Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

FIS1 (fission, mitochondrial 1)

Identity

Alias_namesTTC11
tetratricopeptide repeat domain 11
fission 1 (mitochondrial outer membrane) homolog (yeast)
fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
Alias_symbol (synonym)CGI-135
H_NH0132A01.6
Fis1
Other alias
HGNC (Hugo) FIS1
LocusID (NCBI) 51024
Atlas_Id 54877
Location 7q22.1  [Link to chromosome band 7q22]
Location_base_pair Starts at 101239612 and ends at 101245090 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FIS1 (7q22.1) / SIN3A (15q24.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)FIS1   21689
Cards
Entrez_Gene (NCBI)FIS1  51024  fission, mitochondrial 1
AliasesCGI-135; TTC11
GeneCards (Weizmann)FIS1
Ensembl hg19 (Hinxton)ENSG00000214253 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000214253 [Gene_View]  ENSG00000214253 [Sequence]  chr7:101239612-101245090 [Contig_View]  FIS1 [Vega]
ICGC DataPortalENSG00000214253
TCGA cBioPortalFIS1
AceView (NCBI)FIS1
Genatlas (Paris)FIS1
WikiGenes51024
SOURCE (Princeton)FIS1
Genetics Home Reference (NIH)FIS1
Genomic and cartography
GoldenPath hg38 (UCSC)FIS1  -     chr7:101239612-101245090 -  7q22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FIS1  -     7q22.1   [Description]    (hg19-Feb_2009)
EnsemblFIS1 - 7q22.1 [CytoView hg19]  FIS1 - 7q22.1 [CytoView hg38]
Mapping of homologs : NCBIFIS1 [Mapview hg19]  FIS1 [Mapview hg38]
OMIM609003   
Gene and transcription
Genbank (Entrez)AF151893 AK310968 AK311665 BC003540 BC009428
RefSeq transcript (Entrez)NM_016068
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FIS1
Cluster EST : UnigeneHs.423968 [ NCBI ]
CGAP (NCI)Hs.423968
Alternative Splicing GalleryENSG00000214253
Gene ExpressionFIS1 [ NCBI-GEO ]   FIS1 [ EBI - ARRAY_EXPRESS ]   FIS1 [ SEEK ]   FIS1 [ MEM ]
Gene Expression Viewer (FireBrowse)FIS1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51024
GTEX Portal (Tissue expression)FIS1
Human Protein AtlasENSG00000214253-FIS1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y3D6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y3D6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y3D6
Splice isoforms : SwissVarQ9Y3D6
PhosPhoSitePlusQ9Y3D6
Domains : Interpro (EBI)Fis1    Fis1_cytosol    Fis1_TPR_C    Fis1_TPR_N    TPR-like_helical_dom_sf   
Domain families : Pfam (Sanger)Fis1_TPR_C (PF14853)    Fis1_TPR_N (PF14852)   
Domain families : Pfam (NCBI)pfam14853    pfam14852   
Conserved Domain (NCBI)FIS1
DMDM Disease mutations51024
Blocks (Seattle)FIS1
PDB (SRS)1NZN    1PC2   
PDB (PDBSum)1NZN    1PC2   
PDB (IMB)1NZN    1PC2   
PDB (RSDB)1NZN    1PC2   
Structural Biology KnowledgeBase1NZN    1PC2   
SCOP (Structural Classification of Proteins)1NZN    1PC2   
CATH (Classification of proteins structures)1NZN    1PC2   
SuperfamilyQ9Y3D6
Human Protein Atlas [tissue]ENSG00000214253-FIS1 [tissue]
Peptide AtlasQ9Y3D6
HPRD12352
IPIIPI00007052   IPI00927916   IPI00927222   IPI00927465   IPI01011994   IPI01012374   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y3D6
IntAct (EBI)Q9Y3D6
FunCoupENSG00000214253
BioGRIDFIS1
STRING (EMBL)FIS1
ZODIACFIS1
Ontologies - Pathways
QuickGOQ9Y3D6
Ontology : AmiGOmitochondrial fission  mitochondrial fission  mitochondrial fission  autophagy of mitochondrion  autophagy of mitochondrion  release of cytochrome c from mitochondria  signaling receptor binding  protein binding  mitochondrion  mitochondrial outer membrane  peroxisome  peroxisome  integral component of peroxisomal membrane  integral component of peroxisomal membrane  endoplasmic reticulum  protein targeting to mitochondrion  apoptotic process  positive regulation of cytosolic calcium ion concentration  mitochondrial fusion  regulation of mitochondrion organization  response to muscle activity  membrane  peroxisome fission  peroxisome fission  integral component of mitochondrial outer membrane  integral component of mitochondrial outer membrane  integral component of mitochondrial outer membrane  response to nutrient levels  negative regulation of endoplasmic reticulum calcium ion concentration  protein-containing complex  calcium-mediated signaling using intracellular calcium source  positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  positive regulation of neuron apoptotic process  mitochondrial fragmentation involved in apoptotic process  mitochondrial fragmentation involved in apoptotic process  mitochondrial fragmentation involved in apoptotic process  protein-containing complex binding  protein homooligomerization  positive regulation of mitochondrial calcium ion concentration  mitochondrion morphogenesis  cellular response to glucose stimulus  positive regulation of mitochondrial fission  positive regulation of protein targeting to membrane  cellular response to toxic substance  cellular response to peptide  response to fluoride  cellular response to thapsigargin  response to flavonoid  response to hypobaric hypoxia  positive regulation of intrinsic apoptotic signaling pathway  
