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FGF12 (fibroblast growth factor 12)

Identity

Alias_namesFGF12B
Alias_symbol (synonym)FHF1
Other alias
HGNC (Hugo) FGF12
LocusID (NCBI) 2257
Atlas_Id 40552
Location 3q28  [Link to chromosome band 3q28]
Location_base_pair Starts at 191857182 and ends at 192445388 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
C1orf196 () / FGF12 (3q28)FGF12 (3q28) / LAMP3 (3q27.1)FGF12 (3q28) / OPA1 (3q29)
FGF12 (3q28) / SENP6 (6q14.1)FGF12 (3q28) / SYN3 (22q12.3)SRP9 (1q42.12) / FGF12 (3q28)
TSC22D2 (3q25.1) / FGF12 (3q28)C1orf196 - / FGF12 3q28FGF12 3q28 / LAMP3 3q27.1
FGF12 3q28 / SYN3 22q12.3TSC22D2 3q25.1 / FGF12 3q28

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)FGF12   3668
Cards
Entrez_Gene (NCBI)FGF12  2257  fibroblast growth factor 12
AliasesFGF12B; FHF1
GeneCards (Weizmann)FGF12
Ensembl hg19 (Hinxton)ENSG00000114279 [Gene_View]  chr3:191857182-192445388 [Contig_View]  FGF12 [Vega]
Ensembl hg38 (Hinxton)ENSG00000114279 [Gene_View]  chr3:191857182-192445388 [Contig_View]  FGF12 [Vega]
ICGC DataPortalENSG00000114279
TCGA cBioPortalFGF12
AceView (NCBI)FGF12
Genatlas (Paris)FGF12
WikiGenes2257
SOURCE (Princeton)FGF12
Genetics Home Reference (NIH)FGF12
Genomic and cartography
GoldenPath hg19 (UCSC)FGF12  -     chr3:191857182-192445388 -  3q28   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)FGF12  -     3q28   [Description]    (hg38-Dec_2013)
EnsemblFGF12 - 3q28 [CytoView hg19]  FGF12 - 3q28 [CytoView hg38]
Mapping of homologs : NCBIFGF12 [Mapview hg19]  FGF12 [Mapview hg38]
OMIM601513   
Gene and transcription
Genbank (Entrez)AJ709079 AK125307 AK312513 AK313671 BC022524
RefSeq transcript (Entrez)NM_004113 NM_021032
RefSeq genomic (Entrez)NC_000003 NC_018914 NT_005612 NW_004929311
Consensus coding sequences : CCDS (NCBI)FGF12
Cluster EST : UnigeneHs.390250 [ NCBI ]
CGAP (NCI)Hs.390250
Alternative Splicing GalleryENSG00000114279
Gene ExpressionFGF12 [ NCBI-GEO ]   FGF12 [ EBI - ARRAY_EXPRESS ]   FGF12 [ SEEK ]   FGF12 [ MEM ]
Gene Expression Viewer (FireBrowse)FGF12 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2257
GTEX Portal (Tissue expression)FGF12
Protein : pattern, domain, 3D structure
UniProt/SwissProtP61328   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP61328  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP61328
Splice isoforms : SwissVarP61328
PhosPhoSitePlusP61328
Domaine pattern : Prosite (Expaxy)HBGF_FGF (PS00247)   
Domains : Interpro (EBI)Cytokine_IL1-like    FGF12    Fibroblast_GF_fam    IL-1_fam/FGF_fam   
Domain families : Pfam (Sanger)FGF (PF00167)   
Domain families : Pfam (NCBI)pfam00167   
Domain families : Smart (EMBL)FGF (SM00442)  
Conserved Domain (NCBI)FGF12
DMDM Disease mutations2257
Blocks (Seattle)FGF12
PDB (SRS)1Q1U    4JQ0   
PDB (PDBSum)1Q1U    4JQ0   
PDB (IMB)1Q1U    4JQ0   
PDB (RSDB)1Q1U    4JQ0   
Structural Biology KnowledgeBase1Q1U    4JQ0   
SCOP (Structural Classification of Proteins)1Q1U    4JQ0   
CATH (Classification of proteins structures)1Q1U    4JQ0   
SuperfamilyP61328
Human Protein AtlasENSG00000114279
Peptide AtlasP61328
HPRD03303
IPIIPI00024249   IPI00410208   IPI00925452   IPI00924977   IPI00793679   IPI00925642   
Protein Interaction databases
DIP (DOE-UCLA)P61328
IntAct (EBI)P61328
FunCoupENSG00000114279
BioGRIDFGF12
STRING (EMBL)FGF12
ZODIACFGF12
Ontologies - Pathways
QuickGOP61328
