FGF13 (fibroblast growth factor 13)

2003-02-01  

Identity

HGNC
FGF13
LOCATION
Xq26.3
LOCUSID
2258
ALIAS
DEE90,FGF-13,FGF2,FHF-2,FHF2,LINC00889

Other Information

Locus ID:

NCBI: 2258
MIM: 300070
HGNC: 3670
Ensembl: ENSG00000129682

Variants:

dbSNP: 2258
ClinVar: 2258
TCGA: ENSG00000129682
COSMIC: FGF13

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000129682ENST00000305414Q92913
ENSG00000129682ENST00000315930Q92913
ENSG00000129682ENST00000315930A8K1P5
ENSG00000129682ENST00000421460A0A0C4DG13
ENSG00000129682ENST00000436198Q92913
ENSG00000129682ENST00000441825Q92913
ENSG00000129682ENST00000448673B1B1H9
ENSG00000129682ENST00000455663B1AJW0
ENSG00000129682ENST00000626909Q92913

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9
10
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
Regulation of actin cytoskeletonKEGGko04810
MelanomaKEGGko05218
MAPK signaling pathwayKEGGhsa04010
Regulation of actin cytoskeletonKEGGhsa04810
Pathways in cancerKEGGhsa05200
MelanomaKEGGhsa05218
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Ras signaling pathwayKEGGhsa04014
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015
Muscle contractionREACTOMER-HSA-397014
Cardiac conductionREACTOMER-HSA-5576891
Phase 0 - rapid depolarisationREACTOMER-HSA-5576892
Breast cancerKEGGko05224
Breast cancerKEGGhsa05224

References

Pubmed IDYearTitleCitations
152822812004Fibroblast growth factor homologous factor 2B: association with Nav1.6 and selective colocalization at nodes of Ranvier of dorsal root axons.64
118472212002Not all perlecans are created equal: interactions with fibroblast growth factor (FGF) 2 and FGF receptors.41
279941422017Regulatory module involving FGF13, miR-504, and p53 regulates ribosomal biogenesis and supports cancer cell survival.19
241131642013Upregulated expression of FGF13/FHF2 mediates resistance to platinum drugs in cervical cancer cells.16
260639192015Disruption of Fgf13 causes synaptic excitatory-inhibitory imbalance and genetic epilepsy and febrile seizures plus.16
281628082017FGF13 Selectively Regulates Heat Nociception by Interacting with Na<sub>v</sub>1.7.14
124962622003Identification of a novel domain of fibroblast growth factor 2 controlling its angiogenic properties.8
290591542018Fibroblast growth factor 13 regulates glioma cell invasion and is important for bevacizumab-induced glioma invasion.7
272466242016FGF13 modulates the gating properties of the cardiac sodium channel Na<sub>v</sub>1.5 in an isoform-specific manner.6
288828902017C-terminal phosphorylation of Na<sub>V</sub>1.5 impairs FGF13-dependent regulation of channel inactivation.5

Citation

Dessen P

FGF13 (fibroblast growth factor 13)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40553/fgf13