Atlas of Genetics and Cytogenetics in Oncology and Haematology


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FGFR2 (fibroblast growth factor receptor 2)

Identity

Other namesBEK
CD332
CEK3
ECT1
KGFR
K-sam
TK14
TK25
HGNC (Hugo) FGFR2
LocusID (NCBI) 2263
Location 10q26.13
Location_base_pair Starts at 123237844 and ends at 123357972 bp from pter ( according to hg19-Feb_2009)  [Mapping]
Local_order WDR11 - FGFR2 - ATE1 - NSMCE4A - TACC2.
Note FGFR2 was independently cloned and characterized by several groups as a novel receptor-type tyrosine kinase BEK, KGFR, K-sam, or TK14.

DNA/RNA

Note FGFR2 gene at chromosome 10q26.13 and FGFR1 gene at chromosome 8p12 are paralogs within the human genome.
 
  Structure and alternative splicing of FGFR2 gene.
Description FGFR2 gene, consisting of at least 21 exons, encodes multiple isoforms due to alternative splicing. FGFR2b and FGFR2c with extracellular three Ig-like domains, transmembrane domain and cytoplasmic tyrosine kinase domain, are representative FGFR2 isoforms almost identical except the latter half of the third Ig-like domain. Exon 9 and 10, corresponding to the latter half of the third Ig-like domain, are incorporated into FGFR2b and FGFR2c in a mutually exclusive manner. Splicing silencer sequence within intron 8 and splicing activator sequence within intron 9 are implicated in the regulation of splicing preferentiality for FGFR2b and FGFR2c. Exons 20 and 21 of FGFR2 gene are alternative last exons encoding the C-terminal region of FGFR2 isoforms. Wild type FGFR2 transcripts with exon 21 are expressed in normal cells and most tumor cells, while aberrant FGFR2 transcripts with exon 20 are overexpressed in cases with FGFR2 gene amplification due to the exclusion of exon 21 from the FGFR2 amplicon. FGFR2 gene also encodes transmembrane-type FGFR2 isoforms lacking the first Ig-like domain, and secreted-type FGFR2 isoforms.
Transcription FGFR2b isoform is predominantly expressed in epithelial cells, while FGFR2c isoform preferentially in mesenchymal cells. FGFR2 is expressed in undifferentiated human ES cells, and also in ES-derived embryoid body, endodermal precursors, and neural precursors. FGFR2 is relatively highly expressed in fetal brain. Among adult human tissues, FGFR2 is relatively highly expressed in brain, retina, spinal cord, salivary gland, skin, kidney and uterus. FGFR2 is overexpressed in human breast cancer and gastric cancer due to gene amplification.

Protein

Note FGFR2 functions as transmembrane receptor for FGF family members, such as FGF1 (aFGF), FGF2 (bFGF), FGF3, FGF4 (Kaposi's sarcoma-derived FGF or KFGF), FGF6, FGF7 (keratinocyte growth factor or KGF), FGF9, FGF10, FGF16, FGF20 and FGF22 FGFR2b and FGFR2c are representative FGFR2 isoforms with distinct ligand specificity.
 
  Schematic representation of FGF signaling cascades.
Description FGFR2b and FGFR2c are representative FGFR2 isoforms, consisting of extracellular three Ig-like domains, transmembrane domain, and cytoplasmic tyrosine kinase domain. FGFR2b and FGFR2c are almost identical except the latter half of the third Ig-like domain. The divergence in the latter half of the third Ig-like domain leads to distinct ligand specificity between FGFR2b and FGFR2c. FGFR2b is a high affinity receptor for FGF1, FGF3, FGF7, FGF10 and FGF22, while FGFR2c is a high affinity receptor for FGF1, FGF2, FGF4, FGF6, FGF9, FGF16 and FGF20.
Localisation FGFR2b and FGFR2c with the N-terminal signal peptide and a single transmembrane domain are localized to the plasma membrane.
Function FGFR2 is a high affinity receptor for FGFs associated with heparan sulfate proteoglycans (HSPGs). Ligand-dependent FGFR2 dimerization releases FGFR2 from autoinhibition due to autophosphorylation of a key tyrosine residue within the activation loop of kinase domain. FRS2 (FRS2A) and FRS3 (FRS2B) are tyrosine phosphorylated by FGFR2 to recruit GRB2 and PTPN11 for the activation of SOS - RAS - RAF- MAP3K - MAP2K - MAPK and GAB1 - PI3K - AKT signaling cascades. Phospholipase C-gamma (PLCgamma) is recruited to FGFR2 through its interaction with phosphotyrosine residues on the C-terminal tail of activated FGFR2, which results in the catalysis of phosphatidylinositol diphosphate (PIP2) to diacylglycerol (DAG) and inositol triphosphate (IP3). DAG activates protein kinase C (PKC) signaling cascade, while IP3 induces Ca2+ release from endoplasmic reticulum for the following activation of Calmodulin-Calcineurin-NFAT signaling cascade. FGFR2 transduces FGF signals to the MAPK and PI3K-AKT signaling cascades through FRS2 or FGF3, and to the PKC and NFAT signaling cascades through PLCgamma.
Homology FGFR2b and FGFR2c are almost identical except the latter half of the third Ig-like domain as mentioned above. Among receptor-type tyrosine kinases, FGFR2 isoforms are more homologous to FGFR1 isoforms.

