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FGD5 (FYVE, RhoGEF and PH domain containing 5)

Identity

Alias_symbol (synonym)ZFYVE23
FLJ39957
FLJ00274
Other alias
HGNC (Hugo) FGD5
LocusID (NCBI) 152273
Atlas_Id 43263
Location 3p25.1  [Link to chromosome band 3p25]
Location_base_pair Starts at 14818962 and ends at 14934565 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
BTD (3p25.1) / FGD5 (3p25.1)FGD5 (3p25.1) / MRPL36 (5p15.33)NR2C2 (3p25.1) / FGD5 (3p25.1)
NR2C2 3p25.1 / FGD5 3p25.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)FGD5   19117
Cards
Entrez_Gene (NCBI)FGD5  152273  FYVE, RhoGEF and PH domain containing 5
AliasesZFYVE23
GeneCards (Weizmann)FGD5
Ensembl hg19 (Hinxton)ENSG00000154783 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000154783 [Gene_View]  chr3:14818962-14934565 [Contig_View]  FGD5 [Vega]
ICGC DataPortalENSG00000154783
TCGA cBioPortalFGD5
AceView (NCBI)FGD5
Genatlas (Paris)FGD5
WikiGenes152273
SOURCE (Princeton)FGD5
Genetics Home Reference (NIH)FGD5
Genomic and cartography
GoldenPath hg38 (UCSC)FGD5  -     chr3:14818962-14934565 +  3p25.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FGD5  -     3p25.1   [Description]    (hg19-Feb_2009)
EnsemblFGD5 - 3p25.1 [CytoView hg19]  FGD5 - 3p25.1 [CytoView hg38]
Mapping of homologs : NCBIFGD5 [Mapview hg19]  FGD5 [Mapview hg38]
OMIM614788   
Gene and transcription
Genbank (Entrez)AK057128 AK096856 AK097276 AK123054 AK131078
RefSeq transcript (Entrez)NM_001320276 NM_152536
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FGD5
Cluster EST : UnigeneHs.412406 [ NCBI ]
CGAP (NCI)Hs.412406
Alternative Splicing GalleryENSG00000154783
Gene ExpressionFGD5 [ NCBI-GEO ]   FGD5 [ EBI - ARRAY_EXPRESS ]   FGD5 [ SEEK ]   FGD5 [ MEM ]
Gene Expression Viewer (FireBrowse)FGD5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)152273
GTEX Portal (Tissue expression)FGD5
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6ZNL6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6ZNL6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6ZNL6
Splice isoforms : SwissVarQ6ZNL6
PhosPhoSitePlusQ6ZNL6
Domaine pattern : Prosite (Expaxy)DH_2 (PS50010)    PH_DOMAIN (PS50003)    ZF_FYVE (PS50178)   
Domains : Interpro (EBI)DH-domain    PH_dom-like    PH_domain    Znf_FYVE    Znf_FYVE-rel    Znf_RING/FYVE/PHD   
Domain families : Pfam (Sanger)FYVE (PF01363)    PH (PF00169)    RhoGEF (PF00621)   
Domain families : Pfam (NCBI)pfam01363    pfam00169    pfam00621   
Domain families : Smart (EMBL)FYVE (SM00064)  PH (SM00233)  RhoGEF (SM00325)  
Conserved Domain (NCBI)FGD5
DMDM Disease mutations152273
Blocks (Seattle)FGD5
PDB (SRS)3MPX   
PDB (PDBSum)3MPX   
PDB (IMB)3MPX   
PDB (RSDB)3MPX   
Structural Biology KnowledgeBase3MPX   
SCOP (Structural Classification of Proteins)3MPX   
CATH (Classification of proteins structures)3MPX   
SuperfamilyQ6ZNL6
Human Protein AtlasENSG00000154783
Peptide AtlasQ6ZNL6
HPRD13322
IPIIPI00397955   IPI00554548   IPI01013117   IPI00927209   
Protein Interaction databases
DIP (DOE-UCLA)Q6ZNL6
IntAct (EBI)Q6ZNL6
FunCoupENSG00000154783
BioGRIDFGD5
STRING (EMBL)FGD5
ZODIACFGD5
Ontologies - Pathways
QuickGOQ6ZNL6
Ontology : AmiGOruffle  guanyl-nucleotide exchange factor activity  Rho guanyl-nucleotide exchange factor activity  protein binding  cytoplasm  early endosome  endoplasmic reticulum  Golgi apparatus  cytoskeleton  cytoskeleton organization  regulation of cell shape  lamellipodium  actin cytoskeleton organization  small GTPase binding  ruffle membrane  regulation of Rho protein signal transduction  regulation of GTPase activity  positive regulation of GTPase activity  filopodium assembly  metal ion binding  
Ontology : EGO-EBIruffle  guanyl-nucleotide exchange factor activity  Rho guanyl-nucleotide exchange factor activity  protein binding  cytoplasm  early endosome  endoplasmic reticulum  Golgi apparatus  cytoskeleton  cytoskeleton organization  regulation of cell shape  lamellipodium  actin cytoskeleton organization  small GTPase binding  ruffle membrane  regulation of Rho protein signal transduction  regulation of GTPase activity  positive regulation of GTPase activity  filopodium assembly  metal ion binding  
NDEx NetworkFGD5
Atlas of Cancer Signalling NetworkFGD5
Wikipedia pathwaysFGD5
Orthology - Evolution
OrthoDB152273
GeneTree (enSembl)ENSG00000154783
Phylogenetic Trees/Animal Genes : TreeFamFGD5
HOVERGENQ6ZNL6
HOGENOMQ6ZNL6
Homologs : HomoloGeneFGD5
Homology/Alignments : Family Browser (UCSC)FGD5
Gene fusions - Rearrangements
Fusion : MitelmanNR2C2/FGD5 [3p25.1/3p25.1]  [t(3;3)(p25;p25)]  
Fusion: TCGANR2C2 3p25.1 FGD5 3p25.1 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFGD5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FGD5
dbVarFGD5
ClinVarFGD5
1000_GenomesFGD5 
Exome Variant ServerFGD5
ExAC (Exome Aggregation Consortium)FGD5 (select the gene name)
Genetic variants : HAPMAP152273
Genomic Variants (DGV)FGD5 [DGVbeta]
DECIPHERFGD5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFGD5 
Mutations
ICGC Data PortalFGD5 
TCGA Data PortalFGD5 
Broad Tumor PortalFGD5
OASIS PortalFGD5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFGD5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFGD5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FGD5
DgiDB (Drug Gene Interaction Database)FGD5
DoCM (Curated mutations)FGD5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FGD5 (select a term)
intoGenFGD5
Cancer3DFGD5(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM614788   
Orphanet
MedgenFGD5
Genetic Testing Registry FGD5
NextProtQ6ZNL6 [Medical]
TSGene152273
GENETestsFGD5
Target ValidationFGD5
Huge Navigator FGD5 [HugePedia]
snp3D : Map Gene to Disease152273
BioCentury BCIQFGD5
ClinGenFGD5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD152273
Chemical/Pharm GKB GenePA134874843
Clinical trialFGD5
Miscellaneous
canSAR (ICR)FGD5 (select the gene name)
Probes
Litterature
PubMed9 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFGD5
EVEXFGD5
GoPubMedFGD5
iHOPFGD5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:08:23 CEST 2017

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