Atlas of Genetics and Cytogenetics in Oncology and Haematology


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FGF3 (fibroblast growth factor 3)

Identity

Alias_namesINT2
fibroblast growth factor 3 (murine mammary tumor virus integration site (v-int-2) oncogene homolog)
Alias_symbol (synonym)HBGF-3
HGNC (Hugo) FGF3
LocusID (NCBI) 2248
Atlas_Id 368
Location 11q13.3  [Link to chromosome band 11q13]
Location_base_pair Starts at 69624736 and ends at 69634192 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ATP2A3 (17p13.2) / FGF3 (11q13.3)CPT1A (11q13.3) / FGF3 (11q13.3)FGF3 (11q13.3) / LGR4 (11p14.1)
PTPRN2 (7q36.3) / FGF3 (11q13.3)RBM14 (11q13.2) / FGF3 (11q13.3)ATP2A3 17p13.2 / FGF3 11q13.3
CPT1A 11q13.3 / FGF3 11q13.3FGF3 11q13.3 / LGR4 11p14.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 7 ]
  Bladder: Urothelial carcinomas
Head and Neck: Epidermoid carcinoma
Head and Neck: Laryngeal squamous cell carcinoma
Ovarian tumours : an overview
Ovary: Epithelial tumors
Squamous cell cancer
Lung: Translocations in Adenocarcinoma


