Atlas of Genetics and Cytogenetics in Oncology and Haematology

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Taking over the Atlas
Dear Colleagues,
The Atlas, once more, is in great danger, and I will have to proceed to a collective economic lay-off of all the team involved in the Atlas before the begining of April 2015 (a foundation having suddenly withdrawn its commitment to support the Atlas). I ask you herein if any Scientific Society (a Society of Cytogenetics, of Clinical Genetics, of Hematology, or a Cancer Society, or any other...), any University and/or Hospital, any Charity, or any database would be interested in taking over the Atlas, in whole or in part. If taking charge of the whole lot is too big, a consortium of various actors could be the solution (I am myself trying to find partners). Could you please spread the information, contact the relevant authorities, and find partners.
Survival of the Atlas will be critically dependant upon your ability to find solutions (and urgently!).
Kind regards.
Jean-Loup Huret
Donations are also welcome

Donate (in Euros)

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FGF10 (fibroblast growth factor 10)

Identity

Other names-
HGNC (Hugo) FGF10
LocusID (NCBI) 2255
Location 5p12
Location_base_pair Starts at 44305097 and ends at 44388784 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas)

Solid Tumors AmeloblastomID5945

External links

Nomenclature
HGNC (Hugo)FGF10   3666
Cards
Entrez_Gene (NCBI)FGF10  2255  fibroblast growth factor 10
GeneCards (Weizmann)FGF10
Ensembl hg19 (Hinxton) [Gene_View]  chr5:44305097-44388784 [Contig_View]  FGF10 [Vega]
Ensembl hg38 (Hinxton) [Gene_View]  chr5:44305097-44388784 [Contig_View]  FGF10 [Vega]
cBioPortalFGF10
AceView (NCBI)FGF10
Genatlas (Paris)FGF10
WikiGenes2255
SOURCE (Princeton)FGF10
Genomic and cartography
GoldenPath hg19 (UCSC)FGF10  -     chr5:44305097-44388784 -  5p12   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)FGF10  -     5p12   [Description]    (hg38-Dec_2013)
EnsemblFGF10 - 5p12 [CytoView hg19]  FGF10 - 5p12 [CytoView hg38]
Mapping of homologs : NCBIFGF10 [Mapview hg19]  FGF10 [Mapview hg38]
OMIM149730   180920   602115   
Gene and transcription
Genbank (Entrez)AB002097 AF411527 AF508782 AK315314 BC069561
RefSeq transcript (Entrez)NM_004465
RefSeq genomic (Entrez)AC_000137 NC_000005 NC_018916 NG_011446 NT_006576 NW_001838933 NW_004929321
Consensus coding sequences : CCDS (NCBI)FGF10
Cluster EST : UnigeneHs.664499 [ NCBI ]
CGAP (NCI)Hs.664499
Alternative Splicing : Fast-db (Paris)GSHG0024774
Gene ExpressionFGF10 [ NCBI-GEO ]     FGF10 [ SEEK ]   FGF10 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO15520 (Uniprot)
NextProtO15520  [Medical]
With graphics : InterProO15520
Splice isoforms : SwissVarO15520 (Swissvar)
Domaine pattern : Prosite (Expaxy)HBGF_FGF (PS00247)   
Domains : Interpro (EBI)Cytokine_IL1-like    FGF10    Fibroblast_GF_fam    IL-1_fam/FGF_fam   
Related proteins : CluSTrO15520
Domain families : Pfam (Sanger)FGF (PF00167)   
Domain families : Pfam (NCBI)pfam00167   
Domain families : Smart (EMBL)FGF (SM00442)  
DMDM Disease mutations2255
Blocks (Seattle)O15520
PDB (SRS)1NUN   
PDB (PDBSum)1NUN   
PDB (IMB)1NUN   
PDB (RSDB)1NUN   
Peptide AtlasO15520
HPRD03665
IPIIPI00007307   IPI00964243   
Protein Interaction databases
DIP (DOE-UCLA)O15520
IntAct (EBI)O15520
BioGRIDFGF10
IntegromeDBFGF10
STRING (EMBL)FGF10
Ontologies - Pathways
QuickGOO15520
Ontology : AmiGOactivation of MAPK activity  angiogenesis  metanephros development  organ induction  mesonephros development  blood vessel remodeling  metanephros morphogenesis  fibroblast growth factor receptor binding  type 2 fibroblast growth factor receptor binding  extracellular region  extracellular space  nucleus  plasma membrane  epidermal growth factor receptor signaling pathway  determination of left/right symmetry  salivary gland development  growth factor activity  heparin binding  negative regulation of cell proliferation  insulin receptor signaling pathway  fibroblast growth factor receptor signaling pathway  regulation of smoothened signaling pathway  embryonic pattern specification  cell surface  cell surface  epithelial cell migration  positive regulation of epithelial cell migration  positive regulation of keratinocyte proliferation  pituitary gland development  embryonic genitalia morphogenesis  thyroid gland development  otic vesicle formation  positive regulation of vascular endothelial growth factor receptor signaling pathway  extracellular matrix  pancreas