FHIT (Fragile Histidine Triad)

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FHIT (Fragile Histidine Triad)

Written	2006-12	Teresa Druck, Kay Huebner
		BRT Rm. 940, 460 W. 12th Ave, Columbus, OH 43210

(Note : for Links provided by Atlas : click)

Identity

Alias_names	fragile histidine triad gene
Alias_symbol (synonym)	FRA3B
	AP3Aase
Other alias
HGNC (Hugo)	FHIT
LocusID (NCBI)	2272
Atlas_Id	192
Location	3p14.2 [Link to chromosome band 3p14]
Location_base_pair	Starts at 59747278 and ends at 61251461 bp from pter ( according to hg19-Feb_2009) [Mapping FHIT.png]

Fusion genes (updated 2016)	CADM2 (3p12.1) / FHIT (3p14.2)	CADPS (3p14.2) / FHIT (3p14.2)	FAM172A (5q15) / FHIT (3p14.2)
	FHIT (3p14.2) / CADPS (3p14.2)	FHIT (3p14.2) / CAMK4 (5q22.1)	FHIT (3p14.2) / FAM19A4 (3p14.1)
	FHIT (3p14.2) / HMGA2 (12q14.3)	FHIT (3p14.2) / MYLK-AS1 (3q21.1)	FHIT (3p14.2) / PEG10 (7q21.3)
	FHIT (3p14.2) / PRDM12 (9q34.12)	FHIT (3p14.2) / PTPRG (3p14.2)	FHIT (3p14.2) / RFTN2 (2q33.1)
	FHIT (3p14.2) / RNF139 (8q24.13)	FHIT (3p14.2) / SLC30A6 (2p22.3)	FHIT (3p14.2) / SYNPR (3p14.2)
	FHIT (3p14.2) / UBC (12q24.31)	GNAS (20q13.32) / FHIT (3p14.2)	HMGA2 (12q14.3) / FHIT (3p14.2)
	MTCH2 (11p11.2) / FHIT (3p14.2)	PTPRG (3p14.2) / FHIT (3p14.2)	RNF139 (8q24.13) / FHIT (3p14.2)
	RPAIN (17p13.2) / FHIT (3p14.2)	RRAS2 (11p15.2) / FHIT (3p14.2)	RYBP (3p13) / FHIT (3p14.2)
	SLC17A7 (19q13.33) / FHIT (3p14.2)

DNA/RNA



	Depiction of the more than 1.67 Mb FHIT gene genomic locus with coding exons 5 through 9 (dark purple) and untranslated exons 1-4 and 10 (light purple). The position of the familial kidney cancer associated chromosome translocation is also shown.

Description	The FHIT gene spans more than 1.6 Mb of genomic DNA and is composed of 10 exons.
Transcription	The FHIT gene encodes a 1.1 kb mRNA which is expressed at low levels in most tissue types. FHIT encompasses the common fragile site FRA3B, where carcinogen-induced damage can lead to deletions, translocations and subsequent aberrant transcripts. Aberrant transcripts from this gene have been found in about half of all esophageal carcinomas, stomach carcinomas, and other carcinomas.
Pseudogene	A pseudogene, with sequences nearly identical to the 5'UTR of FHIT, is located on chromosome 1.

Protein

Description	FHIT encodes a 147 amino acid (16.8 kDa) protein that can be phosphorylated at tyrosine 114 by Src family proteins.
Expression	Fhit is expressed at low to moderate levels in most tissue types, with kidney and liver expressing the highest steady state levels
Localisation	Fhit is primarily located in the cytosol, but is also found in the mitochondria.
Function	Fhit protein is a tumor suppressor with reduced or no expression in many types of cancer. Fhit expression is more frequently lost in cancers of individuals with familial mutations causing deficiency in DNA repair genes such as BRCA1 and BRCA2 and MSH2. In vitro Fhit acts as a hydrolase that cleaves diadenosine triphosphate (Ap3A) to ADP and AMP. The Fhit-Ap3A enzyme-substrate complex appears to be the tumor suppressor signal. Restoration of Fhit expression in Fhit-deficient cancer cells causes death by apoptosis, involving the intrinsic caspase pathway, in cancer-derived cells and in tumor xenografts.
Homology	Fhit is similar to a yeast enzyme, diadenosine tetraphosphate (Ap4A) hydrolase and is a member of the large HIT family of proteins characterized by the histidine triad motif, HxHxHxx (where x is a hydrophobic residue).