Mutations

Note Germinal missense mutations of FGFR2 gene occur in congenital skeletal disorders. Intronic single nucleotide polymorphisms (SNPs) of FGFR2 gene are associated with increased cancer risk. Somatic missense mutations or gene amplification of FGFR2 occur in several types of cancer.
 
  Germinal and somatic point mutations of FGFR2.
Germinal Germinal missense mutations of FGFR2 gene occur in congenital skeletal disorders, such as Crouzon syndrome, Jackson-Weiss syndrome, Apert syndrome, Pfeiffer syndrome, and Beare-Stevenson syndrome, which are featured by short-limbed bone dysplasia (craniosynostosis), and syndrome-specific abnormalities, such as Crouzonoid facies, bone syndactyly, limb abnormalities, and cutis gyrata. FGFR2 missense mutations around the third Ig-like domain result in altered ligand-receptor specificity to create the autocrine signaling loop. FGFR2 missense mutations within the tyrosine kinase domain lead to ligand independent activation of FGFR2. Germinal FGFR2 missense mutations cause congenital skeletal disorders due to aberrant FGFR2 signaling activation.
In addition, SNPs within intron 2 of FGFR2 gene are associated with increased risk of breast cancer, partly due to transcriptional upregulation of FGFR2.
Somatic Somatic missense mutations or gene amplification of FGFR2 occur in uterus cancer (endometrial cancer), lung cancer, breast cancer, gastric cancer, and ovarian cancer. Genetic alterations of FGFR2 lead to aberrant activation of FGFR2 signaling cascades due to the creation of autocrine signaling loop or the release of FGFR2 from autoinhibition.

Implicated in

Entity Cancer
Disease Somatic missense mutations or gene amplification of FGFR2 occur in endometrial cancer, lung cancer, breast cancer, gastric cancer, and ovarian cancer as mentioned above. In addition, class switch from FGFR2b to FGFR2c occurs during malignant progression of prostate cancer and bladder cancer. Somatic mutations and class switch of FGFR2 isoforms induce aberrant FGFR2 signaling activation in tumor cells.
Prognosis FGFR2 gene amplification accompanied by FGFR2 overexpression in breast cancer and gastric cancer is associated with poor prognosis. Class switch from FGFR2b to FGFR2c is associated with more malignant phenotype in prostate cancer and bladder cancer.
 
Mechanisms of oncogenic FGFR2 signaling activation.
  
Entity Congenital skeletal disorder
Disease Germinal mutations of FGFR2 gene occur in Crouzon syndrome, Jackson-Weiss syndrome, Apert syndrome, Pfeiffer syndrome, and Beare-Stevenson syndrome. FGFR2 missense mutations cause congenital skeletal disorders due to aberrant FGFR2 signaling activation as mentioned above.
  