development  hair follicle morphogenesis  embryonic camera-type eye development  actin cytoskeleton reorganization  positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle  response to estradiol  response to lipopolysaccharide  positive regulation of ATPase activity  lacrimal gland development  regulation of activin receptor signaling pathway  protein localization to cell surface  somatic stem cell maintenance  Fc-epsilon receptor signaling pathway  chemoattractant activity  wound healing  tissue regeneration  odontogenesis of dentin-containing tooth  muscle cell fate commitment  positive regulation of MAPK cascade  keratinocyte proliferation  innate immune response  positive regulation of DNA repair  positive regulation of DNA replication  positive regulation of Notch signaling pathway  positive regulation of transcription, DNA-templated  positive regulation of mitotic cell cycle  positive regulation of transcription from RNA polymerase II promoter  positive regulation of Ras protein signal transduction  regulation of saliva secretion  neurotrophin TRK receptor signaling pathway  phosphatidylinositol-mediated signaling  positive regulation of fibroblast proliferation  spleen development  thymus development  embryonic digestive tract morphogenesis  branching morphogenesis of an epithelial tube  female genitalia morphogenesis  male genitalia morphogenesis  positive regulation of lymphocyte proliferation  epithelial cell proliferation  urothelial cell proliferation  positive regulation of urothelial cell proliferation  positive regulation of epithelial cell proliferation  positive regulation of peptidyl-tyrosine phosphorylation  white fat cell differentiation  positive chemotaxis  induction of positive chemotaxis  smooth muscle cell differentiation  positive regulation of keratinocyte migration  radial glial cell differentiation  positive regulation of epithelial cell proliferation involved in wound healing  limb bud formation  lung epithelium development  lung saccule development  bronchiole morphogenesis  bud outgrowth involved in lung branching  mesenchymal-epithelial cell signaling involved in lung development  Type II pneumocyte differentiation  fibroblast growth factor receptor signaling pathway involved in mammary gland specification  mammary gland bud formation  submandibular salivary gland formation  epithelial cell proliferation involved in salivary gland morphogenesis  regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling  branch elongation involved in salivary gland morphogenesis  regulation of prostatic bud formation  semicircular canal fusion  mesenchymal cell differentiation involved in lung development  secretion by lung epithelial cell involved in lung growth  lung proximal/distal axis specification  tear secretion  positive regulation of white fat cell proliferation  ERK1 and ERK2 cascade  positive regulation of ERK1 and ERK2 cascade  Harderian gland development  negative regulation of cell cycle arrest  positive regulation of hair follicle cell proliferation  positive regulation of canonical Wnt signaling pathway  negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  
Ontology : EGO-EBIactivation of MAPK activity  angiogenesis  metanephros development  organ induction  mesonephros development  blood vessel remodeling  metanephros morphogenesis  fibroblast growth factor receptor binding  type 2 fibroblast growth factor receptor binding  extracellular region  extracellular space  nucleus  plasma membrane  epidermal growth factor receptor signaling pathway  determination of left/right symmetry  salivary gland development  growth factor activity  heparin binding  negative regulation of cell proliferation  insulin receptor signaling pathway  fibroblast growth factor receptor signaling pathway  regulation of smoothened signaling pathway  embryonic pattern specification  cell surface  cell surface  epithelial cell migration  positive regulation of epithelial cell migration  positive regulation of keratinocyte proliferation  pituitary gland development  embryonic genitalia morphogenesis  thyroid gland development  otic vesicle formation  positive regulation of vascular endothelial growth factor receptor signaling pathway  extracellular matrix  pancreas development  hair follicle morphogenesis  embryonic camera-type eye development  actin cytoskeleton reorganization  positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle  response to estradiol  response to lipopolysaccharide  positive regulation of ATPase activity  lacrimal gland development  