Atlas of Genetics and Cytogenetics in Oncology and Haematology


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FHL1 (four and a half LIM domains 1)

Identity

Other namesFHL-1
FHL1A
FHL1B
FLH1A
KYOT
RBMX1A
RBMX1B
SLIM
SLIM-1
SLIM1
SLIMMER
XMPMA
HGNC (Hugo) FHL1
LocusID (NCBI) 2273
Atlas_Id 45582
Location Xq26.3
Location_base_pair Starts at 135279055 and ends at 135293518 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
BTG3 (21q21.1) / FHL1 (Xq26.3)CTSL (9q21.33) / FHL1 (Xq26.3)FHL1 (Xq26.3) / COX6C (8q22.2)
FHL1 (Xq26.3) / SGCA (17q21.33)PHB2 (12p13.31) / FHL1 (Xq26.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)FHL1   3702
Cards
Entrez_Gene (NCBI)FHL1  2273  four and a half LIM domains 1
AliasesFHL-1; FHL1A; FHL1B; FLH1A; 
KYOT; RBMX1A; RBMX1B; SLIM; SLIM-1; SLIM1; SLIMMER; XMPMA
GeneCards (Weizmann)FHL1
Ensembl hg19 (Hinxton)ENSG00000022267 [Gene_View]  chrX:135279055-135293518 [Contig_View]  FHL1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000022267 [Gene_View]  chrX:135279055-135293518 [Contig_View]  FHL1 [Vega]
ICGC DataPortalENSG00000022267
TCGA cBioPortalFHL1
AceView (NCBI)FHL1
Genatlas (Paris)FHL1
WikiGenes2273
SOURCE (Princeton)FHL1
Genomic and cartography
GoldenPath hg19 (UCSC)FHL1  -     chrX:135279055-135293518 +  Xq26.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)FHL1  -     Xq26.3   [Description]    (hg38-Dec_2013)
EnsemblFHL1 - Xq26.3 [CytoView hg19]  FHL1 - Xq26.3 [CytoView hg38]
Mapping of homologs : NCBIFHL1 [Mapview hg19]  FHL1 [Mapview hg38]
OMIM300163   300695   300696   300717   300718   
Gene and transcription
Genbank (Entrez)AF063002 AF098518 AF220153 AK091702 AK094024
RefSeq transcript (Entrez)NM_001159699 NM_001159700 NM_001159701 NM_001159702 NM_001159703 NM_001159704 NM_001167819 NM_001449
RefSeq genomic (Entrez)NC_000023 NC_018934 NG_015895 NT_011786 NW_004929446
Consensus coding sequences : CCDS (NCBI)FHL1
Cluster EST : UnigeneHs.435369 [ NCBI ]
CGAP (NCI)Hs.435369
Alternative Splicing GalleryENSG00000022267
Gene ExpressionFHL1 [ NCBI-GEO ]   FHL1 [ EBI - ARRAY_EXPRESS ]   FHL1 [ SEEK ]   FHL1 [ MEM ]
Gene Expression Viewer (FireBrowse)FHL1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2273
GTEX Portal (Tissue expression)FHL1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13642 (Uniprot)
NextProtQ13642  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13642
Splice isoforms : SwissVarQ13642 (Swissvar)
PhosPhoSitePlusQ13642
Domaine pattern : Prosite (Expaxy)LIM_DOMAIN_1 (PS00478)    LIM_DOMAIN_2 (PS50023)   
Domains : Interpro (EBI)Znf_LIM   
Domain families : Pfam (Sanger)LIM (PF00412)   
Domain families : Pfam (NCBI)pfam00412   
Domain families : Smart (EMBL)LIM (SM00132)  
DMDM Disease mutations2273
Blocks (Seattle)FHL1
PDB (SRS)1X63    2CUP    2CUR    2EGQ   
PDB (PDBSum)1X63    2CUP    2CUR    2EGQ   
PDB (IMB)1X63    2CUP    2CUR    2EGQ   
PDB (RSDB)1X63    2CUP    2CUR    2EGQ   
Structural Biology KnowledgeBase1X63    2CUP    2CUR    2EGQ   
SCOP (Structural Classification of Proteins)1X63    2CUP    2CUR    2EGQ   
CATH (Classification of proteins structures)1X63    2CUP    2CUR    2EGQ   
SuperfamilyQ13642
Human Protein AtlasENSG00000022267
Peptide AtlasQ13642
HPRD02157
