Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

FGB (fibrinogen beta chain)

Identity

Other namesHEL-S-78p
HGNC (Hugo) FGB
LocusID (NCBI) 2244
Atlas_Id 40548
Location 4q31.3
Location_base_pair Starts at 155484132 and ends at 155493915 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2015)
ARFIP1 4q31.3 / FGB 4q31.3FGB 4q31.3 / PLEKHA5 12p12.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)FGB   3662
Cards
Entrez_Gene (NCBI)FGB  2244  fibrinogen beta chain
GeneCards (Weizmann)FGB
Ensembl hg19 (Hinxton) [Gene_View]  chr4:155484132-155493915 [Contig_View]  FGB [Vega]
Ensembl hg38 (Hinxton) [Gene_View]  chr4:155484132-155493915 [Contig_View]  FGB [Vega]
TCGA cBioPortalFGB
AceView (NCBI)FGB
Genatlas (Paris)FGB
WikiGenes2244
SOURCE (Princeton)FGB
Genomic and cartography
GoldenPath hg19 (UCSC)FGB  -     chr4:155484132-155493915 +  4q31.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)FGB  -     4q31.3   [Description]    (hg38-Dec_2013)
EnsemblFGB - 4q31.3 [CytoView hg19]  FGB - 4q31.3 [CytoView hg38]
Mapping of homologs : NCBIFGB [Mapview hg19]  FGB [Mapview hg38]
OMIM134830   202400   616004   
Gene and transcription
Genbank (Entrez)AI174804 AK303788 AK309592 AK311683 AK312972
RefSeq transcript (Entrez)NM_001184741 NM_005141
RefSeq genomic (Entrez)NC_000004 NC_018915 NG_008833 NT_016354 NW_004929320
Consensus coding sequences : CCDS (NCBI)FGB
Cluster EST : UnigeneHs.300774 [ NCBI ]
CGAP (NCI)Hs.300774
Alternative Splicing : Fast-db (Paris)GSHG0022931
Gene ExpressionFGB [ NCBI-GEO ]     FGB [ SEEK ]   FGB [ MEM ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)2244
Protein : pattern, domain, 3D structure
UniProt/SwissProtP02675 (Uniprot)
NextProtP02675  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP02675
Splice isoforms : SwissVarP02675 (Swissvar)
PhosPhoSitePlusP02675
Domaine pattern : Prosite (Expaxy)FIBRINOGEN_C_1 (PS00514)    FIBRINOGEN_C_2 (PS51406)   
Domains : Interpro (EBI)Fibrinogen_a/b/g_C_1    Fibrinogen_a/b/g_C_2    Fibrinogen_a/b/g_C_dom    Fibrinogen_a/b/g_coil_dom    Fibrinogen_CS   
Domain families : Pfam (Sanger)Fib_alpha (PF08702)    Fibrinogen_C (PF00147)   
Domain families : Pfam (NCBI)pfam08702    pfam00147   
Domain families : Smart (EMBL)FBG (SM00186)  
DMDM Disease mutations2244
Blocks (Seattle)FGB
PDB (SRS)1FZA    1FZB    1FZC    1FZE    1FZF    1FZG    1LT9    1LTJ    1N86    1N8E    1RE3    1RE4    1RF0    1RF1    2A45    2FFD    2H43    2HLO    2HOD    2HPC    2OYH    2OYI    2Q9I    2XNX    2XNY    2Z4E    3BVH    3E1I    3GHG    3H32    3HUS   
PDB (PDBSum)1FZA    1FZB    1FZC    1FZE    1FZF    1FZG    1LT9    1LTJ    1N86    1N8E    1RE3    1RE4    1RF0    1RF1    2A45    2FFD    2H43    2HLO    2HOD    2HPC    2OYH    2OYI    2Q9I    2XNX    2XNY    2Z4E    3BVH    3E1I    3GHG    3H32    3HUS   
PDB (IMB)1FZA    1FZB    1FZC    1FZE    1FZF    1FZG    1LT9    1LTJ    1N86    1N8E    1RE3    1RE4    1RF0    1RF1    2A45    2FFD    2H43    2HLO    2HOD    2HPC    2OYH    2OYI    2Q9I    2XNX    2XNY    2Z4E    3BVH    3E1I    3GHG    3H32    3HUS   
PDB (RSDB)1FZA    1FZB    1FZC    1FZE    1FZF    1FZG    1LT9    1LTJ    1N86    1N8E    1RE3    1RE4    1RF0    1RF1    2A45    2FFD    2H43    2HLO    2HOD    2HPC    2OYH    2OYI    2Q9I    2XNX    2XNY    2Z4E    3BVH    3E1I    3GHG    3H32    3HUS   
Structural Biology KnowledgeBase1FZA    1FZB    1FZC    1FZE    1FZF    1FZG    1LT9    1LTJ    1N86    1N8E    1RE3    1RE4    1RF0    1RF1    2A45    2FFD    2H43    2HLO    2HOD    2HPC    2OYH    2OYI    2Q9I    2XNX    2XNY    2Z4E    3BVH    3E1I    3GHG    3H32    3HUS   
SCOP (Structural Classification of Proteins)1FZA    1FZB    1FZC    1FZE    1FZF    1FZG    1LT9    1LTJ    1N86    1N8E    1RE3    1RE4    1RF0    1RF1    2A45    2FFD    2H43    2HLO    2HOD    2HPC    2OYH    2OYI    2Q9I    2XNX    2XNY    2Z4E    3BVH    3E1I    3GHG    3H32    3HUS   
CATH (Classification of proteins structures)1FZA    1FZB    1FZC    1FZE    1FZF    1FZG    1LT9    1LTJ    1N86    1N8E    1RE3    1RE4    1RF0    1RF1    2A45    2FFD    2H43    2HLO    2HOD    2HPC    2OYH    2OYI    2Q9I    2XNX    2XNY    2Z4E    3BVH    3E1I    3GHG    3H32    3HUS   
Peptide AtlasP02675
HPRD00620
IPIIPI00298497   IPI00816687   IPI00965713   IPI00878769   
Protein Interaction databases
DIP (DOE-UCLA)P02675
IntAct (EBI)P02675
BioGRIDFGB
IntegromeDBFGB
STRING (EMBL)FGB
ZODIACFGB
Ontologies - Pathways
QuickGOP02675
