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FKBP6 (FKBP prolyl isomerase 6)

Identity

Alias_namesFK506-binding protein 6 (36kD)
FK506 binding protein 6, 36kDa
Alias_symbol (synonym)PPIase
FKBP36
Other alias
HGNC (Hugo) FKBP6
LocusID (NCBI) 8468
Atlas_Id 54970
Location 7q11.23  [Link to chromosome band 7q11]
Location_base_pair Starts at 73328232 and ends at 73358637 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AAAS (12q13.13) / FKBP6 (7q11.23)FKBP6 (7q11.23) / RNF167 (17p13.2)MON2 (12q14.1) / FKBP6 (7q11.23)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)FKBP6   3722
Cards
Entrez_Gene (NCBI)FKBP6  8468  FKBP prolyl isomerase 6
AliasesFKBP36
GeneCards (Weizmann)FKBP6
Ensembl hg19 (Hinxton)ENSG00000077800 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000077800 [Gene_View]  ENSG00000077800 [Sequence]  chr7:73328232-73358637 [Contig_View]  FKBP6 [Vega]
ICGC DataPortalENSG00000077800
TCGA cBioPortalFKBP6
AceView (NCBI)FKBP6
Genatlas (Paris)FKBP6
WikiGenes8468
SOURCE (Princeton)FKBP6
Genetics Home Reference (NIH)FKBP6
Genomic and cartography
GoldenPath hg38 (UCSC)FKBP6  -     chr7:73328232-73358637 +  7q11.23   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FKBP6  -     7q11.23   [Description]    (hg19-Feb_2009)
EnsemblFKBP6 - 7q11.23 [CytoView hg19]  FKBP6 - 7q11.23 [CytoView hg38]
Mapping of homologs : NCBIFKBP6 [Mapview hg19]  FKBP6 [Mapview hg38]
OMIM604839   
Gene and transcription
Genbank (Entrez)AA909474 AF038847 AF447060 AK302121 AK310255
RefSeq transcript (Entrez)NM_001135211 NM_001281304 NM_001362789 NM_003602
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FKBP6
Cluster EST : UnigeneHs.661266 [ NCBI ]
CGAP (NCI)Hs.661266
Alternative Splicing GalleryENSG00000077800
Gene ExpressionFKBP6 [ NCBI-GEO ]   FKBP6 [ EBI - ARRAY_EXPRESS ]   FKBP6 [ SEEK ]   FKBP6 [ MEM ]
Gene Expression Viewer (FireBrowse)FKBP6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8468
GTEX Portal (Tissue expression)FKBP6
Human Protein AtlasENSG00000077800-FKBP6 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75344   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75344  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75344
Splice isoforms : SwissVarO75344
PhosPhoSitePlusO75344
Domaine pattern : Prosite (Expaxy)FKBP_PPIASE (PS50059)    TPR_REGION (PS50293)   
Domains : Interpro (EBI)PPIase_FKBP    PPIase_FKBP_dom    TPR-contain_dom    TPR-like_helical_dom_sf    TPR_repeat   
Domain families : Pfam (Sanger)FKBP_C (PF00254)   
Domain families : Pfam (NCBI)pfam00254   
Domain families : Smart (EMBL)TPR (SM00028)  
Conserved Domain (NCBI)FKBP6
DMDM Disease mutations8468
Blocks (Seattle)FKBP6
PDB (SRS)3B7X   
PDB (PDBSum)3B7X   
PDB (IMB)3B7X   
PDB (RSDB)3B7X   
Structural Biology KnowledgeBase3B7X   
SCOP (Structural Classification of Proteins)3B7X   
CATH (Classification of proteins structures)3B7X   
SuperfamilyO75344
Human Protein Atlas [tissue]ENSG00000077800-FKBP6 [tissue]
Peptide AtlasO75344
HPRD05326
IPIIPI00025280   IPI00845394   IPI00913877   IPI00925099   IPI00924456   IPI00927250   IPI00927475   
Protein Interaction databases
DIP (DOE-UCLA)O75344
IntAct (EBI)O75344
FunCoupENSG00000077800
BioGRIDFKBP6
STRING (EMBL)FKBP6
ZODIACFKBP6
Ontologies - Pathways
QuickGOO75344
Ontology : AmiGOprotein peptidyl-prolyl isomerization  synaptonemal complex  peptidyl-prolyl cis-trans isomerase activity  protein binding  FK506 binding  cytoplasm  cytosol  protein folding  spermatogenesis  cell differentiation  gene silencing by RNA  piRNA metabolic process  identical protein binding  DNA methylation involved in gamete generation  positive regulation of viral genome replication  meiotic cell cycle  Hsp90 protein binding  
Ontology : EGO-EBIprotein peptidyl-prolyl isomerization  synaptonemal complex  peptidyl-prolyl cis-trans isomerase activity  protein binding  FK506 binding  cytoplasm  cytosol  protein folding  spermatogenesis  cell differentiation  gene silencing by RNA  piRNA metabolic process  identical protein binding  DNA methylation involved in gamete generation  positive regulation of viral genome replication  meiotic cell cycle  Hsp90 protein binding  
NDEx NetworkFKBP6
Atlas of Cancer Signalling NetworkFKBP6
Wikipedia pathwaysFKBP6
Orthology - Evolution
OrthoDB8468
GeneTree (enSembl)ENSG00000077800
Phylogenetic Trees/Animal Genes : TreeFamFKBP6
HOVERGENO75344
HOGENOMO75344
Homologs : HomoloGeneFKBP6
Homology/Alignments : Family Browser (UCSC)FKBP6
Gene fusions - Rearrangements
Fusion : QuiverFKBP6
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFKBP6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FKBP6
dbVarFKBP6
ClinVarFKBP6
1000_GenomesFKBP6 
Exome Variant ServerFKBP6
ExAC (Exome Aggregation Consortium)ENSG00000077800
GNOMAD BrowserENSG00000077800
Varsome BrowserFKBP6
Genetic variants : HAPMAP8468
Genomic Variants (DGV)FKBP6 [DGVbeta]
DECIPHERFKBP6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFKBP6 
Mutations
ICGC Data PortalFKBP6 
TCGA Data PortalFKBP6 
Broad Tumor PortalFKBP6
OASIS PortalFKBP6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFKBP6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFKBP6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FKBP6
DgiDB (Drug Gene Interaction Database)FKBP6
DoCM (Curated mutations)FKBP6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FKBP6 (select a term)
intoGenFKBP6
Cancer3DFKBP6(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604839   
Orphanet
DisGeNETFKBP6
MedgenFKBP6
Genetic Testing Registry FKBP6
NextProtO75344 [Medical]
TSGene8468
GENETestsFKBP6
Target ValidationFKBP6
Huge Navigator FKBP6 [HugePedia]
snp3D : Map Gene to Disease8468
BioCentury BCIQFKBP6
ClinGenFKBP6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8468
Chemical/Pharm GKB GenePA28163
Clinical trialFKBP6
Miscellaneous
canSAR (ICR)FKBP6 (select the gene name)
Probes
Litterature
PubMed29 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFKBP6
EVEXFKBP6
GoPubMedFKBP6
iHOPFKBP6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 6 11:06:46 CET 2018

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