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FKBP1B (FK506 binding protein 1B)

Identity

Alias_namesFKBP1L
FK506-binding protein 1B (12.6 kD)
FK506 binding protein 1B, 12.6 kDa
Alias_symbol (synonym)OTK4
FKBP12.6
PPIase
FKBP9
Other aliasPKBP1L
HGNC (Hugo) FKBP1B
LocusID (NCBI) 2281
Atlas_Id 56208
Location 2p23.3  [Link to chromosome band 2p23]
Location_base_pair Starts at 24272571 and ends at 24286550 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)FKBP1B   3712
Cards
Entrez_Gene (NCBI)FKBP1B  2281  FK506 binding protein 1B
AliasesFKBP12.6; FKBP1L; OTK4; PKBP1L; 
PPIase
GeneCards (Weizmann)FKBP1B
Ensembl hg19 (Hinxton)ENSG00000119782 [Gene_View]  chr2:24272571-24286550 [Contig_View]  FKBP1B [Vega]
Ensembl hg38 (Hinxton)ENSG00000119782 [Gene_View]  chr2:24272571-24286550 [Contig_View]  FKBP1B [Vega]
ICGC DataPortalENSG00000119782
TCGA cBioPortalFKBP1B
AceView (NCBI)FKBP1B
Genatlas (Paris)FKBP1B
WikiGenes2281
SOURCE (Princeton)FKBP1B
Genetics Home Reference (NIH)FKBP1B
Genomic and cartography
GoldenPath hg19 (UCSC)FKBP1B  -     chr2:24272571-24286550 +  2p23.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)FKBP1B  -     2p23.3   [Description]    (hg38-Dec_2013)
EnsemblFKBP1B - 2p23.3 [CytoView hg19]  FKBP1B - 2p23.3 [CytoView hg38]
Mapping of homologs : NCBIFKBP1B [Mapview hg19]  FKBP1B [Mapview hg38]
OMIM600620   
Gene and transcription
Genbank (Entrez)-
RefSeq transcript (Entrez)NM_001322963 NM_001322964 NM_004116 NM_054033
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FKBP1B
Cluster EST : UnigeneHs.709461 [ NCBI ]
CGAP (NCI)Hs.709461
Alternative Splicing GalleryENSG00000119782
Gene ExpressionFKBP1B [ NCBI-GEO ]   FKBP1B [ EBI - ARRAY_EXPRESS ]   FKBP1B [ SEEK ]   FKBP1B [ MEM ]
Gene Expression Viewer (FireBrowse)FKBP1B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2281
GTEX Portal (Tissue expression)FKBP1B
Protein : pattern, domain, 3D structure
UniProt/SwissProtP68106   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP68106  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP68106
Splice isoforms : SwissVarP68106
Catalytic activity : Enzyme5.2.1.8 [ Enzyme-Expasy ]   5.2.1.85.2.1.8 [ IntEnz-EBI ]   5.2.1.8 [ BRENDA ]   5.2.1.8 [ KEGG ]   
PhosPhoSitePlusP68106
Domaine pattern : Prosite (Expaxy)FKBP_PPIASE (PS50059)   
Domains : Interpro (EBI)PPIase_FKBP    PPIase_FKBP_dom   
Domain families : Pfam (Sanger)FKBP_C (PF00254)   
Domain families : Pfam (NCBI)pfam00254   
Conserved Domain (NCBI)FKBP1B
DMDM Disease mutations2281
Blocks (Seattle)FKBP1B
PDB (SRS)1C9H    3J8E    4C02    4IQ2    4IQC   
PDB (PDBSum)1C9H    3J8E    4C02    4IQ2    4IQC   
PDB (IMB)1C9H    3J8E    4C02    4IQ2    4IQC   
PDB (RSDB)1C9H    3J8E    4C02    4IQ2    4IQC   
Structural Biology KnowledgeBase1C9H    3J8E    4C02    4IQ2    4IQC   
SCOP (Structural Classification of Proteins)1C9H    3J8E    4C02    4IQ2    4IQC   
CATH (Classification of proteins structures)1C9H    3J8E    4C02    4IQ2    4IQC   
SuperfamilyP68106
Human Protein AtlasENSG00000119782
Peptide AtlasP68106
HPRD02795
IPIIPI00396151   IPI00073704   IPI00894000   IPI00893649   IPI00893382   
Protein Interaction databases
DIP (DOE-UCLA)P68106
IntAct (EBI)P68106
FunCoupENSG00000119782
BioGRIDFKBP1B
STRING (EMBL)FKBP1B
ZODIACFKBP1B
Ontologies - Pathways
QuickGOP68106
Ontology : AmiGOprotein peptidyl-prolyl isomerization  peptidyl-prolyl cis-trans isomerase activity  receptor binding  ryanodine-sensitive calcium-release channel activity  protein binding  FK506 binding  cytoplasm  cytosol  'de novo' protein folding  smooth muscle contraction  response to glucose  negative regulation of heart rate  regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum  regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion  regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion  release of sequestered calcium ion into cytosol by sarcoplasmic reticulum  membrane  neuronal action potential propagation  calcium channel inhibitor activity  protein maturation by protein folding  Z disc  insulin secretion  cyclic nucleotide binding  negative regulation of protein phosphatase type 2B activity  sarcoplasmic reticulum membrane  sarcoplasmic reticulum membrane  response to vitamin E  ion transmembrane transport  calcium channel complex  calcium-mediated signaling using intracellular calcium source  protein refolding  T cell proliferation  response to hydrogen peroxide  ion channel binding  positive regulation of axon regeneration  negative regulation of release of sequestered calcium