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FKBP5 (FK506 binding protein 5)

Identity

Other namesAIG6
FKBP51
FKBP54
P54
PPIase
Ptg-10
HGNC (Hugo) FKBP5
LocusID (NCBI) 2289
Location 6p21.31
Location_base_pair Starts at 35541362 and ends at 35696360 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)FKBP5   3721
Entrez_Gene (NCBI)FKBP5  2289  FK506 binding protein 5
Cards
GeneCards (Weizmann)FKBP5
Ensembl (Hinxton)ENSG00000096060 [Gene_View]  chr6:35541362-35696360 [Contig_View]  FKBP5 [Vega]
AceView (NCBI)FKBP5
Genatlas (Paris)FKBP5
SOURCE (Stanford)NM_001145775 NM_001145776 NM_001145777 NM_004117
Genomic and cartography
GoldenPath (UCSC)FKBP5  -  6p21.31   chr6:35541362-35696360 -  6p21.31   [Description]    (hg19-Feb_2009)
EnsemblFKBP5 - 6p21.31 [CytoView]
Mapping of homologs : NCBIFKBP5 [Mapview]
OMIM602623   608516   
Gene and transcription
Genbank (Entrez)AB209893 AF194172 AK222807 AK302704 AK303356
RefSeq transcript (SRS)NM_001145775 NM_001145776 NM_001145777 NM_004117
RefSeq transcript (Entrez)NM_001145775 NM_001145776 NM_001145777 NM_004117
RefSeq genomic (SRS)AC_000138 NC_000006 NC_018917 NG_012645 NT_007592 NW_001838980 NW_004078026
RefSeq genomic (Entrez)AC_000138 NC_000006 NC_018917 NG_012645 NT_007592 NW_001838980 NW_004078026
Consensus coding sequences : CCDS (NCBI)FKBP5
Cluster EST : UnigeneHs.407190 [ SRS ] Hs.407190 [ NCBI ]
CGAP (NCI)Hs.407190
Alternative Splicing : Fast-db (Paris)GSHG0026553
Alternative Splicing GalleryENSG00000096060
Gene ExpressionFKBP5 [ NCBI-GEO ]   FKBP5 [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13451 (SRS) Q13451 (Uniprot)
NextProtQ13451
With graphics : InterProQ13451
Splice isoforms : SwissVarQ13451(Swissvar)
Domaine pattern : Prosite (SRS)FKBP_PPIASE (PS50059)    TPR (PS50005)    TPR_REGION (PS50293)   
Domaine pattern : Prosite (Expaxy)FKBP_PPIASE (PS50059)    TPR (PS50005)    TPR_REGION (PS50293)   
Domains : Interpro (SRS)Elongated_TPR_rpt_dom    PPIase_FKBP    PPIase_FKBP_dom    TPR-1    TPR-contain_dom    TPR-like_helical    TPR_repeat   
Domains : Interpro (EBI)Elongated_TPR_rpt_dom    PPIase_FKBP    PPIase_FKBP_dom    TPR-1    TPR-contain_dom    TPR-like_helical    TPR_repeat   
Related proteins : CluSTrQ13451
Domain families : Pfam (SRS)FKBP_C (PF00254)    TPR_1 (PF00515)   
Domain families : Pfam (Sanger)FKBP_C (PF00254)    TPR_1 (PF00515)   
Domain families : Pfam (NCBI)pfam00254    pfam00515   
DMDM2289
Blocks (Seattle)Q13451
PDB (SRS)1KT0    3O5D    3O5E    3O5F    3O5G    3O5I    3O5J    3O5K    3O5L    3O5M    3O5O    3O5P    3O5Q    3O5R    4DRK    4DRM    4DRN    4DRO    4DRP    4DRQ   
PDB (PDBSum)1KT0    3O5D    3O5E    3O5F    3O5G    3O5I    3O5J    3O5K    3O5L    3O5M    3O5O    3O5P    3O5Q    3O5R    4DRK    4DRM    4DRN    4DRO    4DRP    4DRQ   
PDB (IMB)1KT0    3O5D    3O5E    3O5F    3O5G    3O5I    3O5J    3O5K    3O5L    3O5M    3O5O    3O5P    3O5Q    3O5R    4DRK    4DRM    4DRN    4DRO    4DRP    4DRQ   
PDB (RSDB)1KT0    3O5D    3O5E    3O5F    3O5G    3O5I    3O5J    3O5K    3O5L    3O5M    3O5O    3O5P    3O5Q    3O5R    4DRK    4DRM    4DRN    4DRO    4DRP    4DRQ   
Human Protein AtlasENSG00000096060
HPRD04019
IPIIPI00218775   IPI01010266   IPI01015705   IPI01015323   IPI00443474   IPI00556067   
Protein Interaction databases
DIP (DOE-UCLA)Q13451
IntAct (EBI)Q13451
FunCoupENSG00000096060
REACTOMEFKBP5
Protein Interaction Database2289
BioGRIDFKBP5
InParanoidQ13451
Interologous Interaction database Q13451
IntegromeDBFKBP5
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)FKBP5
SNP (GeneSNP Utah)FKBP5
SNP : HGBaseFKBP5
Genetic variants : HAPMAPFKBP5
Somatic Mutations in Cancer : COSMICFKBP5 
CONAN: Copy Number AnalysisFKBP5 
Mutations and Diseases : HGMDFKBP5
OMIM602623    608516   
GENETests602623    608516   
Disease Genetic AssociationFKBP5
Huge Navigator FKBP5 [HugePedia]  FKBP5 [HugeCancerGEM]
Genomic VariantsFKBP5  FKBP5 [DGVbeta]
snp3D : Map Gene to Disease2289
General knowledge
Homologs : HomoloGeneFKBP5
Homology/Alignments : Family Browser (UCSC)FKBP5
Phylogenetic Trees/Animal Genes : TreeFamFKBP5
Catalytic activity : Enzyme5.2.1.8 [ Enzyme-Expasy ]   5.2.1.8 [ Enzyme-SRS ]   5.2.1.8 [ IntEnz-EBI ]   5.2.1.8 [ BRENDA ]   5.2.1.8 [ KEGG ]   
Chemical/Protein Interactions : CTD2289
Chemical/Pharm GKB GenePA28162
Clinical trialFKBP5
Cancer Resource (Charite)ENSG00000096060
Ontology : AmiGOprotein peptidyl-prolyl isomerization  protein peptidyl-prolyl isomerization  peptidyl-prolyl cis-trans isomerase activity  peptidyl-prolyl cis-trans isomerase activity  FK506 binding  nucleus  nucleolus  cytoplasm  protein folding  membrane  peptidyl-proline modification  heat shock protein binding  chaperone-mediated protein folding  
Ontology : EGO-EBIprotein peptidyl-prolyl isomerization  protein peptidyl-prolyl isomerization  peptidyl-prolyl cis-trans isomerase activity  peptidyl-prolyl cis-trans isomerase activity  FK506 binding  nucleus  nucleolus  cytoplasm  protein folding  membrane  peptidyl-proline modification  heat shock protein binding  chaperone-mediated protein folding  
Other databases
Probes
Litterature
PubMed109 Pubmed reference(s) in Entrez
PubGeneFKBP5
iHOPFKBP5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 1 12:45:31 CEST 2013
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