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FLG2 (filaggrin family member 2)

Identity

Alias_symbol (synonym)IFPS
Other alias
HGNC (Hugo) FLG2
LocusID (NCBI) 388698
Atlas_Id 63409
Location 1q21.3  [Link to chromosome band 1q21]
Location_base_pair Starts at 152348737 and ends at 152360006 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)FLG2   33276
Cards
Entrez_Gene (NCBI)FLG2  388698  filaggrin family member 2
AliasesIFPS
GeneCards (Weizmann)FLG2
Ensembl hg19 (Hinxton)ENSG00000143520 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000143520 [Gene_View]  chr1:152348737-152360006 [Contig_View]  FLG2 [Vega]
ICGC DataPortalENSG00000143520
TCGA cBioPortalFLG2
AceView (NCBI)FLG2
Genatlas (Paris)FLG2
WikiGenes388698
SOURCE (Princeton)FLG2
Genetics Home Reference (NIH)FLG2
Genomic and cartography
GoldenPath hg38 (UCSC)FLG2  -     chr1:152348737-152360006 -  1q21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FLG2  -     1q21.3   [Description]    (hg19-Feb_2009)
EnsemblFLG2 - 1q21.3 [CytoView hg19]  FLG2 - 1q21.3 [CytoView hg38]
Mapping of homologs : NCBIFLG2 [Mapview hg19]  FLG2 [Mapview hg38]
OMIM616284   
Gene and transcription
Genbank (Entrez)AY827490 BC029685 BC063543 BC108269 BX095286
RefSeq transcript (Entrez)NM_001014342
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FLG2
Cluster EST : UnigeneHs.156124 [ NCBI ]
CGAP (NCI)Hs.156124
Alternative Splicing GalleryENSG00000143520
Gene ExpressionFLG2 [ NCBI-GEO ]   FLG2 [ EBI - ARRAY_EXPRESS ]   FLG2 [ SEEK ]   FLG2 [ MEM ]
Gene Expression Viewer (FireBrowse)FLG2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)388698
GTEX Portal (Tissue expression)FLG2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ5D862   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ5D862  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ5D862
Splice isoforms : SwissVarQ5D862
PhosPhoSitePlusQ5D862
Domaine pattern : Prosite (Expaxy)EF_HAND_1 (PS00018)    EF_HAND_2 (PS50222)    S100_CABP (PS00303)   
Domains : Interpro (EBI)EF-hand-dom_pair    EF_Hand_1_Ca_BS    EF_hand_dom    Filaggrin    S-100_dom    S100/CaBP-9k_CS    S100_Ca-bd_sub   
Domain families : Pfam (Sanger)S_100 (PF01023)   
Domain families : Pfam (NCBI)pfam01023   
Domain families : Smart (EMBL)S_100 (SM01394)  
Conserved Domain (NCBI)FLG2
DMDM Disease mutations388698
Blocks (Seattle)FLG2
SuperfamilyQ5D862
Human Protein AtlasENSG00000143520
Peptide AtlasQ5D862
HPRD11815
IPIIPI00397801   
Protein Interaction databases
DIP (DOE-UCLA)Q5D862
IntAct (EBI)Q5D862
FunCoupENSG00000143520
BioGRIDFLG2
STRING (EMBL)FLG2
ZODIACFLG2
Ontologies - Pathways
QuickGOQ5D862
Ontology : AmiGOstructural molecule activity  calcium ion binding  extracellular region  nucleus  cytoplasm  neutrophil degranulation  transition metal ion binding  establishment of skin barrier  extracellular exosome  tertiary granule lumen  
Ontology : EGO-EBIstructural molecule activity  calcium ion binding  extracellular region  nucleus  cytoplasm  neutrophil degranulation  transition metal ion binding  establishment of skin barrier  extracellular exosome  tertiary granule lumen  
NDEx NetworkFLG2
Atlas of Cancer Signalling NetworkFLG2
Wikipedia pathwaysFLG2
Orthology - Evolution
OrthoDB388698
GeneTree (enSembl)ENSG00000143520
Phylogenetic Trees/Animal Genes : TreeFamFLG2
HOVERGENQ5D862
HOGENOMQ5D862
Homologs : HomoloGeneFLG2
Homology/Alignments : Family Browser (UCSC)FLG2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFLG2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FLG2
dbVarFLG2
ClinVarFLG2
1000_GenomesFLG2 
Exome Variant ServerFLG2
ExAC (Exome Aggregation Consortium)FLG2 (select the gene name)
Genetic variants : HAPMAP388698
Genomic Variants (DGV)FLG2 [DGVbeta]
DECIPHERFLG2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFLG2 
Mutations
ICGC Data PortalFLG2 
TCGA Data PortalFLG2 
Broad Tumor PortalFLG2
OASIS PortalFLG2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFLG2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFLG2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FLG2
DgiDB (Drug Gene Interaction Database)FLG2
DoCM (Curated mutations)FLG2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FLG2 (select a term)
intoGenFLG2
Cancer3DFLG2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM616284   
Orphanet
MedgenFLG2
Genetic Testing Registry FLG2
NextProtQ5D862 [Medical]
TSGene388698
GENETestsFLG2
Huge Navigator FLG2 [HugePedia]
snp3D : Map Gene to Disease388698
BioCentury BCIQFLG2
ClinGenFLG2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD388698
Chemical/Pharm GKB GenePA162388694
Clinical trialFLG2
Miscellaneous
canSAR (ICR)FLG2 (select the gene name)
Probes
Litterature
PubMed25 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFLG2
EVEXFLG2
GoPubMedFLG2
iHOPFLG2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 11:12:13 CEST 2017

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