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FKBP1A (FK506 binding protein 1A)

Identity

Alias_namesFKBP1
FK506-binding protein 1A (12kD)
FK506 binding protein 1A, 12kDa
Alias_symbol (synonym)FKBP-12
FKBP12
PKC12
PPIASE
FKBP12C
Other aliasFKBP-1A
PKCI2
HGNC (Hugo) FKBP1A
LocusID (NCBI) 2280
Atlas_Id 50277
Location 20p13  [Link to chromosome band 20p13]
Location_base_pair Starts at 1368977 and ends at 1393172 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
FKBP1A (20p13) / CDS2 (20p12.3)FKBP1A (20p13) / SDCBP2 (20p13)FKBP1A 20p13 / CDS2 20p12.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)FKBP1A   3711
Cards
Entrez_Gene (NCBI)FKBP1A  2280  FK506 binding protein 1A
AliasesFKBP-12; FKBP-1A; FKBP1; FKBP12; 
PKC12; PKCI2; PPIASE
GeneCards (Weizmann)FKBP1A
Ensembl hg19 (Hinxton)ENSG00000088832 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000088832 [Gene_View]  chr20:1368977-1393172 [Contig_View]  FKBP1A [Vega]
ICGC DataPortalENSG00000088832
TCGA cBioPortalFKBP1A
AceView (NCBI)FKBP1A
Genatlas (Paris)FKBP1A
WikiGenes2280
SOURCE (Princeton)FKBP1A
Genetics Home Reference (NIH)FKBP1A
Genomic and cartography
GoldenPath hg38 (UCSC)FKBP1A  -     chr20:1368977-1393172 -  20p13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FKBP1A  -     20p13   [Description]    (hg19-Feb_2009)
EnsemblFKBP1A - 20p13 [CytoView hg19]  FKBP1A - 20p13 [CytoView hg38]
Mapping of homologs : NCBIFKBP1A [Mapview hg19]  FKBP1A [Mapview hg38]
OMIM186945   
Gene and transcription
Genbank (Entrez)AA731598 AB241123 AB241124 AB241125 AF205192
RefSeq transcript (Entrez)NM_000801 NM_001199786 NM_054014
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FKBP1A
Cluster EST : UnigeneHs.700839 [ NCBI ]
CGAP (NCI)Hs.700839
Alternative Splicing GalleryENSG00000088832
Gene ExpressionFKBP1A [ NCBI-GEO ]   FKBP1A [ EBI - ARRAY_EXPRESS ]   FKBP1A [ SEEK ]   FKBP1A [ MEM ]
Gene Expression Viewer (FireBrowse)FKBP1A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2280
GTEX Portal (Tissue expression)FKBP1A
Protein : pattern, domain, 3D structure
UniProt/SwissProtP62942   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP62942  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP62942
Splice isoforms : SwissVarP62942
Catalytic activity : Enzyme5.2.1.8 [ Enzyme-Expasy ]   5.2.1.85.2.1.8 [ IntEnz-EBI ]   5.2.1.8 [ BRENDA ]   5.2.1.8 [ KEGG ]   
PhosPhoSitePlusP62942
Domaine pattern : Prosite (Expaxy)FKBP_PPIASE (PS50059)   
Domains : Interpro (EBI)PPIase_FKBP    PPIase_FKBP_dom   
Domain families : Pfam (Sanger)FKBP_C (PF00254)   
Domain families : Pfam (NCBI)pfam00254   
Conserved Domain (NCBI)FKBP1A
DMDM Disease mutations2280
Blocks (Seattle)FKBP1A
PDB (SRS)1A7X    1B6C    1BKF    1BL4    1D6O    1D7H    1D7I    1D7J    1EYM    1F40    1FAP    1FKB    1FKD    1FKF    1FKG    1FKH    1FKI    1FKJ    1FKR    1FKS    1FKT    1J4H    1J4I    1J4R    1NSG    1QPF    1QPL    2DG3    2DG4    2DG9    2FAP    2FKE    2PPN    2PPO    2PPP    2RSE    3FAP    3H9R    3MDY    4DH0    4FAP    4IPX    4N19    4ODP    4ODQ    4ODR   
PDB (PDBSum)1A7X    1B6C    1BKF    1BL4    1D6O    1D7H    1D7I    1D7J    1EYM    1F40    1FAP    1FKB    1FKD    1FKF    1FKG    1FKH    1FKI    1FKJ    1FKR    1FKS    1FKT    1J4H    1J4I    1J4R    1NSG    1QPF    1QPL    2DG3    2DG4    2DG9    2FAP    2FKE    2PPN    2PPO    2PPP    2RSE    3FAP    3H9R    3MDY    4DH0    4FAP    4IPX    4N19    4ODP    4ODQ    4ODR   
PDB (IMB)1A7X    1B6C    1BKF    1BL4    1D6O    1D7H    1D7I    1D7J    1EYM    1F40    1FAP    1FKB    1FKD    1FKF    1FKG    1FKH    1FKI    1FKJ    1FKR    1FKS    1FKT    1J4H    1J4I    1J4R    1NSG    1QPF    1QPL    2DG3    2DG4    2DG9    2FAP    2FKE    2PPN    2PPO    2PPP    2RSE    3FAP    3H9R    3MDY    4DH0    4FAP    4IPX    4N19    4ODP    4ODQ    4ODR   
