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FGF21 (fibroblast growth factor 21)

Identity

Other alias-
HGNC (Hugo) FGF21
LocusID (NCBI) 26291
Atlas_Id 40560
Location 19q13.33  [Link to chromosome band 19q13]
Location_base_pair Starts at 48755559 and ends at 48758330 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)FGF21   3678
Cards
Entrez_Gene (NCBI)FGF21  26291  fibroblast growth factor 21
Aliases
GeneCards (Weizmann)FGF21
Ensembl hg19 (Hinxton)ENSG00000105550 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000105550 [Gene_View]  chr19:48755559-48758330 [Contig_View]  FGF21 [Vega]
ICGC DataPortalENSG00000105550
TCGA cBioPortalFGF21
AceView (NCBI)FGF21
Genatlas (Paris)FGF21
WikiGenes26291
SOURCE (Princeton)FGF21
Genetics Home Reference (NIH)FGF21
Genomic and cartography
GoldenPath hg38 (UCSC)FGF21  -     chr19:48755559-48758330 +  19q13.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FGF21  -     19q13.33   [Description]    (hg19-Feb_2009)
EnsemblFGF21 - 19q13.33 [CytoView hg19]  FGF21 - 19q13.33 [CytoView hg38]
Mapping of homologs : NCBIFGF21 [Mapview hg19]  FGF21 [Mapview hg38]
OMIM609436   
Gene and transcription
Genbank (Entrez)AB021975 AY359086 BC018404 DQ891786 DQ894970
RefSeq transcript (Entrez)NM_019113
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FGF21
Cluster EST : UnigeneHs.283015 [ NCBI ]
CGAP (NCI)Hs.283015
Alternative Splicing GalleryENSG00000105550
Gene ExpressionFGF21 [ NCBI-GEO ]   FGF21 [ EBI - ARRAY_EXPRESS ]   FGF21 [ SEEK ]   FGF21 [ MEM ]
Gene Expression Viewer (FireBrowse)FGF21 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)26291
GTEX Portal (Tissue expression)FGF21
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NSA1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NSA1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NSA1
Splice isoforms : SwissVarQ9NSA1
PhosPhoSitePlusQ9NSA1
Domaine pattern : Prosite (Expaxy)HBGF_FGF (PS00247)   
Domains : Interpro (EBI)FGF21    Fibroblast_GF_fam    IL1/FGF   
Domain families : Pfam (Sanger)FGF (PF00167)   
Domain families : Pfam (NCBI)pfam00167   
Domain families : Smart (EMBL)FGF (SM00442)  
Conserved Domain (NCBI)FGF21
DMDM Disease mutations26291
Blocks (Seattle)FGF21
SuperfamilyQ9NSA1
Human Protein AtlasENSG00000105550
Peptide AtlasQ9NSA1
HPRD09447
IPIIPI00017149   
Protein Interaction databases
DIP (DOE-UCLA)Q9NSA1
IntAct (EBI)Q9NSA1
FunCoupENSG00000105550
BioGRIDFGF21
STRING (EMBL)FGF21
ZODIACFGF21
Ontologies - Pathways
QuickGOQ9NSA1
Ontology : AmiGOfibroblast growth factor receptor binding  protein binding  extracellular region  extracellular space  cytosol  signal transduction  cell-cell signaling  growth factor activity  positive regulation of cell proliferation  positive regulation of triglyceride catabolic process  regulation of low-density lipoprotein particle clearance  response to activity  endoplasmic reticulum unfolded protein response  response to nutrient levels  cellular response to drug  lipoprotein metabolic process  positive regulation of low-density lipoprotein particle receptor biosynthetic process  positive regulation of glucose import  positive regulation of ERK1 and ERK2 cascade  cellular response to glucose stimulus  cellular response to glucagon stimulus  cellular response to low-density lipoprotein particle stimulus  endothelial cell apoptotic process  positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway  negative regulation of neuron death  response to methionine  negative regulation of endothelial cell apoptotic process  
Ontology : EGO-EBIfibroblast growth factor receptor binding  protein binding  extracellular region  extracellular space  cytosol  signal transduction  cell-cell signaling  growth factor activity  positive regulation of cell proliferation  positive regulation of triglyceride catabolic process  regulation of low-density lipoprotein particle clearance  response to activity  endoplasmic reticulum unfolded protein response  response to nutrient levels  cellular response to drug  lipoprotein metabolic process  positive regulation of low-density lipoprotein particle receptor biosynthetic process  positive regulation of glucose import  positive regulation of ERK1 and ERK2 cascade  cellular response to glucose stimulus  cellular response to glucagon stimulus  cellular response to low-density lipoprotein particle stimulus  endothelial cell apoptotic process  positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway  negative regulation of neuron death  response to methionine  negative regulation of endothelial cell apoptotic process  
Pathways : KEGGMAPK signaling pathway    Ras signaling pathway    Rap1 signaling pathway    PI3K-Akt signaling pathway    Regulation of actin cytoskeleton    Pathways in cancer    Proteoglycans in cancer    Melanoma   
NDEx NetworkFGF21
Atlas of Cancer Signalling NetworkFGF21
Wikipedia pathwaysFGF21
Orthology - Evolution
OrthoDB26291
GeneTree (enSembl)ENSG00000105550
Phylogenetic Trees/Animal Genes : TreeFamFGF21
HOVERGENQ9NSA1
HOGENOMQ9NSA1
Homologs : HomoloGeneFGF21
Homology/Alignments : Family Browser (UCSC)FGF21
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFGF21 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FGF21
dbVarFGF21
ClinVarFGF21
1000_GenomesFGF21 
Exome Variant ServerFGF21
ExAC (Exome Aggregation Consortium)FGF21 (select the gene name)
Genetic variants : HAPMAP26291
Genomic Variants (DGV)FGF21 [DGVbeta]
DECIPHERFGF21 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFGF21 
Mutations
ICGC Data PortalFGF21 
TCGA Data PortalFGF21 
Broad Tumor PortalFGF21
OASIS PortalFGF21 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFGF21  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFGF21
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FGF21
DgiDB (Drug Gene Interaction Database)FGF21
DoCM (Curated mutations)FGF21 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FGF21 (select a term)
intoGenFGF21
Cancer3DFGF21(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609436   
Orphanet
MedgenFGF21
Genetic Testing Registry FGF21
NextProtQ9NSA1 [Medical]
TSGene26291
GENETestsFGF21
Target ValidationFGF21
Huge Navigator FGF21 [HugePedia]
snp3D : Map Gene to Disease26291
BioCentury BCIQFGF21
ClinGenFGF21
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD26291
Chemical/Pharm GKB GenePA28117
Clinical trialFGF21
Miscellaneous
canSAR (ICR)FGF21 (select the gene name)
Probes
Litterature
PubMed181 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFGF21
EVEXFGF21
GoPubMedFGF21
iHOPFGF21
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 17:01:14 CEST 2017

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