External links

Nomenclature
HGNC (Hugo)FGFR2   3689
Cards
AtlasFGFR2ID40570ch10q26
Entrez_Gene (NCBI)FGFR2  2263  fibroblast growth factor receptor 2
GeneCards (Weizmann)FGFR2
Ensembl (Hinxton)ENSG00000066468 [Gene_View]  chr10:123237844-123357972 [Contig_View]  FGFR2 [Vega]
ICGC DataPortalENSG00000066468
cBioPortalFGFR2
AceView (NCBI)FGFR2
Genatlas (Paris)FGFR2
WikiGenes2263
SOURCE (Princeton)NM_000141 NM_001144913 NM_001144914 NM_001144915 NM_001144916 NM_001144917 NM_001144918 NM_001144919 NM_022970 NM_022971 NM_022972 NM_022973 NM_022974 NM_022975 NM_022976 NM_023028 NM_023029 NM_023030
Genomic and cartography
GoldenPath (UCSC)FGFR2  -  10q26.13   chr10:123237844-123357972 -  10q25.3-q26   [Description]    (hg19-Feb_2009)
EnsemblFGFR2 - 10q25.3-q26 [CytoView]
Mapping of homologs : NCBIFGFR2 [Mapview]
OMIM101200   101400   101600   123150   123500   123790   149730   176943   207410   609579   613659   614592   
Gene and transcription
Genbank (Entrez)AB030073 AB030074 AB030075 AB030076 AB030077
RefSeq transcript (Entrez)NM_000141 NM_001144913 NM_001144914 NM_001144915 NM_001144916 NM_001144917 NM_001144918 NM_001144919 NM_022970 NM_022971 NM_022972 NM_022973 NM_022974 NM_022975 NM_022976 NM_023028 NM_023029 NM_023030
RefSeq genomic (Entrez)AC_000142 NC_000010 NC_018921 NG_012449 NT_030059 NW_001838006 NW_004929376
Consensus coding sequences : CCDS (NCBI)FGFR2
Cluster EST : UnigeneHs.533683 [ NCBI ]
CGAP (NCI)Hs.533683
Alternative Splicing : Fast-db (Paris)GSHG0004409
Alternative Splicing GalleryENSG00000066468
Gene ExpressionFGFR2 [ NCBI-GEO ]     FGFR2 [ SEEK ]   FGFR2 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP21802 (Uniprot)
NextProtP21802  [Medical]
With graphics : InterProP21802
Splice isoforms : SwissVarP21802 (Swissvar)
Catalytic activity : Enzyme2.7.10.1 [ Enzyme-Expasy ]   2.7.10.12.7.10.1 [ IntEnz-EBI ]   2.7.10.1 [ BRENDA ]   2.7.10.1 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)   
Domains : Interpro (EBI)FGF_rcpt_2 [organisation]   FGF_rcpt_fam [organisation]   Ig-like_dom [organisation]   Ig-like_fold [organisation]   Ig_I-set [organisation]   Ig_sub2 [organisation]   Kinase-like_dom [organisation]   Prot_kinase_dom [organisation]   Protein_kinase_ATP_BS [organisation]   Ser-Thr/Tyr_kinase_cat_dom [organisation]   Tyr_kinase_AS [organisation]   Tyr_kinase_cat_dom [organisation]  
Related proteins : CluSTrP21802
Domain families : Pfam (Sanger)I-set (PF07679)    Pkinase_Tyr (PF07714)   
Domain families : Pfam (NCBI)pfam07679    pfam07714   
Domain families : Smart (EMBL)IGc2 (SM00408)  TyrKc (SM00219)  
DMDM Disease mutations2263
Blocks (Seattle)P21802
PDB (SRS)1DJS    1E0O    1EV2    1GJO    1II4    1IIL    1NUN    1OEC    1WVZ    2FDB    2PSQ    2PVF    2PVY    2PWL    2PY3    2PZ5    2PZP    2PZR    2Q0B    3B2T    3CAF    3CLY    3CU1    3DAR    3EUU    3OJ2    3OJM    3RI1    4J23    4J95    4J96    4J97    4J98    4J99   
PDB (PDBSum)1DJS    1E0O    1EV2    1GJO    1II4    1IIL    1NUN    1OEC    1WVZ    2FDB    2PSQ    2PVF    2PVY    2PWL    2PY3    2PZ5    2PZP    2PZR    2Q0B    3B2T    3CAF    3CLY    3CU1    3DAR    3EUU    3OJ2    3OJM    3RI1    4J23    4J95    4J96    4J97    4J98    4J99   
PDB (IMB)1DJS    1E0O    1EV2    1GJO    1II4    1IIL    1NUN    1OEC    1WVZ    2FDB    2PSQ    2PVF    2PVY    2PWL    2PY3    2PZ5    2PZP    2PZR    2Q0B    3B2T    3CAF    3CLY    3CU1    3DAR    3EUU    3OJ2    3OJM    3RI1    4J23    4J95    4J96    4J97    4J98    4J99   
PDB (RSDB)1DJS    1E0O    1EV2    1GJO    1II4    1IIL    1NUN    1OEC    1WVZ    2FDB    2PSQ    2PVF    2PVY    2PWL    2PY3    2PZ5    2PZP    2PZR    2Q0B    3B2T    3CAF    3CLY    3CU1    3DAR    3EUU    3OJ2    3OJM    3RI1    4J23    4J95    4J96    4J97    4J98    4J99   
Human Protein AtlasENSG00000066468 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasP21802
HPRD01492
IPIIPI00218416   IPI00218417   IPI00218418   IPI00218419   IPI00218420   IPI00218422   IPI00218423   IPI00647907   IPI00218425   IPI00384713   IPI00759837   IPI00942110   IPI00216602   IPI00873362   IPI00216603   IPI00216604   IPI00216605   IPI00910530   IPI00940780   IPI01011743   IPI00377178   IPI00218421   IPI00977947   IPI00386650   IPI00383509   IPI00218424   IPI01015716   IPI01013993   IPI00643986   
