FEZ1 (fasciculation and elongation protein zeta 1)

2004-05-01  

Identity

HGNC
FEZ1
LOCATION
11q24.2
LOCUSID
9638
ALIAS
UNC-76
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9638
MIM: 604825
HGNC: 3659
Ensembl: ENSG00000149557

Variants:

dbSNP: 9638
ClinVar: 9638
TCGA: ENSG00000149557
COSMIC: FEZ1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000149557ENST00000278919Q99689
ENSG00000149557ENST00000366139Q99689
ENSG00000149557ENST00000524435Q99689
ENSG00000149557ENST00000527534E9PNH2
ENSG00000149557ENST00000577924J3KTR6
ENSG00000149557ENST00000648911Q99689

Expression (GTEx)

0
100
200
300
400
500
600
700
800
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
185839792008Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database.395
172004142007Two binding partners cooperate to activate the molecular motor Kinesin-1.100
128746052003Disrupted-In-Schizophrenia 1, a candidate gene for schizophrenia, participates in neurite outgrowth.92
200845192010Evidence of statistical epistasis between DISC1, CIT and NDEL1 impacting risk for schizophrenia: biological validation with functional neuroimaging.41
220994592011Interaction between FEZ1 and DISC1 in regulation of neuronal development and risk for schizophrenia.39
258188062015HIV-1 capsids bind and exploit the kinesin-1 adaptor FEZ1 for inward movement to the nucleus.38
158433832005Identification of FEZ1 as a protein that interacts with JC virus agnoprotein and microtubules: role of agnoprotein-induced dissociation of FEZ1 from microtubules in viral propagation.27
192512512009Association between genes of Disrupted in schizophrenia 1 (DISC1) interactors and schizophrenia supports the role of the DISC1 pathway in the etiology of major mental illnesses.27
184705332008Age-related changes in the expression of schizophrenia susceptibility genes in the human prefrontal cortex.25
196320972009Genetic association and post-mortem brain mRNA analysis of DISC1 and related genes in schizophrenia.24

Citation

Dessen P

FEZ1 (fasciculation and elongation protein zeta 1)

Atlas Genet Cytogenet Oncol Haematol. 2004-05-01

Online version: http://atlasgeneticsoncology.org/gene/41222/fez1