Atlas of Genetics and Cytogenetics in Oncology and Haematology

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   
X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

FGF12 (fibroblast growth factor 12)

Identity

Alias (NCBI)EIEE47
FGF12B
FHF1
HGNC (Hugo) FGF12
HGNC Alias symbFHF1
HGNC Alias namefibroblast growth factor 12B
 fibroblast growth factor homologous factor 1
 myocyte-activating factor
 fibroblast growth factor FGF-12b
HGNC Previous nameFGF12B
LocusID (NCBI) 2257
Atlas_Id 40552
Location 3q28  [Link to chromosome band 3q28]
Location_base_pair Starts at 192139391 and ends at 192409597 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
C1orf196 () / FGF12 (3q28)FGF12 (3q28) / LAMP3 (3q27.1)FGF12 (3q28) / OPA1 (3q29)
FGF12 (3q28) / SENP6 (6q14.1)FGF12 (3q28) / SYN3 (22q12.3)SRP9 (1q42.12) / FGF12 (3q28)
TSC22D2 (3q25.1) / FGF12 (3q28)C1orf196 - / FGF12 3q28FGF12 3q28 / LAMP3 3q27.1
FGF12 3q28 / SYN3 22q12.3TSC22D2 3q25.1 / FGF12 3q28

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 4 ]
  t(1;3)(p36;q29) C1orf196/FGF12
t(3;3)(q25;q29) TSC22D2/FGF12
t(3;3)(q27;q29) FGF12/LAMP3
t(3;22)(q29;q12) FGF12/SYN3

