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Taking over the Atlas
Dear Colleagues,
The Atlas, once more, is in great danger, and I will have to proceed to a collective economic lay-off of all the team involved in the Atlas before the begining of April 2015 (a foundation having suddenly withdrawn its commitment to support the Atlas). I ask you herein if any Scientific Society (a Society of Cytogenetics, of Clinical Genetics, of Hematology, or a Cancer Society, or any other...), any University and/or Hospital, any Charity, or any database would be interested in taking over the Atlas, in whole or in part. If taking charge of the whole lot is too big, a consortium of various actors could be the solution (I am myself trying to find partners). Could you please spread the information, contact the relevant authorities, and find partners.
Survival of the Atlas will be critically dependant upon your ability to find solutions (and urgently!).
Kind regards.
Jean-Loup Huret
Donations are also welcome

Donate (in Euros)

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FGA (fibrinogen alpha chain)

Identity

Other namesFib2
HGNC (Hugo) FGA
LocusID (NCBI) 2243
Location 4q31.3
Location_base_pair Starts at 155504280 and ends at 155511897 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)FGA   3661
Cards
Entrez_Gene (NCBI)FGA  2243  fibrinogen alpha chain
GeneCards (Weizmann)FGA
Ensembl hg19 (Hinxton)ENSG00000171560 [Gene_View]  chr4:155504280-155511897 [Contig_View]  FGA [Vega]
Ensembl hg38 (Hinxton)ENSG00000171560 [Gene_View]  chr4:155504280-155511897 [Contig_View]  FGA [Vega]
ICGC DataPortalENSG00000171560
cBioPortalFGA
AceView (NCBI)FGA
Genatlas (Paris)FGA
WikiGenes2243
SOURCE (Princeton)FGA
Genomic and cartography
GoldenPath hg19 (UCSC)FGA  -     chr4:155504280-155511897 -  4q31.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)FGA  -     4q31.3   [Description]    (hg38-Dec_2013)
EnsemblFGA - 4q31.3 [CytoView hg19]  FGA - 4q31.3 [CytoView hg38]
Mapping of homologs : NCBIFGA [Mapview hg19]  FGA [Mapview hg38]
OMIM105200   134820   202400   
Gene and transcription
Genbank (Entrez)AK290559 AL531808 AL579998 BC020764 BC070246
RefSeq transcript (Entrez)NM_000508 NM_021871
RefSeq genomic (Entrez)AC_000136 NC_000004 NC_018915 NG_008832 NT_016354 NW_001838921 NW_004929320
Consensus coding sequences : CCDS (NCBI)FGA
Cluster EST : UnigeneHs.351593 [ NCBI ]
CGAP (NCI)Hs.351593
Alternative Splicing : Fast-db (Paris)GSHG0023602
Alternative Splicing GalleryENSG00000171560
Gene ExpressionFGA [ NCBI-GEO ]     FGA [ SEEK ]   FGA [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP02671 (Uniprot)
NextProtP02671  [Medical]
With graphics : InterProP02671
Splice isoforms : SwissVarP02671 (Swissvar)
Domaine pattern : Prosite (Expaxy)FIBRINOGEN_C_1 (PS00514)    FIBRINOGEN_C_2 (PS51406)   
Domains : Interpro (EBI)Fibrinogen_a/b/g_C_1    Fibrinogen_a/b/g_C_2    Fibrinogen_a/b/g_C_dom    Fibrinogen_a/b/g_coil_dom    Fibrinogen_aC    Fibrinogen_CS   
Related proteins : CluSTrP02671
Domain families : Pfam (Sanger)Fib_alpha (PF08702)    Fibrinogen_aC (PF12160)    Fibrinogen_C (PF00147)   
Domain families : Pfam (NCBI)pfam08702    pfam12160    pfam00147   
Domain families : Smart (EMBL)FBG (SM00186)  
DMDM Disease mutations2243
Blocks (Seattle)P02671
PDB (SRS)1BBR    1DM4    1FZA    1FZB    1FZC    1FZD    1FZE    1FZF    1FZG    1LT9    1LTJ    1N86    1N8E    1RE3    1RE4    1RF0    1RF1    1YCP    2A45    2FFD    2H43    2HLO    2HOD    2HPC    2OYH    2OYI    2Q9I    2XNX    2XNY    2Z4E    3AT0    3BVH    3E1I    3GHG    3H32    3HUS    4F27   
PDB (PDBSum)1BBR    1DM4    1FZA    1FZB    1FZC    1FZD    1FZE    1FZF    1FZG    1LT9    1LTJ    1N86    1N8E    1RE3    1RE4    1RF0    1RF1    1YCP    2A45    2FFD    2H43    2HLO    2HOD    2HPC    2OYH    2OYI    2Q9I    2XNX    2XNY    2Z4E    3AT0    3BVH    3E1I    3GHG    3H32    3HUS    4F27   
PDB (IMB)1BBR    1DM4    1FZA    1FZB    1FZC    1FZD    1FZE    1FZF    1FZG    1LT9    1LTJ    1N86    1N8E    1RE3    1RE4    1RF0    1RF1    1YCP    2A45    2FFD    2H43    2HLO    2HOD    2HPC    2OYH    2OYI    2Q9I    2XNX    2XNY    2Z4E    3AT0    3BVH    3E1I    3GHG    3H32    3HUS    4F27   
PDB (RSDB)1BBR    1DM4    1FZA    1FZB    1FZC    1FZD    1FZE    1FZF    1FZG    1LT9    1LTJ    1N86    1N8E    1RE3    1RE4    1RF0    1RF1    1YCP    2A45    2FFD    2H43    2HLO    2HOD    2HPC    2OYH    2OYI    2Q9I    2XNX    2XNY    2Z4E    3AT0    3BVH    3E1I    3GHG    3H32    3HUS    4F27   
