Atlas of Genetics and Cytogenetics in Oncology and Haematology

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FKBP4 (FKBP prolyl isomerase 4)

Identity

Alias_namesFK506-binding protein 4 (59kD)
FK506 binding protein 4, 59kDa
Alias_symbol (synonym)FKBP59
FKBP52
Other aliasFKBP51
HBI
Hsp56
PPIase
p52
HGNC (Hugo) FKBP4
LocusID (NCBI) 2288
Atlas_Id 45694
Location 12p13.33  [Link to chromosome band 12p13]
Location_base_pair Starts at 2794942 and ends at 2805421 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FKBP4 (12p13.33) / DIP2C (10p15.3)FKBP4 (12p13.33) / EIF5A (17p13.1)FKBP4 (12p13.33) / FKBP4 (12p13.33)
FKBP4 (12p13.33) / NARS (18q21.31)FKBP4 (12p13.33) / PMVK (1q21.3)FKBP4 (12p13.33) / ZFR (5p13.3)
NMT2 (10p13) / FKBP4 (12p13.33)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)FKBP4   3720
Cards
Entrez_Gene (NCBI)FKBP4  2288  FKBP prolyl isomerase 4
AliasesFKBP51; FKBP52; FKBP59; HBI; 
Hsp56; PPIase; p52
GeneCards (Weizmann)FKBP4
Ensembl hg19 (Hinxton)ENSG00000004478 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000004478 [Gene_View]  ENSG00000004478 [Sequence]  chr12:2794942-2805421 [Contig_View]  FKBP4 [Vega]
ICGC DataPortalENSG00000004478
TCGA cBioPortalFKBP4
AceView (NCBI)FKBP4
Genatlas (Paris)FKBP4
WikiGenes2288
SOURCE (Princeton)FKBP4
Genetics Home Reference (NIH)FKBP4
Genomic and cartography
GoldenPath hg38 (UCSC)FKBP4  -     chr12:2794942-2805421 +  12p13.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FKBP4  -     12p13.33   [Description]    (hg19-Feb_2009)
EnsemblFKBP4 - 12p13.33 [CytoView hg19]  FKBP4 - 12p13.33 [CytoView hg38]
Mapping of homologs : NCBIFKBP4 [Mapview hg19]  FKBP4 [Mapview hg38]
OMIM600611   
Gene and transcription
Genbank (Entrez)AK024694 AK313918 BC001786 BC002887 BC007924
RefSeq transcript (Entrez)NM_002014
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FKBP4
Cluster EST : UnigeneHs.713721 [ NCBI ]
CGAP (NCI)Hs.713721
Alternative Splicing GalleryENSG00000004478
Gene ExpressionFKBP4 [ NCBI-GEO ]   FKBP4 [ EBI - ARRAY_EXPRESS ]   FKBP4 [ SEEK ]   FKBP4 [ MEM ]
Gene Expression Viewer (FireBrowse)FKBP4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2288
GTEX Portal (Tissue expression)FKBP4
Human Protein AtlasENSG00000004478-FKBP4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ02790   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ02790  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ02790
Splice isoforms : SwissVarQ02790
Catalytic activity : Enzyme5.2.1.8 [ Enzyme-Expasy ]   5.2.1.85.2.1.8 [ IntEnz-EBI ]   5.2.1.8 [ BRENDA ]   5.2.1.8 [ KEGG ]   
PhosPhoSitePlusQ02790
Domaine pattern : Prosite (Expaxy)FKBP_PPIASE (PS50059)    TPR (PS50005)    TPR_REGION (PS50293)   
Domains : Interpro (EBI)FKBP4    PPIase_FKBP    PPIase_FKBP_dom    TPR-contain_dom    TPR-like_helical_dom_sf    TPR_1    TPR_2    TPR_repeat   
Domain families : Pfam (Sanger)FKBP_C (PF00254)    TPR_1 (PF00515)    TPR_2 (PF07719)   
Domain families : Pfam (NCBI)pfam00254    pfam00515    pfam07719   
Domain families : Smart (EMBL)TPR (SM00028)  
Conserved Domain (NCBI)FKBP4
DMDM Disease mutations2288
Blocks (Seattle)FKBP4
PDB (SRS)1N1A    1P5Q    1Q1C    1QZ2    4DRJ    4LAV    4LAW    4LAX    4LAY    4TW8   
PDB (PDBSum)1N1A    1P5Q    1Q1C    1QZ2    4DRJ    4LAV    4LAW    4LAX    4LAY    4TW8   
PDB (IMB)1N1A    1P5Q    1Q1C    1QZ2    4DRJ    4LAV    4LAW    4LAX    4LAY    4TW8   
PDB (RSDB)1N1A    1P5Q    1Q1C    1QZ2    4DRJ    4LAV    4LAW    4LAX    4LAY    4TW8   
Structural Biology KnowledgeBase1N1A    1P5Q    1Q1C    1QZ2    4DRJ    4LAV    4LAW    4LAX    4LAY    4TW8   
SCOP (Structural Classification of Proteins)1N1A    1P5Q    1Q1C    1QZ2    4DRJ    4LAV    4LAW    4LAX    4LAY    4TW8   
CATH (Classification of proteins structures)1N1A    1P5Q    1Q1C    1QZ2    4DRJ    4LAV    4LAW    4LAX    4LAY    4TW8   
SuperfamilyQ02790
Human Protein Atlas [tissue]ENSG00000004478-FKBP4 [tissue]
Peptide AtlasQ02790
HPRD11794
IPIIPI00219005   IPI00982734   IPI01014894   IPI01014535   IPI01013653   IPI01013304   
Protein Interaction databases
DIP (DOE-UCLA)Q02790
IntAct (EBI)Q02790
FunCoupENSG00000004478
BioGRIDFKBP4
STRING (EMBL)FKBP4
ZODIACFKBP4
Ontologies - Pathways
QuickGOQ02790
