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FLAD1 (flavin adenine dinucleotide synthetase 1)

Identity

Alias_namesFad1, flavin adenine dinucleotide synthetase, homolog (yeast)
FAD1 flavin adenine dinucleotide synthetase homolog (S. cerevisiae)
flavin adenine dinucleotide synthetase
Alias_symbol (synonym)PP591
FAD1
Other aliasFADS
LSMFLAD
HGNC (Hugo) FLAD1
LocusID (NCBI) 80308
Atlas_Id 63408
Location 1q21.3  [Link to chromosome band 1q21]
Location_base_pair Starts at 154983294 and ends at 154993111 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
EFNA3 (1q22) / FLAD1 (1q21.3)EFNA4 (1q22) / FLAD1 (1q21.3)FLAD1 (1q21.3) / EGR3 (8p21.3)
RP11-540D14.8 () / FLAD1 (1q21.3)RP11-540D14.8 FLAD1EFNA4 FLAD1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)FLAD1   24671
Cards
Entrez_Gene (NCBI)FLAD1  80308  flavin adenine dinucleotide synthetase 1
AliasesFAD1; FADS; LSMFLAD; PP591
GeneCards (Weizmann)FLAD1
Ensembl hg19 (Hinxton)ENSG00000160688 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000160688 [Gene_View]  chr1:154983294-154993111 [Contig_View]  FLAD1 [Vega]
ICGC DataPortalENSG00000160688
TCGA cBioPortalFLAD1
AceView (NCBI)FLAD1
Genatlas (Paris)FLAD1
WikiGenes80308
SOURCE (Princeton)FLAD1
Genetics Home Reference (NIH)FLAD1
Genomic and cartography
GoldenPath hg38 (UCSC)FLAD1  -     chr1:154983294-154993111 +  1q21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FLAD1  -     1q21.3   [Description]    (hg19-Feb_2009)
EnsemblFLAD1 - 1q21.3 [CytoView hg19]  FLAD1 - 1q21.3 [CytoView hg38]
Mapping of homologs : NCBIFLAD1 [Mapview hg19]  FLAD1 [Mapview hg38]
OMIM255100   610595   
Gene and transcription
Genbank (Entrez)AF218022 AF481877 AF520568 AK025979 AK090542
RefSeq transcript (Entrez)NM_001184891 NM_001184892 NM_025207 NM_201398
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FLAD1
Cluster EST : UnigeneHs.118666 [ NCBI ]
CGAP (NCI)Hs.118666
Alternative Splicing GalleryENSG00000160688
Gene ExpressionFLAD1 [ NCBI-GEO ]   FLAD1 [ EBI - ARRAY_EXPRESS ]   FLAD1 [ SEEK ]   FLAD1 [ MEM ]
Gene Expression Viewer (FireBrowse)FLAD1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)80308
GTEX Portal (Tissue expression)FLAD1
Human Protein AtlasENSG00000160688-FLAD1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8NFF5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8NFF5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8NFF5
Splice isoforms : SwissVarQ8NFF5
PhosPhoSitePlusQ8NFF5
Domains : Interpro (EBI)FAD_synth_MoaB/Mog-bd    MoaB/Mog_dom    PAPS_reduct    Rossmann-like_a/b/a_fold   
Domain families : Pfam (Sanger)MoCF_biosynth (PF00994)    PAPS_reduct (PF01507)   
Domain families : Pfam (NCBI)pfam00994    pfam01507   
Domain families : Smart (EMBL)MoCF_biosynth (SM00852)  
Conserved Domain (NCBI)FLAD1
DMDM Disease mutations80308
Blocks (Seattle)FLAD1
SuperfamilyQ8NFF5
Human Protein Atlas [tissue]ENSG00000160688-FLAD1 [tissue]
Peptide AtlasQ8NFF5
HPRD17887
IPIIPI00220299   IPI00642864   IPI00398214   IPI00387088   IPI00855871   IPI00641224   IPI00644201   
Protein Interaction databases
DIP (DOE-UCLA)Q8NFF5
IntAct (EBI)Q8NFF5
FunCoupENSG00000160688
BioGRIDFLAD1
STRING (EMBL)FLAD1
ZODIACFLAD1
Ontologies - Pathways
QuickGOQ8NFF5
Ontology : AmiGOFMN adenylyltransferase activity  FMN adenylyltransferase activity  protein binding  ATP binding  cytoplasm  mitochondrial matrix  cytosol  cytosol  plasma membrane  FAD biosynthetic process  FAD biosynthetic process  riboflavin metabolic process  oxidation-reduction process  
Ontology : EGO-EBIFMN adenylyltransferase activity  FMN adenylyltransferase activity  protein binding  ATP binding  cytoplasm  mitochondrial matrix  cytosol  cytosol  plasma membrane  FAD biosynthetic process  FAD biosynthetic process  riboflavin metabolic process  oxidation-reduction process  
Pathways : KEGGRiboflavin metabolism   
NDEx NetworkFLAD1
Atlas of Cancer Signalling NetworkFLAD1
Wikipedia pathwaysFLAD1
Orthology - Evolution
OrthoDB80308
GeneTree (enSembl)ENSG00000160688
Phylogenetic Trees/Animal Genes : TreeFamFLAD1
HOVERGENQ8NFF5
HOGENOMQ8NFF5
Homologs : HomoloGeneFLAD1
Homology/Alignments : Family Browser (UCSC)FLAD1
Gene fusions - Rearrangements
Fusion: TCGARP11-540D14.8 FLAD1
Fusion: TCGAEFNA4 FLAD1
Fusion: Tumor Portal FLAD1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFLAD1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FLAD1
dbVarFLAD1
ClinVarFLAD1
1000_GenomesFLAD1 
Exome Variant ServerFLAD1
ExAC (Exome Aggregation Consortium)ENSG00000160688
GNOMAD BrowserENSG00000160688
Genetic variants : HAPMAP80308
Genomic Variants (DGV)FLAD1 [DGVbeta]
DECIPHERFLAD1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFLAD1 
Mutations
ICGC Data PortalFLAD1 
TCGA Data PortalFLAD1 
Broad Tumor PortalFLAD1
OASIS PortalFLAD1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFLAD1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFLAD1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FLAD1
DgiDB (Drug Gene Interaction Database)FLAD1
DoCM (Curated mutations)FLAD1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FLAD1 (select a term)
intoGenFLAD1
Cancer3DFLAD1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM255100    610595   
Orphanet
MedgenFLAD1
Genetic Testing Registry FLAD1
NextProtQ8NFF5 [Medical]
TSGene80308
GENETestsFLAD1
Target ValidationFLAD1
Huge Navigator FLAD1 [HugePedia]
snp3D : Map Gene to Disease80308
BioCentury BCIQFLAD1
ClinGenFLAD1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD80308
Chemical/Pharm GKB GenePA142671759
Clinical trialFLAD1
Miscellaneous
canSAR (ICR)FLAD1 (select the gene name)
Probes
Litterature
PubMed18 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFLAD1
EVEXFLAD1
GoPubMedFLAD1
iHOPFLAD1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Nov 9 11:47:49 CET 2017

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