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FFAR4 (free fatty acid receptor 4)

Identity

Alias (NCBI)BMIQ10
GPR120
GPR129
GT01
O3FAR1
PGR4
HGNC (Hugo) FFAR4
HGNC Alias symbPGR4
HGNC Previous nameGPR129
 GPR120
 O3FAR1
HGNC Previous nameG protein-coupled receptor 129
 G protein-coupled receptor 120
 omega-3 fatty acid receptor 1
LocusID (NCBI) 338557
Atlas_Id 53816
Location 10q23.33  [Link to chromosome band 10q23]
Location_base_pair Starts at 93566665 and ends at 93590072 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)FFAR4   19061
Cards
Entrez_Gene (NCBI)FFAR4    free fatty acid receptor 4
AliasesBMIQ10; GPR120; GPR129; GT01; 
O3FAR1; PGR4
GeneCards (Weizmann)FFAR4
Ensembl hg19 (Hinxton)ENSG00000186188 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000186188 [Gene_View]  ENSG00000186188 [Sequence]  chr10:93566665-93590072 [Contig_View]  FFAR4 [Vega]
ICGC DataPortalENSG00000186188
TCGA cBioPortalFFAR4
AceView (NCBI)FFAR4
Genatlas (Paris)FFAR4
SOURCE (Princeton)FFAR4
Genetics Home Reference (NIH)FFAR4
Genomic and cartography
GoldenPath hg38 (UCSC)FFAR4  -     chr10:93566665-93590072 +  10q23.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FFAR4  -     10q23.33   [Description]    (hg19-Feb_2009)
GoldenPathFFAR4 - 10q23.33 [CytoView hg19]  FFAR4 - 10q23.33 [CytoView hg38]
ImmunoBaseENSG00000186188
Genome Data Viewer NCBIFFAR4 [Mapview hg19]  
OMIM607514   609044   
Gene and transcription
Genbank (Entrez)AB115768 AI469384 AI732606 AK301525 AY255573
RefSeq transcript (Entrez)NM_001195755 NM_181745
Consensus coding sequences : CCDS (NCBI)FFAR4
Gene ExpressionFFAR4 [ NCBI-GEO ]   FFAR4 [ EBI - ARRAY_EXPRESS ]   FFAR4 [ SEEK ]   FFAR4 [ MEM ]
Gene Expression Viewer (FireBrowse)FFAR4 [ Firebrowse - Broad ]
GenevisibleExpression of FFAR4 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)338557
GTEX Portal (Tissue expression)FFAR4
Human Protein AtlasENSG00000186188-FFAR4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ5NUL3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ5NUL3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ5NUL3
PhosPhoSitePlusQ5NUL3
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)GPCR_Rhodpsn   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Conserved Domain (NCBI)FFAR4
SuperfamilyQ5NUL3
AlphaFold pdb e-kbQ5NUL3   
Human Protein Atlas [tissue]ENSG00000186188-FFAR4 [tissue]
HPRD16422
Protein Interaction databases
DIP (DOE-UCLA)Q5NUL3
IntAct (EBI)Q5NUL3
BioGRIDFFAR4
STRING (EMBL)FFAR4
ZODIACFFAR4
Ontologies - Pathways
QuickGOQ5NUL3
Ontology : AmiGOnegative regulation of cytokine production  G protein-coupled receptor activity  fatty acid binding  fatty acid binding  lysosomal membrane  plasma membrane  plasma membrane  integral component of plasma membrane  cilium  inflammatory response  G protein-coupled receptor signaling pathway  G protein-coupled receptor signaling pathway  phospholipase C-activating G protein-coupled receptor signaling pathway  positive regulation of cytosolic calcium ion concentration  taste receptor activity  endosome membrane  regulation of glucose transmembrane transport  endocytic vesicle  negative regulation of interleukin-1 beta production  ghrelin secretion  negative regulation of apoptotic process  positive regulation of cAMP-mediated signaling  positive regulation of osteoblast differentiation  hormone secretion  negative regulation of inflammatory response  white fat cell differentiation  brown fat cell differentiation  detection of chemical stimulus involved in sensory perception of taste  ciliary membrane  positive regulation of glucagon secretion  positive regulation of ERK1 and ERK2 cascade  negative regulation of somatostatin secretion  positive regulation of brown fat cell differentiation  positive regulation of cold-induced thermogenesis  
Ontology : EGO-EBInegative regulation of cytokine production  G protein-coupled receptor activity  fatty acid binding  fatty acid binding  lysosomal membrane  plasma membrane  plasma membrane  integral component of plasma membrane  cilium  inflammatory response  G protein-coupled receptor signaling pathway  G protein-coupled receptor signaling pathway  phospholipase C-activating G protein-coupled receptor signaling pathway  positive regulation of cytosolic calcium ion concentration  taste receptor activity  endosome membrane  regulation of glucose transmembrane transport  endocytic vesicle  negative regulation of interleukin-1 beta production  ghrelin secretion  negative regulation of apoptotic process  positive regulation of cAMP-mediated signaling  positive regulation of osteoblast differentiation  hormone secretion  negative regulation of inflammatory response  white fat cell differentiation  brown fat cell differentiation  detection of chemical stimulus involved in sensory perception of taste  ciliary membrane  positive regulation of glucagon secretion  positive regulation of ERK1 and ERK2 cascade  negative regulation of somatostatin secretion  positive regulation of brown fat cell differentiation  positive regulation of cold-induced thermogenesis  
NDEx NetworkFFAR4
Atlas of Cancer Signalling NetworkFFAR4
Wikipedia pathwaysFFAR4
Orthology - Evolution
OrthoDB338557
GeneTree (enSembl)ENSG00000186188
Phylogenetic Trees/Animal Genes : TreeFamFFAR4
Homologs : HomoloGeneFFAR4
Homology/Alignments : Family Browser (UCSC)FFAR4
Gene fusions - Rearrangements
Fusion : QuiverFFAR4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFFAR4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FFAR4
dbVarFFAR4
ClinVarFFAR4
MonarchFFAR4
1000_GenomesFFAR4 
Exome Variant ServerFFAR4
GNOMAD BrowserENSG00000186188
Varsome BrowserFFAR4
ACMGFFAR4 variants
VarityQ5NUL3
Genomic Variants (DGV)FFAR4 [DGVbeta]
DECIPHERFFAR4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFFAR4 
Mutations
ICGC Data PortalFFAR4 
TCGA Data PortalFFAR4 
Broad Tumor PortalFFAR4
OASIS PortalFFAR4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFFAR4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DFFAR4
Mutations and Diseases : HGMDFFAR4
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaFFAR4
DgiDB (Drug Gene Interaction Database)FFAR4
DoCM (Curated mutations)FFAR4
CIViC (Clinical Interpretations of Variants in Cancer)FFAR4
Cancer3DFFAR4
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607514    609044   
Orphanet
DisGeNETFFAR4
MedgenFFAR4
Genetic Testing Registry FFAR4
NextProtQ5NUL3 [Medical]
GENETestsFFAR4
Target ValidationFFAR4
Huge Navigator FFAR4 [HugePedia]
ClinGenFFAR4
Clinical trials, drugs, therapy
MyCancerGenomeFFAR4
Protein Interactions : CTDFFAR4
Pharm GKB GenePA134924595
PharosQ5NUL3
Clinical trialFFAR4
Miscellaneous
canSAR (ICR)FFAR4
HarmonizomeFFAR4
DataMed IndexFFAR4
Probes
Litterature
PubMed77 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXFFAR4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:09:22 CEST 2021

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