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FGF19 (fibroblast growth factor 19)

Identity

Alias (NCBI)-
HGNC (Hugo) FGF19
LocusID (NCBI) 9965
Atlas_Id 40558
Location 11q13.3  [Link to chromosome band 11q13]
Location_base_pair Starts at 69698238 and ends at 69704022 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ALG8 (11q14.1) / FGF19 (11q13.3)FGF19 (11q13.3) / KLHL7 (7p15.3)SPTBN2 (11q13.2) / FGF19 (11q13.3)
ALG8 11q14.1 / FGF19 11q13.3SPTBN2 11q13.2 / FGF19 11q13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

 

Nomenclature
HGNC (Hugo)FGF19   3675
Cards
Entrez_Gene (NCBI)FGF19    fibroblast growth factor 19
Aliases
GeneCards (Weizmann)FGF19
Ensembl hg19 (Hinxton)ENSG00000162344 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000162344 [Gene_View]  ENSG00000162344 [Sequence]  chr11:69698238-69704022 [Contig_View]  FGF19 [Vega]
ICGC DataPortalENSG00000162344
TCGA cBioPortalFGF19
AceView (NCBI)FGF19
Genatlas (Paris)FGF19
SOURCE (Princeton)FGF19
Genetics Home Reference (NIH)FGF19
Genomic and cartography
GoldenPath hg38 (UCSC)FGF19  -     chr11:69698238-69704022 -  11q13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FGF19  -     11q13.3   [Description]    (hg19-Feb_2009)
GoldenPathFGF19 - 11q13.3 [CytoView hg19]  FGF19 - 11q13.3 [CytoView hg38]
ImmunoBaseENSG00000162344
Genome Data Viewer NCBIFGF19 [Mapview hg19]  
OMIM603891   
Gene and transcription
Genbank (Entrez)AB018122 AF110400 AY358302 BC017664 BT006729
RefSeq transcript (Entrez)NM_005117
Consensus coding sequences : CCDS (NCBI)FGF19
Gene ExpressionFGF19 [ NCBI-GEO ]   FGF19 [ EBI - ARRAY_EXPRESS ]   FGF19 [ SEEK ]   FGF19 [ MEM ]
Gene Expression Viewer (FireBrowse)FGF19 [ Firebrowse - Broad ]
GenevisibleExpression of FGF19 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9965
GTEX Portal (Tissue expression)FGF19
Human Protein AtlasENSG00000162344-FGF19 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95750   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO95750  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95750
PhosPhoSitePlusO95750
Domaine pattern : Prosite (Expaxy)HBGF_FGF (PS00247)   
Domains : Interpro (EBI)FGF15/19/21    FGF15/FGF19    Fibroblast_GF_fam    IL1/FGF   
Domain families : Pfam (Sanger)FGF (PF00167)   
Domain families : Pfam (NCBI)pfam00167   
Domain families : Smart (EMBL)FGF (SM00442)  
Conserved Domain (NCBI)FGF19
PDB (RSDB)1PWA    2P23    6KTR    6NFJ   
PDB Europe1PWA    2P23    6KTR    6NFJ   
PDB (PDBSum)1PWA    2P23    6KTR    6NFJ   
PDB (IMB)1PWA    2P23    6KTR    6NFJ   
Structural Biology KnowledgeBase1PWA    2P23    6KTR    6NFJ   
SCOP (Structural Classification of Proteins)1PWA    2P23    6KTR    6NFJ   
CATH (Classification of proteins structures)1PWA    2P23    6KTR    6NFJ   
SuperfamilyO95750
AlphaFold pdb e-kbO95750   
Human Protein Atlas [tissue]ENSG00000162344-FGF19 [tissue]
HPRD04868
Protein Interaction databases
DIP (DOE-UCLA)O95750
IntAct (EBI)O95750
BioGRIDFGF19
STRING (EMBL)FGF19
ZODIACFGF19
Ontologies - Pathways
QuickGOO95750
Ontology : AmiGOMAPK cascade  positive regulation of protein phosphorylation  positive regulation of protein phosphorylation  fibroblast growth factor receptor binding  fibroblast growth factor receptor binding  protein binding  extracellular region  extracellular space  cytoplasm  nervous system development  growth factor activity  positive regulation of cell population proliferation  positive regulation of cell population proliferation  fibroblast growth factor receptor signaling pathway  fibroblast growth factor receptor signaling pathway  fibroblast growth factor receptor signaling pathway  fibroblast growth factor receptor signaling pathway  animal organ morphogenesis  positive regulation of gene expression  negative regulation of gene expression  cell differentiation  regulation of cell migration  positive regulation of glucose import  positive regulation of JNK cascade  positive regulation of protein kinase B signaling  positive regulation of ERK1 and ERK2 cascade  negative regulation of bile acid biosynthetic process  
