FKBP3 (FKBP prolyl isomerase 3)

2018-07-01  

Identity

HGNC
FKBP3
LOCATION
14q21.2
LOCUSID
2287
ALIAS
FKBP-25,FKBP-3,FKBP25,PPIase
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2287
MIM: 186947
HGNC: 3719
Ensembl: ENSG00000100442

Variants:

dbSNP: 2287
ClinVar: 2287
TCGA: ENSG00000100442
COSMIC: FKBP3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100442ENST00000216330Q00688
ENSG00000100442ENST00000396062Q00688
ENSG00000100442ENST00000557324G3V5F2

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
191668402009FKBP25, a novel regulator of the p53 pathway, induces the degradation of MDM2 and activation of p53.25
288394652017FKBP3 Promotes Proliferation of Non-Small Cell Lung Cancer Cells through Regulating Sp1/HDAC2/p27.16
248409432014The prolyl isomerase, FKBP25, interacts with RNA-engaged nucleolin and the pre-60S ribosomal subunit.15
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
246676072014Basic Tilted Helix Bundle - a new protein fold in human FKBP25/FKBP3 and HectD1.8
249984442014Rapamycin-binding FKBP25 associates with diverse proteins that form large intracellular entities.7
267629752016Structural basis of nucleic acid recognition by FK506-binding protein 25 (FKBP25), a nuclear immunophilin.6
293611762018The prolyl isomerase FKBP25 regulates microtubule polymerization impacting cell cycle progression and genomic stability.5
290366382017The basic tilted helix bundle domain of the prolyl isomerase FKBP25 is a novel double-stranded RNA binding module.3

Citation

Dessen P

FKBP3 (FKBP prolyl isomerase 3)

Atlas Genet Cytogenet Oncol Haematol. 2018-07-01

Online version: http://atlasgeneticsoncology.org/gene/57509/fkbp3