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FGD2 (FYVE, RhoGEF and PH domain containing 2)

Identity

Alias_namesFGD1 family
Alias_symbol (synonym)ZFYVE4
Other alias
HGNC (Hugo) FGD2
LocusID (NCBI) 221472
Atlas_Id 43260
Location 6p21.2  [Link to chromosome band 6p21]
Location_base_pair Starts at 37005647 and ends at 37029069 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
COL1A1 (17q21.33) / FGD2 (6p21.2)FGD2 (6p21.2) / CD74 (5q32)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(6;17)(p21;q21) COL1A1/FGD2


External links

Nomenclature
HGNC (Hugo)FGD2   3664
Cards
Entrez_Gene (NCBI)FGD2  221472  FYVE, RhoGEF and PH domain containing 2
AliasesZFYVE4
GeneCards (Weizmann)FGD2
Ensembl hg19 (Hinxton)ENSG00000146192 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000146192 [Gene_View]  ENSG00000146192 [Sequence]  chr6:37005647-37029069 [Contig_View]  FGD2 [Vega]
ICGC DataPortalENSG00000146192
TCGA cBioPortalFGD2
AceView (NCBI)FGD2
Genatlas (Paris)FGD2
WikiGenes221472
SOURCE (Princeton)FGD2
Genetics Home Reference (NIH)FGD2
Genomic and cartography
GoldenPath hg38 (UCSC)FGD2  -     chr6:37005647-37029069 +  6p21.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FGD2  -     6p21.2   [Description]    (hg19-Feb_2009)
EnsemblFGD2 - 6p21.2 [CytoView hg19]  FGD2 - 6p21.2 [CytoView hg38]
Mapping of homologs : NCBIFGD2 [Mapview hg19]  FGD2 [Mapview hg38]
OMIM605091   
Gene and transcription
Genbank (Entrez)AK024456 AK092732 AK097230 AK097981 AK098248
RefSeq transcript (Entrez)NM_173558
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FGD2
Cluster EST : UnigeneHs.509664 [ NCBI ]
CGAP (NCI)Hs.509664
Alternative Splicing GalleryENSG00000146192
Gene ExpressionFGD2 [ NCBI-GEO ]   FGD2 [ EBI - ARRAY_EXPRESS ]   FGD2 [ SEEK ]   FGD2 [ MEM ]
Gene Expression Viewer (FireBrowse)FGD2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)221472
GTEX Portal (Tissue expression)FGD2
Human Protein AtlasENSG00000146192-FGD2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7Z6J4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ7Z6J4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ7Z6J4
Splice isoforms : SwissVarQ7Z6J4
PhosPhoSitePlusQ7Z6J4
Domaine pattern : Prosite (Expaxy)DH_2 (PS50010)    PH_DOMAIN (PS50003)    ZF_FYVE (PS50178)   
Domains : Interpro (EBI)DBL_dom_sf    DH-domain    FGD1-4_PH2    FGD2_PH1    PH-like_dom_sf    PH_domain    Znf_FYVE    Znf_FYVE-rel    Znf_FYVE_PHD    Znf_RING/FYVE/PHD   
Domain families : Pfam (Sanger)FYVE (PF01363)    PH (PF00169)    RhoGEF (PF00621)   
Domain families : Pfam (NCBI)pfam01363    pfam00169    pfam00621   
Domain families : Smart (EMBL)FYVE (SM00064)  PH (SM00233)  RhoGEF (SM00325)  
Conserved Domain (NCBI)FGD2
DMDM Disease mutations221472
Blocks (Seattle)FGD2
SuperfamilyQ7Z6J4
Human Protein Atlas [tissue]ENSG00000146192-FGD2 [tissue]
Peptide AtlasQ7Z6J4
HPRD05478
IPIIPI00217865   IPI00384678   IPI00442361   IPI00386320   IPI00908514   IPI00871967   IPI00945853   IPI01025258   
Protein Interaction databases
DIP (DOE-UCLA)Q7Z6J4
IntAct (EBI)Q7Z6J4
FunCoupENSG00000146192
BioGRIDFGD2
STRING (EMBL)FGD2
ZODIACFGD2
Ontologies - Pathways
QuickGOQ7Z6J4
