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FGF6 (fibroblast growth factor 6)

Identity

Other aliasHBGF-6
HST2
HGNC (Hugo) FGF6
LocusID (NCBI) 2251
Atlas_Id 40564
Location 12p13.32  [Link to chromosome band 12p13]
Location_base_pair Starts at 4543308 and ends at 4554780 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)FGF6   3684
Cards
Entrez_Gene (NCBI)FGF6  2251  fibroblast growth factor 6
AliasesHBGF-6; HST2
GeneCards (Weizmann)FGF6
Ensembl hg19 (Hinxton)ENSG00000111241 [Gene_View]  chr12:4543308-4554780 [Contig_View]  FGF6 [Vega]
Ensembl hg38 (Hinxton)ENSG00000111241 [Gene_View]  chr12:4543308-4554780 [Contig_View]  FGF6 [Vega]
ICGC DataPortalENSG00000111241
TCGA cBioPortalFGF6
AceView (NCBI)FGF6
Genatlas (Paris)FGF6
WikiGenes2251
SOURCE (Princeton)FGF6
Genetics Home Reference (NIH)FGF6
Genomic and cartography
GoldenPath hg19 (UCSC)FGF6  -     chr12:4543308-4554780 -  12p13.32   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)FGF6  -     12p13.32   [Description]    (hg38-Dec_2013)
EnsemblFGF6 - 12p13.32 [CytoView hg19]  FGF6 - 12p13.32 [CytoView hg38]
Mapping of homologs : NCBIFGF6 [Mapview hg19]  FGF6 [Mapview hg38]
OMIM134921   
Gene and transcription
Genbank (Entrez)BC121097 BC121098 X63454
RefSeq transcript (Entrez)NM_020996
RefSeq genomic (Entrez)NC_000012 NC_018923 NT_009759 NW_004929382
Consensus coding sequences : CCDS (NCBI)FGF6
Cluster EST : UnigeneHs.166015 [ NCBI ]
CGAP (NCI)Hs.166015
Alternative Splicing GalleryENSG00000111241
Gene ExpressionFGF6 [ NCBI-GEO ]   FGF6 [ EBI - ARRAY_EXPRESS ]   FGF6 [ SEEK ]   FGF6 [ MEM ]
Gene Expression Viewer (FireBrowse)FGF6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2251
GTEX Portal (Tissue expression)FGF6
Protein : pattern, domain, 3D structure
UniProt/SwissProtP10767   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP10767  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP10767
Splice isoforms : SwissVarP10767
PhosPhoSitePlusP10767
Domaine pattern : Prosite (Expaxy)HBGF_FGF (PS00247)   
Domains : Interpro (EBI)Cytokine_IL1-like    FGF6    Fibroblast_GF_fam    IL-1_fam/FGF_fam   
Domain families : Pfam (Sanger)FGF (PF00167)   
Domain families : Pfam (NCBI)pfam00167   
Domain families : Smart (EMBL)FGF (SM00442)  
Conserved Domain (NCBI)FGF6
DMDM Disease mutations2251
Blocks (Seattle)FGF6
SuperfamilyP10767
Human Protein AtlasENSG00000111241
Peptide AtlasP10767
HPRD00623
IPIIPI00022396   IPI01012064   
Protein Interaction databases
DIP (DOE-UCLA)P10767
IntAct (EBI)P10767
FunCoupENSG00000111241
BioGRIDFGF6
STRING (EMBL)FGF6
ZODIACFGF6
Ontologies - Pathways
QuickGOP10767
Ontology : AmiGOMAPK cascade  cartilage condensation  angiogenesis  protein tyrosine kinase activity  Ras guanyl-nucleotide exchange factor activity  fibroblast growth factor receptor binding  extracellular region  extracellular space  intracellular  signal transduction  cell-cell signaling  growth factor activity  cell proliferation  positive regulation of cell proliferation  fibroblast growth factor receptor signaling pathway  fibroblast growth factor receptor signaling pathway  regulation of phosphatidylinositol 3-kinase signaling  1-phosphatidylinositol-3-kinase activity  peptidyl-tyrosine phosphorylation  phosphatidylinositol-3-phosphate biosynthetic process  sarcolemma  positive regulation of GTPase activity  myoblast differentiation  phosphatidylinositol phosphorylation  phosphatidylinositol-4,5-bisphosphate 3-kinase activity  phosphatidylinositol-mediated signaling  positive regulation of cell division  
Ontology : EGO-EBIMAPK cascade  cartilage condensation  angiogenesis  protein tyrosine kinase activity  Ras guanyl-nucleotide exchange factor activity  fibroblast growth factor receptor binding  extracellular region  extracellular space  intracellular  signal transduction  cell-cell signaling  growth factor activity  cell proliferation  positive regulation of cell proliferation  fibroblast growth factor receptor signaling pathway  fibroblast growth factor receptor signaling pathway  regulation of phosphatidylinositol 3-kinase signaling  1-phosphatidylinositol-3-kinase activity  peptidyl-tyrosine phosphorylation  phosphatidylinositol-3-phosphate biosynthetic process  sarcolemma  positive regulation of GTPase activity  myoblast differentiation  phosphatidylinositol phosphorylation  phosphatidylinositol-4,5-bisphosphate 3-kinase activity  phosphatidylinositol-mediated signaling  positive regulation of cell division  
Pathways : KEGGMAPK signaling pathway    Ras signaling pathway    Rap1 signaling pathway    PI3K-Akt signaling pathway    Regulation of actin cytoskeleton    Pathways in cancer    Proteoglycans in cancer    Melanoma   
NDEx NetworkFGF6
Atlas of Cancer Signalling NetworkFGF6
Wikipedia pathwaysFGF6
Orthology - Evolution
OrthoDB2251
GeneTree (enSembl)ENSG00000111241
Phylogenetic Trees/Animal Genes : TreeFamFGF6
HOVERGENP10767
HOGENOMP10767
Homologs : HomoloGeneFGF6
Homology/Alignments : Family Browser (UCSC)FGF6
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFGF6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FGF6
dbVarFGF6
ClinVarFGF6
1000_GenomesFGF6 
Exome Variant ServerFGF6
ExAC (Exome Aggregation Consortium)FGF6 (select the gene name)
Genetic variants : HAPMAP2251
Genomic Variants (DGV)FGF6 [DGVbeta]
DECIPHER (Syndromes)12:4543308-4554780  ENSG00000111241
CONAN: Copy Number AnalysisFGF6 
Mutations
ICGC Data PortalFGF6 
TCGA Data PortalFGF6 
Broad Tumor PortalFGF6
OASIS PortalFGF6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFGF6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFGF6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FGF6
DgiDB (Drug Gene Interaction Database)FGF6
DoCM (Curated mutations)FGF6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FGF6 (select a term)
intoGenFGF6
Cancer3DFGF6(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM134921   
Orphanet
MedgenFGF6
Genetic Testing Registry FGF6
NextProtP10767 [Medical]
TSGene2251
GENETestsFGF6
Huge Navigator FGF6 [HugePedia]
snp3D : Map Gene to Disease2251
BioCentury BCIQFGF6
ClinGenFGF6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2251
Chemical/Pharm GKB GenePA28123
Clinical trialFGF6
Miscellaneous
canSAR (ICR)FGF6 (select the gene name)
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFGF6
EVEXFGF6
GoPubMedFGF6
iHOPFGF6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 30 15:01:15 CEST 2017

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