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FGFR1OP2 (FGFR1 oncogene partner 2)

Identity

Alias_symbol (synonym)DKFZp564O1863
Other aliasHSPC123-like
WIT3.0
HGNC (Hugo) FGFR1OP2
LocusID (NCBI) 26127
Atlas_Id 40569
Location 12p11.23  [Link to chromosome band 12p11]
Location_base_pair Starts at 26938372 and ends at 26966648 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FGFR1 (8p11.23) / FGFR1OP2 (12p11.23)FGFR1OP2 (12p11.23) / FGFR1 (8p11.23)FGFR1OP2 (12p11.23) / ITPR2 (12p12.1)
FGFR1OP2 (12p11.23) / SMARCA2 (9p24.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  8p11 myeloproliferative syndrome (FGFR1)
t(8;12)(p12;p11) FGFR1OP2/FGFR1::ins(12;8)(p11;p12p22) FGFR1OP2/FGFR1


External links

Nomenclature
HGNC (Hugo)FGFR1OP2   23098
Cards
Entrez_Gene (NCBI)FGFR1OP2  26127  FGFR1 oncogene partner 2
AliasesHSPC123-like; WIT3.0
GeneCards (Weizmann)FGFR1OP2
Ensembl hg19 (Hinxton)ENSG00000111790 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000111790 [Gene_View]  chr12:26938372-26966648 [Contig_View]  FGFR1OP2 [Vega]
ICGC DataPortalENSG00000111790
TCGA cBioPortalFGFR1OP2
AceView (NCBI)FGFR1OP2
Genatlas (Paris)FGFR1OP2
WikiGenes26127
SOURCE (Princeton)FGFR1OP2
Genetics Home Reference (NIH)FGFR1OP2
Genomic and cartography
GoldenPath hg38 (UCSC)FGFR1OP2  -     chr12:26938372-26966648 +  12p11.23   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FGFR1OP2  -     12p11.23   [Description]    (hg19-Feb_2009)
EnsemblFGFR1OP2 - 12p11.23 [CytoView hg19]  FGFR1OP2 - 12p11.23 [CytoView hg38]
Mapping of homologs : NCBIFGFR1OP2 [Mapview hg19]  FGFR1OP2 [Mapview hg38]
OMIM608858   
Gene and transcription
Genbank (Entrez)AF086411 AF161472 AK001534 AK094888 AL117545
RefSeq transcript (Entrez)NM_001171887 NM_001171888 NM_015633
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FGFR1OP2
Cluster EST : UnigeneHs.591162 [ NCBI ]
CGAP (NCI)Hs.591162
Alternative Splicing GalleryENSG00000111790
Gene ExpressionFGFR1OP2 [ NCBI-GEO ]   FGFR1OP2 [ EBI - ARRAY_EXPRESS ]   FGFR1OP2 [ SEEK ]   FGFR1OP2 [ MEM ]
Gene Expression Viewer (FireBrowse)FGFR1OP2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)26127
GTEX Portal (Tissue expression)FGFR1OP2
Human Protein AtlasENSG00000111790-FGFR1OP2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NVK5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NVK5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NVK5
Splice isoforms : SwissVarQ9NVK5
PhosPhoSitePlusQ9NVK5
Domains : Interpro (EBI)SIKE   
Domain families : Pfam (Sanger)DUF837 (PF05769)   
Domain families : Pfam (NCBI)pfam05769   
Conserved Domain (NCBI)FGFR1OP2
DMDM Disease mutations26127
Blocks (Seattle)FGFR1OP2
SuperfamilyQ9NVK5
Human Protein Atlas [tissue]ENSG00000111790-FGFR1OP2 [tissue]
Peptide AtlasQ9NVK5
HPRD10589
IPIIPI00014903   IPI00418970   IPI00795921   IPI01014895   
Protein Interaction databases
DIP (DOE-UCLA)Q9NVK5
IntAct (EBI)Q9NVK5
FunCoupENSG00000111790
BioGRIDFGFR1OP2
STRING (EMBL)FGFR1OP2
ZODIACFGFR1OP2
Ontologies - Pathways
QuickGOQ9NVK5
Ontology : AmiGOprotein tyrosine kinase activity  protein binding  cytosol  peptidyl-tyrosine phosphorylation  wound healing  protein homodimerization activity  
Ontology : EGO-EBIprotein tyrosine kinase activity  protein binding  cytosol  peptidyl-tyrosine phosphorylation  wound healing  protein homodimerization activity  
NDEx NetworkFGFR1OP2
Atlas of Cancer Signalling NetworkFGFR1OP2
Wikipedia pathwaysFGFR1OP2
Orthology - Evolution
OrthoDB26127
GeneTree (enSembl)ENSG00000111790
Phylogenetic Trees/Animal Genes : TreeFamFGFR1OP2
HOVERGENQ9NVK5
HOGENOMQ9NVK5
Homologs : HomoloGeneFGFR1OP2
Homology/Alignments : Family Browser (UCSC)FGFR1OP2
Gene fusions - Rearrangements
Fusion : MitelmanFGFR1OP2/FGFR1 [12p11.23/8p11.23]  
Tumor Fusion PortalFGFR1OP2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFGFR1OP2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FGFR1OP2
dbVarFGFR1OP2
ClinVarFGFR1OP2
1000_GenomesFGFR1OP2 
Exome Variant ServerFGFR1OP2
ExAC (Exome Aggregation Consortium)ENSG00000111790
GNOMAD BrowserENSG00000111790
Genetic variants : HAPMAP26127
Genomic Variants (DGV)FGFR1OP2 [DGVbeta]
DECIPHERFGFR1OP2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFGFR1OP2 
Mutations
ICGC Data PortalFGFR1OP2 
TCGA Data PortalFGFR1OP2 
Broad Tumor PortalFGFR1OP2
OASIS PortalFGFR1OP2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFGFR1OP2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFGFR1OP2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FGFR1OP2
DgiDB (Drug Gene Interaction Database)FGFR1OP2
DoCM (Curated mutations)FGFR1OP2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FGFR1OP2 (select a term)
intoGenFGFR1OP2
Cancer3DFGFR1OP2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608858   
Orphanet
DisGeNETFGFR1OP2
MedgenFGFR1OP2
Genetic Testing Registry FGFR1OP2
NextProtQ9NVK5 [Medical]
TSGene26127
GENETestsFGFR1OP2
Target ValidationFGFR1OP2
Huge Navigator FGFR1OP2 [HugePedia]
snp3D : Map Gene to Disease26127
BioCentury BCIQFGFR1OP2
ClinGenFGFR1OP2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD26127
Chemical/Pharm GKB GenePA134972108
Clinical trialFGFR1OP2
Miscellaneous
canSAR (ICR)FGFR1OP2 (select the gene name)
Probes
Litterature
PubMed22 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFGFR1OP2
EVEXFGFR1OP2
GoPubMedFGFR1OP2
iHOPFGFR1OP2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:13:20 CET 2017

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