Atlas of Genetics and Cytogenetics in Oncology and Haematology

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FGR (FGR proto-oncogene, Src family tyrosine kinase)

Identity

Alias_namesSRC2
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog
v-fgr feline Gardner-Rasheed sarcoma viral oncogene homolog
feline Gardner-Rasheed sarcoma viral oncogene homolog
Alias_symbol (synonym)c-fgr
p55c-fgr
Other aliasc-src2
p55-Fgr
p58-Fgr
p58c-fgr
HGNC (Hugo) FGR
LocusID (NCBI) 2268
Atlas_Id 40572
Location 1p35.3  [Link to chromosome band 1p35]
Location_base_pair Starts at 27612290 and ends at 27635216 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FGR (1p36.11) / EFCAB2 (1q44)FGR (1p36.11) / SQSTM1 (5q35.3)HLA-DRB5 (6p21.32) / FGR (1p36.11)
MAX (14q23.3) / FGR (1p36.11)RASSF2 (20p13) / FGR (1p36.11)WASF2 (1p36.11) / FGR (1p36.11)
WASF2 1p36.11 / FGR 1p36.11

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]

Solid Tumors TT_t0101p35p36ID103744 TT_t0101p35p36ID103745 TT_t0101p36p36ID103840

External links

Nomenclature
HGNC (Hugo)FGR   3697
Cards
Entrez_Gene (NCBI)FGR  2268  FGR proto-oncogene, Src family tyrosine kinase
AliasesSRC2; c-fgr; c-src2; p55-Fgr; 
p55c-fgr; p58-Fgr; p58c-fgr
GeneCards (Weizmann)FGR
Ensembl hg19 (Hinxton)ENSG00000000938 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000000938 [Gene_View]  ENSG00000000938 [Sequence]  chr1:27612290-27635216 [Contig_View]  FGR [Vega]
ICGC DataPortalENSG00000000938
TCGA cBioPortalFGR
AceView (NCBI)FGR
Genatlas (Paris)FGR
WikiGenes2268
SOURCE (Princeton)FGR
Genetics Home Reference (NIH)FGR
Genomic and cartography
GoldenPath hg38 (UCSC)FGR  -     chr1:27612290-27635216 -  1p35.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FGR  -     1p35.3   [Description]    (hg19-Feb_2009)
GoldenPathFGR - 1p35.3 [CytoView hg19]  FGR - 1p35.3 [CytoView hg38]
ImmunoBaseENSG00000000938
Mapping of homologs : NCBIFGR [Mapview hg19]  FGR [Mapview hg38]
OMIM164940   
Gene and transcription
Genbank (Entrez)AK125143 AK130188 AK301078 AK304846 BC064382
RefSeq transcript (Entrez)NM_001042729 NM_001042747 NM_005248
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FGR
Cluster EST : UnigeneHs.1422 [ NCBI ]
CGAP (NCI)Hs.1422
Alternative Splicing GalleryENSG00000000938
Gene ExpressionFGR [ NCBI-GEO ]   FGR [ EBI - ARRAY_EXPRESS ]   FGR [ SEEK ]   FGR [ MEM ]
Gene Expression Viewer (FireBrowse)FGR [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2268
GTEX Portal (Tissue expression)FGR
Human Protein AtlasENSG00000000938-FGR [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP09769   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP09769  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP09769
Splice isoforms : SwissVarP09769
PhosPhoSitePlusP09769
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)    SH2 (PS50001)    SH3 (PS50002)   
Domains : Interpro (EBI)Fgr_SH2    Kinase-like_dom_sf    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser-Thr/Tyr_kinase_cat_dom    SH2    SH2_dom_sf    SH3-like_dom_sf    SH3_domain    Tyr_kinase_AS    Tyr_kinase_cat_dom   
Domain families : Pfam (Sanger)Pkinase_Tyr (PF07714)    SH2 (PF00017)    SH3_1 (PF00018)   
Domain families : Pfam (NCBI)pfam07714    pfam00017    pfam00018   
Domain families : Smart (EMBL)SH2 (SM00252)  SH3 (SM00326)  TyrKc (SM00219)  
Conserved Domain (NCBI)FGR
DMDM Disease mutations2268
Blocks (Seattle)FGR
SuperfamilyP09769
Human Protein Atlas [tissue]ENSG00000000938-FGR [tissue]
Peptide AtlasP09769
HPRD01288
IPIIPI00016871   IPI00643149   
Protein Interaction databases
DIP (DOE-UCLA)P09769
IntAct (EBI)P09769
FunCoupENSG00000000938
BioGRIDFGR
STRING (EMBL)FGR
ZODIACFGR
Ontologies - Pathways
QuickGOP09769
Ontology : AmiGOphosphotyrosine residue binding  phosphotyrosine residue binding  immune response-regulating cell surface receptor signaling pathway  protein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  signaling receptor binding  protein binding  ATP binding  extracellular region  mitochondrial inner membrane  mitochondrial intermembrane space  cytosol  cytoskeleton  plasma membrane  plasma membrane  protein phosphorylation  transmembrane receptor protein tyrosine kinase signaling pathway  integrin-mediated signaling pathway  integrin-mediated signaling pathway  integrin-mediated signaling pathway  regulation of cell shape  response to virus  positive regulation of phosphatidylinositol 3-kinase signaling  actin cytoskeleton  aggresome  peptidyl-tyrosine phosphorylation  protein kinase