FFAR4 (free fatty acid receptor 4)

2014-03-01  

Identity

HGNC
LOCATION
10q23.33
LOCUSID
ALIAS
BMIQ10,GPR120,GPR129,GT01,O3FAR1,PGR4

Other Information

Locus ID:

NCBI: 338557
MIM: 609044
HGNC: 19061
Ensembl: ENSG00000186188

Variants:

dbSNP: 338557
ClinVar: 338557
TCGA: ENSG00000186188
COSMIC: FFAR4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000186188ENST00000371481Q5NUL3
ENSG00000186188ENST00000371483Q5NUL3
ENSG00000186188ENST00000604414S4R3L2

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Peptide hormone metabolismREACTOMER-HSA-2980736
Incretin synthesis, secretion, and inactivationREACTOMER-HSA-400508
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)REACTOMER-HSA-381771
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Free fatty acid receptorsREACTOMER-HSA-444209

References

Pubmed IDYearTitleCitations
244124882014CD36- and GPR120-mediated Ca²⁺ signaling in human taste bud cells mediates differential responses to fatty acids and is altered in obese mice.49
248171222014Concomitant action of structural elements and receptor phosphorylation determines arrestin-3 interaction with the free fatty acid receptor FFA4.20
244122712014Mechanisms of homologous and heterologous phosphorylation of FFA receptor 4 (GPR120): GRK6 and PKC mediate phosphorylation of Thr³⁴⁷, Ser³⁵⁰, and Ser³⁵⁷ in the C-terminal tail.18
206770142010An approach based on a genome-wide association study reveals candidate loci for narcolepsy.16
251316232015Characterizing pharmacological ligands to study the long-chain fatty acid receptors GPR40/FFA1 and GPR120/FFA4.15
254470532015Tumor necrosis factor α decreases glucagon-like peptide-2 expression by up-regulating G-protein-coupled receptor 120 in Crohn disease.10
314872332020Free Fatty Acid Receptors in Health and Disease.9
262822002015Different roles of GPR120 and GPR40 in the acquisition of malignant properties in pancreatic cancer cells.7
284569932017Linoleic acid induces migration and invasion through FFAR4- and PI3K-/Akt-dependent pathway in MDA-MB-231 breast cancer cells.6
288351312018IL-1β and TNFα inhibit GPR120 (FFAR4) and stimulate GPR84 (EX33) and GPR41 (FFAR3) fatty acid receptor expression in human adipocytes: implications for the anti-inflammatory action of n-3 fatty acids.6

Citation

Dessen P

FFAR4 (free fatty acid receptor 4)

Atlas Genet Cytogenet Oncol Haematol. 2014-03-01

Online version: http://atlasgeneticsoncology.org/gene/53816/ffar4