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FGD6 (FYVE, RhoGEF and PH domain containing 6)

Identity

Alias_symbol (synonym)ZFYVE24
FLJ11183
Other alias
HGNC (Hugo) FGD6
LocusID (NCBI) 55785
Atlas_Id 63369
Location 12q22  [Link to chromosome band 12q22]
Location_base_pair Starts at 95470525 and ends at 95611240 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
FGD6 (12q22) / ARHGAP24 (4q21.23)FGD6 (12q22) / NUP37 (12q23.2)METTL25 (12q21.31) / FGD6 (12q22)
NDUFA12 (12q22) / FGD6 (12q22)SYT1 (12q21.2) / FGD6 (12q22)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)FGD6   21740
Cards
Entrez_Gene (NCBI)FGD6  55785  FYVE, RhoGEF and PH domain containing 6
AliasesZFYVE24
GeneCards (Weizmann)FGD6
Ensembl hg19 (Hinxton)ENSG00000180263 [Gene_View]  chr12:95470525-95611240 [Contig_View]  FGD6 [Vega]
Ensembl hg38 (Hinxton)ENSG00000180263 [Gene_View]  chr12:95470525-95611240 [Contig_View]  FGD6 [Vega]
ICGC DataPortalENSG00000180263
TCGA cBioPortalFGD6
AceView (NCBI)FGD6
Genatlas (Paris)FGD6
WikiGenes55785
SOURCE (Princeton)FGD6
Genetics Home Reference (NIH)FGD6
Genomic and cartography
GoldenPath hg19 (UCSC)FGD6  -     chr12:95470525-95611240 -  12q22   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)FGD6  -     12q22   [Description]    (hg38-Dec_2013)
EnsemblFGD6 - 12q22 [CytoView hg19]  FGD6 - 12q22 [CytoView hg38]
Mapping of homologs : NCBIFGD6 [Mapview hg19]  FGD6 [Mapview hg38]
OMIM613520   
Gene and transcription
Genbank (Entrez)AB037783 AK002045 AK026881 AK124904 AK128492
RefSeq transcript (Entrez)NM_018351
RefSeq genomic (Entrez)NC_000012 NC_018923 NT_029419 NW_004929384
Consensus coding sequences : CCDS (NCBI)FGD6
Cluster EST : UnigeneHs.506381 [ NCBI ]
CGAP (NCI)Hs.506381
Alternative Splicing GalleryENSG00000180263
Gene ExpressionFGD6 [ NCBI-GEO ]   FGD6 [ EBI - ARRAY_EXPRESS ]   FGD6 [ SEEK ]   FGD6 [ MEM ]
Gene Expression Viewer (FireBrowse)FGD6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55785
GTEX Portal (Tissue expression)FGD6
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6ZV73   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6ZV73  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6ZV73
Splice isoforms : SwissVarQ6ZV73
PhosPhoSitePlusQ6ZV73
Domaine pattern : Prosite (Expaxy)DH_2 (PS50010)    PH_DOMAIN (PS50003)    ZF_FYVE (PS50178)   
Domains : Interpro (EBI)DH-domain    PH_domain    PH_like_dom    Znf_FYVE    Znf_FYVE-rel    Znf_RING/FYVE/PHD   
Domain families : Pfam (Sanger)FYVE (PF01363)    PH (PF00169)    RhoGEF (PF00621)   
Domain families : Pfam (NCBI)pfam01363    pfam00169    pfam00621   
Domain families : Smart (EMBL)FYVE (SM00064)  PH (SM00233)  RhoGEF (SM00325)  
Conserved Domain (NCBI)FGD6
DMDM Disease mutations55785
Blocks (Seattle)FGD6
SuperfamilyQ6ZV73
Human Protein AtlasENSG00000180263
Peptide AtlasQ6ZV73
HPRD16892
IPIIPI00419100   IPI00471914   IPI00942099   IPI01022895   IPI01023038   IPI01022661   
Protein Interaction databases
DIP (DOE-UCLA)Q6ZV73
IntAct (EBI)Q6ZV73
FunCoupENSG00000180263
BioGRIDFGD6
STRING (EMBL)FGD6
ZODIACFGD6
Ontologies - Pathways
QuickGOQ6ZV73
Ontology : AmiGOruffle  guanyl-nucleotide exchange factor activity  Rho guanyl-nucleotide exchange factor activity  cytoplasm  Golgi apparatus  cytoskeleton  cytoskeleton organization  regulation of cell shape  lamellipodium  actin cytoskeleton organization  small GTPase binding  regulation of GTPase activity  positive regulation of GTPase activity  positive regulation of GTPase activity  filopodium assembly  metal ion binding  
Ontology : EGO-EBIruffle  guanyl-nucleotide exchange factor activity  Rho guanyl-nucleotide exchange factor activity  cytoplasm  Golgi apparatus  cytoskeleton  cytoskeleton organization  regulation of cell shape  lamellipodium  actin cytoskeleton organization  small GTPase binding  regulation of GTPase activity  positive regulation of GTPase activity  positive regulation of GTPase activity  filopodium assembly  metal ion binding  
NDEx NetworkFGD6
Atlas of Cancer Signalling NetworkFGD6
Wikipedia pathwaysFGD6
Orthology - Evolution
OrthoDB55785
GeneTree (enSembl)ENSG00000180263
Phylogenetic Trees/Animal Genes : TreeFamFGD6
HOVERGENQ6ZV73
HOGENOMQ6ZV73
Homologs : HomoloGeneFGD6
Homology/Alignments : Family Browser (UCSC)FGD6
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFGD6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FGD6
dbVarFGD6
ClinVarFGD6
1000_GenomesFGD6 
Exome Variant ServerFGD6
ExAC (Exome Aggregation Consortium)FGD6 (select the gene name)
Genetic variants : HAPMAP55785
Genomic Variants (DGV)FGD6 [DGVbeta]
DECIPHER (Syndromes)12:95470525-95611240  ENSG00000180263
CONAN: Copy Number AnalysisFGD6 
Mutations
ICGC Data PortalFGD6 
TCGA Data PortalFGD6 
Broad Tumor PortalFGD6
OASIS PortalFGD6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFGD6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFGD6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FGD6
DgiDB (Drug Gene Interaction Database)FGD6
DoCM (Curated mutations)FGD6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FGD6 (select a term)
intoGenFGD6
Cancer3DFGD6(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM613520   
Orphanet
MedgenFGD6
Genetic Testing Registry FGD6
NextProtQ6ZV73 [Medical]
TSGene55785
GENETestsFGD6
Huge Navigator FGD6 [HugePedia]
snp3D : Map Gene to Disease55785
BioCentury BCIQFGD6
ClinGenFGD6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD55785
Chemical/Pharm GKB GenePA134967436
Clinical trialFGD6
Miscellaneous
canSAR (ICR)FGD6 (select the gene name)
Probes
Litterature
PubMed11 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFGD6
EVEXFGD6
GoPubMedFGD6
iHOPFGD6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:04:44 CET 2017

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