FKBP4 (FKBP prolyl isomerase 4)

2007-02-01  

Identity

HGNC
LOCATION
12p13.33
LOCUSID
ALIAS
FKBP51,FKBP52,FKBP59,HBI,Hsp56,PPIase,p52
FUSION GENES

Other Information

Locus ID:

NCBI: 2288
MIM: 600611
HGNC: 3720
Ensembl: ENSG00000004478

Variants:

dbSNP: 2288
ClinVar: 2288
TCGA: ENSG00000004478
COSMIC: FKBP4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000004478ENST00000001008Q02790
ENSG00000004478ENST00000538622F5H1U3
ENSG00000004478ENST00000539181H0YFG2
ENSG00000004478ENST00000543769F5H120
ENSG00000004478ENST00000544366H0YG86
ENSG00000004478ENST00000630279F5H120

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Estrogen signaling pathwayKEGGhsa04915
Estrogen signaling pathwayKEGGko04915
Cellular responses to stressREACTOMER-HSA-2262752
Cellular response to heat stressREACTOMER-HSA-3371556
HSF1-dependent transactivationREACTOMER-HSA-3371571
Attenuation phaseREACTOMER-HSA-3371568

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
155910612005FK506-binding proteins 51 and 52 differentially regulate dynein interaction and nuclear translocation of the glucocorticoid receptor in mammalian cells.184
126065802003The Hsp90-binding peptidylprolyl isomerase FKBP52 potentiates glucocorticoid signaling in vivo.101
158315252005Physiological role for the cochaperone FKBP52 in androgen receptor signaling.72
1515955020043D structure of human FK506-binding protein 52: implications for the assembly of the glucocorticoid receptor/Hsp90/immunophilin heterocomplex.59
168734452006FK506-binding protein 52 is essential to uterine reproductive physiology controlled by the progesterone receptor A isoform.47
195455462009Modulation of glucocorticoid receptor nuclear translocation in neurons by immunophilins FKBP51 and FKBP52: implications for major depressive disorder.40
201338042010A role for FKBP52 in Tau protein function.40
192548102009The glucocorticoid receptor heterocomplex gene STIP1 is associated with improved lung function in asthmatic subjects treated with inhaled corticosteroids.39
126035282003Wnt signaling in hepatocellular carcinoma: analysis of mutation and expression of beta-catenin, T-cell factor-4 and glycogen synthase kinase 3-beta genes.37
181625402008Binding of rapamycin analogs to calcium channels and FKBP52 contributes to their neuroprotective activities.31

Citation

Dessen P

FKBP4 (FKBP prolyl isomerase 4)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45694/fkbp4