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FGF3 (fibroblast growth factor 3)

Identity

Other namesHBGF-3
INT2
HGNC (Hugo) FGF3
LocusID (NCBI) 2248
Atlas_Id 368
Location 11q13.3
Location_base_pair Starts at 69624736 and ends at 69634192 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2015)
ATP2A3 17p13.2 / FGF3 11q13.3CPT1A 11q13.3 / FGF3 11q13.3FGF3 11q13.3 / LGR4 11p14.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas)
  Bladder: Urothelial carcinomas
Head and Neck: Epidermoid carcinoma
Head and Neck: Laryngeal squamous cell carcinoma
Ovarian tumours : an overview
Ovary: Epithelial tumors
Squamous cell cancer
Lung: Translocations in Adenocarcinoma

External links

Nomenclature
HGNC (Hugo)FGF3   3681
Cards
Entrez_Gene (NCBI)FGF3  2248  fibroblast growth factor 3
GeneCards (Weizmann)FGF3
Ensembl hg19 (Hinxton) [Gene_View]  chr11:69624736-69634192 [Contig_View]  FGF3 [Vega]
Ensembl hg38 (Hinxton) [Gene_View]  chr11:69624736-69634192 [Contig_View]  FGF3 [Vega]
TCGA cBioPortalFGF3
AceView (NCBI)FGF3
Genatlas (Paris)FGF3
WikiGenes2248
SOURCE (Princeton)FGF3
Genomic and cartography
GoldenPath hg19 (UCSC)FGF3  -     chr11:69624736-69634192 -  11q13.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)FGF3  -     11q13.3   [Description]    (hg38-Dec_2013)
EnsemblFGF3 - 11q13.3 [CytoView hg19]  FGF3 - 11q13.3 [CytoView hg38]
Mapping of homologs : NCBIFGF3 [Mapview hg19]  FGF3 [Mapview hg38]
OMIM164950   610706   
Gene and transcription
Genbank (Entrez)BC113739
RefSeq transcript (Entrez)NM_005247
RefSeq genomic (Entrez)NC_000011 NC_018922 NG_009016 NT_167190 NW_004929380
Consensus coding sequences : CCDS (NCBI)FGF3
Cluster EST : UnigeneHs.37092 [ NCBI ]
CGAP (NCI)Hs.37092
Alternative Splicing : Fast-db (Paris)GSHG0005976
Gene ExpressionFGF3 [ NCBI-GEO ]     FGF3 [ SEEK ]   FGF3 [ MEM ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)2248
Protein : pattern, domain, 3D structure
UniProt/SwissProtP11487 (Uniprot)
NextProtP11487  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP11487
Splice isoforms : SwissVarP11487 (Swissvar)
PhosPhoSitePlusP11487
Domaine pattern : Prosite (Expaxy)HBGF_FGF (PS00247)   
Domains : Interpro (EBI)Cytokine_IL1-like    FGF3    Fibroblast_GF_fam    IL-1_fam/FGF_fam   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Domain families : Smart (EMBL)FGF (SM00442)  
DMDM Disease mutations2248
Blocks (Seattle)FGF3
Peptide AtlasP11487
HPRD01289
IPIIPI00005729   
Protein Interaction databases
DIP (DOE-UCLA)P11487
IntAct (EBI)P11487
BioGRIDFGF3
IntegromeDBFGF3
STRING (EMBL)FGF3
ZODIACFGF3
Ontologies - Pathways
QuickGOP11487
Ontology : AmiGOMAPK cascade  activation of MAPKK activity  organ induction  fibroblast growth factor receptor binding  protein binding  extracellular region  Golgi apparatus  signal transduction  epidermal growth factor receptor signaling pathway  small GTPase mediated signal transduction  Ras protein signal transduction  cell-cell signaling  axon guidance  growth factor activity  positive regulation of cell proliferation  insulin receptor signaling pathway  fibroblast growth factor receptor signaling pathway  fibroblast growth factor receptor signaling pathway  anatomical structure morphogenesis  otic vesicle formation  post-anal tail morphogenesis  Fc-epsilon receptor signaling pathway  innate immune response  vascular endothelial growth factor receptor signaling pathway  neurotrophin TRK receptor signaling pathway  phosphatidylinositol-mediated signaling  thymus development  semicircular canal morphogenesis  positive regulation of cell division  negative regulation of cardiac muscle tissue development  
Ontology : EGO-EBIMAPK cascade  activation of MAPKK activity  organ induction  fibroblast growth factor receptor binding  protein binding  extracellular region  Golgi apparatus  signal transduction  epidermal growth factor receptor signaling pathway  small GTPase mediated signal transduction  Ras protein signal transduction  cell-cell signaling  axon guidance  growth factor activity  positive regulation of cell proliferation  insulin receptor signaling pathway  fibroblast growth factor receptor signaling pathway  fibroblast growth factor receptor signaling pathway  anatomical structure morphogenesis  otic vesicle formation  post-anal tail morphogenesis  Fc-epsilon receptor signaling pathway  innate immune response  vascular endothelial growth factor receptor signaling pathway  neurotrophin TRK receptor signaling pathway  phosphatidylinositol-mediated signaling  thymus development  semicircular canal morphogenesis  positive regulation of cell division  negative regulation of cardiac muscle tissue development  
Pathways : KEGGMAPK signaling pathway    Ras signaling pathway    Rap1 signaling pathway    PI3K-Akt signaling pathway    Regulation of actin cytoskeleton    Pathways in cancer    Proteoglycans in cancer    Melanoma   
Protein Interaction DatabaseFGF3
Atlas of Cancer Signalling NetworkFGF3
Wikipedia pathwaysFGF3
Orthology - Evolution
OrthoDB2248
Phylogenetic Trees/Animal Genes : TreeFamFGF3
Homologs : HomoloGeneFGF3
Homology/Alignments : Family Browser (UCSC)FGF3
Gene fusions - Rearrangements
Fusion: TCGAATP2A3 17p13.2 FGF3 11q13.3 BRCA
Fusion: TCGACPT1A 11q13.3 FGF3 11q13.3 HNSC
Fusion: TCGAFGF3 11q13.3 LGR4 11p14.1 LUSC
Polymorphisms : SNP, variants
NCBI Variation ViewerFGF3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FGF3
dbVarFGF3
ClinVarFGF3
1000_GenomesFGF3 
Exome Variant ServerFGF3
SNP (GeneSNP Utah)FGF3
SNP : HGBaseFGF3
Genetic variants : HAPMAPFGF3
Genomic Variants (DGV)FGF3 [DGVbeta]
Mutations
ICGC Data PortalFGF3 
TCGA Data PortalFGF3 
Tumor PortalFGF3
TCGA Copy Number PortalFGF3
Somatic Mutations in Cancer : COSMICFGF3 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FGF3
DgiDB (Drug Gene Interaction Database)FGF3
DoCM (Curated mutations)FGF3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FGF3 (select a term)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)11:69624736-69634192
CONAN: Copy Number AnalysisFGF3 
Mutations and Diseases : HGMDFGF3
OMIM164950    610706   
MedgenFGF3
NextProtP11487 [Medical]
TSGene2248
GENETestsFGF3
Huge Navigator FGF3 [HugePedia]  FGF3 [HugeCancerGEM]
snp3D : Map Gene to Disease2248
BioCentury BCIQFGF3
General knowledge
Chemical/Protein Interactions : CTD2248
Chemical/Pharm GKB GenePA28120
Clinical trialFGF3
Other databases
Probes
Litterature
PubMed39 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFGF3
GoPubMedFGF3
iHOPFGF3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Sat Jan 16 18:38:19 CET 2016

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