FKBPL (FKBP prolyl isomerase like)

2010-03-01  

Identity

HGNC
FKBPL
LOCATION
6p21.32
LOCUSID
63943
ALIAS
DIR1,FKBP4,NG7,WISP39
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 63943
MIM: 617076
HGNC: 13949
Ensembl: ENSG00000204315

Variants:

dbSNP: 63943
ClinVar: 63943
TCGA: ENSG00000204315
COSMIC: FKBPL

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000204315ENST00000375156Q9UIM3
ENSG00000204315ENST00000375156A0A024RCQ6

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G2-G2/M phasesREACTOMER-HSA-453274
G2/M TransitionREACTOMER-HSA-69275
The role of GTSE1 in G2/M progression after G2 checkpointREACTOMER-HSA-8852276

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
198514452009High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.51
156641932005Regulation of p21(WAF1/CIP1) stability by WISp39, a Hsp90 binding TPR protein.47
226949562012Genome-wide association study of age-related macular degeneration identifies associated variants in the TNXB-FKBPL-NOTCH4 region of chromosome 6p21.3.38
186696032008A novel FK506-like binding protein interacts with the glucocorticoid receptor and regulates steroid receptor signaling.19
201036312010FKBPL regulates estrogen receptor signaling and determines response to endocrine therapy.13
239124582014Identification of RBCK1 as a novel regulator of FKBPL: implications for tumor growth and response to tamoxifen.11
202109972010Alterations in the steroid hormone receptor co-chaperone FKBPL are associated with male infertility: a case-control study.9
202109972010Alterations in the steroid hormone receptor co-chaperone FKBPL are associated with male infertility: a case-control study.9
234574602013The anti-migratory effects of FKBPL and its peptide derivative, AD-01: regulation of CD44 and the cytoskeletal pathway.8
257672772015FKBPL is a critical antiangiogenic regulator of developmental and pathological angiogenesis.8

Citation

Dessen P

FKBPL (FKBP prolyl isomerase like)

Atlas Genet Cytogenet Oncol Haematol. 2010-03-01

Online version: http://atlasgeneticsoncology.org/gene/51402/fkbpl