Atlas of Genetics and Cytogenetics in Oncology and Haematology

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FGF10 (fibroblast growth factor 10)

Identity

Alias (NCBI)-
HGNC (Hugo) FGF10
LocusID (NCBI) 2255
Atlas_Id 40550
Location 5p12  [Link to chromosome band 5p12]
Location_base_pair Starts at 44300252 and ends at 44389420 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
HEATR6 (17q23.1)::FGF10 (5p12)NIPBL (5p13.2)::FGF10 (5p12)RICTOR (5p13.1)::FGF10 (5p12)
HEATR6 17q23.1::FGF10 5p12NIPBL 5p13.2::FGF10 5p12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

 

Nomenclature
HGNC (Hugo)FGF10   3666
Cards
Entrez_Gene (NCBI)FGF10    fibroblast growth factor 10
Aliases
GeneCards (Weizmann)FGF10
Ensembl hg19 (Hinxton)ENSG00000070193 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000070193 [Gene_View]  ENSG00000070193 [Sequence]  chr5:44300252-44389420 [Contig_View]  FGF10 [Vega]
ICGC DataPortalENSG00000070193
TCGA cBioPortalFGF10
AceView (NCBI)FGF10
Genatlas (Paris)FGF10
SOURCE (Princeton)FGF10
Genetics Home Reference (NIH)FGF10
Genomic and cartography
GoldenPath hg38 (UCSC)FGF10  -     chr5:44300252-44389420 -  5p12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FGF10  -     5p12   [Description]    (hg19-Feb_2009)
GoldenPathFGF10 - 5p12 [CytoView hg19]  FGF10 - 5p12 [CytoView hg38]
ImmunoBaseENSG00000070193
Genome Data Viewer NCBIFGF10 [Mapview hg19]  
OMIM149730   180920   602115   
Gene and transcription
Genbank (Entrez)AB002097 AF411527 AF508782 AK023508 AK315314
RefSeq transcript (Entrez)NM_004465
Consensus coding sequences : CCDS (NCBI)FGF10
Gene ExpressionFGF10 [ NCBI-GEO ]   FGF10 [ EBI - ARRAY_EXPRESS ]   FGF10 [ SEEK ]   FGF10 [ MEM ]
Gene Expression Viewer (FireBrowse)FGF10 [ Firebrowse - Broad ]
GenevisibleExpression of FGF10 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2255
GTEX Portal (Tissue expression)FGF10
Human Protein AtlasENSG00000070193-FGF10 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO15520   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO15520  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO15520
PhosPhoSitePlusO15520
Domaine pattern : Prosite (Expaxy)HBGF_FGF (PS00247)   
Domains : Interpro (EBI)FGF10    Fibroblast_GF_fam    IL1/FGF   
Domain families : Pfam (Sanger)FGF (PF00167)   
Domain families : Pfam (NCBI)pfam00167   
Domain families : Smart (EMBL)FGF (SM00442)  
Conserved Domain (NCBI)FGF10
PDB (RSDB)1NUN   
PDB Europe1NUN   
PDB (PDBSum)1NUN   
PDB (IMB)1NUN   
Structural Biology KnowledgeBase1NUN   
SCOP (Structural Classification of Proteins)1NUN   
CATH (Classification of proteins structures)1NUN   
SuperfamilyO15520
AlphaFold pdb e-kbO15520   
Human Protein Atlas [tissue]ENSG00000070193-FGF10 [tissue]
HPRD03665
Protein Interaction databases
DIP (DOE-UCLA)O15520
IntAct (EBI)O15520
BioGRIDFGF10
STRING (EMBL)FGF10
ZODIACFGF10
Ontologies - Pathways
QuickGOO15520
Ontology : AmiGOestablishment of mitotic spindle orientation  MAPK cascade  activation of MAPK activity  angiogenesis  metanephros development  organ induction  mesonephros development  positive regulation of protein phosphorylation  blood vessel remodeling  metanephros morphogenesis  fibroblast growth factor receptor binding  fibroblast growth factor receptor binding  type 2 fibroblast growth factor receptor binding  type 2 fibroblast growth factor receptor binding  protein binding  extracellular region  extracellular space  extracellular space  nucleus  cytoplasm  plasma membrane  determination of left/right symmetry  salivary gland development  growth factor activity  growth factor activity  heparin binding  positive regulation of cell population proliferation  negative regulation of cell population proliferation  fibroblast growth factor receptor signaling pathway  fibroblast growth factor receptor signaling pathway  regulation of smoothened signaling pathway  embryonic pattern specification  animal organ morphogenesis  cell surface  cell surface  positive regulation of gene expression  positive regulation of epithelial cell migration  positive regulation of epithelial cell migration  positive regulation of keratinocyte proliferation  pituitary gland development  cell differentiation  regulation of cell migration  embryonic genitalia morphogenesis  thyroid gland development  otic vesicle formation  positive regulation of vascular endothelial growth factor receptor signaling pathway  pancreas development  hair follicle morphogenesis  embryonic camera-type eye development  actin cytoskeleton reorganization  response to estradiol  response to lipopolysaccharide  positive regulation of ATPase activity  lacrimal gland development  regulation of activin receptor signaling pathway  protein localization to cell surface  somatic stem cell population maintenance  chemoattractant activity  chemoattractant activity  wound healing  wound healing  tissue regeneration  odontogenesis of dentin-containing tooth  muscle cell fate commitment  positive regulation of MAPK cascade  