Protein Interaction databases
DIP (DOE-UCLA)P21802
IntAct (EBI)P21802
FunCoupENSG00000066468
BioGRIDFGFR2
InParanoidP21802
Interologous Interaction database P21802
IntegromeDBFGFR2
STRING (EMBL)FGFR2
Ontologies - Pathways
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  angiogenesis  ureteric bud development  in utero embryonic development  epithelial to mesenchymal transition  positive regulation of mesenchymal cell proliferation  outflow tract septum morphogenesis  membranous septum morphogenesis  protein tyrosine kinase activity  fibroblast growth factor-activated receptor activity  fibroblast growth factor-activated receptor activity  fibroblast growth factor-activated receptor activity  protein binding  ATP binding  extracellular region  nucleus  nucleolus  cytoplasm  Golgi apparatus  plasma membrane  integral component of plasma membrane  cell cortex  apoptotic process  epidermal growth factor receptor signaling pathway  cell-cell signaling  axonogenesis  neuromuscular junction development  heparin binding  positive regulation of cell proliferation  positive regulation of cell proliferation  positive regulation of cell proliferation  insulin receptor signaling pathway  fibroblast growth factor receptor signaling pathway  fibroblast growth factor receptor signaling pathway  fibroblast growth factor receptor signaling pathway  fibroblast growth factor receptor signaling pathway  regulation of smoothened signaling pathway  post-embryonic development  embryonic pattern specification  organ morphogenesis  cell surface  regulation of cell fate commitment  positive regulation of phospholipase activity  membrane  integral component of membrane  cytoplasmic membrane-bounded vesicle  morphogenesis of embryonic epithelium  fibroblast growth factor binding  fibroblast growth factor binding  peptidyl-tyrosine phosphorylation  orbitofrontal cortex development  ventricular zone neuroblast division  pyramidal neuron development  gland morphogenesis  positive regulation of Wnt signaling pathway  bone mineralization  lung development  epithelial cell differentiation  midbrain development  otic vesicle formation  extracellular matrix  hair follicle morphogenesis  lacrimal gland development  regulation of osteoblast proliferation  multicellular organism growth  organ growth  fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow  fibroblast growth factor receptor signaling pathway involved in hemopoiesis  fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow  fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development  Fc-epsilon receptor signaling pathway  regulation of multicellular organism growth  regulation of fibroblast growth factor receptor signaling pathway  inner ear morphogenesis  odontogenesis  protein homodimerization activity  intracellular membrane-bounded organelle  positive regulation of MAPK cascade  innate immune response  cell fate commitment  regulation of osteoblast differentiation  positive regulation of cell cycle  negative regulation of mitosis  positive regulation of transcription from RNA polymerase II promoter  protein autophosphorylation  neurotrophin TRK receptor signaling pathway  phosphatidylinositol-mediated signaling  lung alveolus development  mesodermal cell differentiation  synaptic vesicle transport  embryonic digestive tract morphogenesis  embryonic organ morphogenesis  digestive tract development  embryonic organ development  reproductive structure development  positive regulation of smooth muscle cell proliferation  embryonic cranial skeleton morphogenesis  skeletal system morphogenesis  epidermis morphogenesis  branching morphogenesis of a nerve  mesenchymal cell differentiation  positive regulation of epithelial cell proliferation  negative regulation of epithelial cell proliferation  regulation of smooth muscle cell differentiation  positive regulation of cell division  ventricular cardiac muscle