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FGF3 (fibroblast growth factor 3)

Identity

Alias (NCBI)HBGF-3
INT2
HGNC (Hugo) FGF3
HGNC Alias symbHBGF-3
HGNC Alias nameINT-2 proto-oncogene protein
 oncogene INT2
 V-INT2 murine mammary tumor virus integration site oncogene homolog
 murine mammary tumor virus integration site 2, mouse
HGNC Previous nameINT2
HGNC Previous namefibroblast growth factor 3 (murine mammary tumor virus integration site (v-int-2) oncogene homolog)
LocusID (NCBI) 2248
Atlas_Id 368
Location 11q13.3  [Link to chromosome band 11q13]
Location_base_pair Starts at 69809968 and ends at 69819416 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ATP2A3 (17p13.2) / FGF3 (11q13.3)CPT1A (11q13.3) / FGF3 (11q13.3)FGF3 (11q13.3) / LGR4 (11p14.1)
PTPRN2 (7q36.3) / FGF3 (11q13.3)RBM14 (11q13.2) / FGF3 (11q13.3)ATP2A3 17p13.2 / FGF3 11q13.3
CPT1A 11q13.3 / FGF3 11q13.3FGF3 11q13.3 / LGR4 11p14.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)FGF3   3681
Cards
Entrez_Gene (NCBI)FGF3    fibroblast growth factor 3
AliasesHBGF-3; INT2
GeneCards (Weizmann)FGF3
Ensembl hg19 (Hinxton)ENSG00000186895 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000186895 [Gene_View]  ENSG00000186895 [Sequence]  chr11:69809968-69819416 [Contig_View]  FGF3 [Vega]
ICGC DataPortalENSG00000186895
TCGA cBioPortalFGF3
AceView (NCBI)FGF3
Genatlas (Paris)FGF3
SOURCE (Princeton)FGF3
Genetics Home Reference (NIH)FGF3
Genomic and cartography
GoldenPath hg38 (UCSC)FGF3  -     chr11:69809968-69819416 -  11q13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FGF3  -     11q13.3   [Description]    (hg19-Feb_2009)
GoldenPathFGF3 - 11q13.3 [CytoView hg19]  FGF3 - 11q13.3 [CytoView hg38]
ImmunoBaseENSG00000186895
Genome Data Viewer NCBIFGF3 [Mapview hg19]  
OMIM164950   610706   
Gene and transcription
Genbank (Entrez)BC113739
RefSeq transcript (Entrez)NM_005247
Consensus coding sequences : CCDS (NCBI)FGF3
Gene ExpressionFGF3 [ NCBI-GEO ]   FGF3 [ EBI - ARRAY_EXPRESS ]   FGF3 [ SEEK ]   FGF3 [ MEM ]
Gene Expression Viewer (FireBrowse)FGF3 [ Firebrowse - Broad ]
GenevisibleExpression of FGF3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2248
GTEX Portal (Tissue expression)FGF3
Human Protein AtlasENSG00000186895-FGF3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP11487   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP11487  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP11487
PhosPhoSitePlusP11487
Domaine pattern : Prosite (Expaxy)HBGF_FGF (PS00247)   
Domains : Interpro (EBI)FGF3    Fibroblast_GF_fam    IL1/FGF   
Domain families : Pfam (Sanger)FGF (PF00167)   
Domain families : Pfam (NCBI)pfam00167   
Domain families : Smart (EMBL)FGF (SM00442)  
Conserved Domain (NCBI)FGF3
SuperfamilyP11487
AlphaFold pdb e-kbP11487   
Human Protein Atlas [tissue]ENSG00000186895-FGF3 [tissue]
HPRD01289
Protein Interaction databases
DIP (DOE-UCLA)P11487
IntAct (EBI)P11487
BioGRIDFGF3
STRING (EMBL)FGF3
ZODIACFGF3
Ontologies - Pathways
QuickGOP11487
Ontology : AmiGOMAPK cascade  positive regulation of protein phosphorylation  fibroblast growth factor receptor binding  protein binding  extracellular region  extracellular space  cytoplasm  signal transduction  cell-cell signaling  growth factor activity  positive regulation of cell population proliferation  positive regulation of cell population proliferation  fibroblast growth factor receptor signaling pathway  fibroblast growth factor receptor signaling pathway  fibroblast growth factor receptor signaling pathway  anatomical structure morphogenesis  animal organ morphogenesis  positive regulation of gene expression  cell differentiation  regulation of cell migration  positive regulation of cell division  positive regulation of protein kinase B signaling  negative regulation of cardiac muscle tissue development  
