Atlas of Genetics and Cytogenetics in Oncology and Haematology


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FGA (fibrinogen alpha chain)

Identity

Alias_namesfibrinogen
Other aliasFib2
HGNC (Hugo) FGA
LocusID (NCBI) 2243
Atlas_Id 45994
Location 4q31.3  [Link to chromosome band 4q31]
Location_base_pair Starts at 154583126 and ends at 154590766 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
FGA (4q31.3) / NEU1 (6p21.33)FGA (4q31.3) / PIK3IP1 (22q12.2)FGA (4q31.3) / RUNX1 (21q22.12)
RPS16 (19q13.2) / FGA (4q31.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)FGA   3661
LRG (Locus Reference Genomic)LRG_557
Cards
Entrez_Gene (NCBI)FGA  2243  fibrinogen alpha chain
AliasesFib2
GeneCards (Weizmann)FGA
Ensembl hg19 (Hinxton)ENSG00000171560 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000171560 [Gene_View]  chr4:154583126-154590766 [Contig_View]  FGA [Vega]
ICGC DataPortalENSG00000171560
TCGA cBioPortalFGA
AceView (NCBI)FGA
Genatlas (Paris)FGA
WikiGenes2243
SOURCE (Princeton)FGA
Genetics Home Reference (NIH)FGA
Genomic and cartography
GoldenPath hg38 (UCSC)FGA  -     chr4:154583126-154590766 -  4q31.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FGA  -     4q31.3   [Description]    (hg19-Feb_2009)
EnsemblFGA - 4q31.3 [CytoView hg19]  FGA - 4q31.3 [CytoView hg38]
Mapping of homologs : NCBIFGA [Mapview hg19]  FGA [Mapview hg38]
OMIM105200   134820   202400   616004   
Gene and transcription
Genbank (Entrez)AF090936 AK290559 AL531808 AL579998 BC020764
RefSeq transcript (Entrez)NM_000508 NM_021871
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FGA
Cluster EST : UnigeneHs.612036 [ NCBI ]
CGAP (NCI)Hs.612036
Alternative Splicing GalleryENSG00000171560
Gene ExpressionFGA [ NCBI-GEO ]   FGA [ EBI - ARRAY_EXPRESS ]   FGA [ SEEK ]   FGA [ MEM ]
Gene Expression Viewer (FireBrowse)FGA [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2243
GTEX Portal (Tissue expression)FGA
Protein : pattern, domain, 3D structure
UniProt/SwissProtP02671   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP02671  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP02671
Splice isoforms : SwissVarP02671
PhosPhoSitePlusP02671
Domaine pattern : Prosite (Expaxy)FIBRINOGEN_C_1 (PS00514)    FIBRINOGEN_C_2 (PS51406)   
Domains : Interpro (EBI)Fibrinogen_a/b/g_C_1    Fibrinogen_a/b/g_C_2    Fibrinogen_a/b/g_C_dom    Fibrinogen_a/b/g_coil_dom    Fibrinogen_aC    Fibrinogen_CS   
Domain families : Pfam (Sanger)Fib_alpha (PF08702)    Fibrinogen_aC (PF12160)    Fibrinogen_C (PF00147)   
Domain families : Pfam (NCBI)pfam08702    pfam12160    pfam00147   
Domain families : Smart (EMBL)FBG (SM00186)  Fib_alpha (SM01212)  
Conserved Domain (NCBI)FGA
DMDM Disease mutations2243
Blocks (Seattle)FGA
PDB (SRS)1BBR    1DM4    1FPH    1FZA    1FZB    1FZC    1FZD    1FZE    1FZF    1FZG    1LT9    1LTJ    1N86    1N8E    1RE3    1RE4    1RF0    1RF1    1YCP    2A45    2FFD    2H43    2HLO    2HOD    2HPC    2OYH    2OYI    2Q9I    2XNX    2XNY    2Z4E    3AT0    3BVH    3E1I    3GHG    3H32    3HUS    4F27    5CFA   
PDB (PDBSum)1BBR    1DM4    1FPH    1FZA    1FZB    1FZC    1FZD    1FZE    1FZF    1FZG    1LT9    1LTJ    1N86    1N8E    1RE3    1RE4    1RF0    1RF1    1YCP    2A45    2FFD    2H43    2HLO    2HOD    2HPC    2OYH    2OYI    2Q9I    2XNX    2XNY    2Z4E    3AT0    3BVH    3E1I    3GHG    3H32    3HUS    4F27    5CFA   