tissue morphogenesis  positive regulation of cardiac muscle cell proliferation  excitatory synapse  limb bud formation  bone development  bone morphogenesis  coronal suture morphogenesis  branching involved in prostate gland morphogenesis  branching involved in salivary gland morphogenesis  bud elongation involved in lung branching  lung lobe morphogenesis  lung-associated mesenchyme development  positive regulation of epithelial cell proliferation involved in lung morphogenesis  prostate gland morphogenesis  prostate epithelial cord elongation  prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis  squamous basal epithelial stem cell differentiation involved in prostate gland acinus development  fibroblast growth factor receptor signaling pathway involved in mammary gland specification  lateral sprouting from an epithelium  mammary gland bud formation  epithelial cell proliferation involved in salivary gland morphogenesis  branch elongation involved in salivary gland morphogenesis  branching involved in labyrinthine layer morphogenesis  regulation of branching involved in prostate gland morphogenesis  regulation of morphogenesis of a branching structure  mesenchymal cell differentiation involved in lung development  mesenchymal cell proliferation involved in lung development  endodermal digestive tract morphogenesis  lens fiber cell development  regulation of ERK1 and ERK2 cascade  positive regulation of ERK1 and ERK2 cascade  positive regulation of canonical Wnt signaling pathway  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  angiogenesis  ureteric bud development  in utero embryonic development  epithelial to mesenchymal transition  positive regulation of mesenchymal cell proliferation  outflow tract septum morphogenesis  membranous septum morphogenesis  protein tyrosine kinase activity  fibroblast growth factor-activated receptor activity  fibroblast growth factor-activated receptor activity  fibroblast growth factor-activated receptor activity  protein binding  ATP binding  extracellular region  nucleus  nucleolus  cytoplasm  Golgi apparatus  plasma membrane  integral component of plasma membrane  cell cortex  apoptotic process  epidermal growth factor receptor signaling pathway  cell-cell signaling  axonogenesis  neuromuscular junction development  heparin binding  positive regulation of cell proliferation  positive regulation of cell proliferation  positive regulation of cell proliferation  insulin receptor signaling pathway  fibroblast growth factor receptor signaling pathway  fibroblast growth factor receptor signaling pathway  fibroblast growth factor receptor signaling pathway  fibroblast growth factor receptor signaling pathway  regulation of smoothened signaling pathway  post-embryonic development  embryonic pattern specification  organ morphogenesis  cell surface  regulation of cell fate commitment  positive regulation of phospholipase activity  membrane  integral component of membrane  cytoplasmic membrane-bounded vesicle  morphogenesis of embryonic epithelium  fibroblast growth factor binding  fibroblast growth factor binding  peptidyl-tyrosine phosphorylation  orbitofrontal cortex development  ventricular zone neuroblast division  pyramidal neuron development  gland morphogenesis  positive regulation of Wnt signaling pathway  bone mineralization  lung development  epithelial cell differentiation  midbrain development  otic vesicle formation  extracellular matrix  hair follicle morphogenesis  lacrimal gland development  regulation of osteoblast proliferation  multicellular organism growth  organ growth  fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow  fibroblast growth factor receptor signaling pathway involved in hemopoiesis  fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow  fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development  Fc-epsilon receptor signaling pathway  regulation of multicellular organism growth  regulation of fibroblast growth factor receptor signaling pathway  inner ear morphogenesis  odontogenesis  protein homodimerization activity  intracellular