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FKBP2 (FK506 binding protein 2)

Identity

Alias_namesFK506-binding protein 2 (13kD)
FK506 binding protein 2, 13kDa
Alias_symbol (synonym)FKBP-13
PPIase
Other alias
HGNC (Hugo) FKBP2
LocusID (NCBI) 2286
Atlas_Id 63397
Location 11q13.1  [Link to chromosome band 11q13]
Location_base_pair Starts at 64241132 and ends at 64244135 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DPP3 (11q13.2) / FKBP2 (11q13.1)FKBP2 (11q13.1) / PLEC (8q24.3)FKBP2 (11q13.1) / TRIM8 (10q24.32)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(11;11)(q13;q13) DPP3/FKBP2

External links

Nomenclature
HGNC (Hugo)FKBP2   3718
Cards
Entrez_Gene (NCBI)FKBP2  2286  FK506 binding protein 2
AliasesFKBP-13; PPIase
GeneCards (Weizmann)FKBP2
Ensembl hg19 (Hinxton)ENSG00000173486 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000173486 [Gene_View]  ENSG00000173486 [Sequence]  chr11:64241132-64244135 [Contig_View]  FKBP2 [Vega]
ICGC DataPortalENSG00000173486
TCGA cBioPortalFKBP2
AceView (NCBI)FKBP2
Genatlas (Paris)FKBP2
WikiGenes2286
SOURCE (Princeton)FKBP2
Genetics Home Reference (NIH)FKBP2
Genomic and cartography
GoldenPath hg38 (UCSC)FKBP2  -     chr11:64241132-64244135 +  11q13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FKBP2  -     11q13.1   [Description]    (hg19-Feb_2009)
EnsemblFKBP2 - 11q13.1 [CytoView hg19]  FKBP2 - 11q13.1 [CytoView hg38]
Mapping of homologs : NCBIFKBP2 [Mapview hg19]  FKBP2 [Mapview hg38]
OMIM186946   
Gene and transcription
Genbank (Entrez)AW450265 BC003384 BC091475 BT009861 BU682774
RefSeq transcript (Entrez)NM_001135208 NM_004470 NM_057092
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FKBP2
Cluster EST : UnigeneHs.227729 [ NCBI ]
CGAP (NCI)Hs.227729
Alternative Splicing GalleryENSG00000173486
Gene ExpressionFKBP2 [ NCBI-GEO ]   FKBP2 [ EBI - ARRAY_EXPRESS ]   FKBP2 [ SEEK ]   FKBP2 [ MEM ]
Gene Expression Viewer (FireBrowse)FKBP2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2286
GTEX Portal (Tissue expression)FKBP2
Human Protein AtlasENSG00000173486-FKBP2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP26885   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP26885  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP26885
Splice isoforms : SwissVarP26885
Catalytic activity : Enzyme5.2.1.8 [ Enzyme-Expasy ]   5.2.1.85.2.1.8 [ IntEnz-EBI ]   5.2.1.8 [ BRENDA ]   5.2.1.8 [ KEGG ]   
PhosPhoSitePlusP26885
Domaine pattern : Prosite (Expaxy)FKBP_PPIASE (PS50059)   
Domains : Interpro (EBI)PPIase_FKBP    PPIase_FKBP_dom   
Domain families : Pfam (Sanger)FKBP_C (PF00254)   
Domain families : Pfam (NCBI)pfam00254   
Conserved Domain (NCBI)FKBP2
DMDM Disease mutations2286
Blocks (Seattle)FKBP2
PDB (SRS)2PBC    4NNR   
PDB (PDBSum)2PBC    4NNR   
PDB (IMB)2PBC    4NNR   
PDB (RSDB)2PBC    4NNR   
Structural Biology KnowledgeBase2PBC    4NNR   
SCOP (Structural Classification of Proteins)2PBC    4NNR   
CATH (Classification of proteins structures)2PBC    4NNR   
SuperfamilyP26885
Human Protein Atlas [tissue]ENSG00000173486-FKBP2 [tissue]
Peptide AtlasP26885
HPRD01742
IPIIPI00002535   IPI01013732   
Protein Interaction databases
DIP (DOE-UCLA)P26885
IntAct (EBI)P26885
FunCoupENSG00000173486
BioGRIDFKBP2
STRING (EMBL)FKBP2
ZODIACFKBP2
Ontologies - Pathways
QuickGOP26885
Ontology : AmiGOprotein peptidyl-prolyl isomerization  peptidyl-prolyl cis-trans isomerase activity  protein binding  FK506 binding  endoplasmic reticulum  endoplasmic reticulum membrane  chaperone-mediated protein folding  extracellular exosome  
Ontology : EGO-EBIprotein peptidyl-prolyl isomerization  peptidyl-prolyl cis-trans isomerase activity  protein binding  FK506 binding  endoplasmic reticulum  endoplasmic reticulum membrane  chaperone-mediated protein folding  extracellular exosome  
NDEx NetworkFKBP2
Atlas of Cancer Signalling NetworkFKBP2
Wikipedia pathwaysFKBP2
Orthology - Evolution
OrthoDB2286
GeneTree (enSembl)ENSG00000173486
Phylogenetic Trees/Animal Genes : TreeFamFKBP2
HOVERGENP26885
HOGENOMP26885
Homologs : HomoloGeneFKBP2
Homology/Alignments : Family Browser (UCSC)FKBP2
Gene fusions - Rearrangements
Fusion : QuiverFKBP2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFKBP2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FKBP2
dbVarFKBP2
ClinVarFKBP2
1000_GenomesFKBP2 
Exome Variant ServerFKBP2
ExAC (Exome Aggregation Consortium)ENSG00000173486
GNOMAD BrowserENSG00000173486
Varsome BrowserFKBP2
Genetic variants : HAPMAP2286
Genomic Variants (DGV)FKBP2 [DGVbeta]
DECIPHERFKBP2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFKBP2 
Mutations
ICGC Data PortalFKBP2 
TCGA Data PortalFKBP2 
Broad Tumor PortalFKBP2
OASIS PortalFKBP2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFKBP2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFKBP2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FKBP2
DgiDB (Drug Gene Interaction Database)FKBP2
DoCM (Curated mutations)FKBP2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FKBP2 (select a term)
intoGenFKBP2
Cancer3DFKBP2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM186946   
Orphanet
DisGeNETFKBP2
MedgenFKBP2
Genetic Testing Registry FKBP2
NextProtP26885 [Medical]
TSGene2286
GENETestsFKBP2
Target ValidationFKBP2
Huge Navigator FKBP2 [HugePedia]
snp3D : Map Gene to Disease2286
BioCentury BCIQFKBP2
ClinGenFKBP2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2286
Chemical/Pharm GKB GenePA28159
Clinical trialFKBP2
Miscellaneous
canSAR (ICR)FKBP2 (select the gene name)
Probes
Litterature
PubMed23 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFKBP2
EVEXFKBP2
GoPubMedFKBP2
iHOPFKBP2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Jul 30 13:46:01 CEST 2018
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