Atlas of Genetics and Cytogenetics in Oncology and Haematology


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FGF23 (fibroblast growth factor 23)

Identity

Other namesADHR
FGFN
HPDR2
HYPF
PHPTC
HGNC (Hugo) FGF23
LocusID (NCBI) 8074
Location 12p13.32
Location_base_pair Starts at 4477393 and ends at 4488894 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)FGF23   3680
Cards
Entrez_Gene (NCBI)FGF23  8074  fibroblast growth factor 23
GeneCards (Weizmann)FGF23
Ensembl (Hinxton)ENSG00000118972 [Gene_View]  chr12:4477393-4488894 [Contig_View]  FGF23 [Vega]
ICGC DataPortalENSG00000118972
cBioPortalFGF23
AceView (NCBI)FGF23
Genatlas (Paris)FGF23
WikiGenes8074
SOURCE (Princeton)NM_020638
Genomic and cartography
GoldenPath (UCSC)FGF23  -  12p13.32   chr12:4477393-4488894 -  12p13.32   [Description]    (hg19-Feb_2009)
EnsemblFGF23 - 12p13.32 [CytoView]
Mapping of homologs : NCBIFGF23 [Mapview]
OMIM193100   211900   605380   
Gene and transcription
Genbank (Entrez)AB037973 AB047858 AF263537 AY358323 BC069333
RefSeq transcript (Entrez)NM_020638
RefSeq genomic (Entrez)AC_000144 NC_000012 NC_018923 NG_007087 NT_009759 NW_001838049 NW_004929382
Consensus coding sequences : CCDS (NCBI)FGF23
Cluster EST : UnigeneHs.287370 [ NCBI ]
CGAP (NCI)Hs.287370
Alternative Splicing : Fast-db (Paris)GSHG0007187
Alternative Splicing GalleryENSG00000118972
Gene ExpressionFGF23 [ NCBI-GEO ]     FGF23 [ SEEK ]   FGF23 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9GZV9 (Uniprot)
NextProtQ9GZV9  [Medical]
With graphics : InterProQ9GZV9
Splice isoforms : SwissVarQ9GZV9 (Swissvar)
Domaine pattern : Prosite (Expaxy)HBGF_FGF (PS00247)   
Domains : Interpro (EBI)Cytokine_IL1-like [organisation]   FGF23 [organisation]   Fibroblast_GF_fam [organisation]   IL-1_fam/FGF_fam [organisation]  
Related proteins : CluSTrQ9GZV9
Domain families : Pfam (Sanger)FGF (PF00167)   
Domain families : Pfam (NCBI)pfam00167   
Domain families : Smart (EMBL)FGF (SM00442)  
DMDM Disease mutations8074
Blocks (Seattle)Q9GZV9
PDB (SRS)2P39   
PDB (PDBSum)2P39   
PDB (IMB)2P39   
PDB (RSDB)2P39   
Human Protein AtlasENSG00000118972 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasQ9GZV9
HPRD05648
IPIIPI00026407   
Protein Interaction databases
DIP (DOE-UCLA)Q9GZV9
IntAct (EBI)Q9GZV9
FunCoupENSG00000118972
BioGRIDFGF23
InParanoidQ9GZV9
Interologous Interaction database Q9GZV9
IntegromeDBFGF23
STRING (EMBL)FGF23
Ontologies - Pathways
Ontology : AmiGOtype 1 fibroblast growth factor receptor binding  extracellular region  extracellular space  extracellular space  extracellular space  phosphate-containing compound metabolic process  epidermal growth factor receptor signaling pathway  growth factor activity  insulin receptor signaling pathway  fibroblast growth factor receptor signaling pathway  regulation of phosphate transport  positive regulation of vitamin D 24-hydroxylase activity  cell differentiation  negative regulation of bone mineralization  cellular phosphate ion homeostasis  Fc-epsilon receptor signaling pathway  vitamin D catabolic process  innate immune response  negative regulation of osteoblast differentiation  positive regulation of transcription, DNA-dependent  negative regulation of hormone secretion  neurotrophin TRK receptor signaling pathway  phosphatidylinositol-mediated signaling  phosphate ion homeostasis  positive regulation of ERK1 and ERK2 cascade  positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway  
Ontology : EGO-EBItype 1 fibroblast growth factor receptor binding  extracellular region  extracellular space  extracellular space  extracellular space  phosphate-containing compound metabolic process  epidermal growth factor receptor signaling pathway  growth factor activity  insulin receptor signaling pathway  fibroblast growth factor receptor signaling pathway  regulation of phosphate transport  positive regulation of vitamin D 24-hydroxylase activity  cell differentiation  negative regulation of bone mineralization  cellular phosphate ion homeostasis  Fc-epsilon receptor signaling pathway  vitamin D catabolic process  innate immune response  negative regulation of osteoblast differentiation  positive regulation of transcription, DNA-dependent  negative regulation of hormone secretion  neurotrophin TRK receptor signaling pathway  phosphatidylinositol-mediated signaling  phosphate ion homeostasis  positive regulation of ERK1 and ERK2 cascade  positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway  
Pathways : KEGGMAPK signaling pathway    Ras signaling pathway    Rap1 signaling pathway    PI3K-Akt signaling pathway    Regulation of actin cytoskeleton    Pathways in cancer    Proteoglycans in cancer    Melanoma   
Protein Interaction DatabaseFGF23
Wikipedia pathwaysFGF23
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)FGF23
snp3D : Map Gene to Disease8074
SNP (GeneSNP Utah)FGF23
SNP : HGBaseFGF23
Genetic variants : HAPMAPFGF23
Exome VariantFGF23
1000_GenomesFGF23 
ICGC programENSG00000118972 
Somatic Mutations in Cancer : COSMICFGF23 
CONAN: Copy Number AnalysisFGF23 
Mutations and Diseases : HGMDFGF23
Genomic VariantsFGF23  FGF23 [DGVbeta]
dbVarFGF23
ClinVarFGF23
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM193100    211900    605380   
MedgenFGF23
GENETestsFGF23
Disease Genetic AssociationFGF23
Huge Navigator FGF23 [HugePedia]  FGF23 [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneFGF23
Homology/Alignments : Family Browser (UCSC)FGF23
Phylogenetic Trees/Animal Genes : TreeFamFGF23
Chemical/Protein Interactions : CTD8074
Chemical/Pharm GKB GenePA28119
Clinical trialFGF23
Cancer Resource (Charite)ENSG00000118972
Other databases
Probes
Litterature
PubMed213 Pubmed reference(s) in Entrez
CoreMineFGF23
iHOPFGF23
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jul 11 16:55:51 CEST 2014

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