IPIIPI00647207   IPI00055606   IPI00922730   IPI00922769   IPI00902610   IPI00930706   IPI00029028   IPI00014398   IPI00645286   IPI00643324   IPI00644118   IPI00644668   IPI00641404   IPI00639828   
Protein Interaction databases
DIP (DOE-UCLA)Q13642
IntAct (EBI)Q13642
FunCoupENSG00000022267
BioGRIDFHL1
STRING (EMBL)FHL1
ZODIACFHL1
Ontologies - Pathways
QuickGOQ13642
Ontology : AmiGOregulation of membrane depolarization  molecular_function  protein binding  nucleus  cytoplasm  cytosol  plasma membrane  focal adhesion  muscle organ development  zinc ion binding  organ morphogenesis  negative regulation of G2/M transition of mitotic cell cycle  cell differentiation  negative regulation of cell growth  positive regulation of potassium ion transport  ion channel binding  regulation of potassium ion transmembrane transporter activity  negative regulation of G1/S transition of mitotic cell cycle  
Ontology : EGO-EBIregulation of membrane depolarization  molecular_function  protein binding  nucleus  cytoplasm  cytosol  plasma membrane  focal adhesion  muscle organ development  zinc ion binding  organ morphogenesis  negative regulation of G2/M transition of mitotic cell cycle  cell differentiation  negative regulation of cell growth  positive regulation of potassium ion transport  ion channel binding  regulation of potassium ion transmembrane transporter activity  negative regulation of G1/S transition of mitotic cell cycle  
NDEx Network
Atlas of Cancer Signalling NetworkFHL1
Wikipedia pathwaysFHL1
Orthology - Evolution
OrthoDB2273
GeneTree (enSembl)ENSG00000022267
Phylogenetic Trees/Animal Genes : TreeFamFHL1
Homologs : HomoloGeneFHL1
Homology/Alignments : Family Browser (UCSC)FHL1
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerFHL1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FHL1
dbVarFHL1
ClinVarFHL1
1000_GenomesFHL1 
Exome Variant ServerFHL1
ExAC (Exome Aggregation Consortium)FHL1 (select the gene name)
Genetic variants : HAPMAP2273
Genomic Variants (DGV)FHL1 [DGVbeta]
Mutations
ICGC Data PortalFHL1 
TCGA Data PortalFHL1 
Broad Tumor PortalFHL1
OASIS PortalFHL1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFHL1 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)Leiden Muscular Dystrophy pages
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FHL1
DgiDB (Drug Gene Interaction Database)FHL1
DoCM (Curated mutations)FHL1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FHL1 (select a term)
intoGenFHL1
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)X:135279055-135293518  ENSG00000022267
CONAN: Copy Number AnalysisFHL1 
Mutations and Diseases : HGMDFHL1
OMIM300163    300695    300696    300717    300718   
MedgenFHL1
Genetic Testing Registry FHL1
NextProtQ13642 [Medical]
TSGene2273
GENETestsFHL1
Huge Navigator FHL1 [HugePedia]
snp3D : Map Gene to Disease2273
BioCentury BCIQFHL1
ClinGenFHL1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2273
Chemical/Pharm GKB GenePA28141
Clinical trialFHL1
Miscellaneous
canSAR (ICR)FHL1 (select the gene name)
Probes
Litterature
PubMed94 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFHL1
EVEXFHL1
GoPubMedFHL1
iHOPFHL1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat May 28 11:02:51 CEST 2016

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