PDB (IMB)1BBR    1DM4    1FPH    1FZA    1FZB    1FZC    1FZD    1FZE    1FZF    1FZG    1LT9    1LTJ    1N86    1N8E    1RE3    1RE4    1RF0    1RF1    1YCP    2A45    2FFD    2H43    2HLO    2HOD    2HPC    2OYH    2OYI    2Q9I    2XNX    2XNY    2Z4E    3AT0    3BVH    3E1I    3GHG    3H32    3HUS    4F27    5CFA   
PDB (RSDB)1BBR    1DM4    1FPH    1FZA    1FZB    1FZC    1FZD    1FZE    1FZF    1FZG    1LT9    1LTJ    1N86    1N8E    1RE3    1RE4    1RF0    1RF1    1YCP    2A45    2FFD    2H43    2HLO    2HOD    2HPC    2OYH    2OYI    2Q9I    2XNX    2XNY    2Z4E    3AT0    3BVH    3E1I    3GHG    3H32    3HUS    4F27    5CFA   
Structural Biology KnowledgeBase1BBR    1DM4    1FPH    1FZA    1FZB    1FZC    1FZD    1FZE    1FZF    1FZG    1LT9    1LTJ    1N86    1N8E    1RE3    1RE4    1RF0    1RF1    1YCP    2A45    2FFD    2H43    2HLO    2HOD    2HPC    2OYH    2OYI    2Q9I    2XNX    2XNY    2Z4E    3AT0    3BVH    3E1I    3GHG    3H32    3HUS    4F27    5CFA   
SCOP (Structural Classification of Proteins)1BBR    1DM4    1FPH    1FZA    1FZB    1FZC    1FZD    1FZE    1FZF    1FZG    1LT9    1LTJ    1N86    1N8E    1RE3    1RE4    1RF0    1RF1    1YCP    2A45    2FFD    2H43    2HLO    2HOD    2HPC    2OYH    2OYI    2Q9I    2XNX    2XNY    2Z4E    3AT0    3BVH    3E1I    3GHG    3H32    3HUS    4F27    5CFA   
CATH (Classification of proteins structures)1BBR    1DM4    1FPH    1FZA    1FZB    1FZC    1FZD    1FZE    1FZF    1FZG    1LT9    1LTJ    1N86    1N8E    1RE3    1RE4    1RF0    1RF1    1YCP    2A45    2FFD    2H43    2HLO    2HOD    2HPC    2OYH    2OYI    2Q9I    2XNX    2XNY    2Z4E    3AT0    3BVH    3E1I    3GHG    3H32    3HUS    4F27    5CFA   
SuperfamilyP02671
Human Protein AtlasENSG00000171560
Peptide AtlasP02671
HPRD00619
IPIIPI00021885   IPI00029717   IPI00902755   IPI00871469   
Protein Interaction databases
DIP (DOE-UCLA)P02671
IntAct (EBI)P02671
FunCoupENSG00000171560
BioGRIDFGA
STRING (EMBL)FGA
ZODIACFGA
Ontologies - Pathways
QuickGOP02671
Ontology : AmiGOtoll-like receptor signaling pathway  adaptive immune response  platelet degranulation  receptor binding  structural molecule activity  structural molecule activity  protein binding  extracellular region  extracellular region  fibrinogen complex  extracellular space  plasma membrane  cell cortex  protein complex assembly  cell-matrix adhesion  blood coagulation  external side of plasma membrane  cell surface  extracellular matrix organization  protein binding, bridging  platelet alpha granule  platelet alpha granule lumen  plasminogen activation  positive regulation of heterotypic cell-cell adhesion  fibrinolysis  induction of bacterial agglutination  cellular protein complex assembly  cellular protein metabolic process  innate immune response  positive regulation of vasoconstriction  positive regulation of exocytosis  metal ion binding  positive regulation of protein secretion  cell adhesion molecule binding  protein polymerization  response to calcium ion  extracellular exosome  positive regulation of ERK1 and ERK2 cascade  platelet aggregation  platelet aggregation  blood coagulation, common pathway  blood coagulation, fibrin clot formation  blood microparticle  positive regulation of peptide hormone secretion  positive regulation of substrate adhesion-dependent cell spreading  negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  extracellular vesicle  negative regulation of endothelial cell apoptotic process  
