Atlas of Genetics and Cytogenetics in Oncology and Haematology

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FGF19 (fibroblast growth factor 19)

Identity

Other alias-
HGNC (Hugo) FGF19
LocusID (NCBI) 9965
Atlas_Id 40558
Location 11q13.3  [Link to chromosome band 11q13]
Location_base_pair Starts at 69698238 and ends at 69704338 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ALG8 (11q14.1) / FGF19 (11q13.3)FGF19 (11q13.3) / KLHL7 (7p15.3)SPTBN2 (11q13.2) / FGF19 (11q13.3)
ALG8 11q14.1 / FGF19 11q13.3SPTBN2 11q13.2 / FGF19 11q13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(11;11)(q13;q13) SPTBN2/FGF19
t(11;11)(q13;q14) ALG8/FGF19

External links

Nomenclature
HGNC (Hugo)FGF19   3675
Cards
Entrez_Gene (NCBI)FGF19  9965  fibroblast growth factor 19
Aliases
GeneCards (Weizmann)FGF19
Ensembl hg19 (Hinxton)ENSG00000162344 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000162344 [Gene_View]  ENSG00000162344 [Sequence]  chr11:69698238-69704338 [Contig_View]  FGF19 [Vega]
ICGC DataPortalENSG00000162344
TCGA cBioPortalFGF19
AceView (NCBI)FGF19
Genatlas (Paris)FGF19
WikiGenes9965
SOURCE (Princeton)FGF19
Genetics Home Reference (NIH)FGF19
Genomic and cartography
GoldenPath hg38 (UCSC)FGF19  -     chr11:69698238-69704338 -  11q13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FGF19  -     11q13.3   [Description]    (hg19-Feb_2009)
EnsemblFGF19 - 11q13.3 [CytoView hg19]  FGF19 - 11q13.3 [CytoView hg38]
Mapping of homologs : NCBIFGF19 [Mapview hg19]  FGF19 [Mapview hg38]
OMIM603891   
Gene and transcription
Genbank (Entrez)AB018122 AF110400 AY358302 BC017664 BT006729
RefSeq transcript (Entrez)NM_005117
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FGF19
Cluster EST : UnigeneHs.249200 [ NCBI ]
CGAP (NCI)Hs.249200
Alternative Splicing GalleryENSG00000162344
Gene ExpressionFGF19 [ NCBI-GEO ]   FGF19 [ EBI - ARRAY_EXPRESS ]   FGF19 [ SEEK ]   FGF19 [ MEM ]
Gene Expression Viewer (FireBrowse)FGF19 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9965
GTEX Portal (Tissue expression)FGF19
Human Protein AtlasENSG00000162344-FGF19 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95750   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO95750  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95750
Splice isoforms : SwissVarO95750
PhosPhoSitePlusO95750
Domaine pattern : Prosite (Expaxy)HBGF_FGF (PS00247)   
Domains : Interpro (EBI)FGF15/FGF19    Fibroblast_GF_fam    IL1/FGF   
Domain families : Pfam (Sanger)FGF (PF00167)   
Domain families : Pfam (NCBI)pfam00167   
Domain families : Smart (EMBL)FGF (SM00442)  
Conserved Domain (NCBI)FGF19
DMDM Disease mutations9965
Blocks (Seattle)FGF19
PDB (SRS)1PWA    2P23   
PDB (PDBSum)1PWA    2P23   
PDB (IMB)1PWA    2P23   
PDB (RSDB)1PWA    2P23   
Structural Biology KnowledgeBase1PWA    2P23   
SCOP (Structural Classification of Proteins)1PWA    2P23   
CATH (Classification of proteins structures)1PWA    2P23   
SuperfamilyO95750
Human Protein Atlas [tissue]ENSG00000162344-FGF19 [tissue]
Peptide AtlasO95750
HPRD04868
IPIIPI00032908   
Protein Interaction databases
DIP (DOE-UCLA)O95750
IntAct (EBI)O95750
FunCoupENSG00000162344
BioGRIDFGF19
STRING (EMBL)FGF19
ZODIACFGF19
Ontologies - Pathways
QuickGOO95750