membrane-bounded organelle  positive regulation of MAPK cascade  innate immune response  cell fate commitment  regulation of osteoblast differentiation  positive regulation of cell cycle  negative regulation of mitosis  positive regulation of transcription from RNA polymerase II promoter  protein autophosphorylation  neurotrophin TRK receptor signaling pathway  phosphatidylinositol-mediated signaling  lung alveolus development  mesodermal cell differentiation  synaptic vesicle transport  embryonic digestive tract morphogenesis  embryonic organ morphogenesis  digestive tract development  embryonic organ development  reproductive structure development  positive regulation of smooth muscle cell proliferation  embryonic cranial skeleton morphogenesis  skeletal system morphogenesis  epidermis morphogenesis  branching morphogenesis of a nerve  mesenchymal cell differentiation  positive regulation of epithelial cell proliferation  negative regulation of epithelial cell proliferation  regulation of smooth muscle cell differentiation  positive regulation of cell division  ventricular cardiac muscle tissue morphogenesis  positive regulation of cardiac muscle cell proliferation  excitatory synapse  limb bud formation  bone development  bone morphogenesis  coronal suture morphogenesis  branching involved in prostate gland morphogenesis  branching involved in salivary gland morphogenesis  bud elongation involved in lung branching  lung lobe morphogenesis  lung-associated mesenchyme development  positive regulation of epithelial cell proliferation involved in lung morphogenesis  prostate gland morphogenesis  prostate epithelial cord elongation  prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis  squamous basal epithelial stem cell differentiation involved in prostate gland acinus development  fibroblast growth factor receptor signaling pathway involved in mammary gland specification  lateral sprouting from an epithelium  mammary gland bud formation  epithelial cell proliferation involved in salivary gland morphogenesis  branch elongation involved in salivary gland morphogenesis  branching involved in labyrinthine layer morphogenesis  regulation of branching involved in prostate gland morphogenesis  regulation of morphogenesis of a branching structure  mesenchymal cell differentiation involved in lung development  mesenchymal cell proliferation involved in lung development  endodermal digestive tract morphogenesis  lens fiber cell development  regulation of ERK1 and ERK2 cascade  positive regulation of ERK1 and ERK2 cascade  positive regulation of canonical Wnt signaling pathway  
Pathways : KEGGMAPK signaling pathway    Ras signaling pathway    Rap1 signaling pathway    Endocytosis    PI3K-Akt signaling pathway    Regulation of actin cytoskeleton    Pathways in cancer    Prostate cancer   
Protein Interaction DatabaseFGFR2
Wikipedia pathwaysFGFR2
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)FGFR2
snp3D : Map Gene to Disease2263
SNP (GeneSNP Utah)FGFR2
SNP : HGBaseFGFR2
Genetic variants : HAPMAPFGFR2
Exome VariantFGFR2
1000_GenomesFGFR2 
ICGC programENSG00000066468 
Cancer Gene: CensusFGFR2 
Somatic Mutations in Cancer : COSMICFGFR2 
CONAN: Copy Number AnalysisFGFR2 
Mutations and Diseases : HGMDFGFR2
Genomic VariantsFGFR2  FGFR2 [DGVbeta]
dbVarFGFR2
ClinVarFGFR2
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM101200    101400    101600    123150    123500    123790    149730    176943    207410    609579    613659    614592   
MedgenFGFR2
GENETestsFGFR2
Disease Genetic AssociationFGFR2
Huge Navigator FGFR2 [HugePedia]  FGFR2 [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneFGFR2
Homology/Alignments : Family Browser (UCSC)FGFR2
Phylogenetic Trees/Animal Genes : TreeFamFGFR2
Chemical/Protein Interactions : CTD2263
Chemical/Pharm GKB GenePA28128
Drug Sensitivity FGFR2
Clinical trialFGFR2
Cancer Resource (Charite)ENSG00000066468
Other databases
Other databasehttp://cancergenome.broadinstitute.org/index.php?tgene=FGFR2
Probes
Litterature
PubMed412 Pubmed reference(s) in Entrez
CoreMineFGFR2
iHOPFGFR2
OncoSearchFGFR2