Mutations

Note	The following FHIT polymorphisms have been described: 524 A/G (exon 6) silent 545 G/A (exon 6) silent 626 C/T (exon 7) silent 651 G/T (exon 8) valine to phenylalanine 656 T/C (exon 8) silent several intronic splice regions
Somatic	No bona fide somatic point mutations thus far confirmed.

Implicated in

Note

Entity	Various types of cancer
Disease	Loss of expression occurs in more than 60% of human cancers; loss is very early in some cancers such as lung cancer. In a large, 4 generation family, a balanced translocation between FHIT (in intron 3) at 3p14.2 and TRC8, a patched related gene, at chromosome 8q24 is associated with bilateral, multifocal clear cell kidney carcinoma. Also, microsatellite loci within the FHIT gene, were shown to be closely linked to a gene that contributes to susceptibility to familial prostate cancer.
Prognosis	There are numerous reports of association of Fhit loss with specific prognostic or other clinical features of specific types of cancer.
Cytogenetics	The FHIT locus is involved in translocations and deletions in some fraction of many types of cancer, likely due to the recombinogenicity of the fragile region within FHIT and subsequent selective growth or survival advantage of cells with reduced Fhit protein expression.

Bibliography

Analysis of the FHIT gene and FRA3B region in sporadic breast cancer, preneoplastic lesions, and familial breast cancer probands.

Ahmadian M, Wistuba II, Fong KM, Behrens C, Kodagoda DR, Saboorian MH, Shay J, Tomlinson GE, Blum J, Minna JD, Gazdar AF

Cancer research. 1997 ; 57 (17) : 3664-3668.

PMID 9288768

Fhit, a putative tumor suppressor in humans, is a dinucleoside 5',5'-P1,P3-triphosphate hydrolase.

Barnes LD, Garrison PN, Siprashvili Z, Guranowski A, Robinson AK, Ingram SW, Croce CM, Ohta M, Huebner K

Biochemistry. 1996 ; 35 (36) : 11529-11535.

PMID 8794732

Hint, Fhit, and GalT: function, structure, evolution, and mechanism of three branches of the histidine triad superfamily of nucleotide hydrolases and transferases.

Brenner C

Biochemistry. 2002 ; 41 (29) : 9003-9014.

PMID 12119013

The histidine triad superfamily of nucleotide-binding proteins.

Brenner C, Bieganowski P, Pace HC, Huebner K

Journal of cellular physiology. 1999 ; 181 (2) : 179-187.

PMID 10497298

Purification and crystallization of complexes modeling the active state of the fragile histidine triad protein.

Brenner C, Pace HC, Garrison PN, Robinson AK, Rosler A, Liu XH, Blackburn GM, Croce CM, Huebner K, Barnes LD

Protein engineering. 1997 ; 10 (12) : 1461-1463.

PMID 9543008

FHITness and cancer.

Druck T, Berk L, Huebner K

Oncology research. 1998 ; 10 (7) : 341-345.

PMID 10063967

Structure and expression of the human FHIT gene in normal and tumor cells.

Druck T, Hadaczek P, Fu TB, Ohta M, Siprashvili Z, Baffa R, Negrini M, Kastury K, Veronese ML, Rosen D, Rothstein J, McCue P, Cotticelli MG, Inoue H, Croce CM, Huebner K

Cancer research. 1997 ; 57 (3) : 504-512.

PMID 9012482

Fragile histidine triad expression delays tumor development and induces apoptosis in human pancreatic cancer.

Dumon KR, Ishii H, Vecchione A, Trapasso F, Baldassarre G, Chakrani F, Druck T, Rosato EF, Williams NN, Baffa R, During MJ, Huebner K, Croce CM

Cancer research. 2001 ; 61 (12) : 4827-4836.

PMID 11406559

Translocation breakpoints in FHIT and FRA3B in both homologs of chromosome 3 in an esophageal adenocarcinoma.

