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FFAR1 (free fatty acid receptor 1)

Identity

Alias_namesGPR40
G protein-coupled receptor 40
Alias_symbol (synonym)FFA1R
Other aliasGPCR40
HGNC (Hugo) FFAR1
LocusID (NCBI) 2864
Atlas_Id 43619
Location 19q13.12  [Link to chromosome band 19q13]
Location_base_pair Starts at 35351542 and ends at 35352464 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)FFAR1   4498
Cards
Entrez_Gene (NCBI)FFAR1  2864  free fatty acid receptor 1
AliasesFFA1R; GPCR40; GPR40
GeneCards (Weizmann)FFAR1
Ensembl hg19 (Hinxton)ENSG00000126266 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000126266 [Gene_View]  chr19:35351542-35352464 [Contig_View]  FFAR1 [Vega]
ICGC DataPortalENSG00000126266
TCGA cBioPortalFFAR1
AceView (NCBI)FFAR1
Genatlas (Paris)FFAR1
WikiGenes2864
SOURCE (Princeton)FFAR1
Genetics Home Reference (NIH)FFAR1
Genomic and cartography
GoldenPath hg38 (UCSC)FFAR1  -     chr19:35351542-35352464 +  19q13.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FFAR1  -     19q13.12   [Description]    (hg19-Feb_2009)
EnsemblFFAR1 - 19q13.12 [CytoView hg19]  FFAR1 - 19q13.12 [CytoView hg38]
Mapping of homologs : NCBIFFAR1 [Mapview hg19]  FFAR1 [Mapview hg38]
OMIM603820   
Gene and transcription
Genbank (Entrez)BC039436 BC095536 BC120943 BC120944 EF611308
RefSeq transcript (Entrez)NM_005303
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FFAR1
Cluster EST : UnigeneHs.248127 [ NCBI ]
CGAP (NCI)Hs.248127
Alternative Splicing GalleryENSG00000126266
Gene ExpressionFFAR1 [ NCBI-GEO ]   FFAR1 [ EBI - ARRAY_EXPRESS ]   FFAR1 [ SEEK ]   FFAR1 [ MEM ]
Gene Expression Viewer (FireBrowse)FFAR1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2864
GTEX Portal (Tissue expression)FFAR1
Human Protein AtlasENSG00000126266-FFAR1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO14842   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO14842  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO14842
Splice isoforms : SwissVarO14842
PhosPhoSitePlusO14842
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)GPCR_Rhodpsn    GPCR_Rhodpsn_7TM    GPR40-rel_orph    GPR40_recept_FA   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Conserved Domain (NCBI)FFAR1
DMDM Disease mutations2864
Blocks (Seattle)FFAR1
PDB (SRS)4PHU   
PDB (PDBSum)4PHU   
PDB (IMB)4PHU   
PDB (RSDB)4PHU   
Structural Biology KnowledgeBase4PHU   
SCOP (Structural Classification of Proteins)4PHU   
CATH (Classification of proteins structures)4PHU   
SuperfamilyO14842
Human Protein Atlas [tissue]ENSG00000126266-FFAR1 [tissue]
Peptide AtlasO14842
HPRD04822
IPIIPI00024206   
Protein Interaction databases
DIP (DOE-UCLA)O14842
IntAct (EBI)O14842
FunCoupENSG00000126266
BioGRIDFFAR1
STRING (EMBL)FFAR1
ZODIACFFAR1
Ontologies - Pathways
QuickGOO14842
Ontology : AmiGOG-protein coupled receptor activity  guanyl-nucleotide exchange factor activity  plasma membrane  plasma membrane  integral component of plasma membrane  G-protein coupled receptor signaling pathway  lipid binding  insulin secretion  positive regulation of insulin secretion  glucose homeostasis  positive regulation of GTPase activity  bioactive lipid receptor activity  positive regulation of calcium ion transport  response to fatty acid  
Ontology : EGO-EBIG-protein coupled receptor activity  guanyl-nucleotide exchange factor activity  plasma membrane  plasma membrane  integral component of plasma membrane  G-protein coupled receptor signaling pathway  lipid binding  insulin secretion  positive regulation of insulin secretion  glucose homeostasis  positive regulation of GTPase activity  bioactive lipid receptor activity  positive regulation of calcium ion transport  response to fatty acid  
Pathways : KEGGInsulin secretion   
NDEx NetworkFFAR1
Atlas of Cancer Signalling NetworkFFAR1
Wikipedia pathwaysFFAR1
Orthology - Evolution
OrthoDB2864
GeneTree (enSembl)ENSG00000126266
Phylogenetic Trees/Animal Genes : TreeFamFFAR1
HOVERGENO14842
HOGENOMO14842
Homologs : HomoloGeneFFAR1
Homology/Alignments : Family Browser (UCSC)FFAR1
Gene fusions - Rearrangements
Fusion: Tumor Portal FFAR1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFFAR1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FFAR1
dbVarFFAR1
ClinVarFFAR1
1000_GenomesFFAR1 
Exome Variant ServerFFAR1
ExAC (Exome Aggregation Consortium)ENSG00000126266
GNOMAD BrowserENSG00000126266
Genetic variants : HAPMAP2864
Genomic Variants (DGV)FFAR1 [DGVbeta]
DECIPHERFFAR1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFFAR1 
Mutations
ICGC Data PortalFFAR1 
TCGA Data PortalFFAR1 
Broad Tumor PortalFFAR1
OASIS PortalFFAR1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFFAR1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFFAR1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FFAR1
DgiDB (Drug Gene Interaction Database)FFAR1
DoCM (Curated mutations)FFAR1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FFAR1 (select a term)
intoGenFFAR1
Cancer3DFFAR1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603820   
Orphanet
MedgenFFAR1
Genetic Testing Registry FFAR1
NextProtO14842 [Medical]
TSGene2864
GENETestsFFAR1
Target ValidationFFAR1
Huge Navigator FFAR1 [HugePedia]
snp3D : Map Gene to Disease2864
BioCentury BCIQFFAR1
ClinGenFFAR1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2864
Chemical/Pharm GKB GenePA28887
Clinical trialFFAR1
Miscellaneous
canSAR (ICR)FFAR1 (select the gene name)
Probes
Litterature
PubMed57 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFFAR1
EVEXFFAR1
GoPubMedFFAR1
iHOPFFAR1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Nov 9 12:49:57 CET 2017

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