FFAR1 (free fatty acid receptor 1)

2007-02-01  

Identity

HGNC
FFAR1
LOCATION
19q13.12
LOCUSID
2864
ALIAS
FFA1R,GPCR40,GPR40

Other Information

Locus ID:

NCBI: 2864
MIM: 603820
HGNC: 4498
Ensembl: ENSG00000126266

Variants:

dbSNP: 2864
ClinVar: 2864
TCGA: ENSG00000126266
COSMIC: FFAR1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000126266ENST00000246553O14842

Expression (GTEx)

0
1
2
3
4
5
6
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Insulin secretionKEGGhsa04911
Metabolism of proteinsREACTOMER-HSA-392499
Peptide hormone metabolismREACTOMER-HSA-2980736
Incretin synthesis, secretion, and inactivationREACTOMER-HSA-400508
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)REACTOMER-HSA-381771
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)REACTOMER-HSA-400511
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Free fatty acid receptorsREACTOMER-HSA-444209
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907
MetabolismREACTOMER-HSA-1430728
Integration of energy metabolismREACTOMER-HSA-163685
Regulation of insulin secretionREACTOMER-HSA-422356
Free fatty acids regulate insulin secretionREACTOMER-HSA-400451
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretionREACTOMER-HSA-434316

References

Pubmed IDYearTitleCitations
126295512003Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40.358
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
250430592014High-resolution structure of the human GPR40 receptor bound to allosteric agonist TAK-875.64
194014342009Overexpression of GPR40 in pancreatic beta-cells augments glucose-stimulated insulin secretion and improves glucose tolerance in normal and diabetic mice.57
156955162005Oleate promotes the proliferation of breast cancer cells via the G protein-coupled receptor GPR40.37
176995192007Identification of residues important for agonist recognition and activation in GPR40.35
221061002012The effects of TAK-875, a selective G protein-coupled receptor 40/free fatty acid 1 agonist, on insulin and glucagon secretion in isolated rat and human islets.31
294146872018Palmitic Acid Hydroxystearic Acids Activate GPR40, Which Is Involved in Their Beneficial Effects on Glucose Homeostasis.29
285815122017Structural basis for the cooperative allosteric activation of the free fatty acid receptor GPR40.26
240359972013FFAR1 is involved in both the acute and chronic effects of palmitate on insulin secretion.21

Citation

Dessen P

FFAR1 (free fatty acid receptor 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43619/ffar1