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FGD1 (FYVE, RhoGEF and PH domain containing 1)

Identity

Other namesAAS
FGDY
MRXS16
ZFYVE3
HGNC (Hugo) FGD1
LocusID (NCBI) 2245
Location Xp11.22
Location_base_pair Starts at 54471887 and ends at 54522599 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)FGD1   3663
Cards
Entrez_Gene (NCBI)FGD1  2245  FYVE, RhoGEF and PH domain containing 1
GeneCards (Weizmann)FGD1
Ensembl (Hinxton)ENSG00000102302 [Gene_View]  chrX:54471887-54522599 [Contig_View]  FGD1 [Vega]
AceView (NCBI)FGD1
Genatlas (Paris)FGD1
WikiGenes2245
SOURCE (Princeton)NM_004463
Genomic and cartography
GoldenPath (UCSC)FGD1  -  Xp11.22   chrX:54471887-54522599 -  Xp11.22   [Description]    (hg19-Feb_2009)
EnsemblFGD1 - Xp11.22 [CytoView]
Mapping of homologs : NCBIFGD1 [Mapview]
OMIM300546   305400   
Gene and transcription
Genbank (Entrez)AK226117 AK299635 BC034530 U11690
RefSeq transcript (Entrez)NM_004463
RefSeq genomic (Entrez)AC_000155 NC_000023 NC_018934 NG_008054 NT_011630 NW_001842370 NW_004929442
Consensus coding sequences : CCDS (NCBI)FGD1
Cluster EST : UnigeneHs.709201 [ NCBI ]
CGAP (NCI)Hs.709201
Alternative Splicing : Fast-db (Paris)GSHG0032120
Alternative Splicing GalleryENSG00000102302
Gene ExpressionFGD1 [ NCBI-GEO ]     FGD1 [ SEEK ]   FGD1 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP98174 (Uniprot)
NextProtP98174  [Medical]
With graphics : InterProP98174
Splice isoforms : SwissVarP98174 (Swissvar)
Domaine pattern : Prosite (Expaxy)DH_1 (PS00741)    DH_2 (PS50010)    PH_DOMAIN (PS50003)    ZF_FYVE (PS50178)   
Domains : Interpro (EBI)DH-domain    PH_like_dom    Pleckstrin_homology    Znf_FYVE    Znf_FYVE-rel    Znf_RING/FYVE/PHD   
Related proteins : CluSTrP98174
Domain families : Pfam (Sanger)FYVE (PF01363)    PH (PF00169)    RhoGEF (PF00621)   
Domain families : Pfam (NCBI)pfam01363    pfam00169    pfam00621   
Domain families : Smart (EMBL)FYVE (SM00064)  PH (SM00233)  RhoGEF (SM00325)  
DMDM Disease mutations2245
Blocks (Seattle)P98174
Human Protein AtlasENSG00000102302
Peptide AtlasP98174
HPRD02373
IPIIPI00024312   
Protein Interaction databases
DIP (DOE-UCLA)P98174
IntAct (EBI)P98174
FunCoupENSG00000102302
BioGRIDFGD1
InParanoidP98174
Interologous Interaction database P98174
IntegromeDBFGD1
STRING (EMBL)FGD1
Ontologies - Pathways
Ontology : AmiGOruffle  guanyl-nucleotide exchange factor activity  Rho guanyl-nucleotide exchange factor activity  phospholipid binding  nucleus  cytoplasm  cytoplasm  Golgi apparatus  cytosol  cytoskeleton  plasma membrane  cytoskeleton organization  signal transduction  small GTPase mediated signal transduction  multicellular organismal development  regulation of cell shape  organ morphogenesis  lamellipodium  actin cytoskeleton organization  small GTPase binding  positive regulation of apoptotic process  regulation of Cdc42 GTPase activity  filopodium assembly  metal ion binding  neurotrophin TRK receptor signaling pathway  regulation of small GTPase mediated signal transduction  apoptotic signaling pathway  
Ontology : EGO-EBIruffle  guanyl-nucleotide exchange factor activity  Rho guanyl-nucleotide exchange factor activity  phospholipid binding  nucleus  cytoplasm  cytoplasm  Golgi apparatus  cytosol  cytoskeleton  plasma membrane  cytoskeleton organization  signal transduction  small GTPase mediated signal transduction  multicellular organismal development  regulation of cell shape  organ morphogenesis  lamellipodium  actin cytoskeleton organization  small GTPase binding  positive regulation of apoptotic process  regulation of Cdc42 GTPase activity  filopodium assembly  metal ion binding  neurotrophin TRK receptor signaling pathway  regulation of small GTPase mediated signal transduction  apoptotic signaling pathway  
Pathways : KEGGRegulation of actin cytoskeleton   
REACTOMEFGD1
Protein Interaction DatabaseFGD1
Wikipedia pathwaysFGD1
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)FGD1
SNP (GeneSNP Utah)FGD1
SNP : HGBaseFGD1
Genetic variants : HAPMAPFGD1
1000_GenomesFGD1 
ICGC programENSG00000102302 
Somatic Mutations in Cancer : COSMICFGD1 
CONAN: Copy Number AnalysisFGD1 
Mutations and Diseases : HGMDFGD1
OMIM300546    305400   
GENETestsFGD1
Disease Genetic AssociationFGD1
Huge Navigator FGD1 [HugePedia]  FGD1 [HugeCancerGEM]
Genomic VariantsFGD1  FGD1 [DGVbeta]
Exome VariantFGD1
dbVarFGD1
ClinVarFGD1
snp3D : Map Gene to Disease2245
General knowledge
Homologs : HomoloGeneFGD1
Homology/Alignments : Family Browser (UCSC)FGD1
Phylogenetic Trees/Animal Genes : TreeFamFGD1
Chemical/Protein Interactions : CTD2245
Chemical/Pharm GKB GenePA28102
Clinical trialFGD1
Cancer Resource (Charite)ENSG00000102302
Other databases
Probes
Litterature
PubMed40 Pubmed reference(s) in Entrez
CoreMineFGD1
iHOPFGD1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Apr 18 17:08:28 CEST 2014

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