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FLG (filaggrin)

Identity

Other aliasATOD2
HGNC (Hugo) FLG
LocusID (NCBI) 2312
Atlas_Id 53756
Location 1q21.3  [Link to chromosome band 1q21]
Location_base_pair Starts at 152302175 and ends at 152325203 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)FLG   3748
LRG (Locus Reference Genomic)LRG_1028
Cards
Entrez_Gene (NCBI)FLG  2312  filaggrin
AliasesATOD2
GeneCards (Weizmann)FLG
Ensembl hg19 (Hinxton)ENSG00000143631 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000143631 [Gene_View]  ENSG00000143631 [Sequence]  chr1:152302175-152325203 [Contig_View]  FLG [Vega]
ICGC DataPortalENSG00000143631
TCGA cBioPortalFLG
AceView (NCBI)FLG
Genatlas (Paris)FLG
WikiGenes2312
SOURCE (Princeton)FLG
Genetics Home Reference (NIH)FLG
Genomic and cartography
GoldenPath hg38 (UCSC)FLG  -     chr1:152302175-152325203 -  1q21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FLG  -     1q21.3   [Description]    (hg19-Feb_2009)
EnsemblFLG - 1q21.3 [CytoView hg19]  FLG - 1q21.3 [CytoView hg38]
Mapping of homologs : NCBIFLG [Mapview hg19]  FLG [Mapview hg38]
OMIM135940   146700   605803   
Gene and transcription
Genbank (Entrez)AB208881 L01090 M24355 M60495 M60499
RefSeq transcript (Entrez)NM_002016
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FLG
Cluster EST : UnigeneHs.654510 [ NCBI ]
CGAP (NCI)Hs.654510
Alternative Splicing GalleryENSG00000143631
Gene ExpressionFLG [ NCBI-GEO ]   FLG [ EBI - ARRAY_EXPRESS ]   FLG [ SEEK ]   FLG [ MEM ]
Gene Expression Viewer (FireBrowse)FLG [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2312
GTEX Portal (Tissue expression)FLG
Human Protein AtlasENSG00000143631-FLG [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP20930   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP20930  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP20930
Splice isoforms : SwissVarP20930
PhosPhoSitePlusP20930
Domaine pattern : Prosite (Expaxy)EF_HAND_1 (PS00018)    EF_HAND_2 (PS50222)    S100_CABP (PS00303)   
Domains : Interpro (EBI)EF-hand-dom_pair    EF_Hand_1_Ca_BS    EF_hand_dom    Filaggrin    S-100_dom    S100/CaBP-9k_CS    S100_Ca-bd_sub   
Domain families : Pfam (Sanger)Filaggrin (PF03516)    S_100 (PF01023)   
Domain families : Pfam (NCBI)pfam03516    pfam01023   
Domain families : Smart (EMBL)S_100 (SM01394)  
Conserved Domain (NCBI)FLG
DMDM Disease mutations2312
Blocks (Seattle)FLG
PDB (SRS)4PCW   
PDB (PDBSum)4PCW   
PDB (IMB)4PCW   
PDB (RSDB)4PCW   
Structural Biology KnowledgeBase4PCW   
SCOP (Structural Classification of Proteins)4PCW   
CATH (Classification of proteins structures)4PCW   
SuperfamilyP20930
Human Protein Atlas [tissue]ENSG00000143631-FLG [tissue]
Peptide AtlasP20930
HPRD15920
IPIIPI00026256   IPI00386035   IPI01010849   IPI00746718   IPI00514731   IPI01012547   
Protein Interaction databases
DIP (DOE-UCLA)P20930
IntAct (EBI)P20930
FunCoupENSG00000143631
BioGRIDFLG
STRING (EMBL)FLG
ZODIACFLG
Ontologies - Pathways
QuickGOP20930
Ontology : AmiGOcornified envelope  structural molecule activity  calcium ion binding  protein binding  nucleus  cytosol  intermediate filament  multicellular organism development  peptide cross-linking  keratinocyte differentiation  structural constituent of epidermis  keratohyalin granule  intracellular membrane-bounded organelle  transition metal ion binding  establishment of skin barrier  cornification  
Ontology : EGO-EBIcornified envelope  structural molecule activity  calcium ion binding  protein binding  nucleus  cytosol  intermediate filament  multicellular organism development  peptide cross-linking  keratinocyte differentiation  structural constituent of epidermis  keratohyalin granule  intracellular membrane-bounded organelle  transition metal ion binding  establishment of skin barrier  cornification  
NDEx NetworkFLG
Atlas of Cancer Signalling NetworkFLG
Wikipedia pathwaysFLG
Orthology - Evolution
OrthoDB2312
GeneTree (enSembl)ENSG00000143631
Phylogenetic Trees/Animal Genes : TreeFamFLG
HOVERGENP20930
HOGENOMP20930
Homologs : HomoloGeneFLG
Homology/Alignments : Family Browser (UCSC)FLG
Gene fusions - Rearrangements
Fusion : QuiverFLG
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFLG [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FLG
dbVarFLG
ClinVarFLG
1000_GenomesFLG 
Exome Variant ServerFLG
ExAC (Exome Aggregation Consortium)ENSG00000143631
GNOMAD BrowserENSG00000143631
Genetic variants : HAPMAP2312
Genomic Variants (DGV)FLG [DGVbeta]
DECIPHERFLG [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFLG 
Mutations
ICGC Data PortalFLG 
TCGA Data PortalFLG 
Broad Tumor PortalFLG
OASIS PortalFLG [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFLG  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFLG
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FLG
DgiDB (Drug Gene Interaction Database)FLG
DoCM (Curated mutations)FLG (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FLG (select a term)
intoGenFLG
Cancer3DFLG(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM135940    146700    605803   
Orphanet
DisGeNETFLG
MedgenFLG
Genetic Testing Registry FLG
NextProtP20930 [Medical]
TSGene2312
GENETestsFLG
Target ValidationFLG
Huge Navigator FLG [HugePedia]
snp3D : Map Gene to Disease2312
BioCentury BCIQFLG
ClinGenFLG
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2312
Chemical/Pharm GKB GenePA28169
Clinical trialFLG
Miscellaneous
canSAR (ICR)FLG (select the gene name)
Probes
Litterature
PubMed316 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFLG
EVEXFLG
GoPubMedFLG
iHOPFLG
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jun 22 16:25:57 CEST 2018

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