FIS1 (fission, mitochondrial 1)

2014-09-01  

Identity

HGNC
FIS1
LOCATION
7q22.1
LOCUSID
51024
ALIAS
CGI-135,TTC11
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51024
MIM: 609003
HGNC: 21689
Ensembl: ENSG00000214253

Variants:

dbSNP: 51024
ClinVar: 51024
TCGA: ENSG00000214253
COSMIC: FIS1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000214253ENST00000223136Q9Y3D6
ENSG00000214253ENST00000435848C9JXH1
ENSG00000214253ENST00000442303F8WD11
ENSG00000214253ENST00000449367F8WBT1
ENSG00000214253ENST00000473527F5H509
ENSG00000214253ENST00000474120F5H8A8

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Mitophagy - animalKEGGko04137
Mitophagy - animalKEGGhsa04137

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
153562672004Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis.334
128610262003The mitochondrial protein hFis1 regulates mitochondrial fission in mammalian cells through an interaction with the dynamin-like protein DLP1.277
127838922003hFis1, a novel component of the mammalian mitochondrial fission machinery.219
149969422004Levels of human Fis1 at the mitochondrial outer membrane regulate mitochondrial morphology.120
211839552011Fis1 and Bap31 bridge the mitochondria-ER interface to establish a platform for apoptosis induction.120
161075622005A role for Fis1 in both mitochondrial and peroxisomal fission in mammalian cells.93
175451592007Mitochondrial fission and fusion mediators, hFis1 and OPA1, modulate cellular senescence.92
239213782013Adaptor proteins MiD49 and MiD51 can act independently of Mff and Fis1 in Drp1 recruitment and are specific for mitochondrial fission.88
168835692006Formation of elongated giant mitochondria in DFO-induced cellular senescence: involvement of enhanced fusion process through modulation of Fis1.80
185150602008High levels of Fis1, a pro-fission mitochondrial protein, trigger autophagy.74

Citation

Dessen P

FIS1 (fission, mitochondrial 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-09-01

Online version: http://atlasgeneticsoncology.org/gene/54877/fis1