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FGF4 (fibroblast growth factor 4)

Identity

Alias_namesHSTF1
heparin secretory transforming protein 1
Alias_symbol (synonym)K-FGF
HBGF-4
HST
HST-1
KFGF
Other alias
HGNC (Hugo) FGF4
LocusID (NCBI) 2249
Atlas_Id 414
Location 11q13.3  [Link to chromosome band 11q13]
Location_base_pair Starts at 69773029 and ends at 69775403 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  Head and Neck: Epidermoid carcinoma
Head and Neck: Laryngeal squamous cell carcinoma


External links

Nomenclature
HGNC (Hugo)FGF4   3682
Cards
Entrez_Gene (NCBI)FGF4  2249  fibroblast growth factor 4
AliasesHBGF-4; HST; HST-1; HSTF1; 
K-FGF; KFGF
GeneCards (Weizmann)FGF4
Ensembl hg19 (Hinxton)ENSG00000075388 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000075388 [Gene_View]  chr11:69773029-69775403 [Contig_View]  FGF4 [Vega]
ICGC DataPortalENSG00000075388
TCGA cBioPortalFGF4
AceView (NCBI)FGF4
Genatlas (Paris)FGF4
WikiGenes2249
SOURCE (Princeton)FGF4
Genetics Home Reference (NIH)FGF4
Genomic and cartography
GoldenPath hg38 (UCSC)FGF4  -     chr11:69773029-69775403 -  11q13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FGF4  -     11q13.3   [Description]    (hg19-Feb_2009)
EnsemblFGF4 - 11q13.3 [CytoView hg19]  FGF4 - 11q13.3 [CytoView hg38]
Mapping of homologs : NCBIFGF4 [Mapview hg19]  FGF4 [Mapview hg38]
OMIM164980   
Gene and transcription
Genbank (Entrez)AW340506 BC156333 BC172495 CN429959 FJ456981
RefSeq transcript (Entrez)NM_002007
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FGF4
Cluster EST : UnigeneHs.1755 [ NCBI ]
CGAP (NCI)Hs.1755
Alternative Splicing GalleryENSG00000075388
Gene ExpressionFGF4 [ NCBI-GEO ]   FGF4 [ EBI - ARRAY_EXPRESS ]   FGF4 [ SEEK ]   FGF4 [ MEM ]
Gene Expression Viewer (FireBrowse)FGF4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2249
GTEX Portal (Tissue expression)FGF4
Human Protein AtlasENSG00000075388-FGF4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP08620   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP08620  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP08620
Splice isoforms : SwissVarP08620
PhosPhoSitePlusP08620
Domaine pattern : Prosite (Expaxy)HBGF_FGF (PS00247)   
Domains : Interpro (EBI)FGF4    Fibroblast_GF_fam    IL1/FGF   
Domain families : Pfam (Sanger)FGF (PF00167)   
Domain families : Pfam (NCBI)pfam00167   
Domain families : Smart (EMBL)FGF (SM00442)  
Conserved Domain (NCBI)FGF4
DMDM Disease mutations2249
Blocks (Seattle)FGF4
PDB (SRS)1IJT   
PDB (PDBSum)1IJT   
PDB (IMB)1IJT   
PDB (RSDB)1IJT   
Structural Biology KnowledgeBase1IJT   
SCOP (Structural Classification of Proteins)1IJT   
CATH (Classification of proteins structures)1IJT   
SuperfamilyP08620
Human Protein Atlas [tissue]ENSG00000075388-FGF4 [tissue]
Peptide AtlasP08620
HPRD01294
IPIIPI00029760   IPI00028232   
Protein Interaction databases
DIP (DOE-UCLA)P08620
IntAct (EBI)P08620
FunCoupENSG00000075388
BioGRIDFGF4
STRING (EMBL)FGF4
ZODIACFGF4
Ontologies - Pathways
QuickGOP08620
Ontology : AmiGOMAPK cascade  cartilage condensation  protein tyrosine kinase activity  Ras guanyl-nucleotide exchange factor activity  fibroblast growth factor receptor binding  extracellular region  intracellular  signal transduction  cell-cell signaling  growth factor activity  heparin binding  positive regulation of cell proliferation  fibroblast growth factor receptor signaling pathway  fibroblast growth factor receptor signaling pathway  mesenchymal cell proliferation  regulation of phosphatidylinositol 3-kinase signaling  1-phosphatidylinositol-3-kinase activity  peptidyl-tyrosine phosphorylation  stem cell population maintenance  embryonic hindlimb morphogenesis  phosphatidylinositol-3-phosphate biosynthetic process  odontogenesis of dentin-containing tooth  negative regulation of apoptotic process  positive regulation of GTPase activity  positive regulation of transcription from RNA polymerase II promoter  phosphatidylinositol phosphorylation  phosphatidylinositol-4,5-bisphosphate 3-kinase activity  phosphatidylinositol-mediated signaling  positive regulation of cell division  cranial suture morphogenesis  apoptotic process involved in morphogenesis  chondroblast differentiation  positive regulation of ERK1 and ERK2 cascade  regulation of endothelial cell chemotaxis to fibroblast growth factor  
