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FGF18 (fibroblast growth factor 18)

Identity

Alias_symbol (synonym)FGF-18
ZFGF5
Other alias
HGNC (Hugo) FGF18
LocusID (NCBI) 8817
Atlas_Id 40557
Location 5q35.1  [Link to chromosome band 5q35]
Location_base_pair Starts at 171419663 and ends at 171457626 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
PALM2-AKAP2 (9q31.3) / FGF18 (5q35.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)FGF18   3674
Cards
Entrez_Gene (NCBI)FGF18  8817  fibroblast growth factor 18
AliasesFGF-18; ZFGF5
GeneCards (Weizmann)FGF18
Ensembl hg19 (Hinxton)ENSG00000156427 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000156427 [Gene_View]  chr5:171419663-171457626 [Contig_View]  FGF18 [Vega]
ICGC DataPortalENSG00000156427
TCGA cBioPortalFGF18
AceView (NCBI)FGF18
Genatlas (Paris)FGF18
WikiGenes8817
SOURCE (Princeton)FGF18
Genetics Home Reference (NIH)FGF18
Genomic and cartography
GoldenPath hg38 (UCSC)FGF18  -     chr5:171419663-171457626 +  5q35.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FGF18  -     5q35.1   [Description]    (hg19-Feb_2009)
EnsemblFGF18 - 5q35.1 [CytoView hg19]  FGF18 - 5q35.1 [CytoView hg38]
Mapping of homologs : NCBIFGF18 [Mapview hg19]  FGF18 [Mapview hg38]
OMIM603726   
Gene and transcription
Genbank (Entrez)AB007422 AF075292 AF211188 AM393798 AY358811
RefSeq transcript (Entrez)NM_003862 NM_033649
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FGF18
Cluster EST : UnigeneHs.87191 [ NCBI ]
CGAP (NCI)Hs.87191
Alternative Splicing GalleryENSG00000156427
Gene ExpressionFGF18 [ NCBI-GEO ]   FGF18 [ EBI - ARRAY_EXPRESS ]   FGF18 [ SEEK ]   FGF18 [ MEM ]
Gene Expression Viewer (FireBrowse)FGF18 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8817
GTEX Portal (Tissue expression)FGF18
Protein : pattern, domain, 3D structure
UniProt/SwissProtO76093   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO76093  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO76093
Splice isoforms : SwissVarO76093
PhosPhoSitePlusO76093
Domaine pattern : Prosite (Expaxy)HBGF_FGF (PS00247)   
Domains : Interpro (EBI)FGF18    Fibroblast_GF_fam    IL1/FGF   
Domain families : Pfam (Sanger)FGF (PF00167)   
Domain families : Pfam (NCBI)pfam00167   
Domain families : Smart (EMBL)FGF (SM00442)  
Conserved Domain (NCBI)FGF18
DMDM Disease mutations8817
Blocks (Seattle)FGF18
PDB (SRS)4CJM   
PDB (PDBSum)4CJM   
PDB (IMB)4CJM   
PDB (RSDB)4CJM   
Structural Biology KnowledgeBase4CJM   
SCOP (Structural Classification of Proteins)4CJM   
CATH (Classification of proteins structures)4CJM   
SuperfamilyO76093
Human Protein AtlasENSG00000156427
Peptide AtlasO76093
HPRD04766
IPIIPI00008830   
Protein Interaction databases
DIP (DOE-UCLA)O76093
IntAct (EBI)O76093
FunCoupENSG00000156427
BioGRIDFGF18
STRING (EMBL)FGF18
ZODIACFGF18
Ontologies - Pathways
QuickGOO76093
Ontology : AmiGOMAPK cascade  angiogenesis  regulation of endothelial cell proliferation  intramembranous ossification  endochondral ossification  chondrocyte development  protein tyrosine kinase activity  Ras guanyl-nucleotide exchange factor activity  type 1 fibroblast growth factor receptor binding  type 2 fibroblast growth factor receptor binding  extracellular region  extracellular space  nucleolus  signal transduction  cell-cell signaling  growth factor activity  positive regulation of cell proliferation  fibroblast growth factor receptor signaling pathway  anatomical structure morphogenesis  regulation of phosphatidylinositol 3-kinase signaling  1-phosphatidylinositol-3-kinase activity  peptidyl-tyrosine phosphorylation  lung development  positive regulation of vascular endothelial growth factor receptor signaling pathway  positive regulation of chondrocyte differentiation  phosphatidylinositol-3-phosphate biosynthetic process  positive regulation of MAP kinase activity  positive regulation of GTPase activity  phosphatidylinositol phosphorylation  phosphatidylinositol-4,5-bisphosphate 3-kinase activity  phosphatidylinositol-mediated signaling  positive regulation of ERK1 and ERK2 cascade  regulation of sprouting angiogenesis  positive regulation of endothelial cell chemotaxis to fibroblast growth factor  
