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FGD3 (FYVE, RhoGEF and PH domain containing 3)

Identity

Alias_namesFGD1 family, member 3
Alias_symbol (synonym)FLJ00004
ZFYVE5
Other alias
HGNC (Hugo) FGD3
LocusID (NCBI) 89846
Atlas_Id 63366
Location 9q22.31  [Link to chromosome band 9q22]
Location_base_pair Starts at 92947319 and ends at 93036236 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
FAM120A (9q22.31) / FGD3 (9q22.31)TGFBR3 (1p22.1) / FGD3 (9q22.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)FGD3   16027
Cards
Entrez_Gene (NCBI)FGD3  89846  FYVE, RhoGEF and PH domain containing 3
AliasesZFYVE5
GeneCards (Weizmann)FGD3
Ensembl hg19 (Hinxton)ENSG00000127084 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000127084 [Gene_View]  chr9:92947319-93036236 [Contig_View]  FGD3 [Vega]
ICGC DataPortalENSG00000127084
TCGA cBioPortalFGD3
AceView (NCBI)FGD3
Genatlas (Paris)FGD3
WikiGenes89846
SOURCE (Princeton)FGD3
Genetics Home Reference (NIH)FGD3
Genomic and cartography
GoldenPath hg38 (UCSC)FGD3  -     chr9:92947319-93036236 +  9q22.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FGD3  -     9q22.31   [Description]    (hg19-Feb_2009)
EnsemblFGD3 - 9q22.31 [CytoView hg19]  FGD3 - 9q22.31 [CytoView hg38]
Mapping of homologs : NCBIFGD3 [Mapview hg19]  FGD3 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AK000004 AK225843 AK292676 AK301974 AY211386
RefSeq transcript (Entrez)NM_001083536 NM_001286993 NM_033086
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FGD3
Cluster EST : UnigeneHs.411081 [ NCBI ]
CGAP (NCI)Hs.411081
Alternative Splicing GalleryENSG00000127084
Gene ExpressionFGD3 [ NCBI-GEO ]   FGD3 [ EBI - ARRAY_EXPRESS ]   FGD3 [ SEEK ]   FGD3 [ MEM ]
Gene Expression Viewer (FireBrowse)FGD3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)89846
GTEX Portal (Tissue expression)FGD3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ5JSP0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ5JSP0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ5JSP0
Splice isoforms : SwissVarQ5JSP0
PhosPhoSitePlusQ5JSP0
Domaine pattern : Prosite (Expaxy)DH_2 (PS50010)    PH_DOMAIN (PS50003)    ZF_FYVE (PS50178)   
Domains : Interpro (EBI)DH-domain    PH_dom-like    PH_domain    Znf_FYVE    Znf_FYVE-rel    Znf_FYVE_PHD    Znf_RING/FYVE/PHD   
Domain families : Pfam (Sanger)FYVE (PF01363)    PH (PF00169)    RhoGEF (PF00621)   
Domain families : Pfam (NCBI)pfam01363    pfam00169    pfam00621   
Domain families : Smart (EMBL)FYVE (SM00064)  PH (SM00233)  RhoGEF (SM00325)  
Conserved Domain (NCBI)FGD3
DMDM Disease mutations89846
Blocks (Seattle)FGD3
PDB (SRS)2COC   
PDB (PDBSum)2COC   
PDB (IMB)2COC   
PDB (RSDB)2COC   
Structural Biology KnowledgeBase2COC   
SCOP (Structural Classification of Proteins)2COC   
CATH (Classification of proteins structures)2COC   
SuperfamilyQ5JSP0
Human Protein AtlasENSG00000127084
Peptide AtlasQ5JSP0
HPRD10957
IPIIPI00384357   IPI00413785   IPI01012767   IPI01013561   
Protein Interaction databases
DIP (DOE-UCLA)Q5JSP0
IntAct (EBI)Q5JSP0
FunCoupENSG00000127084
BioGRIDFGD3
STRING (EMBL)FGD3
ZODIACFGD3
Ontologies - Pathways
QuickGOQ5JSP0
Ontology : AmiGOruffle  guanyl-nucleotide exchange factor activity  guanyl-nucleotide exchange factor activity  Rho guanyl-nucleotide exchange factor activity  cytoplasm  Golgi apparatus  cytosol  cytoskeleton  cytoskeleton organization  regulation of cell shape  lamellipodium  actin cytoskeleton organization  small GTPase binding  regulation of Rho protein signal transduction  positive regulation of apoptotic process  regulation of GTPase activity  positive regulation of GTPase activity  filopodium assembly  metal ion binding  regulation of small GTPase mediated signal transduction  
Ontology : EGO-EBIruffle  guanyl-nucleotide exchange factor activity  guanyl-nucleotide exchange factor activity  Rho guanyl-nucleotide exchange factor activity  cytoplasm  Golgi apparatus  cytosol  cytoskeleton  cytoskeleton organization  regulation of cell shape  lamellipodium  actin cytoskeleton organization  small GTPase binding  regulation of Rho protein signal transduction  positive regulation of apoptotic process  regulation of GTPase activity  positive regulation of GTPase activity  filopodium assembly  metal ion binding  regulation of small GTPase mediated signal transduction  
Pathways : KEGGRegulation of actin cytoskeleton   
NDEx NetworkFGD3
Atlas of Cancer Signalling NetworkFGD3
Wikipedia pathwaysFGD3
Orthology - Evolution
OrthoDB89846
GeneTree (enSembl)ENSG00000127084
Phylogenetic Trees/Animal Genes : TreeFamFGD3
HOVERGENQ5JSP0
HOGENOMQ5JSP0
Homologs : HomoloGeneFGD3
Homology/Alignments : Family Browser (UCSC)FGD3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFGD3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FGD3
dbVarFGD3
ClinVarFGD3
1000_GenomesFGD3 
Exome Variant ServerFGD3
ExAC (Exome Aggregation Consortium)FGD3 (select the gene name)
Genetic variants : HAPMAP89846
Genomic Variants (DGV)FGD3 [DGVbeta]
DECIPHERFGD3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFGD3 
Mutations
ICGC Data PortalFGD3 
TCGA Data PortalFGD3 
Broad Tumor PortalFGD3
OASIS PortalFGD3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFGD3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFGD3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FGD3
DgiDB (Drug Gene Interaction Database)FGD3
DoCM (Curated mutations)FGD3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FGD3 (select a term)
intoGenFGD3
Cancer3DFGD3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenFGD3
Genetic Testing Registry FGD3
NextProtQ5JSP0 [Medical]
TSGene89846
GENETestsFGD3
Target ValidationFGD3
Huge Navigator FGD3 [HugePedia]
snp3D : Map Gene to Disease89846
BioCentury BCIQFGD3
ClinGenFGD3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD89846
Chemical/Pharm GKB GenePA28104
Clinical trialFGD3
Miscellaneous
canSAR (ICR)FGD3 (select the gene name)
Probes
Litterature
PubMed14 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFGD3
EVEXFGD3
GoPubMedFGD3
iHOPFGD3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:08:27 CEST 2017

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