ion into cytosol  positive regulation of sequestering of calcium ion  regulation of cytosolic calcium ion concentration  regulation of cytosolic calcium ion concentration  response to redox state  regulation of ryanodine-sensitive calcium-release channel activity  regulation of ryanodine-sensitive calcium-release channel activity  regulation of ryanodine-sensitive calcium-release channel activity  negative regulation of ryanodine-sensitive calcium-release channel activity  chaperone-mediated protein folding  negative regulation of insulin secretion involved in cellular response to glucose stimulus  cell communication by electrical coupling involved in cardiac conduction  regulation of cardiac conduction  
Ontology : EGO-EBIprotein peptidyl-prolyl isomerization  peptidyl-prolyl cis-trans isomerase activity  receptor binding  ryanodine-sensitive calcium-release channel activity  protein binding  FK506 binding  cytoplasm  cytosol  'de novo' protein folding  smooth muscle contraction  response to glucose  negative regulation of heart rate  regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum  regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion  regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion  release of sequestered calcium ion into cytosol by sarcoplasmic reticulum  membrane  neuronal action potential propagation  calcium channel inhibitor activity  protein maturation by protein folding  Z disc  insulin secretion  cyclic nucleotide binding  negative regulation of protein phosphatase type 2B activity  sarcoplasmic reticulum membrane  sarcoplasmic reticulum membrane  response to vitamin E  ion transmembrane transport  calcium channel complex  calcium-mediated signaling using intracellular calcium source  protein refolding  T cell proliferation  response to hydrogen peroxide  ion channel binding  positive regulation of axon regeneration  negative regulation of release of sequestered calcium ion into cytosol  positive regulation of sequestering of calcium ion  regulation of cytosolic calcium ion concentration  regulation of cytosolic calcium ion concentration  response to redox state  regulation of ryanodine-sensitive calcium-release channel activity  regulation of ryanodine-sensitive calcium-release channel activity  regulation of ryanodine-sensitive calcium-release channel activity  negative regulation of ryanodine-sensitive calcium-release channel activity  chaperone-mediated protein folding  negative regulation of insulin secretion involved in cellular response to glucose stimulus  cell communication by electrical coupling involved in cardiac conduction  regulation of cardiac conduction  
NDEx NetworkFKBP1B
Atlas of Cancer Signalling NetworkFKBP1B
Wikipedia pathwaysFKBP1B
Orthology - Evolution
OrthoDB2281
GeneTree (enSembl)ENSG00000119782
Phylogenetic Trees/Animal Genes : TreeFamFKBP1B
HOVERGENP68106
HOGENOMP68106
Homologs : HomoloGeneFKBP1B
Homology/Alignments : Family Browser (UCSC)FKBP1B
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFKBP1B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FKBP1B
dbVarFKBP1B
ClinVarFKBP1B
1000_GenomesFKBP1B 
Exome Variant ServerFKBP1B
ExAC (Exome Aggregation Consortium)FKBP1B (select the gene name)
Genetic variants : HAPMAP2281
Genomic Variants (DGV)FKBP1B [DGVbeta]
DECIPHER (Syndromes)2:24272571-24286550  ENSG00000119782
CONAN: Copy Number AnalysisFKBP1B 
Mutations
ICGC Data PortalFKBP1B 
TCGA Data PortalFKBP1B 
Broad Tumor PortalFKBP1B
OASIS PortalFKBP1B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFKBP1B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFKBP1B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FKBP1B
DgiDB (Drug Gene Interaction Database)FKBP1B
DoCM (Curated mutations)FKBP1B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FKBP1B (select a term)
intoGenFKBP1B
Cancer3DFKBP1B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600620   
Orphanet
MedgenFKBP1B
Genetic Testing Registry FKBP1B
NextProtP68106 [Medical]
TSGene2281
GENETestsFKBP1B
Huge Navigator FKBP1B [HugePedia]
snp3D : Map Gene to Disease2281
BioCentury BCIQFKBP1B
ClinGenFKBP1B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2281
Chemical/Pharm GKB GenePA28154
Clinical trialFKBP1B
Miscellaneous
canSAR (ICR)FKBP1B (select the gene name)
Probes
Litterature
PubMed36 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFKBP1B
EVEXFKBP1B
GoPubMedFKBP1B
iHOPFKBP1B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:06:15 CET 2017

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