Fang JM, Arlt MF, Burgess AC, Dagenais SL, Beer DG, Glover TW

Genes, chromosomes & cancer. 2001 ; 30 (3) : 292-298.

PMID 11170287

Muir-Torre-like syndrome in Fhit-deficient mice.

Fong LY, Fidanza V, Zanesi N, Lock LF, Siracusa LD, Mancini R, Siprashvili Z, Ottey M, Martin SE, Druck T, McCue PA, Croce CM, Huebner K

Proceedings of the National Academy of Sciences of the United States of America. 2000 ; 97 (9) : 4742-4747.

PMID 10758156

The hereditary renal cell carcinoma 3;8 translocation fuses FHIT to a patched-related gene, TRC8.

Gemmill RM, West JD, Boldog F, Tanaka N, Robinson LJ, Smith DI, Li F, Drabkin HA

Proceedings of the National Academy of Sciences of the United States of America. 1998 ; 95 (16) : 9572-9577.

PMID 9689122

Instability at chromosomal fragile sites.

Glover TW

Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer. 1998 ; 154 : 185-199.

PMID 10027000

Concordant loss of fragile gene expression early in breast cancer development.

Guler G, Uner A, Guler N, Han SY, Iliopoulos D, McCue P, Huebner K

Pathology international. 2005 ; 55 (8) : 471-478.

PMID 15998374

Loss of fragile histidine triad (FHIT) expression and microsatellite instability in periocular sebaceous gland carcinoma in patients with Muir-Torre syndrome.

Holbach LM, von Moller A, Decker C, Jünemann AG, Rummelt-Hofmann C, Ballhausen WG

American journal of ophthalmology. 2002 ; 134 (1) : 147-148.

PMID 12095833

Cancer and the FRA3B/FHIT fragile locus: it's a HIT.

Huebner K, Croce CM

British journal of cancer. 2003 ; 88 (10) : 1501-1506.

PMID 12771912

The role of the FHIT/FRA3B locus in cancer.

Huebner K, Garrison PN, Barnes LD, Croce CM

Annual review of genetics. 1998 ; 32 : 7-31.

PMID 9928473

Fragile genes as biomarkers: epigenetic control of WWOX and FHIT in lung, breast and bladder cancer.

Iliopoulos D, Guler G, Han SY, Johnston D, Druck T, McCorkell KA, Palazzo J, McCue PA, Baffa R, Huebner K

Oncogene. 2005 ; 24 (9) : 1625-1633.

PMID 15674328

Effect of adenoviral transduction of the fragile histidine triad gene into esophageal cancer cells.

Ishii H, Dumon KR, Vecchione A, Trapasso F, Mimori K, Alder H, Mori M, Sozzi G, Baffa R, Huebner K, Croce CM

Cancer research. 2001 ; 61 (4) : 1578-1584.

PMID 11245468

Induction of apoptosis and inhibition of tumorigenicity and tumor growth by adenovirus vector-mediated fragile histidine triad (FHIT) gene overexpression.

Ji L, Fang B, Yen N, Fong K, Minna JD, Roth JA

Cancer research. 1999 ; 59 (14) : 3333-3339.

PMID 10416589

Genetic linkage of prostate cancer risk to the chromosome 3 region bearing FHIT.

Larson GP, Ding Y, Cheng LS, Lundberg C, Gagalang V, Rivas G, Geller L, Weitzel J, MacDonald D, Archambeau J, Slater J, Neuberg D, Daly MB, Angel I, Benson AB 3rd, Smith K, Kirkwood JM, O'Dwyer PJ, Raskay B, Sutphen R, Drew R, Stewart JA, Werndli J, Johnson D, Ruckdeschel JC, Elston RC, Krontiris TG

Cancer research. 2005 ; 65 (3) : 805-814.

PMID 15705877

The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers.

Ohta M, Inoue H, Cotticelli MG, Kastury K, Baffa R, Palazzo J, Siprashvili Z, Mori M, McCue P, Druck T, Croce CM, Huebner K

Cell. 1996 ; 84 (4) : 587-597.

PMID 8598045

Genetic, biochemical, and crystallographic characterization of Fhit-substrate complexes as the active signaling form of Fhit.