External links

Nomenclature
HGNC (Hugo)FGF3   3681
Cards
Entrez_Gene (NCBI)FGF3  2248  fibroblast growth factor 3
AliasesHBGF-3; INT2
GeneCards (Weizmann)FGF3
Ensembl hg19 (Hinxton)ENSG00000186895 [Gene_View]  chr11:69624736-69634192 [Contig_View]  FGF3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000186895 [Gene_View]  chr11:69624736-69634192 [Contig_View]  FGF3 [Vega]
ICGC DataPortalENSG00000186895
TCGA cBioPortalFGF3
AceView (NCBI)FGF3
Genatlas (Paris)FGF3
WikiGenes2248
SOURCE (Princeton)FGF3
Genetics Home Reference (NIH)FGF3
Genomic and cartography
GoldenPath hg19 (UCSC)FGF3  -     chr11:69624736-69634192 -  11q13.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)FGF3  -     11q13.3   [Description]    (hg38-Dec_2013)
EnsemblFGF3 - 11q13.3 [CytoView hg19]  FGF3 - 11q13.3 [CytoView hg38]
Mapping of homologs : NCBIFGF3 [Mapview hg19]  FGF3 [Mapview hg38]
OMIM164950   610706   
Gene and transcription
Genbank (Entrez)BC113739
RefSeq transcript (Entrez)NM_005247
RefSeq genomic (Entrez)NC_000011 NC_018922 NG_009016 NT_167190 NW_004929380
Consensus coding sequences : CCDS (NCBI)FGF3
Cluster EST : UnigeneHs.37092 [ NCBI ]
CGAP (NCI)Hs.37092
Alternative Splicing GalleryENSG00000186895
Gene ExpressionFGF3 [ NCBI-GEO ]   FGF3 [ EBI - ARRAY_EXPRESS ]   FGF3 [ SEEK ]   FGF3 [ MEM ]
Gene Expression Viewer (FireBrowse)FGF3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2248
GTEX Portal (Tissue expression)FGF3
Protein : pattern, domain, 3D structure
UniProt/SwissProtP11487   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP11487  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP11487
Splice isoforms : SwissVarP11487
PhosPhoSitePlusP11487
Domaine pattern : Prosite (Expaxy)HBGF_FGF (PS00247)   
Domains : Interpro (EBI)Cytokine_IL1-like    FGF3    Fibroblast_GF_fam    IL-1_fam/FGF_fam   
Domain families : Pfam (Sanger)FGF (PF00167)   
Domain families : Pfam (NCBI)pfam00167   
Domain families : Smart (EMBL)FGF (SM00442)  
Conserved Domain (NCBI)FGF3
DMDM Disease mutations2248
Blocks (Seattle)FGF3
SuperfamilyP11487
Human Protein AtlasENSG00000186895
Peptide AtlasP11487
HPRD01289
IPIIPI00005729   
Protein Interaction databases
DIP (DOE-UCLA)P11487
IntAct (EBI)P11487
FunCoupENSG00000186895
BioGRIDFGF3
STRING (EMBL)FGF3
ZODIACFGF3
Ontologies - Pathways
QuickGOP11487
Ontology : AmiGOMAPK cascade  protein tyrosine kinase activity  Ras guanyl-nucleotide exchange factor activity  fibroblast growth factor receptor binding  protein binding  extracellular region  intracellular  signal transduction  cell-cell signaling  multicellular organism development  growth factor activity  positive regulation of cell proliferation  fibroblast growth factor receptor signaling pathway  fibroblast growth factor receptor signaling pathway  anatomical structure morphogenesis  regulation of phosphatidylinositol 3-kinase signaling  1-phosphatidylinositol-3-kinase activity  peptidyl-tyrosine phosphorylation  cell differentiation  phosphatidylinositol-3-phosphate biosynthetic process  positive regulation of GTPase activity  phosphatidylinositol phosphorylation  phosphatidylinositol-4,5-bisphosphate 3-kinase activity  phosphatidylinositol-mediated signaling  positive regulation of cell division  negative regulation of cardiac muscle tissue development  
Ontology : EGO-EBIMAPK cascade  protein tyrosine kinase activity  Ras guanyl-nucleotide exchange factor activity  fibroblast growth factor receptor binding  protein binding  extracellular region  intracellular  signal transduction  cell-cell signaling  multicellular organism development  growth factor activity  positive regulation of cell proliferation  fibroblast growth factor receptor signaling pathway  fibroblast growth factor receptor signaling pathway  anatomical structure morphogenesis  regulation of phosphatidylinositol 3-kinase signaling  1-phosphatidylinositol-3-kinase activity  peptidyl-tyrosine phosphorylation  cell differentiation  phosphatidylinositol-3-phosphate biosynthetic process  positive regulation of GTPase activity  phosphatidylinositol phosphorylation  phosphatidylinositol-4,5-bisphosphate 3-kinase activity  phosphatidylinositol-mediated signaling  positive regulation of cell division  negative regulation of cardiac muscle tissue development  
Pathways : KEGGMAPK signaling pathway    Ras signaling pathway    Rap1 signaling pathway    PI3K-Akt signaling pathway    Regulation of actin cytoskeleton    Pathways in cancer    Proteoglycans in cancer    Melanoma   
NDEx NetworkFGF3
Atlas of Cancer Signalling NetworkFGF3
Wikipedia pathwaysFGF3
Orthology - Evolution
OrthoDB2248
GeneTree (enSembl)ENSG00000186895
Phylogenetic Trees/Animal Genes : TreeFamFGF3
HOVERGENP11487
HOGENOMP11487
Homologs : HomoloGeneFGF3
Homology/Alignments : Family Browser (UCSC)FGF3
Gene fusions - Rearrangements
Fusion : MitelmanATP2A3/FGF3 [17p13.2/11q13.3]  [t(11;17)(q13;p13)]  
Fusion : MitelmanCPT1A/FGF3 [11q13.3/11q13.3]  [t(11;11)(q13;q13)]  
Fusion : MitelmanFGF3/LGR4 [11q13.3/11p14.1]  [t(11;11)(p14;q13)]  
Fusion : MitelmanRBM14/FGF3 [11q13.2/11q13.3]  [t(11;11)(q13;q13)]  
Fusion: TCGAATP2A3 17p13.2 FGF3 11q13.3 BRCA
Fusion: TCGACPT1A 11q13.3 FGF3 11q13.3 HNSC
Fusion: TCGAFGF3 11q13.3 LGR4 11p14.1 LUSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFGF3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FGF3
dbVarFGF3
ClinVarFGF3
1000_GenomesFGF3 
Exome Variant ServerFGF3
ExAC (Exome Aggregation Consortium)FGF3 (select the gene name)
Genetic variants : HAPMAP2248
Genomic Variants (DGV)FGF3 [DGVbeta]
DECIPHER (Syndromes)11:69624736-69634192  ENSG00000186895
CONAN: Copy Number AnalysisFGF3 
Mutations
ICGC Data PortalFGF3 
TCGA Data PortalFGF3 
Broad Tumor PortalFGF3
OASIS PortalFGF3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFGF3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFGF3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FGF3
DgiDB (Drug Gene Interaction Database)FGF3
DoCM (Curated mutations)FGF3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FGF3 (select a term)
intoGenFGF3
Cancer3DFGF3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM164950    610706   
Orphanet2539    11926    14379   
MedgenFGF3
Genetic Testing Registry FGF3
NextProtP11487 [Medical]
TSGene2248
GENETestsFGF3
Huge Navigator FGF3 [HugePedia]
snp3D : Map Gene to Disease2248
BioCentury BCIQFGF3
ClinGenFGF3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2248
Chemical/Pharm GKB GenePA28120
Clinical trialFGF3
Miscellaneous
canSAR (ICR)FGF3 (select the gene name)
Probes
Litterature
PubMed41 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFGF3
EVEXFGF3
GoPubMedFGF3
iHOPFGF3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Nov 18 19:37:30 CET 2016

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