FGD5 (FYVE, RhoGEF and PH domain containing 5)

2006-10-01  

Identity

HGNC
LOCATION
3p25.1
LOCUSID
ALIAS
ZFYVE23
FUSION GENES

Other Information

Locus ID:

NCBI: 152273
MIM: 614788
HGNC: 19117
Ensembl: ENSG00000154783

Variants:

dbSNP: 152273
ClinVar: 152273
TCGA: ENSG00000154783
COSMIC: FGD5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000154783ENST00000285046Q6ZNL6
ENSG00000154783ENST00000285046A0A2X0SFF2
ENSG00000154783ENST00000457774H7C0G2
ENSG00000154783ENST00000543601B7ZM68
ENSG00000154783ENST00000640506A0A1W2PRG7

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
226615142012Endothelial cell-specific FGD5 involvement in vascular pruning defines neovessel fate in mice.22
223287762012FGD5 mediates proangiogenic action of vascular endothelial growth factor in human vascular endothelial cells.14
289276652017FGD5 sustains vascular endothelial growth factor A (VEGFA) signaling through inhibition of proteasome-mediated VEGF receptor 2 degradation.5
267489012016Expression of pro-angiogenic genes in mesenchymal stem cells derived from dermis of patients with psoriasis.4
290511402017FGD5 Regulates VEGF Receptor-2 Coupling to PI3 Kinase and Receptor Recycling.3
312677152019VE-PTP inhibition stabilizes endothelial junctions by activating FGD5.3
229229602012Facio-genital dysplasia-5 regulates matrix adhesion and survival of human endothelial cells.2
281242852017FGD5 amplification in breast cancer patients is associated with tumour proliferation and a poorer prognosis.2
303081282019Structure and function of the Fgd family of divergent FYVE domain proteins 1.1
300524772018Characterization of FGD5 Expression in Primary Breast Cancers and Lymph Node Metastases.0

Citation

Dessen P

FGD5 (FYVE, RhoGEF and PH domain containing 5)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43263/fgd5