Pace HC, Garrison PN, Robinson AK, Barnes LD, Draganescu A, Rösler A, Blackburn GM, Siprashvili Z, Croce CM, Huebner K, Brenner C

Proceedings of the National Academy of Sciences of the United States of America. 1998 ; 95 (10) : 5484-5489.

PMID 9576908

Fhit is a physiological target of the protein kinase Src.

Pekarsky Y, Garrison PN, Palamarchuk A, Zanesi N, Aqeilan RI, Huebner K, Barnes LD, Croce CM

Proceedings of the National Academy of Sciences of the United States of America. 2004 ; 101 (11) : 3775-3779.

PMID 15007172

Loss of heterozygosity at the FHIT gene in different solid human tumours and its association with survival in colorectal cancer patients.

Petursdottir TE, Hafsteinsdottir SH, Jonasson JG, Moller PH, Thorsteinsdottir U, Huiping C, Egilsson V, Ingvarsson S

Anticancer research. 2002 ; 22 (6A) : 3205-3212.

PMID 12530066

Fhit modulation of the Akt-survivin pathway in lung cancer cells: Fhit-tyrosine 114 (Y114) is essential.

Semba S, Trapasso F, Fabbri M, McCorkell KA, Volinia S, Druck T, Iliopoulos D, Pekarsky Y, Ishii H, Garrison PN, Barnes LD, Croce CM, Huebner K

Oncogene. 2006 ; 25 (20) : 2860-2872.

PMID 16407838

Replacement of Fhit in cancer cells suppresses tumorigenicity.

Siprashvili Z, Sozzi G, Barnes LD, McCue P, Robinson AK, Eryomin V, Sard L, Tagliabue E, Greco A, Fusetti L, Schwartz G, Pierotti MA, Croce CM, Huebner K

Proceedings of the National Academy of Sciences of the United States of America. 1997 ; 94 (25) : 13771-13776.

PMID 9391102

Designed FHIT alleles establish that Fhit-induced apoptosis in cancer cells is limited by substrate binding.

Trapasso F, Krakowiak A, Cesari R, Arkles J, Yendamuri S, Ishii H, Vecchione A, Kuroki T, Bieganowski P, Pace HC, Huebner K, Croce CM, Brenner C

Proceedings of the National Academy of Sciences of the United States of America. 2003 ; 100 (4) : 1592-1597.

PMID 12574506

The fragile histidine triad/common chromosome fragile site 3B locus and repair-deficient cancers.

Turner BC, Ottey M, Zimonjic DB, Potoczek M, Hauck WW, Pequignot E, Keck-Waggoner CL, Sevignani C, Aldaz CM, McCue PA, Palazzo J, Huebner K, Popescu NC

Cancer research. 2002 ; 62 (14) : 4054-4060.

PMID 12124341

Two-hit inactivation of FHIT by loss of heterozygosity and hypermethylation in breast cancer.

Yang Q, Nakamura M, Nakamura Y, Yoshimura G, Suzuma T, Umemura T, Shimizu Y, Mori I, Sakurai T, Kakudo K

Clinical cancer research : an official journal of the American Association for Cancer Research. 2002 ; 8 (9) : 2890-2893.

PMID 12231533

5' CpG island methylation of the FHIT gene is correlated with loss of gene expression in lung and breast cancer.

Zöchbauer-Müller S, Fong KM, Maitra A, Lam S, Geradts J, Ashfaq R, Virmani AK, Milchgrub S, Gazdar AF, Minna JD

Cancer research. 2001 ; 61 (9) : 3581-3585.

PMID 11325823

The tumor spectrum in FHIT-deficient mice.

Zanesi N, Fidanza V, Fong LY, Mancini R, Druck T, Valtieri M, Rüdiger T, McCue PA, Croce CM, Huebner K

Proceedings of the National Academy of Sciences of the United States of America. 2001 ; 98 (18) : 10250-10255.

PMID 11517343

Citation

This paper should be referenced as such :

Huebner, K ; Druck, T

FHIT (fragile histidine triad)

Atlas Genet Cytogenet Oncol Haematol. 2007;11(2):96-98.