Bibliography

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J Biol Chem. 1990 Aug 5;265(22):12767-70.
PMID 2165484
 
Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors.
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EMBO J. 1990 Sep;9(9):2685-92.
PMID 1697263
 
Related fibroblast growth factor receptor genes exist in the human genome.
Houssaint E, Blanquet PR, Champion-Arnaud P, Gesnel MC, Torriglia A, Courtois Y, Breathnach R.
Proc Natl Acad Sci U S A. 1990 Oct;87(20):8180-4.
PMID 2172978
 
BEK and FLG, two receptors to members of the FGF family, are amplified in subsets of human breast cancers.
Adnane J, Gaudray P, Dionne CA, Crumley G, Jaye M, Schlessinger J, Jeanteur P, Birnbaum D, Theillet C.
Oncogene. 1991 Apr;6(4):659-63.
PMID 1851551
 
Multiple mRNAs code for proteins related to the BEK fibroblast growth factor receptor.
Champion-Arnaud P, Ronsin C, Gilbert E, Gesnel MC, Houssaint E, Breathnach R.
Oncogene. 1991 Jun;6(6):979-87.
PMID 1648704
 
PCR-based identification of new receptors: molecular cloning of a receptor for fibroblast growth factors.
Raz V, Kelman Z, Avivi A, Neufeld G, Givol D, Yarden Y.
Oncogene. 1991 May;6(5):753-60.
PMID 1711190
 
Expression cDNA cloning of the KGF receptor by creation of a transforming autocrine loop.
Miki T, Fleming TP, Bottaro DP, Rubin JS, Ron D, Aaronson SA.
Science. 1991 Jan 4;251(4989):72-5.
PMID 1846048
 
A novel form of fibroblast growth factor receptor 2. Alternative splicing of the third immunoglobulin-like domain confers ligand binding specificity.
Dell KR, Williams LT.
J Biol Chem. 1992 Oct 15;267(29):21225-9.
PMID 1400433
 
BEK, a receptor for multiple members of the fibroblast growth factor (FGF) family, maps to human chromosome 10q25.3-q26.
Dionne CA, Modi WS, Crumley G, O'Brien SJ, Schlessinger J, Jaye M.
Cytogenet Cell Genet. 1992;60(1):34-6.
PMID 1582255
 
K-sam gene encodes secreted as well as transmembrane receptor tyrosine kinase.
Katoh M, Hattori Y, Sasaki H, Tanaka M, Sugano K, Yazaki Y, Sugimura T, Terada M.
Proc Natl Acad Sci U S A. 1992 Apr 1;89(7):2960-4.
PMID 1313574
 
Expression of basic fibroblast growth factor, FGFR1 and FGFR2 in normal and malignant human breast, and comparison with other normal tissues.
Luqmani YA, Graham M, Coombes RC.
Br J Cancer. 1992 Aug;66(2):273-80.
PMID 1380281
 
A confined variable region confers ligand specificity on fibroblast growth factor receptors: implications for the origin of the immunoglobulin fold.
Yayon A, Zimmer Y, Shen GH, Avivi A, Yarden Y, Givol D.
EMBO J. 1992 May;11(5):1885-90.
PMID 1316275
 
Control of BEK and K-SAM splice sites in alternative splicing of the fibroblast growth factor receptor 2 pre-mRNA.
Gilbert E, Del Gatto F, Champion-Arnaud P, Gesnel MC, Breathnach R.
Mol Cell Biol. 1993 Sep;13(9):5461-8.
PMID 8355693
 
DNA amplification in human gastric carcinomas
Mor O, Ranzani GN, Ravia Y, Rotman G, Gutman M, Manor A, Amadori D, Houldsworth J, Hollstein M, Schwab M, Shiloh Y.
Cancer Genet Cytogenet. 1993 Feb;65(2):111-4.
PMID 8453595
 
Exon switching and activation of stromal and embryonic fibroblast growth factor (FGF)-FGF receptor genes in prostate epithelial cells accompany stromal independence and malignancy.
Yan G, Fukabori Y, McBride G, Nikolaropolous S, McKeehan WL.
Mol Cell Biol. 1993 Aug;13(8):4513-22.
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Written08-2008Masaru Katoh
Genetics and Cell Biology Section, National Cancer Center, Japan

Citation

This paper should be referenced as such :
Katoh, M
FGFR2 (fibroblast growth factor receptor 2)
Atlas Genet Cytogenet Oncol Haematol. 2009;13(7):477-482.
Free online version   Free pdf version   [Bibliographic record ]
URL : http://AtlasGeneticsOncology.org/Genes/FGFR2ID40570ch10q26.html

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