Ontology : AmiGOregulation of membrane depolarization  fibroblast growth factor receptor binding  protein binding  extracellular space  intracellular  nucleus  signal transduction  JNK cascade  cell-cell signaling  synaptic transmission  nervous system development  heart development  growth factor activity  heparin binding  adult locomotory behavior  fibroblast growth factor receptor signaling pathway  fibroblast growth factor receptor signaling pathway  positive regulation of sodium ion transport  sodium channel regulator activity  ion channel binding  neuromuscular process  cardiac muscle cell action potential involved in contraction  regulation of sodium ion transmembrane transport  regulation of sodium ion transmembrane transporter activity  negative regulation of cation channel activity  
Ontology : EGO-EBIregulation of membrane depolarization  fibroblast growth factor receptor binding  protein binding  extracellular space  intracellular  nucleus  signal transduction  JNK cascade  cell-cell signaling  synaptic transmission  nervous system development  heart development  growth factor activity  heparin binding  adult locomotory behavior  fibroblast growth factor receptor signaling pathway  fibroblast growth factor receptor signaling pathway  positive regulation of sodium ion transport  sodium channel regulator activity  ion channel binding  neuromuscular process  cardiac muscle cell action potential involved in contraction  regulation of sodium ion transmembrane transport  regulation of sodium ion transmembrane transporter activity  negative regulation of cation channel activity  
Pathways : KEGGMAPK signaling pathway    Ras signaling pathway    Rap1 signaling pathway    PI3K-Akt signaling pathway    Regulation of actin cytoskeleton    Pathways in cancer    Proteoglycans in cancer    Melanoma   
NDEx NetworkFGF12
Atlas of Cancer Signalling NetworkFGF12
Wikipedia pathwaysFGF12
Orthology - Evolution
OrthoDB2257
GeneTree (enSembl)ENSG00000114279
Phylogenetic Trees/Animal Genes : TreeFamFGF12
HOVERGENP61328
HOGENOMP61328
Homologs : HomoloGeneFGF12
Homology/Alignments : Family Browser (UCSC)FGF12
Gene fusions - Rearrangements
Fusion : MitelmanFGF12/LAMP3 [3q28/3q27.1]  
Fusion : MitelmanFGF12/SYN3 [3q28/22q12.3]  [t(3;22)(q29;q12)]  
Fusion : MitelmanTSC22D2/FGF12 [3q25.1/3q28]  [t(3;3)(q25;q29)]  
Fusion: TCGAC1orf196 - FGF12 3q28 LUSC
Fusion: TCGAFGF12 3q28 LAMP3 3q27.1 LGG
Fusion: TCGAFGF12 3q28 SYN3 22q12.3 BRCA
Fusion: TCGATSC22D2 3q25.1 FGF12 3q28 BLCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFGF12 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FGF12
dbVarFGF12
ClinVarFGF12
1000_GenomesFGF12 
Exome Variant ServerFGF12
ExAC (Exome Aggregation Consortium)FGF12 (select the gene name)
Genetic variants : HAPMAP2257
Genomic Variants (DGV)FGF12 [DGVbeta]
DECIPHER (Syndromes)3:191857182-192445388  ENSG00000114279
CONAN: Copy Number AnalysisFGF12 
Mutations
ICGC Data PortalFGF12 
TCGA Data PortalFGF12 
Broad Tumor PortalFGF12
OASIS PortalFGF12 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFGF12  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFGF12
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FGF12
DgiDB (Drug Gene Interaction Database)FGF12
DoCM (Curated mutations)FGF12 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FGF12 (select a term)
intoGenFGF12
Cancer3DFGF12(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601513   
Orphanet
MedgenFGF12
Genetic Testing Registry FGF12
NextProtP61328 [Medical]
TSGene2257
GENETestsFGF12
Huge Navigator FGF12 [HugePedia]
snp3D : Map Gene to Disease2257
BioCentury BCIQFGF12
ClinGenFGF12
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2257
Chemical/Pharm GKB GenePA28108
Clinical trialFGF12
Miscellaneous
canSAR (ICR)FGF12 (select the gene name)
Probes
Litterature
PubMed35 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFGF12
EVEXFGF12
GoPubMedFGF12
iHOPFGF12
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:06:05 CET 2017

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