Free journal version : [ pdf ] [ DOI ]

On line version : http://AtlasGeneticsOncology.org/Genes/FHITID192ch3p14.html

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 10 ]

Uterus: Carcinoma of the cervix
Kidney: Clear cell renal cell carcinoma
Head and Neck: Epidermoid carcinoma
Head and Neck: Laryngeal squamous cell carcinoma
Lung: small cell cancer
Head and Neck: Oral squamous cell carcinoma
Kidney: Renal cell carcinoma: an overview
Head and Neck: Salivary gland tumors: an overview
Squamous cell cancer
Lung: Translocations in Small Cell Carcinoma

Other Cancer prone implicated (Data extracted from papers in the Atlas) [ 1 ]

Familial clear cell renal cancer

External links

	Nomenclature
HGNC (Hugo)	FHIT 3701
	Cards
Atlas	FHITID192ch3p14
Entrez_Gene (NCBI)	FHIT 2272 fragile histidine triad
Aliases	AP3Aase; FRA3B
GeneCards (Weizmann)	FHIT
Ensembl hg19 (Hinxton)	ENSG00000189283 [Gene_View]
Ensembl hg38 (Hinxton)	ENSG00000189283 [Gene_View] chr3:59747278-61251461 [Contig_View] FHIT [Vega]
ICGC DataPortal	ENSG00000189283
TCGA cBioPortal	FHIT
AceView (NCBI)	FHIT
Genatlas (Paris)	FHIT
WikiGenes	2272
SOURCE (Princeton)	FHIT
Genetics Home Reference (NIH)	FHIT
	Genomic and cartography
GoldenPath hg38 (UCSC)	FHIT - chr3:59747278-61251461 - 3p14.2 [Description] (hg38-Dec_2013)
GoldenPath hg19 (UCSC)	FHIT - 3p14.2 [Description] (hg19-Feb_2009)
Ensembl	FHIT - 3p14.2 [CytoView hg19] FHIT - 3p14.2 [CytoView hg38]
Mapping of homologs : NCBI	FHIT [Mapview hg19] FHIT [Mapview hg38]
OMIM	601153
	Gene and transcription
Genbank (Entrez)	AK127931 AK289824 BC032336 BC057223 BE246370
RefSeq transcript (Entrez)	NM_001166243 NM_001320899 NM_001320900 NM_001320901 NM_002012
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)	FHIT
Cluster EST : Unigene	Hs.655995 [ NCBI ]
CGAP (NCI)	Hs.655995
Alternative Splicing Gallery	ENSG00000189283
Gene Expression	FHIT [ NCBI-GEO ] FHIT [ EBI - ARRAY_EXPRESS ] FHIT [ SEEK ] FHIT [ MEM ]
Gene Expression Viewer (FireBrowse)	FHIT [ Firebrowse - Broad ]
SOURCE (Princeton)	Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60]
Genevisible	Expression in : [tissues] [cell-lines] [cancer] [perturbations]
BioGPS (Tissue expression)	2272
GTEX Portal (Tissue expression)	FHIT
	Protein : pattern, domain, 3D structure
UniProt/SwissProt	P49789 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction]
NextProt	P49789 [Sequence] [Exons] [Medical] [Publications]
With graphics : InterPro	P49789
Splice isoforms : SwissVar	P49789
Catalytic activity : Enzyme	3.6.1.29 [ Enzyme-Expasy ] 3.6.1.29 3.6.1.29 [ IntEnz-EBI ] 3.6.1.29 [ BRENDA ] 3.6.1.29 [ KEGG ]
PhosPhoSitePlus	P49789
Domaine pattern : Prosite (Expaxy)	HIT_1 (PS00892) HIT_2 (PS51084)
Domains : Interpro (EBI)	Histidine_triad_CS Histidine_triad_HIT HIT-like
Domain families : Pfam (Sanger)	HIT (PF01230)
Domain families : Pfam (NCBI)	pfam01230
Conserved Domain (NCBI)	FHIT
DMDM Disease mutations	2272
Blocks (Seattle)	FHIT