Ontology : AmiGOruffle  guanyl-nucleotide exchange factor activity  guanyl-nucleotide exchange factor activity  Rho guanyl-nucleotide exchange factor activity  protein binding  nucleus  cytoplasm  Golgi apparatus  cytosol  cytoskeleton  cytoskeleton organization  G protein-coupled receptor signaling pathway  regulation of cell shape  lamellipodium  actin cytoskeleton organization  small GTPase binding  early endosome membrane  ruffle membrane  regulation of Rho protein signal transduction  positive regulation of apoptotic process  regulation of GTPase activity  positive regulation of JUN kinase activity  filopodium assembly  metal ion binding  regulation of small GTPase mediated signal transduction  phosphatidylinositol phosphate binding  
Ontology : EGO-EBIruffle  guanyl-nucleotide exchange factor activity  guanyl-nucleotide exchange factor activity  Rho guanyl-nucleotide exchange factor activity  protein binding  nucleus  cytoplasm  Golgi apparatus  cytosol  cytoskeleton  cytoskeleton organization  G protein-coupled receptor signaling pathway  regulation of cell shape  lamellipodium  actin cytoskeleton organization  small GTPase binding  early endosome membrane  ruffle membrane  regulation of Rho protein signal transduction  positive regulation of apoptotic process  regulation of GTPase activity  positive regulation of JUN kinase activity  filopodium assembly  metal ion binding  regulation of small GTPase mediated signal transduction  phosphatidylinositol phosphate binding  
NDEx NetworkFGD2
Atlas of Cancer Signalling NetworkFGD2
Wikipedia pathwaysFGD2
Orthology - Evolution
OrthoDB221472
GeneTree (enSembl)ENSG00000146192
Phylogenetic Trees/Animal Genes : TreeFamFGD2
HOVERGENQ7Z6J4
HOGENOMQ7Z6J4
Homologs : HomoloGeneFGD2
Homology/Alignments : Family Browser (UCSC)FGD2
Gene fusions - Rearrangements
Fusion : MitelmanCOL1A1/FGD2 [17q21.33/6p21.2]  [t(6;17)(p21;q21)]  
Fusion : QuiverFGD2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFGD2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FGD2
dbVarFGD2
ClinVarFGD2
1000_GenomesFGD2 
Exome Variant ServerFGD2
ExAC (Exome Aggregation Consortium)ENSG00000146192
GNOMAD BrowserENSG00000146192
Varsome BrowserFGD2
Genetic variants : HAPMAP221472
Genomic Variants (DGV)FGD2 [DGVbeta]
DECIPHERFGD2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFGD2 
Mutations
ICGC Data PortalFGD2 
TCGA Data PortalFGD2 
Broad Tumor PortalFGD2
OASIS PortalFGD2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFGD2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFGD2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FGD2
DgiDB (Drug Gene Interaction Database)FGD2
DoCM (Curated mutations)FGD2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FGD2 (select a term)
intoGenFGD2
Cancer3DFGD2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605091   
Orphanet
DisGeNETFGD2
MedgenFGD2
Genetic Testing Registry FGD2
NextProtQ7Z6J4 [Medical]
TSGene221472
GENETestsFGD2
Target ValidationFGD2
Huge Navigator FGD2 [HugePedia]
snp3D : Map Gene to Disease221472
BioCentury BCIQFGD2
ClinGenFGD2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD221472
Chemical/Pharm GKB GenePA28103
Clinical trialFGD2
Miscellaneous
canSAR (ICR)FGD2 (select the gene name)
Probes
Litterature
PubMed14 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFGD2
EVEXFGD2
GoPubMedFGD2
iHOPFGD2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:06:28 CET 2018

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