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FGD4 (FYVE, RhoGEF and PH domain containing 4)

Identity

Other namesCMT4H
FRABP
ZFYVE6
HGNC (Hugo) FGD4
LocusID (NCBI) 121512
Location 12p11.21
Location_base_pair Starts at 32655041 and ends at 32798984 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)FGD4   19125
Cards
Entrez_Gene (NCBI)FGD4  121512  FYVE, RhoGEF and PH domain containing 4
GeneCards (Weizmann)FGD4
Ensembl (Hinxton)ENSG00000139132 [Gene_View]  chr12:32655041-32798984 [Contig_View]  FGD4 [Vega]
ICGC DataPortalENSG00000139132
AceView (NCBI)FGD4
Genatlas (Paris)FGD4
WikiGenes121512
SOURCE (Princeton)NM_139241
Genomic and cartography
GoldenPath (UCSC)FGD4  -  12p11.21   chr12:32655041-32798984 +  12p11.21   [Description]    (hg19-Feb_2009)
EnsemblFGD4 - 12p11.21 [CytoView]
Mapping of homologs : NCBIFGD4 [Mapview]
OMIM609311   611104   
Gene and transcription
Genbank (Entrez)AK057294 AK091689 AK124654 AK297025 AK303334
RefSeq transcript (Entrez)NM_139241
RefSeq genomic (Entrez)AC_000144 NC_000012 NC_018923 NG_008626 NT_009714 NW_001838055 NW_004929383
Consensus coding sequences : CCDS (NCBI)FGD4
Cluster EST : UnigeneHs.117835 [ NCBI ]
CGAP (NCI)Hs.117835
Alternative Splicing : Fast-db (Paris)GSHG0006579
Alternative Splicing GalleryENSG00000139132
Gene ExpressionFGD4 [ NCBI-GEO ]     FGD4 [ SEEK ]   FGD4 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96M96 (Uniprot)
NextProtQ96M96  [Medical]
With graphics : InterProQ96M96
Splice isoforms : SwissVarQ96M96 (Swissvar)
Domaine pattern : Prosite (Expaxy)DH_2 (PS50010)    PH_DOMAIN (PS50003)    ZF_FYVE (PS50178)   
Domains : Interpro (EBI)DH-domain    PH_like_dom    Pleckstrin_homology    Znf_FYVE    Znf_FYVE-rel    Znf_RING/FYVE/PHD   
Related proteins : CluSTrQ96M96
Domain families : Pfam (Sanger)FYVE (PF01363)    PH (PF00169)    RhoGEF (PF00621)   
Domain families : Pfam (NCBI)pfam01363    pfam00169    pfam00621   
Domain families : Smart (EMBL)FYVE (SM00064)  PH (SM00233)  RhoGEF (SM00325)  
DMDM Disease mutations121512
Blocks (Seattle)Q96M96
Human Protein AtlasENSG00000139132
Peptide AtlasQ96M96
HPRD16891
IPIIPI00065435   IPI00940940   IPI00429579   IPI01009704   IPI01022292   IPI01021852   IPI01022310   IPI00554726   IPI00983851   IPI00980854   IPI00980605   IPI00982642   
Protein Interaction databases
DIP (DOE-UCLA)Q96M96
IntAct (EBI)Q96M96
FunCoupENSG00000139132
BioGRIDFGD4
IntegromeDBFGD4
STRING (EMBL)FGD4
Ontologies - Pathways
QuickGOQ96M96
Ontology : AmiGOruffle  actin binding  guanyl-nucleotide exchange factor activity  Rho guanyl-nucleotide exchange factor activity  cytoplasm  Golgi apparatus  cytosol  cytoskeleton organization  small GTPase mediated signal transduction  regulation of cell shape  actin cytoskeleton  lamellipodium  lamellipodium assembly  microspike assembly  actin cytoskeleton organization  filopodium  small GTPase binding  positive regulation of Rho GTPase activity  positive regulation of apoptotic process  regulation of Cdc42 GTPase activity  positive regulation of GTPase activity  filopodium assembly  metal ion binding  neurotrophin TRK receptor signaling pathway  regulation of small GTPase mediated signal transduction  apoptotic signaling pathway  
Ontology : EGO-EBIruffle  actin binding  guanyl-nucleotide exchange factor activity  Rho guanyl-nucleotide exchange factor activity  cytoplasm  Golgi apparatus  cytosol  cytoskeleton organization  small GTPase mediated signal transduction  regulation of cell shape  actin cytoskeleton  lamellipodium  lamellipodium assembly  microspike assembly  actin cytoskeleton organization  filopodium  small GTPase binding  positive regulation of Rho GTPase activity  positive regulation of apoptotic process  regulation of Cdc42 GTPase activity  positive regulation of GTPase activity  filopodium assembly  metal ion binding  neurotrophin TRK receptor signaling pathway  regulation of small GTPase mediated signal transduction  apoptotic signaling pathway  
Protein Interaction DatabaseFGD4
Wikipedia pathwaysFGD4
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)FGD4
SNP (GeneSNP Utah)FGD4
SNP : HGBaseFGD4
Genetic variants : HAPMAPFGD4
1000_GenomesFGD4 
ICGC programENSG00000139132 
CONAN: Copy Number AnalysisFGD4 
Somatic Mutations in Cancer : COSMICFGD4 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)Leiden Muscular Dystrophy pages
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
DECIPHER (Syndromes)12:32655041-32798984
Mutations and Diseases : HGMDFGD4
OMIM609311    611104   
MedgenFGD4
GENETestsFGD4
Disease Genetic AssociationFGD4
Huge Navigator FGD4 [HugePedia]  FGD4 [HugeCancerGEM]
Genomic VariantsFGD4  FGD4 [DGVbeta]
Exome VariantFGD4
dbVarFGD4
ClinVarFGD4
snp3D : Map Gene to Disease121512
General knowledge
Homologs : HomoloGeneFGD4
Homology/Alignments : Family Browser (UCSC)FGD4
Phylogenetic Trees/Animal Genes : TreeFamFGD4
Chemical/Protein Interactions : CTD121512
Chemical/Pharm GKB GenePA134907925
Clinical trialFGD4
Cancer Resource (Charite)ENSG00000139132
Other databases
Probes
Litterature
PubMed24 Pubmed reference(s) in Entrez
CoreMineFGD4
GoPubMedFGD4
iHOPFGD4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Nov 8 17:25:44 CET 2014

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