEV  -     2q35   [Description]    (hg19-Feb_2009)
EnsemblFEV - 2q35 [CytoView hg19]  FEV - 2q35 [CytoView hg38]
Mapping of homologs : NCBIFEV [Mapview hg19]  FEV [Mapview hg38]
OMIM607150   
Gene and transcription
Genbank (Entrez)BC023511 DQ893402 DQ896784 Y08976
RefSeq transcript (Entrez)NM_017521
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FEV
Cluster EST : UnigeneHs.234759 [ NCBI ]
CGAP (NCI)Hs.234759
Alternative Splicing GalleryENSG00000163497
Gene ExpressionFEV [ NCBI-GEO ]   FEV [ EBI - ARRAY_EXPRESS ]   FEV [ SEEK ]   FEV [ MEM ]
Gene Expression Viewer (FireBrowse)FEV [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)54738
GTEX Portal (Tissue expression)FEV
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ99581   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ99581  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ99581
Splice isoforms : SwissVarQ99581
PhosPhoSitePlusQ99581
Domaine pattern : Prosite (Expaxy)ETS_DOMAIN_1 (PS00345)    ETS_DOMAIN_2 (PS00346)    ETS_DOMAIN_3 (PS50061)   
Domains : Interpro (EBI)Ets_dom    WHTH_DNA-bd_dom   
Domain families : Pfam (Sanger)Ets (PF00178)   
Domain families : Pfam (NCBI)pfam00178   
Domain families : Smart (EMBL)ETS (SM00413)  
Conserved Domain (NCBI)FEV
DMDM Disease mutations54738
Blocks (Seattle)FEV
PDB (SRS)2YPR    3ZP5   
PDB (PDBSum)2YPR    3ZP5   
PDB (IMB)2YPR    3ZP5   
PDB (RSDB)2YPR    3ZP5   
Structural Biology KnowledgeBase2YPR    3ZP5   
SCOP (Structural Classification of Proteins)2YPR    3ZP5   
CATH (Classification of proteins structures)2YPR    3ZP5   
SuperfamilyQ99581
Human Protein AtlasENSG00000163497
Peptide AtlasQ99581
HPRD06193
IPIIPI00013984   
Protein Interaction databases
DIP (DOE-UCLA)Q99581
IntAct (EBI)Q99581
FunCoupENSG00000163497
BioGRIDFEV
STRING (EMBL)FEV
ZODIACFEV
Ontologies - Pathways
QuickGOQ99581
Ontology : AmiGORNA polymerase II transcription factor activity, sequence-specific DNA binding  transcription factor activity, sequence-specific DNA binding  transcription corepressor activity  nucleus  regulation of transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  positive regulation of gene expression  nuclear speck  cell differentiation  neuron maturation  sequence-specific DNA binding  neuron fate specification  negative regulation of nucleic acid-templated transcription  
Ontology : EGO-EBIRNA polymerase II transcription factor activity, sequence-specific DNA binding  transcription factor activity, sequence-specific DNA binding  transcription corepressor activity  nucleus  regulation of transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  positive regulation of gene expression  nuclear speck  cell differentiation  neuron maturation  sequence-specific DNA binding  neuron fate specification  negative regulation of nucleic acid-templated transcription  
Pathways : KEGGTranscriptional misregulation in cancer   
NDEx NetworkFEV
Atlas of Cancer Signalling NetworkFEV
Wikipedia pathwaysFEV
Orthology - Evolution
OrthoDB54738
GeneTree (enSembl)ENSG00000163497
Phylogenetic Trees/Animal Genes : TreeFamFEV
HOVERGENQ99581
HOGENOMQ99581
Homologs : HomoloGeneFEV
Homology/Alignments : Family Browser (UCSC)FEV
Gene fusions - Rearrangements
Fusion : MitelmanEWSR1/FEV [22q12.2/2q35]  [t(2;22)(q35;q12)]  
Fusion : MitelmanFUS/FEV [16p11.2/2q35]  [t(2;16)(q35;p11)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFEV [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FEV
dbVarFEV
ClinVarFEV
1000_GenomesFEV 
Exome Variant ServerFEV
ExAC (Exome Aggregation Consortium)FEV (select the gene name)
Genetic variants : HAPMAP54738
Genomic Variants (DGV)FEV [DGVbeta]
DECIPHERFEV [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFEV 
Mutations
ICGC Data PortalFEV 
TCGA Data PortalFEV 
Broad Tumor PortalFEV
OASIS PortalFEV [ Somatic mutations - Copy number]
Cancer Gene: CensusFEV 
Somatic Mutations in Cancer : COSMICFEV  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFEV
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FEV
DgiDB (Drug Gene Interaction Database)FEV
DoCM (Curated mutations)FEV (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FEV (select a term)
intoGenFEV
Cancer3DFEV(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607150   
Orphanet
MedgenFEV
Genetic Testing Registry FEV
NextProtQ99581 [Medical]
TSGene54738
GENETestsFEV
Target ValidationFEV
Huge Navigator FEV [HugePedia]
snp3D : Map Gene to Disease54738
BioCentury BCIQFEV
ClinGenFEV
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD54738
Chemical/Pharm GKB GenePA134875093
Clinical trialFEV
Miscellaneous
canSAR (ICR)FEV (select the gene name)
Probes
Litterature
PubMed18 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFEV
EVEXFEV
GoPubMedFEV
iHOPFEV
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:33:50 CEST 2017

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