Ontology : EGO-EBIMAPK cascade  positive regulation of protein phosphorylation  fibroblast growth factor receptor binding  protein binding  extracellular region  extracellular space  cytoplasm  signal transduction  cell-cell signaling  growth factor activity  positive regulation of cell population proliferation  positive regulation of cell population proliferation  fibroblast growth factor receptor signaling pathway  fibroblast growth factor receptor signaling pathway  fibroblast growth factor receptor signaling pathway  anatomical structure morphogenesis  animal organ morphogenesis  positive regulation of gene expression  cell differentiation  regulation of cell migration  positive regulation of cell division  positive regulation of protein kinase B signaling  negative regulation of cardiac muscle tissue development  
Pathways : KEGGMAPK signaling pathway    Ras signaling pathway    Rap1 signaling pathway    PI3K-Akt signaling pathway    Regulation of actin cytoskeleton    Pathways in cancer    Proteoglycans in cancer    Melanoma   
NDEx NetworkFGF3
Atlas of Cancer Signalling NetworkFGF3
Wikipedia pathwaysFGF3
Orthology - Evolution
OrthoDB2248
GeneTree (enSembl)ENSG00000186895
Phylogenetic Trees/Animal Genes : TreeFamFGF3
Homologs : HomoloGeneFGF3
Homology/Alignments : Family Browser (UCSC)FGF3
Gene fusions - Rearrangements
Fusion : MitelmanATP2A3/FGF3 [17p13.2/11q13.3]  
Fusion : MitelmanCPT1A/FGF3 [11q13.3/11q13.3]  
Fusion : MitelmanFGF3/LGR4 [11q13.3/11p14.1]  
Fusion : MitelmanRBM14/FGF3 [11q13.2/11q13.3]  
Fusion : QuiverFGF3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFGF3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FGF3
dbVarFGF3
ClinVarFGF3
MonarchFGF3
1000_GenomesFGF3 
Exome Variant ServerFGF3
GNOMAD BrowserENSG00000186895
Varsome BrowserFGF3
ACMGFGF3 variants
VarityP11487
Genomic Variants (DGV)FGF3 [DGVbeta]
DECIPHERFGF3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFGF3 
Mutations
ICGC Data PortalFGF3 
TCGA Data PortalFGF3 
Broad Tumor PortalFGF3
OASIS PortalFGF3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFGF3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DFGF3
Mutations and Diseases : HGMDFGF3
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaFGF3
DgiDB (Drug Gene Interaction Database)FGF3
DoCM (Curated mutations)FGF3
CIViC (Clinical Interpretations of Variants in Cancer)FGF3
Cancer3DFGF3
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM164950    610706   
Orphanet2539    11926    14379   
DisGeNETFGF3
MedgenFGF3
Genetic Testing Registry FGF3
NextProtP11487 [Medical]
GENETestsFGF3
Target ValidationFGF3
Huge Navigator FGF3 [HugePedia]
ClinGenFGF3
Clinical trials, drugs, therapy
MyCancerGenomeFGF3
Protein Interactions : CTDFGF3
Pharm GKB GenePA28120
Pharm GKB PathwaysPA165980050   
PharosP11487
Clinical trialFGF3
Miscellaneous
canSAR (ICR)FGF3
HarmonizomeFGF3
DataMed IndexFGF3
Probes
Litterature
PubMed51 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXFGF3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:09:27 CEST 2021

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