PDB (RSDB)1A7X    1B6C    1BKF    1BL4    1D6O    1D7H    1D7I    1D7J    1EYM    1F40    1FAP    1FKB    1FKD    1FKF    1FKG    1FKH    1FKI    1FKJ    1FKR    1FKS    1FKT    1J4H    1J4I    1J4R    1NSG    1QPF    1QPL    2DG3    2DG4    2DG9    2FAP    2FKE    2PPN    2PPO    2PPP    2RSE    3FAP    3H9R    3MDY    4DH0    4FAP    4IPX    4N19    4ODP    4ODQ    4ODR   
Structural Biology KnowledgeBase1A7X    1B6C    1BKF    1BL4    1D6O    1D7H    1D7I    1D7J    1EYM    1F40    1FAP    1FKB    1FKD    1FKF    1FKG    1FKH    1FKI    1FKJ    1FKR    1FKS    1FKT    1J4H    1J4I    1J4R    1NSG    1QPF    1QPL    2DG3    2DG4    2DG9    2FAP    2FKE    2PPN    2PPO    2PPP    2RSE    3FAP    3H9R    3MDY    4DH0    4FAP    4IPX    4N19    4ODP    4ODQ    4ODR   
SCOP (Structural Classification of Proteins)1A7X    1B6C    1BKF    1BL4    1D6O    1D7H    1D7I    1D7J    1EYM    1F40    1FAP    1FKB    1FKD    1FKF    1FKG    1FKH    1FKI    1FKJ    1FKR    1FKS    1FKT    1J4H    1J4I    1J4R    1NSG    1QPF    1QPL    2DG3    2DG4    2DG9    2FAP    2FKE    2PPN    2PPO    2PPP    2RSE    3FAP    3H9R    3MDY    4DH0    4FAP    4IPX    4N19    4ODP    4ODQ    4ODR   
CATH (Classification of proteins structures)1A7X    1B6C    1BKF    1BL4    1D6O    1D7H    1D7I    1D7J    1EYM    1F40    1FAP    1FKB    1FKD    1FKF    1FKG    1FKH    1FKI    1FKJ    1FKR    1FKS    1FKT    1J4H    1J4I    1J4R    1NSG    1QPF    1QPL    2DG3    2DG4    2DG9    2FAP    2FKE    2PPN    2PPO    2PPP    2RSE    3FAP    3H9R    3MDY    4DH0    4FAP    4IPX    4N19    4ODP    4ODQ    4ODR   
SuperfamilyP62942
Human Protein AtlasENSG00000088832
Peptide AtlasP62942
HPRD01741
IPIIPI00413778   IPI01018111   IPI00759644   IPI00647507   
Protein Interaction databases
DIP (DOE-UCLA)P62942
IntAct (EBI)P62942
FunCoupENSG00000088832
BioGRIDFKBP1A
STRING (EMBL)FKBP1A
ZODIACFKBP1A
Ontologies - Pathways
QuickGOP62942
Ontology : AmiGOprotein peptidyl-prolyl isomerization  heart morphogenesis  peptidyl-prolyl cis-trans isomerase activity  peptidyl-prolyl cis-trans isomerase activity  signal transducer activity  transforming growth factor beta receptor binding  transforming growth factor beta receptor binding  protein binding  macrolide binding  FK506 binding  FK506 binding  cytoplasm  cytosol  cytosol  protein folding  'de novo' protein folding  transforming growth factor beta receptor signaling pathway  SMAD protein complex assembly  terminal cisterna  membrane  calcium channel inhibitor activity  protein maturation by protein folding  Z disc  positive regulation of protein ubiquitination  positive regulation of protein binding  negative regulation of phosphoprotein phosphatase activity  regulation of protein localization  regulation of activin receptor signaling pathway  type I transforming growth factor beta receptor binding  protein refolding  T cell activation  positive regulation of I-kappaB kinase/NF-kappaB signaling  ion channel binding  ion channel binding  SMAD binding  activin binding  regulation of immune response  negative regulation of release of sequestered calcium ion into cytosol  ventricular cardiac muscle tissue morphogenesis  regulation of ryanodine-sensitive calcium-release channel activity  regulation of ryanodine-sensitive calcium-release channel activity  negative regulation of ryanodine-sensitive calcium-release channel activity  heart trabecula formation  chaperone-mediated protein folding  extracellular exosome  calcium ion transmembrane transport  supramolecular fiber organization  regulation of amyloid precursor protein catabolic process  amyloid fibril formation  
