Atlas of Genetics and Cytogenetics in Oncology and Haematology

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FGF9 (fibroblast growth factor 9)

Identity

Alias_namesfibroblast growth factor 9 (glia-activating factor)
Other aliasFGF-9
GAF
HBFG-9
HBGF-9
SYNS3
HGNC (Hugo) FGF9
LocusID (NCBI) 2254
Atlas_Id 40567
Location 13q12.11  [Link to chromosome band 13q12]
Location_base_pair Starts at 21671076 and ends at 21704501 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)FGF9   3687
Cards
Entrez_Gene (NCBI)FGF9  2254  fibroblast growth factor 9
AliasesFGF-9; GAF; HBFG-9; HBGF-9; 
SYNS3
GeneCards (Weizmann)FGF9
Ensembl hg19 (Hinxton)ENSG00000102678 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000102678 [Gene_View]  ENSG00000102678 [Sequence]  chr13:21671076-21704501 [Contig_View]  FGF9 [Vega]
ICGC DataPortalENSG00000102678
TCGA cBioPortalFGF9
AceView (NCBI)FGF9
Genatlas (Paris)FGF9
WikiGenes2254
SOURCE (Princeton)FGF9
Genetics Home Reference (NIH)FGF9
Genomic and cartography
GoldenPath hg38 (UCSC)FGF9  -     chr13:21671076-21704501 +  13q12.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FGF9  -     13q12.11   [Description]    (hg19-Feb_2009)
GoldenPathFGF9 - 13q12.11 [CytoView hg19]  FGF9 - 13q12.11 [CytoView hg38]
ImmunoBaseENSG00000102678
Mapping of homologs : NCBIFGF9 [Mapview hg19]  FGF9 [Mapview hg38]
OMIM600921   612961   
Gene and transcription
Genbank (Entrez)AK095571 AK290792 BC069692 BC103978 BC103979
RefSeq transcript (Entrez)NM_002010
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FGF9
Cluster EST : UnigeneHs.111 [ NCBI ]
CGAP (NCI)Hs.111
Alternative Splicing GalleryENSG00000102678
Gene ExpressionFGF9 [ NCBI-GEO ]   FGF9 [ EBI - ARRAY_EXPRESS ]   FGF9 [ SEEK ]   FGF9 [ MEM ]
Gene Expression Viewer (FireBrowse)FGF9 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2254
GTEX Portal (Tissue expression)FGF9
Human Protein AtlasENSG00000102678-FGF9 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP31371   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP31371  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP31371
Splice isoforms : SwissVarP31371
PhosPhoSitePlusP31371
Domaine pattern : Prosite (Expaxy)HBGF_FGF (PS00247)   
Domains : Interpro (EBI)FGF9    Fibroblast_GF_fam    IL1/FGF   
Domain families : Pfam (Sanger)FGF (PF00167)   
Domain families : Pfam (NCBI)pfam00167   
Domain families : Smart (EMBL)FGF (SM00442)  
Conserved Domain (NCBI)FGF9
DMDM Disease mutations2254
Blocks (Seattle)FGF9
PDB (RSDB)1G82    1IHK    5W59   
PDB Europe1G82    1IHK    5W59   
PDB (PDBSum)1G82    1IHK    5W59   
PDB (IMB)1G82    1IHK    5W59   
Structural Biology KnowledgeBase1G82    1IHK    5W59   
SCOP (Structural Classification of Proteins)1G82    1IHK    5W59   
CATH (Classification of proteins structures)1G82    1IHK    5W59   
SuperfamilyP31371
Human Protein Atlas [tissue]ENSG00000102678-FGF9 [tissue]
Peptide AtlasP31371
HPRD02951
IPIIPI00011172   
Protein Interaction databases
DIP (DOE-UCLA)P31371
IntAct (EBI)P31371
FunCoupENSG00000102678
BioGRIDFGF9
STRING (EMBL)FGF9
ZODIACFGF9
Ontologies - Pathways
QuickGOP31371
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  MAPK cascade  angiogenesis  osteoblast differentiation  eye development  positive regulation of mesenchymal cell proliferation  chondrocyte differentiation  protein tyrosine kinase activity  Ras guanyl-nucleotide exchange factor activity  fibroblast growth factor receptor binding  extracellular region  basement membrane  extracellular space  cytoplasm  protein import into nucleus  signal transduction  cell-cell signaling  growth factor activity  heparin binding  positive regulation of cell proliferation  fibroblast growth factor receptor signaling pathway  fibroblast growth factor receptor signaling pathway  male gonad development  regulation of signaling receptor activity  positive regulation of gene expression  1-phosphatidylinositol-3-kinase activity  peptidyl-tyrosine phosphorylation  substantia nigra development  negative regulation of Wnt signaling pathway  male sex determination  embryonic limb morphogenesis  positive regulation of vascular endothelial growth factor receptor signaling pathway  positive regulation of activin receptor signaling pathway  phosphatidylinositol-3-phosphate biosynthetic process  inner ear morphogenesis  positive regulation of MAPK cascade  positive regulation of smoothened signaling pathway  phosphatidylinositol phosphorylation  phosphatidylinositol-4,5-bisphosphate 3-kinase activity  regulation of timing of cell differentiation  embryonic digestive tract development  embryonic skeletal system development  positive regulation of epithelial cell proliferation  positive regulation of cell division  positive regulation of protein