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FLACC1 (flagellum associated containing coiled-coil domains 1)

Identity

Alias_namesALS2CR12
amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 12
ALS2 chromosome region 12
Other alias
HGNC (Hugo) FLACC1
LocusID (NCBI) 130540
Atlas_Id 55388
Location 2q33.1  [Link to chromosome band 2q33]
Location_base_pair Starts at 201288271 and ends at 201357398 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CASP8 2q33.1 / ALS2CR12 2q33.1FAM126B 2q33.1 / ALS2CR12 2q33.1ORC2 2q33.1 / ALS2CR12 2q33.1
PPTC7 12q24.11 / ALS2CR12 2q33.1
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 4 ]

Solid Tumors TT_t0202q33q33ID105346 TT_t0202q33q33ID105350 TT_t0202q33q33ID105355 TT_t0212q33q24ID105013


External links

Nomenclature
HGNC (Hugo)FLACC1   14439
Cards
Entrez_Gene (NCBI)FLACC1  130540  flagellum associated containing coiled-coil domains 1
AliasesALS2CR12
GeneCards (Weizmann)FLACC1
Ensembl hg19 (Hinxton)ENSG00000155749 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000155749 [Gene_View]  ENSG00000155749 [Sequence]  chr2:201288271-201357398 [Contig_View]  FLACC1 [Vega]
ICGC DataPortalENSG00000155749
TCGA cBioPortalFLACC1
AceView (NCBI)FLACC1
Genatlas (Paris)FLACC1
WikiGenes130540
SOURCE (Princeton)FLACC1
Genetics Home Reference (NIH)FLACC1
Genomic and cartography
GoldenPath hg38 (UCSC)FLACC1  -     chr2:201288271-201357398 -  -   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FLACC1  -     -   [Description]    (hg19-Feb_2009)
GoldenPathFLACC1 - - [CytoView hg19]  FLACC1 - - [CytoView hg38]
ImmunoBaseENSG00000155749
Mapping of homologs : NCBIFLACC1 [Mapview hg19]  FLACC1 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AB053314 AK124115 AK292283 BC031603 BX095441
RefSeq transcript (Entrez)NM_001127391 NM_001289993 NM_139163
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FLACC1
Cluster EST : UnigeneHs.107944 [ NCBI ]
CGAP (NCI)Hs.107944
Alternative Splicing GalleryENSG00000155749
Gene ExpressionFLACC1 [ NCBI-GEO ]   FLACC1 [ EBI - ARRAY_EXPRESS ]   FLACC1 [ SEEK ]   FLACC1 [ MEM ]
Gene Expression Viewer (FireBrowse)FLACC1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)130540
GTEX Portal (Tissue expression)FLACC1
Human Protein AtlasENSG00000155749-FLACC1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96Q35   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96Q35  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96Q35
Splice isoforms : SwissVarQ96Q35
PhosPhoSitePlusQ96Q35
Domains : Interpro (EBI)ALS2CR12   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)FLACC1
DMDM Disease mutations130540
Blocks (Seattle)FLACC1
SuperfamilyQ96Q35
Human Protein Atlas [tissue]ENSG00000155749-FLACC1 [tissue]
Peptide AtlasQ96Q35
HPRD12444
IPIIPI00044666   IPI00749257   IPI00926958   IPI00925341   IPI00927652   
Protein Interaction databases
DIP (DOE-UCLA)Q96Q35
IntAct (EBI)Q96Q35
FunCoupENSG00000155749
BioGRIDFLACC1
STRING (EMBL)FLACC1
ZODIACFLACC1
Ontologies - Pathways
QuickGOQ96Q35
Ontology : AmiGOouter dense fiber  molecular_function  protein binding  cellular_component  cytoplasm  sperm fibrous sheath  sperm flagellum  
Ontology : EGO-EBIouter dense fiber  molecular_function  protein binding  cellular_component  cytoplasm  sperm fibrous sheath  sperm flagellum  
NDEx NetworkFLACC1
Atlas of Cancer Signalling NetworkFLACC1
Wikipedia pathwaysFLACC1
Orthology - Evolution
OrthoDB130540
GeneTree (enSembl)ENSG00000155749
Phylogenetic Trees/Animal Genes : TreeFamFLACC1
HOGENOMQ96Q35
Homologs : HomoloGeneFLACC1
Homology/Alignments : Family Browser (UCSC)FLACC1
Gene fusions - Rearrangements
Fusion : MitelmanCASP8/ALS2CR12 [2q33.1/2q33.1]  [t(2;2)(q33;q33)]  
Fusion : MitelmanFAM126B/ALS2CR12 [2q33.1/2q33.1]  [t(2;2)(q33;q33)]  
Fusion : MitelmanORC2/ALS2CR12 [2q33.1/2q33.1]  [t(2;2)(q33;q33)]  
Fusion : MitelmanPPTC7/ALS2CR12 [12q24.11/2q33.1]  [t(2;12)(q33;q24)]  
Fusion PortalCASP8 2q33.1 ALS2CR12 2q33.1 BRCA
Fusion PortalFAM126B 2q33.1 ALS2CR12 2q33.1 LUAD
Fusion PortalORC2 2q33.1 ALS2CR12 2q33.1 BRCA
Fusion PortalPPTC7 12q24.11 ALS2CR12 2q33.1 BRCA
Fusion : QuiverFLACC1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFLACC1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FLACC1
dbVarFLACC1
ClinVarFLACC1
1000_GenomesFLACC1 
Exome Variant ServerFLACC1
ExAC (Exome Aggregation Consortium)ENSG00000155749
GNOMAD BrowserENSG00000155749
Varsome BrowserFLACC1
Genetic variants : HAPMAP130540
Genomic Variants (DGV)FLACC1 [DGVbeta]
DECIPHERFLACC1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFLACC1 
Mutations
ICGC Data PortalFLACC1 
TCGA Data PortalFLACC1 
Broad Tumor PortalFLACC1
OASIS PortalFLACC1 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDFLACC1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FLACC1
DgiDB (Drug Gene Interaction Database)FLACC1
DoCM (Curated mutations)FLACC1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FLACC1 (select a term)
intoGenFLACC1
Cancer3DFLACC1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETFLACC1
MedgenFLACC1
Genetic Testing Registry FLACC1
NextProtQ96Q35 [Medical]
TSGene130540
GENETestsFLACC1
Target ValidationFLACC1
Huge Navigator FLACC1 [HugePedia]
snp3D : Map Gene to Disease130540
BioCentury BCIQFLACC1
ClinGenFLACC1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD130540
Chemical/Pharm GKB GenePA24735
Clinical trialFLACC1
Miscellaneous
canSAR (ICR)FLACC1 (select the gene name)
DataMed IndexFLACC1
Probes
Litterature
PubMed24 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFLACC1
EVEXFLACC1
GoPubMedFLACC1
iHOPFLACC1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Aug 26 18:08:40 CEST 2019

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