Atlas of Genetics and Cytogenetics in Oncology and Haematology

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FGF22 (fibroblast growth factor 22)

Identity

Other alias-
HGNC (Hugo) FGF22
LocusID (NCBI) 27006
Atlas_Id 40561
Location 19p13.3  [Link to chromosome band 19p13]
Location_base_pair Starts at 639926 and ends at 643604 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)FGF22   3679
Cards
Entrez_Gene (NCBI)FGF22  27006  fibroblast growth factor 22
Aliases
GeneCards (Weizmann)FGF22
Ensembl hg19 (Hinxton)ENSG00000070388 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000070388 [Gene_View]  ENSG00000070388 [Sequence]  chr19:639926-643604 [Contig_View]  FGF22 [Vega]
ICGC DataPortalENSG00000070388
TCGA cBioPortalFGF22
AceView (NCBI)FGF22
Genatlas (Paris)FGF22
WikiGenes27006
SOURCE (Princeton)FGF22
Genetics Home Reference (NIH)FGF22
Genomic and cartography
GoldenPath hg38 (UCSC)FGF22  -     chr19:639926-643604 +  19p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FGF22  -     19p13.3   [Description]    (hg19-Feb_2009)
EnsemblFGF22 - 19p13.3 [CytoView hg19]  FGF22 - 19p13.3 [CytoView hg38]
Mapping of homologs : NCBIFGF22 [Mapview hg19]  FGF22 [Mapview hg38]
OMIM605831   
Gene and transcription
Genbank (Entrez)AB021925 AY359084 BC137444 BC137445 BC144645
RefSeq transcript (Entrez)NM_001300812 NM_020637
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FGF22
Cluster EST : UnigeneHs.248087 [ NCBI ]
CGAP (NCI)Hs.248087
Alternative Splicing GalleryENSG00000070388
Gene ExpressionFGF22 [ NCBI-GEO ]   FGF22 [ EBI - ARRAY_EXPRESS ]   FGF22 [ SEEK ]   FGF22 [ MEM ]
Gene Expression Viewer (FireBrowse)FGF22 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)27006
GTEX Portal (Tissue expression)FGF22
Human Protein AtlasENSG00000070388-FGF22 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9HCT0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9HCT0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9HCT0
Splice isoforms : SwissVarQ9HCT0
PhosPhoSitePlusQ9HCT0
Domains : Interpro (EBI)FGF22    Fibroblast_GF_fam    IL1/FGF   
Domain families : Pfam (Sanger)FGF (PF00167)   
Domain families : Pfam (NCBI)pfam00167   
Domain families : Smart (EMBL)FGF (SM00442)  
Conserved Domain (NCBI)FGF22
DMDM Disease mutations27006
Blocks (Seattle)FGF22
SuperfamilyQ9HCT0
Human Protein Atlas [tissue]ENSG00000070388-FGF22 [tissue]
Peptide AtlasQ9HCT0
HPRD05784
IPIIPI00030814   IPI00016958   
Protein Interaction databases
DIP (DOE-UCLA)Q9HCT0
IntAct (EBI)Q9HCT0
FunCoupENSG00000070388
BioGRIDFGF22
STRING (EMBL)FGF22
ZODIACFGF22
Ontologies - Pathways
QuickGOQ9HCT0
Ontology : AmiGOMAPK cascade  protein tyrosine kinase activity  Ras guanyl-nucleotide exchange factor activity  fibroblast growth factor receptor binding  extracellular region  extracellular space  nucleolus  Golgi apparatus  growth factor activity  fibroblast growth factor receptor signaling pathway  cell surface  regulation of signaling receptor activity  1-phosphatidylinositol-3-kinase activity  peptidyl-tyrosine phosphorylation  cell differentiation  phosphatidylinositol-3-phosphate biosynthetic process  phosphatidylinositol phosphorylation  phosphatidylinositol-4,5-bisphosphate 3-kinase activity  positive regulation of protein kinase B signaling  
Ontology : EGO-EBIMAPK cascade  protein tyrosine kinase activity  Ras guanyl-nucleotide exchange factor activity  fibroblast growth factor receptor binding  extracellular region  extracellular space  nucleolus  Golgi apparatus  growth factor activity  fibroblast growth factor receptor signaling pathway  cell surface  regulation of signaling receptor activity  1-phosphatidylinositol-3-kinase activity  peptidyl-tyrosine phosphorylation  cell differentiation  phosphatidylinositol-3-phosphate biosynthetic process  phosphatidylinositol phosphorylation  phosphatidylinositol-4,5-bisphosphate 3-kinase activity  positive regulation of protein kinase B signaling  
Pathways : KEGGMAPK signaling pathway    Ras signaling pathway    Rap1 signaling pathway    PI3K-Akt signaling pathway    Regulation of actin cytoskeleton    Pathways in cancer    Proteoglycans in cancer    Melanoma   
NDEx NetworkFGF22
Atlas of Cancer Signalling NetworkFGF22
Wikipedia pathwaysFGF22
Orthology - Evolution
OrthoDB27006
GeneTree (enSembl)ENSG00000070388
Phylogenetic Trees/Animal Genes : TreeFamFGF22
HOGENOMQ9HCT0
Homologs : HomoloGeneFGF22
Homology/Alignments : Family Browser (UCSC)FGF22
Gene fusions - Rearrangements
Fusion : QuiverFGF22
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFGF22 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FGF22
dbVarFGF22
ClinVarFGF22
1000_GenomesFGF22 
Exome Variant ServerFGF22
ExAC (Exome Aggregation Consortium)ENSG00000070388
GNOMAD BrowserENSG00000070388
Varsome BrowserFGF22
Genetic variants : HAPMAP27006
Genomic Variants (DGV)FGF22 [DGVbeta]
DECIPHERFGF22 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFGF22 
Mutations
ICGC Data PortalFGF22 
TCGA Data PortalFGF22 
Broad Tumor PortalFGF22
OASIS PortalFGF22 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFGF22  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFGF22
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FGF22
DgiDB (Drug Gene Interaction Database)FGF22
DoCM (Curated mutations)FGF22 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FGF22 (select a term)
intoGenFGF22
Cancer3DFGF22(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605831   
Orphanet
DisGeNETFGF22
MedgenFGF22
Genetic Testing Registry FGF22
NextProtQ9HCT0 [Medical]
TSGene27006
GENETestsFGF22
Target ValidationFGF22
Huge Navigator FGF22 [HugePedia]
snp3D : Map Gene to Disease27006
BioCentury BCIQFGF22
ClinGenFGF22
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD27006
Chemical/Pharm GKB GenePA28118
Clinical trialFGF22
Miscellaneous
canSAR (ICR)FGF22 (select the gene name)
Probes
Litterature
PubMed13 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFGF22
EVEXFGF22
GoPubMedFGF22
iHOPFGF22
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Dec 21 15:19:58 CET 2018
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