Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

FGF23 (fibroblast growth factor 23)

Identity

Other namesADHR
FGFN
HPDR2
HYPF
PHPTC
HGNC (Hugo) FGF23
LocusID (NCBI) 8074
Atlas_Id 40562
Location 12p13.32
Location_base_pair Starts at 4477393 and ends at 4488894 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
RECQL (12p12.1) / FGF23 (12p13.32)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)FGF23   3680
Cards
Entrez_Gene (NCBI)FGF23  8074  fibroblast growth factor 23
AliasesADHR; FGFN; HPDR2; HYPF; 
PHPTC
GeneCards (Weizmann)FGF23
Ensembl hg19 (Hinxton)ENSG00000118972 [Gene_View]  chr12:4477393-4488894 [Contig_View]  FGF23 [Vega]
Ensembl hg38 (Hinxton)ENSG00000118972 [Gene_View]  chr12:4477393-4488894 [Contig_View]  FGF23 [Vega]
ICGC DataPortalENSG00000118972
TCGA cBioPortalFGF23
AceView (NCBI)FGF23
Genatlas (Paris)FGF23
WikiGenes8074
SOURCE (Princeton)FGF23
Genomic and cartography
GoldenPath hg19 (UCSC)FGF23  -     chr12:4477393-4488894 -  12p13.32   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)FGF23  -     12p13.32   [Description]    (hg38-Dec_2013)
EnsemblFGF23 - 12p13.32 [CytoView hg19]  FGF23 - 12p13.32 [CytoView hg38]
Mapping of homologs : NCBIFGF23 [Mapview hg19]  FGF23 [Mapview hg38]
OMIM193100   605380   
Gene and transcription
Genbank (Entrez)AB037973 AB047858 AF263537 AY358323 BC069333
RefSeq transcript (Entrez)NM_020638
RefSeq genomic (Entrez)NC_000012 NC_018923 NG_007087 NT_009759 NW_004929382
Consensus coding sequences : CCDS (NCBI)FGF23
Cluster EST : UnigeneHs.287370 [ NCBI ]
CGAP (NCI)Hs.287370
Alternative Splicing GalleryENSG00000118972
Gene ExpressionFGF23 [ NCBI-GEO ]   FGF23 [ EBI - ARRAY_EXPRESS ]   FGF23 [ SEEK ]   FGF23 [ MEM ]
Gene Expression Viewer (FireBrowse)FGF23 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8074
GTEX Portal (Tissue expression)FGF23
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9GZV9 (Uniprot)
NextProtQ9GZV9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9GZV9
Splice isoforms : SwissVarQ9GZV9 (Swissvar)
PhosPhoSitePlusQ9GZV9
Domains : Interpro (EBI)Cytokine_IL1-like    FGF23    Fibroblast_GF_fam    IL-1_fam/FGF_fam   
Domain families : Pfam (Sanger)FGF (PF00167)   
Domain families : Pfam (NCBI)pfam00167   
Domain families : Smart (EMBL)FGF (SM00442)  
DMDM Disease mutations8074
Blocks (Seattle)FGF23
PDB (SRS)2P39   
PDB (PDBSum)2P39   
PDB (IMB)2P39   
PDB (RSDB)2P39   
Structural Biology KnowledgeBase2P39   
SCOP (Structural Classification of Proteins)2P39   
CATH (Classification of proteins structures)2P39   
SuperfamilyQ9GZV9
Human Protein AtlasENSG00000118972
Peptide AtlasQ9GZV9
HPRD05648
IPIIPI00026407   
Protein Interaction databases
DIP (DOE-UCLA)Q9GZV9
IntAct (EBI)Q9GZV9
FunCoupENSG00000118972
BioGRIDFGF23
STRING (EMBL)FGF23
ZODIACFGF23
Ontologies - Pathways
QuickGOQ9GZV9
Ontology : AmiGOMAPK cascade  protein tyrosine kinase activity  Ras guanyl-nucleotide exchange factor activity  type 1 fibroblast growth factor receptor binding  extracellular region  extracellular space  extracellular space  Golgi lumen  growth factor activity  fibroblast growth factor receptor signaling pathway  regulation of phosphate transport  positive regulation of vitamin D 24-hydroxylase activity  regulation of phosphatidylinositol 3-kinase signaling  1-phosphatidylinositol-3-kinase activity  peptidyl-tyrosine phosphorylation  cell differentiation  negative regulation of bone mineralization  cellular phosphate ion homeostasis  response to magnesium ion  phosphatidylinositol-3-phosphate biosynthetic process  vitamin D catabolic process  positive regulation of GTPase activity  cellular response to leptin stimulus  negative regulation of osteoblast differentiation  positive regulation of transcription, DNA-templated  phosphatidylinositol phosphorylation  negative regulation of hormone secretion  phosphatidylinositol-4,5-bisphosphate 3-kinase activity  phosphatidylinositol-mediated signaling  phosphate ion homeostasis  positive regulation of ERK1 and ERK2 cascade  cellular response to vitamin D  cellular response to interleukin-6  cellular response to parathyroid hormone stimulus  positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway  response to sodium phosphate  