Ontology : EGO-EBIMAPK cascade  cartilage condensation  protein tyrosine kinase activity  Ras guanyl-nucleotide exchange factor activity  fibroblast growth factor receptor binding  extracellular region  intracellular  signal transduction  cell-cell signaling  growth factor activity  heparin binding  positive regulation of cell proliferation  fibroblast growth factor receptor signaling pathway  fibroblast growth factor receptor signaling pathway  mesenchymal cell proliferation  regulation of phosphatidylinositol 3-kinase signaling  1-phosphatidylinositol-3-kinase activity  peptidyl-tyrosine phosphorylation  stem cell population maintenance  embryonic hindlimb morphogenesis  phosphatidylinositol-3-phosphate biosynthetic process  odontogenesis of dentin-containing tooth  negative regulation of apoptotic process  positive regulation of GTPase activity  positive regulation of transcription from RNA polymerase II promoter  phosphatidylinositol phosphorylation  phosphatidylinositol-4,5-bisphosphate 3-kinase activity  phosphatidylinositol-mediated signaling  positive regulation of cell division  cranial suture morphogenesis  apoptotic process involved in morphogenesis  chondroblast differentiation  positive regulation of ERK1 and ERK2 cascade  regulation of endothelial cell chemotaxis to fibroblast growth factor  
Pathways : KEGGMAPK signaling pathway    Ras signaling pathway    Rap1 signaling pathway    PI3K-Akt signaling pathway    Regulation of actin cytoskeleton    Pathways in cancer    Proteoglycans in cancer    Melanoma   
NDEx NetworkFGF4
Atlas of Cancer Signalling NetworkFGF4
Wikipedia pathwaysFGF4
Orthology - Evolution
OrthoDB2249
GeneTree (enSembl)ENSG00000075388
Phylogenetic Trees/Animal Genes : TreeFamFGF4
HOVERGENP08620
HOGENOMP08620
Homologs : HomoloGeneFGF4
Homology/Alignments : Family Browser (UCSC)FGF4
Gene fusions - Rearrangements
Tumor Fusion PortalFGF4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFGF4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FGF4
dbVarFGF4
ClinVarFGF4
1000_GenomesFGF4 
Exome Variant ServerFGF4
ExAC (Exome Aggregation Consortium)ENSG00000075388
GNOMAD BrowserENSG00000075388
Genetic variants : HAPMAP2249
Genomic Variants (DGV)FGF4 [DGVbeta]
DECIPHERFGF4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFGF4 
Mutations
ICGC Data PortalFGF4 
TCGA Data PortalFGF4 
Broad Tumor PortalFGF4
OASIS PortalFGF4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFGF4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFGF4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FGF4
DgiDB (Drug Gene Interaction Database)FGF4
DoCM (Curated mutations)FGF4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FGF4 (select a term)
intoGenFGF4
Cancer3DFGF4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM164980   
Orphanet
DisGeNETFGF4
MedgenFGF4
Genetic Testing Registry FGF4
NextProtP08620 [Medical]
TSGene2249
GENETestsFGF4
Target ValidationFGF4
Huge Navigator FGF4 [HugePedia]
snp3D : Map Gene to Disease2249
BioCentury BCIQFGF4
ClinGenFGF4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2249
Chemical/Pharm GKB GenePA28121
Clinical trialFGF4
Miscellaneous
canSAR (ICR)FGF4 (select the gene name)
Probes
Litterature
PubMed52 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFGF4
EVEXFGF4
GoPubMedFGF4
iHOPFGF4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:13:19 CET 2017

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