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FEZ1 (fasciculation and elongation protein zeta 1)

Identity

Alias_symbol (synonym)UNC-76
Other alias
HGNC (Hugo) FEZ1
LocusID (NCBI) 9638
Atlas_Id 41222
Location 11q24.2  [Link to chromosome band 11q24]
Location_base_pair Starts at 125488200 and ends at 125496310 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
IQCJ-SCHIP1 (3q25.32) / FEZ1 (11q24.2)MBP (18q23) / FEZ1 (11q24.2)SBF2 (11p15.4) / FEZ1 (11q24.2)
SNHG1 (11q12.3) / FEZ1 (11q24.2)SBF2 11p15.4 / FEZ1 11q24.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(11;11)(p15;q24) SBF2/FEZ1

External links

Nomenclature
HGNC (Hugo)FEZ1   3659
Cards
Entrez_Gene (NCBI)FEZ1  9638  fasciculation and elongation protein zeta 1
AliasesUNC-76
GeneCards (Weizmann)FEZ1
Ensembl hg19 (Hinxton)ENSG00000149557 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000149557 [Gene_View]  ENSG00000149557 [Sequence]  chr11:125488200-125496310 [Contig_View]  FEZ1 [Vega]
ICGC DataPortalENSG00000149557
TCGA cBioPortalFEZ1
AceView (NCBI)FEZ1
Genatlas (Paris)FEZ1
WikiGenes9638
SOURCE (Princeton)FEZ1
Genetics Home Reference (NIH)FEZ1
Genomic and cartography
GoldenPath hg38 (UCSC)FEZ1  -     chr11:125488200-125496310 -  11q24.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FEZ1  -     11q24.2   [Description]    (hg19-Feb_2009)
FEZ1 - 11q24.2 [CytoView hg19]  FEZ1 - 11q24.2 [CytoView hg38]
Mapping of homologs : NCBIFEZ1 [Mapview hg19]  FEZ1 [Mapview hg38]
OMIM604825   
Gene and transcription
Genbank (Entrez)AK296554 BC009545 BM663785 CN310685 CR456817
RefSeq transcript (Entrez)NM_005103 NM_022549
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FEZ1
Cluster EST : UnigeneHs.732083 [ NCBI ]
CGAP (NCI)Hs.732083
Alternative Splicing GalleryENSG00000149557
Gene ExpressionFEZ1 [ NCBI-GEO ]   FEZ1 [ EBI - ARRAY_EXPRESS ]   FEZ1 [ SEEK ]   FEZ1 [ MEM ]
Gene Expression Viewer (FireBrowse)FEZ1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9638
GTEX Portal (Tissue expression)FEZ1
Human Protein AtlasENSG00000149557-FEZ1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ99689   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ99689  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ99689
Splice isoforms : SwissVarQ99689
PhosPhoSitePlusQ99689
Domains : Interpro (EBI)FEZ    FEZ_1   
Domain families : Pfam (Sanger)FEZ (PF07763)   
Domain families : Pfam (NCBI)pfam07763   
Conserved Domain (NCBI)FEZ1
DMDM Disease mutations9638
Blocks (Seattle)FEZ1
SuperfamilyQ99689
Human Protein Atlas [tissue]ENSG00000149557-FEZ1 [tissue]
Peptide AtlasQ99689
HPRD09212
IPIIPI00017070   IPI00910476   IPI00976322   IPI00979641   
Protein Interaction databases
DIP (DOE-UCLA)Q99689
IntAct (EBI)Q99689
FunCoupENSG00000149557
BioGRIDFEZ1
STRING (EMBL)FEZ1
ZODIACFEZ1
Ontologies - Pathways
QuickGOQ99689
Ontology : AmiGOprotein binding  cytoplasm  Golgi apparatus  microtubule organizing center  microtubule  plasma membrane  cell adhesion  nervous system development  axon guidance  axon  negative regulation of autophagosome assembly  
Ontology : EGO-EBIprotein binding  cytoplasm  Golgi apparatus  microtubule organizing center  microtubule  plasma membrane  cell adhesion  nervous system development  axon guidance  axon  negative regulation of autophagosome assembly  
NDEx NetworkFEZ1
Atlas of Cancer Signalling NetworkFEZ1
Wikipedia pathwaysFEZ1
Orthology - Evolution
OrthoDB9638
GeneTree (enSembl)ENSG00000149557
Phylogenetic Trees/Animal Genes : TreeFamFEZ1
HOGENOMQ99689
Homologs : HomoloGeneFEZ1
Homology/Alignments : Family Browser (UCSC)FEZ1
Gene fusions - Rearrangements
Fusion : MitelmanSBF2/FEZ1 [11p15.4/11q24.2]  [t(11;11)(p15;q24)]  
Fusion PortalSBF2 11p15.4 FEZ1 11q24.2 BRCA
Fusion : QuiverFEZ1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFEZ1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FEZ1
dbVarFEZ1
ClinVarFEZ1
1000_GenomesFEZ1 
Exome Variant ServerFEZ1
ExAC (Exome Aggregation Consortium)ENSG00000149557
GNOMAD BrowserENSG00000149557
Varsome BrowserFEZ1
Genetic variants : HAPMAP9638
Genomic Variants (DGV)FEZ1 [DGVbeta]
DECIPHERFEZ1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFEZ1 
Mutations
ICGC Data PortalFEZ1 
TCGA Data PortalFEZ1 
Broad Tumor PortalFEZ1
OASIS PortalFEZ1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFEZ1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFEZ1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FEZ1
DgiDB (Drug Gene Interaction Database)FEZ1
DoCM (Curated mutations)FEZ1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FEZ1 (select a term)
intoGenFEZ1
Cancer3DFEZ1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604825   
Orphanet
DisGeNETFEZ1
MedgenFEZ1
Genetic Testing Registry FEZ1
NextProtQ99689 [Medical]
TSGene9638
GENETestsFEZ1
Target ValidationFEZ1
Huge Navigator FEZ1 [HugePedia]
snp3D : Map Gene to Disease9638
BioCentury BCIQFEZ1
ClinGenFEZ1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9638
Chemical/Pharm GKB GenePA28100
Clinical trialFEZ1
Miscellaneous
canSAR (ICR)FEZ1 (select the gene name)
DataMed IndexFEZ1
Probes
Litterature
PubMed50 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFEZ1
EVEXFEZ1
GoPubMedFEZ1
iHOPFEZ1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 21 15:46:22 CET 2019
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