Ontology : EGO-EBIMAPK cascade  protein tyrosine kinase activity  Ras guanyl-nucleotide exchange factor activity  type 1 fibroblast growth factor receptor binding  extracellular region  extracellular space  extracellular space  Golgi lumen  growth factor activity  fibroblast growth factor receptor signaling pathway  regulation of phosphate transport  positive regulation of vitamin D 24-hydroxylase activity  regulation of phosphatidylinositol 3-kinase signaling  1-phosphatidylinositol-3-kinase activity  peptidyl-tyrosine phosphorylation  cell differentiation  negative regulation of bone mineralization  cellular phosphate ion homeostasis  response to magnesium ion  phosphatidylinositol-3-phosphate biosynthetic process  vitamin D catabolic process  positive regulation of GTPase activity  cellular response to leptin stimulus  negative regulation of osteoblast differentiation  positive regulation of transcription, DNA-templated  phosphatidylinositol phosphorylation  negative regulation of hormone secretion  phosphatidylinositol-4,5-bisphosphate 3-kinase activity  phosphatidylinositol-mediated signaling  phosphate ion homeostasis  positive regulation of ERK1 and ERK2 cascade  cellular response to vitamin D  cellular response to interleukin-6  cellular response to parathyroid hormone stimulus  positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway  response to sodium phosphate  
Pathways : KEGGMAPK signaling pathway    Ras signaling pathway    Rap1 signaling pathway    PI3K-Akt signaling pathway    Regulation of actin cytoskeleton    Pathways in cancer    Proteoglycans in cancer    Melanoma   
NDEx Network
Atlas of Cancer Signalling NetworkFGF23
Wikipedia pathwaysFGF23
Orthology - Evolution
OrthoDB8074
GeneTree (enSembl)ENSG00000118972
Phylogenetic Trees/Animal Genes : TreeFamFGF23
Homologs : HomoloGeneFGF23
Homology/Alignments : Family Browser (UCSC)FGF23
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerFGF23 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FGF23
dbVarFGF23
ClinVarFGF23
1000_GenomesFGF23 
Exome Variant ServerFGF23
ExAC (Exome Aggregation Consortium)FGF23 (select the gene name)
Genetic variants : HAPMAP8074
Genomic Variants (DGV)FGF23 [DGVbeta]
Mutations
ICGC Data PortalFGF23 
TCGA Data PortalFGF23 
Broad Tumor PortalFGF23
OASIS PortalFGF23 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFGF23 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)LOVD - Munich Open Variation Database
BioMutasearch FGF23
DgiDB (Drug Gene Interaction Database)FGF23
DoCM (Curated mutations)FGF23 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FGF23 (select a term)
intoGenFGF23
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)12:4477393-4488894  ENSG00000118972
CONAN: Copy Number AnalysisFGF23 
Mutations and Diseases : HGMDFGF23
OMIM193100    605380   
MedgenFGF23
Genetic Testing Registry FGF23
NextProtQ9GZV9 [Medical]
TSGene8074
GENETestsFGF23
Huge Navigator FGF23 [HugePedia]
snp3D : Map Gene to Disease8074
BioCentury BCIQFGF23
ClinGenFGF23
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8074
Chemical/Pharm GKB GenePA28119
Clinical trialFGF23
Miscellaneous
canSAR (ICR)FGF23 (select the gene name)
Probes
Litterature
PubMed321 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFGF23
EVEXFGF23
GoPubMedFGF23
iHOPFGF23
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat May 28 11:02:48 CEST 2016

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.