FHOD1 (formin homology 2 domain containing 1)

2012-03-01  

Identity

HGNC
FHOD1
LOCATION
16q22.1
LOCUSID
29109
ALIAS
FHOS
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 29109
MIM: 606881
HGNC: 17905
Ensembl: ENSG00000135723

Variants:

dbSNP: 29109
ClinVar: 29109
TCGA: ENSG00000135723
COSMIC: FHOD1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000135723ENST00000258201Q9Y613
ENSG00000135723ENST00000561922H3BVE7
ENSG00000135723ENST00000567509J3KTH7
ENSG00000135723ENST00000567561J3KT53
ENSG00000135723ENST00000568595J3QR24

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
221445832012MicroRNA-200c represses migration and invasion of breast cancer cells by targeting actin-regulatory proteins FHOD1 and PPM1F.91
182396832008The mammalian formin FHOD1 is activated through phosphorylation by ROCK and mediates thrombin-induced stress fibre formation in endothelial cells.53
248806672014FHOD1 interaction with nesprin-2G mediates TAN line formation and nuclear movement.47
186949412008The Diaphanous-related Formin FHOD1 associates with ROCK1 and promotes Src-dependent plasma membrane blebbing.29
163612492006Biochemical characterization of the diaphanous autoregulatory interaction in the formin homology protein FHOD1.27
187863952008The human formin FHOD1 contains a bipartite structure of FH3 and GTPase-binding domains required for activation.27
234443742013FHOD1 is a combined actin filament capping and bundling factor that selectively associates with actin arcs and stress fibers.26
150517282004Formin homology domain protein (FHOD1) is a cyclic GMP-dependent protein kinase I-binding protein and substrate in vascular smooth muscle cells.18
240863982013FHOD1, a formin upregulated in epithelial-mesenchymal transition, participates in cancer cell migration and invasion.18
158783442005FHOD1 coordinates actin filament and microtubule alignment to mediate cell elongation.16

Citation

Dessen P

FHOD1 (formin homology 2 domain containing 1)

Atlas Genet Cytogenet Oncol Haematol. 2012-03-01

Online version: http://atlasgeneticsoncology.org/gene/52628/fhod1