Ontology : EGO-EBItoll-like receptor signaling pathway  adaptive immune response  platelet degranulation  receptor binding  structural molecule activity  structural molecule activity  protein binding  extracellular region  extracellular region  fibrinogen complex  extracellular space  plasma membrane  cell cortex  protein complex assembly  cell-matrix adhesion  blood coagulation  external side of plasma membrane  cell surface  extracellular matrix organization  protein binding, bridging  platelet alpha granule  platelet alpha granule lumen  plasminogen activation  positive regulation of heterotypic cell-cell adhesion  fibrinolysis  induction of bacterial agglutination  cellular protein complex assembly  cellular protein metabolic process  innate immune response  positive regulation of vasoconstriction  positive regulation of exocytosis  metal ion binding  positive regulation of protein secretion  cell adhesion molecule binding  protein polymerization  response to calcium ion  extracellular exosome  positive regulation of ERK1 and ERK2 cascade  platelet aggregation  platelet aggregation  blood coagulation, common pathway  blood coagulation, fibrin clot formation  blood microparticle  positive regulation of peptide hormone secretion  positive regulation of substrate adhesion-dependent cell spreading  negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  extracellular vesicle  negative regulation of endothelial cell apoptotic process  
Pathways : BIOCARTAFibrinolysis Pathway [Genes]    Extrinsic Prothrombin Activation Pathway [Genes]    Intrinsic Prothrombin Activation Pathway [Genes]    Acute Myocardial Infarction [Genes]   
Pathways : KEGGComplement and coagulation cascades   
NDEx NetworkFGA
Atlas of Cancer Signalling NetworkFGA
Wikipedia pathwaysFGA
Orthology - Evolution
OrthoDB2243
GeneTree (enSembl)ENSG00000171560
Phylogenetic Trees/Animal Genes : TreeFamFGA
HOVERGENP02671
HOGENOMP02671
Homologs : HomoloGeneFGA
Homology/Alignments : Family Browser (UCSC)FGA
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFGA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FGA
dbVarFGA
ClinVarFGA
1000_GenomesFGA 
Exome Variant ServerFGA
ExAC (Exome Aggregation Consortium)FGA (select the gene name)
Genetic variants : HAPMAP2243
Genomic Variants (DGV)FGA [DGVbeta]
DECIPHERFGA [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFGA 
Mutations
ICGC Data PortalFGA 
TCGA Data PortalFGA 
Broad Tumor PortalFGA
OASIS PortalFGA [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFGA  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFGA
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FGA
DgiDB (Drug Gene Interaction Database)FGA
DoCM (Curated mutations)FGA (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FGA (select a term)
intoGenFGA
Cancer3DFGA(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM105200    134820    202400    616004   
Orphanet19580    12404    13898    13897    14752   
MedgenFGA
Genetic Testing Registry FGA
NextProtP02671 [Medical]
TSGene2243
GENETestsFGA
Target ValidationFGA
Huge Navigator FGA [HugePedia]
snp3D : Map Gene to Disease2243
BioCentury BCIQFGA
ClinGenFGA
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2243
Chemical/Pharm GKB GenePA429
Clinical trialFGA
Miscellaneous
canSAR (ICR)FGA (select the gene name)
Probes
Litterature
PubMed324 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFGA
EVEXFGA
GoPubMedFGA
iHOPFGA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:33:51 CEST 2017

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