Ontology : AmiGOMAPK cascade  positive regulation of protein phosphorylation  Ras guanyl-nucleotide exchange factor activity  fibroblast growth factor receptor binding  protein binding  extracellular region  intracellular  nervous system development  growth factor activity  positive regulation of cell proliferation  fibroblast growth factor receptor signaling pathway  fibroblast growth factor receptor signaling pathway  fibroblast growth factor receptor signaling pathway  regulation of receptor activity  negative regulation of gene expression  1-phosphatidylinositol-3-kinase activity  phosphatidylinositol-3-phosphate biosynthetic process  positive regulation of glucose import  positive regulation of JNK cascade  phosphatidylinositol phosphorylation  phosphatidylinositol-4,5-bisphosphate 3-kinase activity  positive regulation of protein kinase B signaling  positive regulation of ERK1 and ERK2 cascade  negative regulation of bile acid biosynthetic process  
Ontology : EGO-EBIMAPK cascade  positive regulation of protein phosphorylation  Ras guanyl-nucleotide exchange factor activity  fibroblast growth factor receptor binding  protein binding  extracellular region  intracellular  nervous system development  growth factor activity  positive regulation of cell proliferation  fibroblast growth factor receptor signaling pathway  fibroblast growth factor receptor signaling pathway  fibroblast growth factor receptor signaling pathway  regulation of receptor activity  negative regulation of gene expression  1-phosphatidylinositol-3-kinase activity  phosphatidylinositol-3-phosphate biosynthetic process  positive regulation of glucose import  positive regulation of JNK cascade  phosphatidylinositol phosphorylation  phosphatidylinositol-4,5-bisphosphate 3-kinase activity  positive regulation of protein kinase B signaling  positive regulation of ERK1 and ERK2 cascade  negative regulation of bile acid biosynthetic process  
Pathways : KEGGRegulation of actin cytoskeleton    MAPK signaling pathway   
NDEx NetworkFGF19
Atlas of Cancer Signalling NetworkFGF19
Wikipedia pathwaysFGF19
Orthology - Evolution
OrthoDB9965
GeneTree (enSembl)ENSG00000162344
Phylogenetic Trees/Animal Genes : TreeFamFGF19
HOVERGENO95750
HOGENOMO95750
Homologs : HomoloGeneFGF19
Homology/Alignments : Family Browser (UCSC)FGF19
Gene fusions - Rearrangements
Fusion : MitelmanALG8/FGF19 [11q14.1/11q13.3]  [t(11;11)(q13;q14)]  
Fusion : MitelmanSPTBN2/FGF19 [11q13.2/11q13.3]  [t(11;11)(q13;q13)]  
Fusion PortalALG8 11q14.1 FGF19 11q13.3 HNSC
Fusion PortalSPTBN2 11q13.2 FGF19 11q13.3 BRCA
Fusion : QuiverFGF19
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFGF19 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FGF19
dbVarFGF19
ClinVarFGF19
1000_GenomesFGF19 
Exome Variant ServerFGF19
ExAC (Exome Aggregation Consortium)ENSG00000162344
GNOMAD BrowserENSG00000162344
Genetic variants : HAPMAP9965
Genomic Variants (DGV)FGF19 [DGVbeta]
DECIPHERFGF19 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFGF19 
Mutations
ICGC Data PortalFGF19 
TCGA Data PortalFGF19 
Broad Tumor PortalFGF19
OASIS PortalFGF19 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFGF19  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFGF19
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FGF19
DgiDB (Drug Gene Interaction Database)FGF19
DoCM (Curated mutations)FGF19 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FGF19 (select a term)
intoGenFGF19
Cancer3DFGF19(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603891   
Orphanet
DisGeNETFGF19
MedgenFGF19
Genetic Testing Registry FGF19
NextProtO95750 [Medical]
TSGene9965
GENETestsFGF19
Target ValidationFGF19
Huge Navigator FGF19 [HugePedia]
snp3D : Map Gene to Disease9965
BioCentury BCIQFGF19
ClinGenFGF19
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9965
Chemical/Pharm GKB GenePA28114
Clinical trialFGF19
Miscellaneous
canSAR (ICR)FGF19 (select the gene name)
Probes
Litterature
PubMed91 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFGF19
EVEXFGF19
GoPubMedFGF19
iHOPFGF19
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jun 22 16:25:45 CEST 2018
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