Ontology : AmiGOadaptive immune response  platelet degranulation  receptor binding  structural molecule activity  protein binding  extracellular region  extracellular region  fibrinogen complex  extracellular space  plasma membrane  cell cortex  cell-matrix adhesion  signal transduction  blood coagulation  external side of plasma membrane  cell surface  platelet activation  extracellular matrix organization  protein binding, bridging  platelet alpha granule  platelet alpha granule lumen  plasminogen activation  positive regulation of heterotypic cell-cell adhesion  fibrinolysis  induction of bacterial agglutination  cellular protein complex assembly  cellular response to leptin stimulus  innate immune response  positive regulation of vasoconstriction  positive regulation of exocytosis  positive regulation of protein secretion  cell adhesion molecule binding  chaperone binding  protein polymerization  response to calcium ion  extracellular exosome  positive regulation of ERK1 and ERK2 cascade  platelet aggregation  cellular response to interleukin-1  blood coagulation, fibrin clot formation  blood microparticle  positive regulation of peptide hormone secretion  positive regulation of substrate adhesion-dependent cell spreading  negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  extracellular vesicle  negative regulation of endothelial cell apoptotic process  
Ontology : EGO-EBIadaptive immune response  platelet degranulation  receptor binding  structural molecule activity  protein binding  extracellular region  extracellular region  fibrinogen complex  extracellular space  plasma membrane  cell cortex  cell-matrix adhesion  signal transduction  blood coagulation  external side of plasma membrane  cell surface  platelet activation  extracellular matrix organization  protein binding, bridging  platelet alpha granule  platelet alpha granule lumen  plasminogen activation  positive regulation of heterotypic cell-cell adhesion  fibrinolysis  induction of bacterial agglutination  cellular protein complex assembly  cellular response to leptin stimulus  innate immune response  positive regulation of vasoconstriction  positive regulation of exocytosis  positive regulation of protein secretion  cell adhesion molecule binding  chaperone binding  protein polymerization  response to calcium ion  extracellular exosome  positive regulation of ERK1 and ERK2 cascade  platelet aggregation  cellular response to interleukin-1  blood coagulation, fibrin clot formation  blood microparticle  positive regulation of peptide hormone secretion  positive regulation of substrate adhesion-dependent cell spreading  negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  extracellular vesicle  negative regulation of endothelial cell apoptotic process  
Pathways : BIOCARTAExtrinsic Prothrombin Activation Pathway [Genes]    Intrinsic Prothrombin Activation Pathway [Genes]    Acute Myocardial Infarction [Genes]    Fibrinolysis Pathway [Genes]   
Pathways : KEGGComplement and coagulation cascades   
Protein Interaction DatabaseFGB
Atlas of Cancer Signalling NetworkFGB
Wikipedia pathwaysFGB
Orthology - Evolution
OrthoDB2244
Phylogenetic Trees/Animal Genes : TreeFamFGB
Homologs : HomoloGeneFGB
Homology/Alignments : Family Browser (UCSC)FGB
Gene fusions - Rearrangements
Fusion: TCGAARFIP1 4q31.3 FGB 4q31.3 BRCA
Fusion: TCGAFGB 4q31.3 PLEKHA5 12p12.3 LUAD
Polymorphisms : SNP, variants
NCBI Variation ViewerFGB [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FGB
dbVarFGB
ClinVarFGB
1000_GenomesFGB 
Exome Variant ServerFGB
SNP (GeneSNP Utah)FGB
SNP : HGBaseFGB
Genetic variants : HAPMAPFGB
Genomic Variants (DGV)FGB [DGVbeta]
Mutations
ICGC Data PortalFGB 
TCGA Data PortalFGB 
Tumor PortalFGB
TCGA Copy Number PortalFGB
Somatic Mutations in Cancer : COSMICFGB 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FGB
DgiDB (Drug Gene Interaction Database)FGB
DoCM (Curated mutations)FGB (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FGB (select a term)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)4:155484132-155493915
CONAN: Copy Number AnalysisFGB 
Mutations and Diseases : HGMDFGB
OMIM134830    202400    616004   
MedgenFGB
NextProtP02675 [Medical]
TSGene2244
GENETestsFGB
Huge Navigator FGB [HugePedia]  FGB [HugeCancerGEM]
snp3D : Map Gene to Disease2244
BioCentury BCIQFGB
General knowledge
Chemical/Protein Interactions : CTD2244
Chemical/Pharm GKB GenePA163
Clinical trialFGB
Other databases
Probes
Litterature
PubMed357 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFGB
GoPubMedFGB
iHOPFGB
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Jan 16 18:38:05 CET 2016

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.