kinase B signaling  positive regulation of cardiac muscle cell proliferation  lung-associated mesenchyme development  positive regulation of canonical Wnt signaling pathway  positive regulation of vascular smooth muscle cell proliferation  positive regulation of vascular smooth muscle cell proliferation  positive regulation of vascular associated smooth muscle cell migration  negative regulation of vascular smooth muscle cell differentiation involved in phenotypic switching  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  MAPK cascade  angiogenesis  osteoblast differentiation  eye development  positive regulation of mesenchymal cell proliferation  chondrocyte differentiation  protein tyrosine kinase activity  Ras guanyl-nucleotide exchange factor activity  fibroblast growth factor receptor binding  extracellular region  basement membrane  extracellular space  cytoplasm  protein import into nucleus  signal transduction  cell-cell signaling  growth factor activity  heparin binding  positive regulation of cell proliferation  fibroblast growth factor receptor signaling pathway  fibroblast growth factor receptor signaling pathway  male gonad development  regulation of signaling receptor activity  positive regulation of gene expression  1-phosphatidylinositol-3-kinase activity  peptidyl-tyrosine phosphorylation  substantia nigra development  negative regulation of Wnt signaling pathway  male sex determination  embryonic limb morphogenesis  positive regulation of vascular endothelial growth factor receptor signaling pathway  positive regulation of activin receptor signaling pathway  phosphatidylinositol-3-phosphate biosynthetic process  inner ear morphogenesis  positive regulation of MAPK cascade  positive regulation of smoothened signaling pathway  phosphatidylinositol phosphorylation  phosphatidylinositol-4,5-bisphosphate 3-kinase activity  regulation of timing of cell differentiation  embryonic digestive tract development  embryonic skeletal system development  positive regulation of epithelial cell proliferation  positive regulation of cell division  positive regulation of protein kinase B signaling  positive regulation of cardiac muscle cell proliferation  lung-associated mesenchyme development  positive regulation of canonical Wnt signaling pathway  positive regulation of vascular smooth muscle cell proliferation  positive regulation of vascular smooth muscle cell proliferation  positive regulation of vascular associated smooth muscle cell migration  negative regulation of vascular smooth muscle cell differentiation involved in phenotypic switching  
Pathways : KEGGMAPK signaling pathway    Ras signaling pathway    Rap1 signaling pathway    PI3K-Akt signaling pathway    Regulation of actin cytoskeleton    Pathways in cancer    Proteoglycans in cancer    Melanoma   
NDEx NetworkFGF9
Atlas of Cancer Signalling NetworkFGF9
Wikipedia pathwaysFGF9
Orthology - Evolution
OrthoDB2254
GeneTree (enSembl)ENSG00000102678
Phylogenetic Trees/Animal Genes : TreeFamFGF9
HOGENOMP31371
Homologs : HomoloGeneFGF9
Homology/Alignments : Family Browser (UCSC)FGF9
Gene fusions - Rearrangements
Fusion : QuiverFGF9
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFGF9 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FGF9
dbVarFGF9
ClinVarFGF9
1000_GenomesFGF9 
Exome Variant ServerFGF9
ExAC (Exome Aggregation Consortium)ENSG00000102678
GNOMAD BrowserENSG00000102678
Varsome BrowserFGF9
Genetic variants : HAPMAP2254
Genomic Variants (DGV)FGF9 [DGVbeta]
DECIPHERFGF9 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFGF9 
Mutations
ICGC Data PortalFGF9 
TCGA Data PortalFGF9 
Broad Tumor PortalFGF9
OASIS PortalFGF9 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFGF9  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFGF9
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FGF9
DgiDB (Drug Gene Interaction Database)FGF9
DoCM (Curated mutations)FGF9 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FGF9 (select a term)
intoGenFGF9
Cancer3DFGF9(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600921    612961   
Orphanet2896   
DisGeNETFGF9
MedgenFGF9
Genetic Testing Registry FGF9
NextProtP31371 [Medical]
TSGene2254
GENETestsFGF9
Target ValidationFGF9
Huge Navigator FGF9 [HugePedia]
snp3D : Map Gene to Disease2254
BioCentury BCIQFGF9
ClinGenFGF9
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2254
Chemical/Pharm GKB GenePA28126
Clinical trialFGF9
Miscellaneous
canSAR (ICR)FGF9 (select the gene name)
DataMed IndexFGF9
Probes
Litterature
PubMed82 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFGF9
EVEXFGF9
GoPubMedFGF9
iHOPFGF9
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Jul 8 11:20:16 CEST 2019
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