Human Protein AtlasENSG00000171560
Peptide AtlasP02671
HPRD00619
IPIIPI00021885   IPI00029717   IPI00902755   IPI00871469   
Protein Interaction databases
DIP (DOE-UCLA)P02671
IntAct (EBI)P02671
FunCoupENSG00000171560
BioGRIDFGA
IntegromeDBFGA
STRING (EMBL)FGA
Ontologies - Pathways
QuickGOP02671
Ontology : AmiGOplatelet degranulation  receptor binding  structural molecule activity  structural molecule activity  protein binding  extracellular region  extracellular region  fibrinogen complex  extracellular space  plasma membrane  cell cortex  cell-matrix adhesion  signal transduction  blood coagulation  external side of plasma membrane  cell surface  platelet activation  extracellular matrix organization  protein binding, bridging  platelet alpha granule  platelet alpha granule lumen  positive regulation of heterotypic cell-cell adhesion  cellular protein complex assembly  positive regulation of vasoconstriction  positive regulation of exocytosis  positive regulation of protein secretion  cell adhesion molecule binding  protein polymerization  response to calcium ion  extracellular vesicular exosome  positive regulation of ERK1 and ERK2 cascade  platelet aggregation  blood coagulation, common pathway  blood microparticle  positive regulation of peptide hormone secretion  positive regulation of substrate adhesion-dependent cell spreading  negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  negative regulation of blood coagulation, common pathway  negative regulation of endothelial cell apoptotic process  
Ontology : EGO-EBIplatelet degranulation  receptor binding  structural molecule activity  structural molecule activity  protein binding  extracellular region  extracellular region  fibrinogen complex  extracellular space  plasma membrane  cell cortex  cell-matrix adhesion  signal transduction  blood coagulation  external side of plasma membrane  cell surface  platelet activation  extracellular matrix organization  protein binding, bridging  platelet alpha granule  platelet alpha granule lumen  positive regulation of heterotypic cell-cell adhesion  cellular protein complex assembly  positive regulation of vasoconstriction  positive regulation of exocytosis  positive regulation of protein secretion  cell adhesion molecule binding  protein polymerization  response to calcium ion  extracellular vesicular exosome  positive regulation of ERK1 and ERK2 cascade  platelet aggregation  blood coagulation, common pathway  blood microparticle  positive regulation of peptide hormone secretion  positive regulation of substrate adhesion-dependent cell spreading  negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  negative regulation of blood coagulation, common pathway  negative regulation of endothelial cell apoptotic process  
Pathways : BIOCARTAFibrinolysis Pathway [Genes]    Extrinsic Prothrombin Activation Pathway [Genes]    Intrinsic Prothrombin Activation Pathway [Genes]    Acute Myocardial Infarction [Genes]   
Pathways : KEGGComplement and coagulation cascades   
Protein Interaction DatabaseFGA
DoCM (Curated mutations)FGA
Wikipedia pathwaysFGA
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerFGA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FGA
dbVarFGA
ClinVarFGA
1000_GenomesFGA 
Exome Variant ServerFGA
SNP (GeneSNP Utah)FGA
SNP : HGBaseFGA
Genetic variants : HAPMAPFGA
Genomic Variants (DGV)FGA [DGVbeta]
Mutations
ICGC Data PortalENSG00000171560 
Somatic Mutations in Cancer : COSMICFGA 
CONAN: Copy Number AnalysisFGA 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)4:155504280-155511897
Mutations and Diseases : HGMDFGA
OMIM105200    134820    202400   
MedgenFGA
NextProtP02671 [Medical]
GENETestsFGA
Disease Genetic AssociationFGA
Huge Navigator FGA [HugePedia]  FGA [HugeCancerGEM]
snp3D : Map Gene to Disease2243
DGIdb (Drug Gene Interaction db)FGA
General knowledge
Homologs : HomoloGeneFGA
Homology/Alignments : Family Browser (UCSC)FGA
Phylogenetic Trees/Animal Genes : TreeFamFGA
Chemical/Protein Interactions : CTD2243
Chemical/Pharm GKB GenePA429
Clinical trialFGA
Cancer Resource (Charite)ENSG00000171560
Other databases
Probes
Litterature
PubMed280 Pubmed reference(s) in Entrez
CoreMineFGA
GoPubMedFGA
iHOPFGA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2014Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Feb 14 15:49:59 CET 2015

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jlhuret@AtlasGeneticsOncology.org.