Ontology : EGO-EBIMAPK cascade  positive regulation of protein phosphorylation  positive regulation of protein phosphorylation  fibroblast growth factor receptor binding  fibroblast growth factor receptor binding  protein binding  extracellular region  extracellular space  cytoplasm  nervous system development  growth factor activity  positive regulation of cell population proliferation  positive regulation of cell population proliferation  fibroblast growth factor receptor signaling pathway  fibroblast growth factor receptor signaling pathway  fibroblast growth factor receptor signaling pathway  fibroblast growth factor receptor signaling pathway  animal organ morphogenesis  positive regulation of gene expression  negative regulation of gene expression  cell differentiation  regulation of cell migration  positive regulation of glucose import  positive regulation of JNK cascade  positive regulation of protein kinase B signaling  positive regulation of ERK1 and ERK2 cascade  negative regulation of bile acid biosynthetic process  
Pathways : KEGGMAPK signaling pathway    Ras signaling pathway    Rap1 signaling pathway    PI3K-Akt signaling pathway    Regulation of actin cytoskeleton    Pathways in cancer    Proteoglycans in cancer    Melanoma   
NDEx NetworkFGF19
Atlas of Cancer Signalling NetworkFGF19
Wikipedia pathwaysFGF19
Orthology - Evolution
OrthoDB9965
GeneTree (enSembl)ENSG00000162344
Phylogenetic Trees/Animal Genes : TreeFamFGF19
Homologs : HomoloGeneFGF19
Homology/Alignments : Family Browser (UCSC)FGF19
Gene fusions - Rearrangements
Fusion : MitelmanALG8/FGF19 [11q14.1/11q13.3]  
Fusion : MitelmanSPTBN2/FGF19 [11q13.2/11q13.3]  
Fusion : QuiverFGF19
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFGF19 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FGF19
dbVarFGF19
ClinVarFGF19
MonarchFGF19
1000_GenomesFGF19 
Exome Variant ServerFGF19
GNOMAD BrowserENSG00000162344
Varsome BrowserFGF19
ACMGFGF19 variants
VarityO95750
Genomic Variants (DGV)FGF19 [DGVbeta]
DECIPHERFGF19 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFGF19 
Mutations
ICGC Data PortalFGF19 
TCGA Data PortalFGF19 
Broad Tumor PortalFGF19
OASIS PortalFGF19 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFGF19  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DFGF19
Mutations and Diseases : HGMDFGF19
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaFGF19
DgiDB (Drug Gene Interaction Database)FGF19
DoCM (Curated mutations)FGF19
CIViC (Clinical Interpretations of Variants in Cancer)FGF19
Cancer3DFGF19
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603891   
Orphanet
DisGeNETFGF19
MedgenFGF19
Genetic Testing Registry FGF19
NextProtO95750 [Medical]
GENETestsFGF19
Target ValidationFGF19
Huge Navigator FGF19 [HugePedia]
ClinGenFGF19
Clinical trials, drugs, therapy
MyCancerGenomeFGF19
Protein Interactions : CTDFGF19
Pharm GKB GenePA28114
PharosO95750
Clinical trialFGF19
Miscellaneous
canSAR (ICR)FGF19
HarmonizomeFGF19
DataMed IndexFGF19
Probes
Litterature
PubMed127 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXFGF19
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:09:26 CEST 2021
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