negative regulation of cell differentiation  positive regulation of DNA repair  positive regulation of Notch signaling pathway  positive regulation of transcription by RNA polymerase II  positive regulation of Ras protein signal transduction  regulation of saliva secretion  positive regulation of fibroblast proliferation  spleen development  thymus development  embryonic digestive tract morphogenesis  branching morphogenesis of an epithelial tube  female genitalia morphogenesis  male genitalia morphogenesis  positive regulation of lymphocyte proliferation  epithelial cell proliferation  urothelial cell proliferation  positive regulation of urothelial cell proliferation  positive regulation of urothelial cell proliferation  positive regulation of epithelial cell proliferation  positive regulation of epithelial cell proliferation  positive regulation of peptidyl-tyrosine phosphorylation  white fat cell differentiation  positive chemotaxis  positive chemotaxis  positive chemotaxis  induction of positive chemotaxis  smooth muscle cell differentiation  positive regulation of keratinocyte migration  regulation of cell cycle  positive regulation of protein kinase B signaling  radial glial cell differentiation  positive regulation of epithelial cell proliferation involved in wound healing  limb development  limb bud formation  lung epithelium development  lung saccule development  bronchiole morphogenesis  bud outgrowth involved in lung branching  bud elongation involved in lung branching  mesenchymal-epithelial cell signaling involved in lung development  type II pneumocyte differentiation  prostatic bud formation  fibroblast growth factor receptor signaling pathway involved in mammary gland specification  fibroblast growth factor receptor signaling pathway involved in mammary gland specification  mammary gland bud formation  submandibular salivary gland formation  epithelial cell proliferation involved in salivary gland morphogenesis  regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling  branch elongation involved in salivary gland morphogenesis  semicircular canal fusion  mesenchymal cell differentiation involved in lung development  secretion by lung epithelial cell involved in lung growth  secretion by lung epithelial cell involved in lung growth  lung proximal/distal axis specification  collagen-containing extracellular matrix  tear secretion  positive regulation of white fat cell proliferation  ERK1 and ERK2 cascade  positive regulation of ERK1 and ERK2 cascade  positive regulation of ERK1 and ERK2 cascade  Harderian gland development  positive regulation of hair follicle cell proliferation  positive regulation of canonical Wnt signaling pathway  positive regulation of G1/S transition of mitotic cell cycle  negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  
Ontology : EGO-EBIestablishment of mitotic spindle orientation  MAPK cascade  activation of MAPK activity  angiogenesis  metanephros development  organ induction  mesonephros development  positive regulation of protein phosphorylation  blood vessel remodeling  metanephros morphogenesis  fibroblast growth factor receptor binding  fibroblast growth factor receptor binding  type 2 fibroblast growth factor receptor binding  type 2 fibroblast growth factor receptor binding  protein binding  extracellular region  extracellular space  extracellular space  nucleus  cytoplasm  plasma membrane  determination of left/right symmetry  salivary gland development  growth factor activity  growth factor activity  heparin binding  positive regulation of cell population proliferation  negative regulation of cell population proliferation  fibroblast growth factor receptor signaling pathway  fibroblast growth factor receptor signaling pathway  regulation of smoothened signaling pathway  embryonic pattern specification  animal organ morphogenesis  cell surface  cell surface  positive regulation of gene expression  positive regulation of epithelial cell migration  positive regulation of epithelial cell migration  positive regulation of keratinocyte proliferation  pituitary gland development  cell differentiation  regulation of cell migration  embryonic genitalia morphogenesis  thyroid gland development  otic vesicle formation  positive regulation of vascular endothelial growth factor receptor signaling pathway  pancreas development  hair follicle morphogenesis  embryonic camera-type eye development  actin cytoskeleton reorganization  response to estradiol  response to lipopolysaccharide  positive regulation of ATPase activity  lacrimal gland development  regulation of activin receptor signaling pathway  protein localization to cell surface  somatic stem cell population maintenance  chemoattractant activity  chemoattractant activity  wound healing  wound healing  tissue regeneration  odontogenesis of dentin-containing tooth  muscle cell fate commitment  positive regulation of MAPK cascade  negative regulation of cell differentiation  positive regulation of DNA repair  positive