PDB (SRS)	1FHI 1FIT 2FHI 2FIT 3FIT 4FIT 5FIT 6FIT
PDB (PDBSum)	1FHI 1FIT 2FHI 2FIT 3FIT 4FIT 5FIT 6FIT
PDB (IMB)	1FHI 1FIT 2FHI 2FIT 3FIT 4FIT 5FIT 6FIT
PDB (RSDB)	1FHI 1FIT 2FHI 2FIT 3FIT 4FIT 5FIT 6FIT
Structural Biology KnowledgeBase	1FHI 1FIT 2FHI 2FIT 3FIT 4FIT 5FIT 6FIT
SCOP (Structural Classification of Proteins)	1FHI 1FIT 2FHI 2FIT 3FIT 4FIT 5FIT 6FIT
CATH (Classification of proteins structures)	1FHI 1FIT 2FHI 2FIT 3FIT 4FIT 5FIT 6FIT
Superfamily	P49789
Human Protein Atlas	ENSG00000189283
Peptide Atlas	P49789
HPRD	03096
IPI	IPI00028095 IPI00930501 IPI00946848
	Protein Interaction databases
DIP (DOE-UCLA)	P49789
IntAct (EBI)	P49789
FunCoup	ENSG00000189283
BioGRID	FHIT
STRING (EMBL)	FHIT
ZODIAC	FHIT
	Ontologies - Pathways
QuickGO	P49789
Ontology : AmiGO	nucleotide binding fibrillar center catalytic activity protein binding cytoplasm mitochondrion cytosol plasma membrane purine nucleotide metabolic process transcription, DNA-templated regulation of transcription, DNA-templated nucleotide metabolic process hydrolase activity ubiquitin protein ligase binding negative regulation of proteasomal ubiquitin-dependent protein catabolic process identical protein binding bis(5'-adenosyl)-triphosphatase activity extracellular exosome intrinsic apoptotic signaling pathway by p53 class mediator
Ontology : EGO-EBI	nucleotide binding fibrillar center catalytic activity protein binding cytoplasm mitochondrion cytosol plasma membrane purine nucleotide metabolic process transcription, DNA-templated regulation of transcription, DNA-templated nucleotide metabolic process hydrolase activity ubiquitin protein ligase binding negative regulation of proteasomal ubiquitin-dependent protein catabolic process identical protein binding bis(5'-adenosyl)-triphosphatase activity extracellular exosome intrinsic apoptotic signaling pathway by p53 class mediator
Pathways : KEGG	Purine metabolism Small cell lung cancer Non-small cell lung cancer
NDEx Network	FHIT
Atlas of Cancer Signalling Network	FHIT
Wikipedia pathways	FHIT
	Orthology - Evolution
OrthoDB	2272
GeneTree (enSembl)	ENSG00000189283
Phylogenetic Trees/Animal Genes : TreeFam	FHIT
HOVERGEN	P49789
HOGENOM	P49789
Homologs : HomoloGene	FHIT
Homology/Alignments : Family Browser (UCSC)	FHIT
	Gene fusions - Rearrangements
Fusion : Mitelman	CADM2/FHIT [3p12.1/3p14.2] [t(3;3)(p12;p14)]
Fusion : Mitelman	CADPS/FHIT [3p14.2/3p14.2] [t(3;3)(p14;p14)]
Fusion : Mitelman	FAM172A/FHIT [5q15/3p14.2] [t(3;5)(p14;q15)]
Fusion : Mitelman	FHIT/CADPS [3p14.2/3p14.2] [t(3;3)(p14;p14)]
Fusion : Mitelman	FHIT/CAMK4 [3p14.2/5q22.1] [t(3;5)(p14;q22)]
Fusion : Mitelman	FHIT/FAM19A4 [3p14.2/3p14.1] [t(3;3)(p14;p14)]
Fusion : Mitelman	FHIT/PTPRG [3p14.2/3p14.2] [t(3;3)(p14;p14)]
Fusion : Mitelman	FHIT/SYNPR [3p14.2/3p14.2] [t(3;3)(p14;p14)]
Fusion : Mitelman	HMGA2/FHIT [12q14.3/3p14.2] [ins(3;12)(p14;q14q14)]
Fusion : Mitelman	MTCH2/FHIT [11p11.2/3p14.2] [t(3;11)(p14;p11)]