Ontology : EGO-EBImitochondrial fission  mitochondrial fission  mitochondrial fission  autophagy of mitochondrion  autophagy of mitochondrion  release of cytochrome c from mitochondria  signaling receptor binding  protein binding  mitochondrion  mitochondrial outer membrane  peroxisome  peroxisome  integral component of peroxisomal membrane  integral component of peroxisomal membrane  endoplasmic reticulum  protein targeting to mitochondrion  apoptotic process  positive regulation of cytosolic calcium ion concentration  mitochondrial fusion  regulation of mitochondrion organization  response to muscle activity  membrane  peroxisome fission  peroxisome fission  integral component of mitochondrial outer membrane  integral component of mitochondrial outer membrane  integral component of mitochondrial outer membrane  response to nutrient levels  negative regulation of endoplasmic reticulum calcium ion concentration  protein-containing complex  calcium-mediated signaling using intracellular calcium source  positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  positive regulation of neuron apoptotic process  mitochondrial fragmentation involved in apoptotic process  mitochondrial fragmentation involved in apoptotic process  mitochondrial fragmentation involved in apoptotic process  protein-containing complex binding  protein homooligomerization  positive regulation of mitochondrial calcium ion concentration  mitochondrion morphogenesis  cellular response to glucose stimulus  positive regulation of mitochondrial fission  positive regulation of protein targeting to membrane  cellular response to toxic substance  cellular response to peptide  response to fluoride  cellular response to thapsigargin  response to flavonoid  response to hypobaric hypoxia  positive regulation of intrinsic apoptotic signaling pathway  
NDEx NetworkFIS1
Atlas of Cancer Signalling NetworkFIS1
Wikipedia pathwaysFIS1
Orthology - Evolution
OrthoDB51024
GeneTree (enSembl)ENSG00000214253
Phylogenetic Trees/Animal Genes : TreeFamFIS1
HOVERGENQ9Y3D6
HOGENOMQ9Y3D6
Homologs : HomoloGeneFIS1
Homology/Alignments : Family Browser (UCSC)FIS1
Gene fusions - Rearrangements
Fusion : QuiverFIS1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFIS1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FIS1
dbVarFIS1
ClinVarFIS1
1000_GenomesFIS1 
Exome Variant ServerFIS1
ExAC (Exome Aggregation Consortium)ENSG00000214253
GNOMAD BrowserENSG00000214253
Varsome BrowserFIS1
Genetic variants : HAPMAP51024
Genomic Variants (DGV)FIS1 [DGVbeta]
DECIPHERFIS1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFIS1 
Mutations
ICGC Data PortalFIS1 
TCGA Data PortalFIS1 
Broad Tumor PortalFIS1
OASIS PortalFIS1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFIS1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFIS1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch FIS1
DgiDB (Drug Gene Interaction Database)FIS1
DoCM (Curated mutations)FIS1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FIS1 (select a term)
intoGenFIS1
Cancer3DFIS1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609003   
Orphanet
DisGeNETFIS1
MedgenFIS1
Genetic Testing Registry FIS1
NextProtQ9Y3D6 [Medical]
TSGene51024
GENETestsFIS1
Target ValidationFIS1
Huge Navigator FIS1 [HugePedia]
snp3D : Map Gene to Disease51024
BioCentury BCIQFIS1
ClinGenFIS1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD51024
Chemical/Pharm GKB GenePA134984211
Clinical trialFIS1
Miscellaneous
canSAR (ICR)FIS1 (select the gene name)
Probes
Litterature
PubMed63 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFIS1
EVEXFIS1
GoPubMedFIS1
iHOPFIS1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:06:43 CET 2018

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.