Ontology : EGO-EBIprotein peptidyl-prolyl isomerization  heart morphogenesis  peptidyl-prolyl cis-trans isomerase activity  peptidyl-prolyl cis-trans isomerase activity  signal transducer activity  transforming growth factor beta receptor binding  transforming growth factor beta receptor binding  protein binding  macrolide binding  FK506 binding  FK506 binding  cytoplasm  cytosol  cytosol  protein folding  'de novo' protein folding  transforming growth factor beta receptor signaling pathway  SMAD protein complex assembly  terminal cisterna  membrane  calcium channel inhibitor activity  protein maturation by protein folding  Z disc  positive regulation of protein ubiquitination  positive regulation of protein binding  negative regulation of phosphoprotein phosphatase activity  regulation of protein localization  regulation of activin receptor signaling pathway  type I transforming growth factor beta receptor binding  protein refolding  T cell activation  positive regulation of I-kappaB kinase/NF-kappaB signaling  ion channel binding  ion channel binding  SMAD binding  activin binding  regulation of immune response  negative regulation of release of sequestered calcium ion into cytosol  ventricular cardiac muscle tissue morphogenesis  regulation of ryanodine-sensitive calcium-release channel activity  regulation of ryanodine-sensitive calcium-release channel activity  negative regulation of ryanodine-sensitive calcium-release channel activity  heart trabecula formation  chaperone-mediated protein folding  extracellular exosome  calcium ion transmembrane transport  supramolecular fiber organization  regulation of amyloid precursor protein catabolic process  amyloid fibril formation  
NDEx NetworkFKBP1A
Atlas of Cancer Signalling NetworkFKBP1A
Wikipedia pathwaysFKBP1A
Orthology - Evolution
OrthoDB2280
GeneTree (enSembl)ENSG00000088832
Phylogenetic Trees/Animal Genes : TreeFamFKBP1A
HOVERGENP62942
HOGENOMP62942
Homologs : HomoloGeneFKBP1A
Homology/Alignments : Family Browser (UCSC)FKBP1A
Gene fusions - Rearrangements
Fusion : MitelmanFKBP1A/CDS2 [20p13/20p12.3]  
Fusion: TCGAFKBP1A 20p13 CDS2 20p12.3 HNSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFKBP1A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FKBP1A
dbVarFKBP1A
ClinVarFKBP1A
1000_GenomesFKBP1A 
Exome Variant ServerFKBP1A
ExAC (Exome Aggregation Consortium)FKBP1A (select the gene name)
Genetic variants : HAPMAP2280
Genomic Variants (DGV)FKBP1A [DGVbeta]
DECIPHERFKBP1A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFKBP1A 
Mutations
ICGC Data PortalFKBP1A 
TCGA Data PortalFKBP1A 
Broad Tumor PortalFKBP1A
OASIS PortalFKBP1A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFKBP1A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFKBP1A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FKBP1A
DgiDB (Drug Gene Interaction Database)FKBP1A
DoCM (Curated mutations)FKBP1A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FKBP1A (select a term)
intoGenFKBP1A
Cancer3DFKBP1A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM186945   
Orphanet
MedgenFKBP1A
Genetic Testing Registry FKBP1A
NextProtP62942 [Medical]
TSGene2280
GENETestsFKBP1A
Huge Navigator FKBP1A [HugePedia]
snp3D : Map Gene to Disease2280
BioCentury BCIQFKBP1A
ClinGenFKBP1A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2280
Chemical/Pharm GKB GenePA28153
Clinical trialFKBP1A
Miscellaneous
canSAR (ICR)FKBP1A (select the gene name)
Probes
Litterature
PubMed132 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFKBP1A
EVEXFKBP1A
GoPubMedFKBP1A
iHOPFKBP1A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:16:05 CEST 2017

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