binding  cell differentiation  bone mineralization  positive regulation of cell migration  extrinsic component of cytoplasmic side of plasma membrane  ruffle membrane  secretory granule lumen  immunoglobulin receptor binding  Fc-gamma receptor I complex binding  peptidyl-tyrosine autophosphorylation  Fc-gamma receptor signaling pathway involved in phagocytosis  positive regulation of mast cell degranulation  neutrophil degranulation  positive regulation of phosphatidylinositol 3-kinase activity  innate immune response  regulation of innate immune response  regulation of protein kinase activity  protein autophosphorylation  skeletal system morphogenesis  positive regulation of cytokine secretion  regulation of phagocytosis  defense response to Gram-positive bacterium  extracellular exosome  
Ontology : EGO-EBIphosphotyrosine residue binding  phosphotyrosine residue binding  immune response-regulating cell surface receptor signaling pathway  protein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  signaling receptor binding  protein binding  ATP binding  extracellular region  mitochondrial inner membrane  mitochondrial intermembrane space  cytosol  cytoskeleton  plasma membrane  plasma membrane  protein phosphorylation  transmembrane receptor protein tyrosine kinase signaling pathway  integrin-mediated signaling pathway  integrin-mediated signaling pathway  integrin-mediated signaling pathway  regulation of cell shape  response to virus  positive regulation of phosphatidylinositol 3-kinase signaling  actin cytoskeleton  aggresome  peptidyl-tyrosine phosphorylation  protein kinase binding  cell differentiation  bone mineralization  positive regulation of cell migration  extrinsic component of cytoplasmic side of plasma membrane  ruffle membrane  secretory granule lumen  immunoglobulin receptor binding  Fc-gamma receptor I complex binding  peptidyl-tyrosine autophosphorylation  Fc-gamma receptor signaling pathway involved in phagocytosis  positive regulation of mast cell degranulation  neutrophil degranulation  positive regulation of phosphatidylinositol 3-kinase activity  innate immune response  regulation of innate immune response  regulation of protein kinase activity  protein autophosphorylation  skeletal system morphogenesis  positive regulation of cytokine secretion  regulation of phagocytosis  defense response to Gram-positive bacterium  extracellular exosome  
Pathways : KEGGChemokine signaling pathway    Epstein-Barr virus infection   
NDEx NetworkFGR
Atlas of Cancer Signalling NetworkFGR
Wikipedia pathwaysFGR
Orthology - Evolution
OrthoDB2268
GeneTree (enSembl)ENSG00000000938
Phylogenetic Trees/Animal Genes : TreeFamFGR
HOGENOMP09769
Homologs : HomoloGeneFGR
Homology/Alignments : Family Browser (UCSC)FGR
Gene fusions - Rearrangements
Fusion : MitelmanWASF2/FGR [1p36.11/1p36.11]  [t(1;1)(p36;p36)]  
Fusion PortalWASF2 1p36.11 FGR 1p36.11 LUSC
Fusion : QuiverFGR
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFGR [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FGR
dbVarFGR
ClinVarFGR
1000_GenomesFGR 
Exome Variant ServerFGR
ExAC (Exome Aggregation Consortium)ENSG00000000938
GNOMAD BrowserENSG00000000938
Varsome BrowserFGR
Genetic variants : HAPMAP2268
Genomic Variants (DGV)FGR [DGVbeta]
DECIPHERFGR [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFGR 
Mutations
ICGC Data PortalFGR 
TCGA Data PortalFGR 
Broad Tumor PortalFGR
OASIS PortalFGR [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFGR  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DFGR
Mutations and Diseases : HGMDFGR
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FGR
DgiDB (Drug Gene Interaction Database)FGR
DoCM (Curated mutations)FGR (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FGR (select a term)
intoGenFGR
Cancer3DFGR(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM164940   
Orphanet
DisGeNETFGR
MedgenFGR
Genetic Testing Registry FGR
NextProtP09769 [Medical]
TSGene2268
GENETestsFGR
Target ValidationFGR
Huge Navigator FGR [HugePedia]
snp3D : Map Gene to Disease2268
BioCentury BCIQFGR
ClinGenFGR
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2268
Chemical/Pharm GKB GenePA28135
Clinical trialFGR
Miscellaneous
canSAR (ICR)FGR (select the gene name)
DataMed IndexFGR
Probes
Litterature
PubMed100 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFGR
EVEXFGR
GoPubMedFGR
iHOPFGR
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Aug 12 15:34:13 CEST 2019
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