regulation of activin receptor signaling pathway  protein localization to cell surface  somatic stem cell maintenance  Fc-epsilon receptor signaling pathway  chemoattractant activity  wound healing  tissue regeneration  odontogenesis of dentin-containing tooth  muscle cell fate commitment  positive regulation of MAPK cascade  keratinocyte proliferation  innate immune response  positive regulation of DNA repair  positive regulation of DNA replication  positive regulation of Notch signaling pathway  positive regulation of transcription, DNA-templated  positive regulation of mitotic cell cycle  positive regulation of transcription from RNA polymerase II promoter  positive regulation of Ras protein signal transduction  regulation of saliva secretion  neurotrophin TRK receptor signaling pathway  phosphatidylinositol-mediated signaling  positive regulation of fibroblast proliferation  spleen development  thymus development  embryonic digestive tract morphogenesis  branching morphogenesis of an epithelial tube  female genitalia morphogenesis  male genitalia morphogenesis  positive regulation of lymphocyte proliferation  epithelial cell proliferation  urothelial cell proliferation  positive regulation of urothelial cell proliferation  positive regulation of epithelial cell proliferation  positive regulation of peptidyl-tyrosine phosphorylation  white fat cell differentiation  positive chemotaxis  induction of positive chemotaxis  smooth muscle cell differentiation  positive regulation of keratinocyte migration  radial glial cell differentiation  positive regulation of epithelial cell proliferation involved in wound healing  limb bud formation  lung epithelium development  lung saccule development  bronchiole morphogenesis  bud outgrowth involved in lung branching  mesenchymal-epithelial cell signaling involved in lung development  Type II pneumocyte differentiation  fibroblast growth factor receptor signaling pathway involved in mammary gland specification  mammary gland bud formation  submandibular salivary gland formation  epithelial cell proliferation involved in salivary gland morphogenesis  regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling  branch elongation involved in salivary gland morphogenesis  regulation of prostatic bud formation  semicircular canal fusion  mesenchymal cell differentiation involved in lung development  secretion by lung epithelial cell involved in lung growth  lung proximal/distal axis specification  tear secretion  positive regulation of white fat cell proliferation  ERK1 and ERK2 cascade  positive regulation of ERK1 and ERK2 cascade  Harderian gland development  negative regulation of cell cycle arrest  positive regulation of hair follicle cell proliferation  positive regulation of canonical Wnt signaling pathway  negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  
Pathways : KEGGMAPK signaling pathway    Ras signaling pathway    Rap1 signaling pathway    PI3K-Akt signaling pathway    Regulation of actin cytoskeleton    Pathways in cancer    Proteoglycans in cancer    Melanoma   
Protein Interaction DatabaseFGF10
DoCM (Curated mutations)FGF10
Wikipedia pathwaysFGF10
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerFGF10 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FGF10
dbVarFGF10
ClinVarFGF10
1000_GenomesFGF10 
Exome Variant ServerFGF10
SNP (GeneSNP Utah)FGF10
SNP : HGBaseFGF10
Genetic variants : HAPMAPFGF10
Genomic Variants (DGV)FGF10 [DGVbeta]
Mutations
Somatic Mutations in Cancer : COSMICFGF10 
CONAN: Copy Number AnalysisFGF10 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)5:44305097-44388784
Mutations and Diseases : HGMDFGF10
OMIM149730    180920    602115   
MedgenFGF10
NextProtO15520 [Medical]
GENETestsFGF10
Disease Genetic AssociationFGF10
Huge Navigator FGF10 [HugePedia]  FGF10 [HugeCancerGEM]
snp3D : Map Gene to Disease2255
DGIdb (Drug Gene Interaction db)FGF10
General knowledge
Homologs : HomoloGeneFGF10
Homology/Alignments : Family Browser (UCSC)FGF10
Phylogenetic Trees/Animal Genes : TreeFamFGF10
Chemical/Protein Interactions : CTD2255
Chemical/Pharm GKB GenePA28106
Clinical trialFGF10
Other databases
Probes
Litterature
PubMed85 Pubmed reference(s) in Entrez
CoreMineFGF10
GoPubMedFGF10
iHOPFGF10
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2014Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Feb 14 15:50:09 CET 2015
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For comments and suggestions or contributions, please contact us

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