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FKBP4 (FKBP prolyl isomerase 4)

Identity

Alias (NCBI)FKBP51
FKBP52
FKBP59
HBI
Hsp56
PPIase
p52
HGNC (Hugo) FKBP4
HGNC Alias symbFKBP59
FKBP52
HGNC Previous nameFK506-binding protein 4 (59kD)
 FK506 binding protein 4, 59kDa
 FK506 binding protein 4
LocusID (NCBI) 2288
Atlas_Id 45694
Location 12p13.33  [Link to chromosome band 12p13]
Location_base_pair Starts at 2794970 and ends at 2805421 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FKBP4 (12p13.33) / DIP2C (10p15.3)FKBP4 (12p13.33) / EIF5A (17p13.1)FKBP4 (12p13.33) / FKBP4 (12p13.33)
FKBP4 (12p13.33) / NARS (18q21.31)FKBP4 (12p13.33) / PMVK (1q21.3)FKBP4 (12p13.33) / ZFR (5p13.3)
NMT2 (10p13) / FKBP4 (12p13.33)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

 

Nomenclature
HGNC (Hugo)FKBP4   3720
Cards
Entrez_Gene (NCBI)FKBP4    FKBP prolyl isomerase 4
AliasesFKBP51; FKBP52; FKBP59; HBI; 
Hsp56; PPIase; p52
GeneCards (Weizmann)FKBP4
Ensembl hg19 (Hinxton)ENSG00000004478 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000004478 [Gene_View]  ENSG00000004478 [Sequence]  chr12:2794970-2805421 [Contig_View]  FKBP4 [Vega]
ICGC DataPortalENSG00000004478
TCGA cBioPortalFKBP4
AceView (NCBI)FKBP4
Genatlas (Paris)FKBP4
SOURCE (Princeton)FKBP4
Genetics Home Reference (NIH)FKBP4
Genomic and cartography
GoldenPath hg38 (UCSC)FKBP4  -     chr12:2794970-2805421 +  12p13.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FKBP4  -     12p13.33   [Description]    (hg19-Feb_2009)
GoldenPathFKBP4 - 12p13.33 [CytoView hg19]  FKBP4 - 12p13.33 [CytoView hg38]
ImmunoBaseENSG00000004478
Genome Data Viewer NCBIFKBP4 [Mapview hg19]  
OMIM600611   
Gene and transcription
Genbank (Entrez)AK024694 AK313918 BC001786 BC002887 BC007924
RefSeq transcript (Entrez)NM_002014
Consensus coding sequences : CCDS (NCBI)FKBP4
Gene ExpressionFKBP4 [ NCBI-GEO ]   FKBP4 [ EBI - ARRAY_EXPRESS ]   FKBP4 [ SEEK ]   FKBP4 [ MEM ]
Gene Expression Viewer (FireBrowse)FKBP4 [ Firebrowse - Broad ]
GenevisibleExpression of FKBP4 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2288
GTEX Portal (Tissue expression)FKBP4
Human Protein AtlasENSG00000004478-FKBP4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ02790   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ02790  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ02790
Catalytic activity : Enzyme5.2.1.8 [ Enzyme-Expasy ]   5.2.1.85.2.1.8 [ IntEnz-EBI ]   5.2.1.8 [ BRENDA ]   5.2.1.8 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ02790
Domaine pattern : Prosite (Expaxy)FKBP_PPIASE (PS50059)    TPR (PS50005)    TPR_REGION (PS50293)   
Domains : Interpro (EBI)FKBP4    PPIase_FKBP_dom    TPR-contain_dom    TPR-like_helical_dom_sf    TPR_1    TPR_2    TPR_repeat   
Domain families : Pfam (Sanger)FKBP_C (PF00254)    TPR_1 (PF00515)    TPR_2 (PF07719)   
Domain families : Pfam (NCBI)pfam00254    pfam00515    pfam07719   
Domain families : Smart (EMBL)TPR (SM00028)  
Conserved Domain (NCBI)FKBP4
PDB (RSDB)1N1A    1P5Q    1Q1C    1QZ2    4DRJ    4LAV    4LAW    4LAX    4LAY    4TW8    6RCY   
PDB Europe1N1A    1P5Q    1Q1C    1QZ2    4DRJ    4LAV    4LAW    4LAX    4LAY    4TW8    6RCY   
PDB (PDBSum)1N1A    1P5Q    1Q1C    1QZ2    4DRJ    4LAV    4LAW    4LAX    4LAY    4TW8    6RCY   
PDB (IMB)1N1A    1P5Q    1Q1C    1QZ2    4DRJ    4LAV    4LAW    4LAX    4LAY    4TW8    6RCY   
Structural Biology KnowledgeBase1N1A    1P5Q    1Q1C    1QZ2    4DRJ    4LAV    4LAW    4LAX    4LAY    4TW8    6RCY   
SCOP (Structural Classification of Proteins)1N1A    1P5Q    1Q1C    1QZ2    4DRJ    4LAV    4LAW    4LAX    4LAY    4TW8    6RCY   
CATH (Classification of proteins structures)1N1A    1P5Q    1Q1C    1QZ2    4DRJ    4LAV    4LAW    4LAX    4LAY    4TW8    6RCY   
SuperfamilyQ02790
AlphaFold pdb e-kbQ02790   