regulation of Notch signaling pathway  positive regulation of transcription by RNA polymerase II  positive regulation of Ras protein signal transduction  regulation of saliva secretion  positive regulation of fibroblast proliferation  spleen development  thymus development  embryonic digestive tract morphogenesis  branching morphogenesis of an epithelial tube  female genitalia morphogenesis  male genitalia morphogenesis  positive regulation of lymphocyte proliferation  epithelial cell proliferation  urothelial cell proliferation  positive regulation of urothelial cell proliferation  positive regulation of urothelial cell proliferation  positive regulation of epithelial cell proliferation  positive regulation of epithelial cell proliferation  positive regulation of peptidyl-tyrosine phosphorylation  white fat cell differentiation  positive chemotaxis  positive chemotaxis  positive chemotaxis  induction of positive chemotaxis  smooth muscle cell differentiation  positive regulation of keratinocyte migration  regulation of cell cycle  positive regulation of protein kinase B signaling  radial glial cell differentiation  positive regulation of epithelial cell proliferation involved in wound healing  limb development  limb bud formation  lung epithelium development  lung saccule development  bronchiole morphogenesis  bud outgrowth involved in lung branching  bud elongation involved in lung branching  mesenchymal-epithelial cell signaling involved in lung development  type II pneumocyte differentiation  prostatic bud formation  fibroblast growth factor receptor signaling pathway involved in mammary gland specification  fibroblast growth factor receptor signaling pathway involved in mammary gland specification  mammary gland bud formation  submandibular salivary gland formation  epithelial cell proliferation involved in salivary gland morphogenesis  regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling  branch elongation involved in salivary gland morphogenesis  semicircular canal fusion  mesenchymal cell differentiation involved in lung development  secretion by lung epithelial cell involved in lung growth  secretion by lung epithelial cell involved in lung growth  lung proximal/distal axis specification  collagen-containing extracellular matrix  tear secretion  positive regulation of white fat cell proliferation  ERK1 and ERK2 cascade  positive regulation of ERK1 and ERK2 cascade  positive regulation of ERK1 and ERK2 cascade  Harderian gland development  positive regulation of hair follicle cell proliferation  positive regulation of canonical Wnt signaling pathway  positive regulation of G1/S transition of mitotic cell cycle  negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  
Pathways : KEGGMAPK signaling pathway    Ras signaling pathway    Rap1 signaling pathway    PI3K-Akt signaling pathway    Regulation of actin cytoskeleton    Pathways in cancer    Proteoglycans in cancer    Melanoma   
NDEx NetworkFGF10
Atlas of Cancer Signalling NetworkFGF10
Wikipedia pathwaysFGF10
Orthology - Evolution
OrthoDB2255
GeneTree (enSembl)ENSG00000070193
Phylogenetic Trees/Animal Genes : TreeFamFGF10
Homologs : HomoloGeneFGF10
Homology/Alignments : Family Browser (UCSC)FGF10
Gene fusions - Rearrangements
Fusion : MitelmanHEATR6::FGF10 [17q23.1/5p12]  
Fusion : MitelmanNIPBL::FGF10 [5p13.2/5p12]  
Fusion : MitelmanRICTOR::FGF10 [5p13.1/5p12]  
Fusion : QuiverFGF10
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFGF10 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FGF10
dbVarFGF10
ClinVarFGF10
MonarchFGF10
1000_GenomesFGF10 
Exome Variant ServerFGF10
GNOMAD BrowserENSG00000070193
Varsome BrowserFGF10
ACMGFGF10 variants
VarityO15520
Genomic Variants (DGV)FGF10 [DGVbeta]
DECIPHERFGF10 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFGF10 
Mutations
ICGC Data PortalFGF10 
TCGA Data PortalFGF10 
Broad Tumor PortalFGF10
OASIS PortalFGF10 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFGF10  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DFGF10
Mutations and Diseases : HGMDFGF10
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaFGF10
DgiDB (Drug Gene Interaction Database)FGF10
DoCM (Curated mutations)FGF10
CIViC (Clinical Interpretations of Variants in Cancer)FGF10
Cancer3DFGF10
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM149730    180920    602115   
Orphanet2207    11735   
DisGeNETFGF10
MedgenFGF10
Genetic Testing Registry FGF10
NextProtO15520 [Medical]
GENETestsFGF10
Target ValidationFGF10
Huge Navigator FGF10 [HugePedia]
ClinGenFGF10 (curated)
Clinical trials, drugs, therapy
MyCancerGenomeFGF10
Protein Interactions : CTDFGF10
Pharm GKB GenePA28106
PharosO15520
Clinical trialFGF10
Miscellaneous
canSAR (ICR)FGF10
HarmonizomeFGF10
ARCHS4FGF10
DataMed IndexFGF10
Probes
Litterature
PubMed114 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXFGF10
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Sun Jan 16 18:10:58 CET 2022
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