Ontology : AmiGOprotein peptidyl-prolyl isomerization  RNA binding  peptidyl-prolyl cis-trans isomerase activity  peptidyl-prolyl cis-trans isomerase activity  protein binding  ATP binding  GTP binding  FK506 binding  nucleoplasm  nucleoplasm  cytoplasm  mitochondrion  cytosol  cytosol  cytosol  microtubule  protein folding  steroid hormone receptor complex assembly  copper ion transport  embryo implantation  negative regulation of neuron projection development  androgen receptor signaling pathway  protein binding, bridging  prostate gland development  heat shock protein binding  negative regulation of microtubule polymerization or depolymerization  negative regulation of microtubule polymerization  protein-containing complex localization  copper-dependent protein binding  protein-containing complex  glucocorticoid receptor binding  neuronal cell body  axonal growth cone  male sex differentiation  tau protein binding  perinuclear region of cytoplasm  phosphoprotein binding  chaperone-mediated protein folding  chaperone-mediated protein folding  extracellular exosome  regulation of cellular response to heat  
Ontology : EGO-EBIprotein peptidyl-prolyl isomerization  RNA binding  peptidyl-prolyl cis-trans isomerase activity  peptidyl-prolyl cis-trans isomerase activity  protein binding  ATP binding  GTP binding  FK506 binding  nucleoplasm  nucleoplasm  cytoplasm  mitochondrion  cytosol  cytosol  cytosol  microtubule  protein folding  steroid hormone receptor complex assembly  copper ion transport  embryo implantation  negative regulation of neuron projection development  androgen receptor signaling pathway  protein binding, bridging  prostate gland development  heat shock protein binding  negative regulation of microtubule polymerization or depolymerization  negative regulation of microtubule polymerization  protein-containing complex localization  copper-dependent protein binding  protein-containing complex  glucocorticoid receptor binding  neuronal cell body  axonal growth cone  male sex differentiation  tau protein binding  perinuclear region of cytoplasm  phosphoprotein binding  chaperone-mediated protein folding  chaperone-mediated protein folding  extracellular exosome  regulation of cellular response to heat  
Pathways : KEGGEstrogen signaling pathway   
NDEx NetworkFKBP4
Atlas of Cancer Signalling NetworkFKBP4
Wikipedia pathwaysFKBP4
Orthology - Evolution
OrthoDB2288
GeneTree (enSembl)ENSG00000004478
Phylogenetic Trees/Animal Genes : TreeFamFKBP4
HOVERGENQ02790
HOGENOMQ02790
Homologs : HomoloGeneFKBP4
Homology/Alignments : Family Browser (UCSC)FKBP4
Gene fusions - Rearrangements
Fusion : QuiverFKBP4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFKBP4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FKBP4
dbVarFKBP4
ClinVarFKBP4
1000_GenomesFKBP4 
Exome Variant ServerFKBP4
ExAC (Exome Aggregation Consortium)ENSG00000004478
GNOMAD BrowserENSG00000004478
Varsome BrowserFKBP4
Genetic variants : HAPMAP2288
Genomic Variants (DGV)FKBP4 [DGVbeta]
DECIPHERFKBP4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFKBP4 
Mutations
ICGC Data PortalFKBP4 
TCGA Data PortalFKBP4 
Broad Tumor PortalFKBP4
OASIS PortalFKBP4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFKBP4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFKBP4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FKBP4
DgiDB (Drug Gene Interaction Database)FKBP4
DoCM (Curated mutations)FKBP4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FKBP4 (select a term)
intoGenFKBP4
Cancer3DFKBP4(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600611   
Orphanet
DisGeNETFKBP4
MedgenFKBP4
Genetic Testing Registry FKBP4
NextProtQ02790 [Medical]
TSGene2288
GENETestsFKBP4
Target ValidationFKBP4
Huge Navigator FKBP4 [HugePedia]
snp3D : Map Gene to Disease2288
BioCentury BCIQFKBP4
ClinGenFKBP4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2288
Chemical/Pharm GKB GenePA28161
Clinical trialFKBP4
Miscellaneous
canSAR (ICR)FKBP4 (select the gene name)
Probes
Litterature
PubMed126 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFKBP4
EVEXFKBP4
GoPubMedFKBP4
iHOPFKBP4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:06:45 CET 2018
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