Ontology : EGO-EBIMAPK cascade  angiogenesis  regulation of endothelial cell proliferation  intramembranous ossification  endochondral ossification  chondrocyte development  protein tyrosine kinase activity  Ras guanyl-nucleotide exchange factor activity  type 1 fibroblast growth factor receptor binding  type 2 fibroblast growth factor receptor binding  extracellular region  extracellular space  nucleolus  signal transduction  cell-cell signaling  growth factor activity  positive regulation of cell proliferation  fibroblast growth factor receptor signaling pathway  anatomical structure morphogenesis  regulation of phosphatidylinositol 3-kinase signaling  1-phosphatidylinositol-3-kinase activity  peptidyl-tyrosine phosphorylation  lung development  positive regulation of vascular endothelial growth factor receptor signaling pathway  positive regulation of chondrocyte differentiation  phosphatidylinositol-3-phosphate biosynthetic process  positive regulation of MAP kinase activity  positive regulation of GTPase activity  phosphatidylinositol phosphorylation  phosphatidylinositol-4,5-bisphosphate 3-kinase activity  phosphatidylinositol-mediated signaling  positive regulation of ERK1 and ERK2 cascade  regulation of sprouting angiogenesis  positive regulation of endothelial cell chemotaxis to fibroblast growth factor  
Pathways : KEGGMAPK signaling pathway    Ras signaling pathway    Rap1 signaling pathway    PI3K-Akt signaling pathway    Regulation of actin cytoskeleton    Pathways in cancer    Proteoglycans in cancer    Melanoma   
NDEx NetworkFGF18
Atlas of Cancer Signalling NetworkFGF18
Wikipedia pathwaysFGF18
Orthology - Evolution
OrthoDB8817
GeneTree (enSembl)ENSG00000156427
Phylogenetic Trees/Animal Genes : TreeFamFGF18
HOVERGENO76093
HOGENOMO76093
Homologs : HomoloGeneFGF18
Homology/Alignments : Family Browser (UCSC)FGF18
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFGF18 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FGF18
dbVarFGF18
ClinVarFGF18
1000_GenomesFGF18 
Exome Variant ServerFGF18
ExAC (Exome Aggregation Consortium)FGF18 (select the gene name)
Genetic variants : HAPMAP8817
Genomic Variants (DGV)FGF18 [DGVbeta]
DECIPHERFGF18 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFGF18 
Mutations
ICGC Data PortalFGF18 
TCGA Data PortalFGF18 
Broad Tumor PortalFGF18
OASIS PortalFGF18 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFGF18  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFGF18
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FGF18
DgiDB (Drug Gene Interaction Database)FGF18
DoCM (Curated mutations)FGF18 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FGF18 (select a term)
intoGenFGF18
Cancer3DFGF18(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603726   
Orphanet
MedgenFGF18
Genetic Testing Registry FGF18
NextProtO76093 [Medical]
TSGene8817
GENETestsFGF18
Huge Navigator FGF18 [HugePedia]
snp3D : Map Gene to Disease8817
BioCentury BCIQFGF18
ClinGenFGF18
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8817
Chemical/Pharm GKB GenePA28113
Clinical trialFGF18
Miscellaneous
canSAR (ICR)FGF18 (select the gene name)
Probes
Litterature
PubMed41 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFGF18
EVEXFGF18
GoPubMedFGF18
iHOPFGF18
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri May 19 12:15:57 CEST 2017

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