Human Protein Atlas [tissue]ENSG00000004478-FKBP4 [tissue]
HPRD11794
Protein Interaction databases
DIP (DOE-UCLA)Q02790
IntAct (EBI)Q02790
BioGRIDFKBP4
STRING (EMBL)FKBP4
ZODIACFKBP4
Ontologies - Pathways
QuickGOQ02790
Ontology : AmiGOprotein peptidyl-prolyl isomerization  RNA binding  peptidyl-prolyl cis-trans isomerase activity  peptidyl-prolyl cis-trans isomerase activity  protein binding  FK506 binding  nucleoplasm  nucleoplasm  cytoplasm  mitochondrion  cytosol  cytosol  cytosol  microtubule  protein folding  copper ion transport  negative regulation of neuron projection development  protein-macromolecule adaptor activity  heat shock protein binding  negative regulation of microtubule polymerization or depolymerization  negative regulation of microtubule polymerization  copper-dependent protein binding  protein-containing complex  neuronal cell body  axonal growth cone  tau protein binding  perinuclear region of cytoplasm  chaperone-mediated protein folding  chaperone-mediated protein folding  extracellular exosome  regulation of cellular response to heat  
Ontology : EGO-EBIprotein peptidyl-prolyl isomerization  RNA binding  peptidyl-prolyl cis-trans isomerase activity  peptidyl-prolyl cis-trans isomerase activity  protein binding  FK506 binding  nucleoplasm  nucleoplasm  cytoplasm  mitochondrion  cytosol  cytosol  cytosol  microtubule  protein folding  copper ion transport  negative regulation of neuron projection development  protein-macromolecule adaptor activity  heat shock protein binding  negative regulation of microtubule polymerization or depolymerization  negative regulation of microtubule polymerization  copper-dependent protein binding  protein-containing complex  neuronal cell body  axonal growth cone  tau protein binding  perinuclear region of cytoplasm  chaperone-mediated protein folding  chaperone-mediated protein folding  extracellular exosome  regulation of cellular response to heat  
Pathways : KEGGEstrogen signaling pathway   
NDEx NetworkFKBP4
Atlas of Cancer Signalling NetworkFKBP4
Wikipedia pathwaysFKBP4
Orthology - Evolution
OrthoDB2288
GeneTree (enSembl)ENSG00000004478
Phylogenetic Trees/Animal Genes : TreeFamFKBP4
Homologs : HomoloGeneFKBP4
Homology/Alignments : Family Browser (UCSC)FKBP4
Gene fusions - Rearrangements
Fusion : QuiverFKBP4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFKBP4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FKBP4
dbVarFKBP4
ClinVarFKBP4
MonarchFKBP4
1000_GenomesFKBP4 
Exome Variant ServerFKBP4
GNOMAD BrowserENSG00000004478
Varsome BrowserFKBP4
ACMGFKBP4 variants
VarityQ02790
Genomic Variants (DGV)FKBP4 [DGVbeta]
DECIPHERFKBP4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFKBP4 
Mutations
ICGC Data PortalFKBP4 
TCGA Data PortalFKBP4 
Broad Tumor PortalFKBP4
OASIS PortalFKBP4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFKBP4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DFKBP4
Mutations and Diseases : HGMDFKBP4
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaFKBP4
DgiDB (Drug Gene Interaction Database)FKBP4
DoCM (Curated mutations)FKBP4
CIViC (Clinical Interpretations of Variants in Cancer)FKBP4
Cancer3DFKBP4
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600611   
Orphanet
DisGeNETFKBP4
MedgenFKBP4
Genetic Testing Registry FKBP4
NextProtQ02790 [Medical]
GENETestsFKBP4
Target ValidationFKBP4
Huge Navigator FKBP4 [HugePedia]
ClinGenFKBP4
Clinical trials, drugs, therapy
MyCancerGenomeFKBP4
Protein Interactions : CTDFKBP4
Pharm GKB GenePA28161
PharosQ02790
Clinical trialFKBP4
Miscellaneous
canSAR (ICR)FKBP4
HarmonizomeFKBP4
DataMed IndexFKBP4
Probes
Litterature
PubMed164 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXFKBP4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:09:35 CEST 2021
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