Fusion : Mitelman	PTPRG/FHIT [3p14.2/3p14.2] [t(3;3)(p14;p14)]
Fusion : Mitelman	RPAIN/FHIT [17p13.2/3p14.2] [t(3;17)(p14;p13)]
Fusion : Mitelman	RRAS2/FHIT [11p15.2/3p14.2] [t(3;11)(p14;p15)]
Fusion : Mitelman	RYBP/FHIT [3p13/3p14.2] [t(3;3)(p13;p14)]
Fusion : COSMIC	FHIT [3p14.2] - HMGA2 [12q14.3] [fusion_1024] [fusion_1025]
Fusion : COSMIC	HMGA2 [12q14.3] - FHIT [3p14.2] [fusion_1022] [fusion_1023]
Fusion: TCGA	CADM2 3p12.1 FHIT 3p14.2 BRCA
Fusion: TCGA	CADPS 3p14.2 FHIT 3p14.2 BRCA
Fusion: TCGA	FAM172A 5q15 FHIT 3p14.2 KIRC
Fusion: TCGA	FHIT 3p14.2 CADPS 3p14.2 LUAD
Fusion: TCGA	FHIT 3p14.2 CAMK4 5q22.1 KIRC
Fusion: TCGA	FHIT 3p14.2 FAM19A4 3p14.1 LUAD
Fusion: TCGA	FHIT 3p14.2 PTPRG 3p14.2 LGG
Fusion: TCGA	FHIT 3p14.2 SYNPR 3p14.2 KIRC
Fusion: TCGA	MTCH2 11p11.2 FHIT 3p14.2 OV
Fusion: TCGA	PTPRG 3p14.2 FHIT 3p14.2 BRCA PRAD
Fusion: TCGA	RPAIN 17p13.2 FHIT 3p14.2 BRCA
Fusion: TCGA	RRAS2 11p15.2 FHIT 3p14.2 PRAD
Fusion: TCGA	RYBP 3p13 FHIT 3p14.2 PRAD
Fusion : TICdb	HMGA2 [12q14.3] - FHIT [3p14.2]
	Polymorphisms : SNP and Copy number variants
NCBI Variation Viewer	FHIT [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)	FHIT
dbVar	FHIT
ClinVar	FHIT
1000_Genomes	FHIT
Exome Variant Server	FHIT
ExAC (Exome Aggregation Consortium)	FHIT (select the gene name)
Genetic variants : HAPMAP	2272
Genomic Variants (DGV)	FHIT [DGVbeta]
DECIPHER	FHIT [patients] [syndromes] [variants] [genes]
CONAN: Copy Number Analysis	FHIT
	Mutations
ICGC Data Portal	FHIT
TCGA Data Portal	FHIT
Broad Tumor Portal	FHIT
OASIS Portal	FHIT [ Somatic mutations - Copy number]
Cancer Gene: Census	FHIT
Somatic Mutations in Cancer : COSMIC	FHIT [overview] [genome browser] [tissue] [distribution]
Mutations and Diseases : HGMD	FHIT
LOVD (Leiden Open Variation Database)	Whole genome datasets
LOVD (Leiden Open Variation Database)	LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)	LOVD 3.0 shared installation
BioMuta	search FHIT
DgiDB (Drug Gene Interaction Database)	FHIT
DoCM (Curated mutations)	FHIT (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)	FHIT (select a term)
intoGen	FHIT
NCG5 (London)	FHIT
Cancer3D	FHIT(select the gene name)
Impact of mutations	[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
	Diseases
OMIM	601153
Orphanet	23138
Medgen	FHIT
Genetic Testing Registry	FHIT
NextProt	P49789 [Medical]
TSGene	2272
GENETests	FHIT
Target Validation	FHIT
Huge Navigator	FHIT [HugePedia]
snp3D : Map Gene to Disease	2272
BioCentury BCIQ	FHIT
ClinGen	FHIT
	Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD	2272
Chemical/Pharm GKB Gene	PA28140
Clinical trial	FHIT
	Miscellaneous
canSAR (ICR)	FHIT (select the gene name)
	Probes
	Litterature
PubMed	314 Pubmed reference(s) in Entrez
GeneRIFs	Gene References Into Functions (Entrez)
CoreMine	FHIT
EVEX	FHIT
GoPubMed	FHIT
iHOP	FHIT

REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI NCBI

indexed on : Fri Jun 30 11:06:55 CEST 2017

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