External links

Nomenclature
HGNC (Hugo)FGF12   3668
Cards
Entrez_Gene (NCBI)FGF12    fibroblast growth factor 12
AliasesEIEE47; FGF12B; FHF1
GeneCards (Weizmann)FGF12
Ensembl hg19 (Hinxton)ENSG00000114279 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000114279 [Gene_View]  ENSG00000114279 [Sequence]  chr3:192139391-192409597 [Contig_View]  FGF12 [Vega]
ICGC DataPortalENSG00000114279
TCGA cBioPortalFGF12
AceView (NCBI)FGF12
Genatlas (Paris)FGF12
SOURCE (Princeton)FGF12
Genetics Home Reference (NIH)FGF12
Genomic and cartography
GoldenPath hg38 (UCSC)FGF12  -     chr3:192139391-192409597 -  3q28   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FGF12  -     3q28   [Description]    (hg19-Feb_2009)
GoldenPathFGF12 - 3q28 [CytoView hg19]  FGF12 - 3q28 [CytoView hg38]
ImmunoBaseENSG00000114279
genome Data Viewer NCBIFGF12 [Mapview hg19]  
OMIM601513   617166   
Gene and transcription
Genbank (Entrez)AJ709079 AK125307 AK312513 AK313671 BC022524
RefSeq transcript (Entrez)NM_001377292 NM_001377293 NM_001377294 NM_004113 NM_021032
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FGF12
Alternative Splicing GalleryENSG00000114279
Gene ExpressionFGF12 [ NCBI-GEO ]   FGF12 [ EBI - ARRAY_EXPRESS ]   FGF12 [ SEEK ]   FGF12 [ MEM ]
Gene Expression Viewer (FireBrowse)FGF12 [ Firebrowse - Broad ]
GenevisibleExpression of FGF12 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2257
GTEX Portal (Tissue expression)FGF12
Human Protein AtlasENSG00000114279-FGF12 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP61328   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP61328  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP61328
Splice isoforms : SwissVarP61328
PhosPhoSitePlusP61328
Domaine pattern : Prosite (Expaxy)HBGF_FGF (PS00247)   
Domains : Interpro (EBI)FGF12    Fibroblast_GF_fam    IL1/FGF   
Domain families : Pfam (Sanger)FGF (PF00167)   
Domain families : Pfam (NCBI)pfam00167   
Domain families : Smart (EMBL)FGF (SM00442)  
Conserved Domain (NCBI)FGF12
Blocks (Seattle)FGF12
PDB (RSDB)1Q1U    4JQ0   
PDB Europe1Q1U    4JQ0   
PDB (PDBSum)1Q1U    4JQ0   
PDB (IMB)1Q1U    4JQ0   
Structural Biology KnowledgeBase1Q1U    4JQ0   
SCOP (Structural Classification of Proteins)1Q1U    4JQ0   
CATH (Classification of proteins structures)1Q1U    4JQ0   
SuperfamilyP61328
Human Protein Atlas [tissue]ENSG00000114279-FGF12 [tissue]
Peptide AtlasP61328
HPRD03303
IPIIPI00024249   IPI00410208   IPI00925452   IPI00924977   IPI00793679   IPI00925642   
Protein Interaction databases
DIP (DOE-UCLA)P61328
IntAct (EBI)P61328
BioGRIDFGF12
STRING (EMBL)FGF12
ZODIACFGF12
Ontologies - Pathways
QuickGOP61328
Ontology : AmiGOregulation of membrane depolarization  protein binding  extracellular space  nucleus  signal transduction  cell-cell signaling  chemical synaptic transmission  nervous system development  heart development  growth factor activity  adult locomotory behavior  fibroblast growth factor receptor signaling pathway  positive regulation of sodium ion transport  sodium channel regulator activity  ion channel binding  synapse  neuromuscular process  cardiac muscle cell action potential involved in contraction  regulation of neuronal action potential  regulation of sodium ion transmembrane transport  regulation of voltage-gated sodium channel activity  regulation of sodium ion transmembrane transporter activity  negative regulation of cation channel activity  
Ontology : EGO-EBIregulation of membrane depolarization  protein binding  extracellular space  nucleus  signal transduction  cell-cell signaling  chemical synaptic transmission  nervous system development  heart development  growth factor activity  adult locomotory behavior  fibroblast growth factor receptor signaling pathway  positive regulation of sodium ion transport  sodium channel regulator activity  ion channel binding  synapse  neuromuscular process  cardiac muscle cell action potential involved in contraction  regulation of neuronal action potential  regulation of sodium ion transmembrane transport  regulation of voltage-gated sodium channel activity  regulation of sodium ion transmembrane transporter activity  negative regulation of cation channel activity  
Pathways : KEGGMAPK signaling pathway    Ras signaling pathway    Rap1 signaling pathway    PI3K-Akt signaling pathway    Regulation of actin cytoskeleton    Pathways in cancer    Proteoglycans in cancer    Melanoma   
NDEx NetworkFGF12
Atlas of Cancer Signalling NetworkFGF12
Wikipedia pathwaysFGF12
Orthology - Evolution
OrthoDB2257
GeneTree (enSembl)ENSG00000114279
Phylogenetic Trees/Animal Genes : TreeFamFGF12
HOGENOMP61328
Homologs : HomoloGeneFGF12
Homology/Alignments : Family Browser (UCSC)FGF12
Gene fusions - Rearrangements
Fusion : MitelmanFGF12/LAMP3 [3q28/3q27.1]  
Fusion : MitelmanFGF12/SYN3 [3q28/22q12.3]  
Fusion : MitelmanTSC22D2/FGF12 [3q25.1/3q28]  
Fusion PortalC1orf196 - FGF12 3q28 LUSC
Fusion PortalFGF12 3q28 LAMP3 3q27.1 LGG
Fusion PortalFGF12 3q28 SYN3 22q12.3 BRCA
Fusion PortalTSC22D2 3q25.1 FGF12 3q28 BLCA
Fusion : QuiverFGF12
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFGF12 [hg38]
dbVarFGF12
ClinVarFGF12
MonarchFGF12
1000_GenomesFGF12 
Exome Variant ServerFGF12
GNOMAD BrowserENSG00000114279
Varsome BrowserFGF12
Genomic Variants (DGV)FGF12 [DGVbeta]
DECIPHERFGF12 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFGF12 
Mutations
ICGC Data PortalFGF12 
TCGA Data PortalFGF12 
Broad Tumor PortalFGF12
OASIS PortalFGF12 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFGF12  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DFGF12
Mutations and Diseases : HGMDFGF12
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FGF12
DgiDB (Drug Gene Interaction Database)FGF12
DoCM (Curated mutations)FGF12 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FGF12 (select a term)
intoGenFGF12
Cancer3DFGF12(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601513    617166   
Orphanet
DisGeNETFGF12
MedgenFGF12
Genetic Testing Registry FGF12
NextProtP61328 [Medical]
GENETestsFGF12
Target ValidationFGF12
Huge Navigator FGF12 [HugePedia]
ClinGenFGF12
Clinical trials, drugs, therapy
MyCancerGenomeFGF12
Protein Interactions : CTD
Pharm GKB GenePA28108
PharosP61328
Clinical trialFGF12
Miscellaneous
canSAR (ICR)FGF12 (select the gene name)
HarmonizomeFGF12
DataMed IndexFGF12
Probes
Litterature
PubMed49 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXFGF12
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jan 1 18:15:41 CET 2021
Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.