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FGD6 (FYVE, RhoGEF and PH domain containing 6)

Identity

Alias (NCBI)ZFYVE24
HGNC (Hugo) FGD6
HGNC Alias symbZFYVE24
FLJ11183
LocusID (NCBI) 55785
Atlas_Id 63369
Location 12q22  [Link to chromosome band 12q22]
Location_base_pair Starts at 95076749 and ends at 95217467 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FGD6 (12q22) / ARHGAP24 (4q21.23)FGD6 (12q22) / NUP37 (12q23.2)METTL25 (12q21.31) / FGD6 (12q22)
NDUFA12 (12q22) / FGD6 (12q22)SYT1 (12q21.2) / FGD6 (12q22)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)FGD6   21740
Cards
Entrez_Gene (NCBI)FGD6    FYVE, RhoGEF and PH domain containing 6
AliasesZFYVE24
GeneCards (Weizmann)FGD6
Ensembl hg19 (Hinxton)ENSG00000180263 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000180263 [Gene_View]  ENSG00000180263 [Sequence]  chr12:95076749-95217467 [Contig_View]  FGD6 [Vega]
ICGC DataPortalENSG00000180263
TCGA cBioPortalFGD6
AceView (NCBI)FGD6
Genatlas (Paris)FGD6
SOURCE (Princeton)FGD6
Genetics Home Reference (NIH)FGD6
Genomic and cartography
GoldenPath hg38 (UCSC)FGD6  -     chr12:95076749-95217467 -  12q22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FGD6  -     12q22   [Description]    (hg19-Feb_2009)
GoldenPathFGD6 - 12q22 [CytoView hg19]  FGD6 - 12q22 [CytoView hg38]
ImmunoBaseENSG00000180263
Genome Data Viewer NCBIFGD6 [Mapview hg19]  
OMIM613520   
Gene and transcription
Genbank (Entrez)AB037783 AK002045 AK026881 AK124904 AK128492
RefSeq transcript (Entrez)NM_018351
Consensus coding sequences : CCDS (NCBI)FGD6
Gene ExpressionFGD6 [ NCBI-GEO ]   FGD6 [ EBI - ARRAY_EXPRESS ]   FGD6 [ SEEK ]   FGD6 [ MEM ]
Gene Expression Viewer (FireBrowse)FGD6 [ Firebrowse - Broad ]
GenevisibleExpression of FGD6 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55785
GTEX Portal (Tissue expression)FGD6
Human Protein AtlasENSG00000180263-FGD6 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6ZV73   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6ZV73  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6ZV73
PhosPhoSitePlusQ6ZV73
Domaine pattern : Prosite (Expaxy)DH_2 (PS50010)    PH_DOMAIN (PS50003)    ZF_FYVE (PS50178)   
Domains : Interpro (EBI)DBL_dom_sf    DH-domain    FGD6_N_PH    PH-like_dom_sf    PH_domain    Znf_FYVE    Znf_FYVE-rel    Znf_RING/FYVE/PHD   
Domain families : Pfam (Sanger)FYVE (PF01363)    PH (PF00169)    RhoGEF (PF00621)   
Domain families : Pfam (NCBI)pfam01363    pfam00169    pfam00621   
Domain families : Smart (EMBL)FYVE (SM00064)  PH (SM00233)  RhoGEF (SM00325)  
Conserved Domain (NCBI)FGD6
SuperfamilyQ6ZV73
AlphaFold pdb e-kbQ6ZV73   
Human Protein Atlas [tissue]ENSG00000180263-FGD6 [tissue]
HPRD16892
Protein Interaction databases
DIP (DOE-UCLA)Q6ZV73
IntAct (EBI)Q6ZV73
BioGRIDFGD6
STRING (EMBL)FGD6
ZODIACFGD6
Ontologies - Pathways
QuickGOQ6ZV73
Ontology : AmiGOruffle  guanyl-nucleotide exchange factor activity  cytoplasm  cytoplasm  Golgi apparatus  cytoskeleton  cytoskeleton organization  regulation of cell shape  lamellipodium  actin cytoskeleton organization  small GTPase binding  regulation of GTPase activity  filopodium assembly  metal ion binding  
Ontology : EGO-EBIruffle  guanyl-nucleotide exchange factor activity  cytoplasm  cytoplasm  Golgi apparatus  cytoskeleton  cytoskeleton organization  regulation of cell shape  lamellipodium  actin cytoskeleton organization  small GTPase binding  regulation of GTPase activity  filopodium assembly  metal ion binding  
NDEx NetworkFGD6
Atlas of Cancer Signalling NetworkFGD6
Wikipedia pathwaysFGD6
Orthology - Evolution
OrthoDB55785
GeneTree (enSembl)ENSG00000180263
Phylogenetic Trees/Animal Genes : TreeFamFGD6
Homologs : HomoloGeneFGD6
Homology/Alignments : Family Browser (UCSC)FGD6
Gene fusions - Rearrangements
Fusion : QuiverFGD6
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFGD6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FGD6
dbVarFGD6
ClinVarFGD6
MonarchFGD6
1000_GenomesFGD6 
Exome Variant ServerFGD6
GNOMAD BrowserENSG00000180263
Varsome BrowserFGD6
ACMGFGD6 variants
VarityQ6ZV73
Genomic Variants (DGV)FGD6 [DGVbeta]
DECIPHERFGD6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFGD6 
Mutations
ICGC Data PortalFGD6 
TCGA Data PortalFGD6 
Broad Tumor PortalFGD6
OASIS PortalFGD6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFGD6  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DFGD6
Mutations and Diseases : HGMDFGD6
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaFGD6
DgiDB (Drug Gene Interaction Database)FGD6
DoCM (Curated mutations)FGD6
CIViC (Clinical Interpretations of Variants in Cancer)FGD6
Cancer3DFGD6
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM613520   
Orphanet
DisGeNETFGD6
MedgenFGD6
Genetic Testing Registry FGD6
NextProtQ6ZV73 [Medical]
GENETestsFGD6
Target ValidationFGD6
Huge Navigator FGD6 [HugePedia]
ClinGenFGD6
Clinical trials, drugs, therapy
MyCancerGenomeFGD6
Protein Interactions : CTDFGD6
Pharm GKB GenePA134967436
PharosQ6ZV73
Clinical trialFGD6
Miscellaneous
canSAR (ICR)FGD6
HarmonizomeFGD6
DataMed IndexFGD6
Probes
Litterature
PubMed23 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXFGD6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:50:30 CEST 2021

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